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Items: 1 to 50 of 135

1.

Identification and Heterologous Expression of the Topopyrone Nonaketide Synthase Gene from Phoma sp.

Kashiwa N, Ebizuka Y, Fujii I.

Chem Pharm Bull (Tokyo). 2016;64(7):947-51. doi: 10.1248/cpb.c16-00172.

2.

Recombinant yeast as a functional tool for understanding bitterness and cucurbitacin biosynthesis in watermelon (Citrullus spp.).

Davidovich-Rikanati R, Shalev L, Baranes N, Meir A, Itkin M, Cohen S, Zimbler K, Portnoy V, Ebizuka Y, Shibuya M, Burger Y, Katzir N, Schaffer AA, Lewinsohn E, Tadmor Y.

Yeast. 2015 Jan;32(1):103-14. doi: 10.1002/yea.3049. Epub 2014 Nov 20.

3.

Cyclization of all-E- and 2Z-geranylfarnesols by a bacterial triterpene synthase: insight into sesterterpene biosynthesis in Aleuritopteris ferns.

Shinozaki J, Shibuya M, Ebizuka Y, Masuda K.

Biosci Biotechnol Biochem. 2013;77(11):2278-82. Epub 2013 Nov 7.

4.

Terretonin biosynthesis requires methylation as essential step for cyclization.

Matsuda Y, Awakawa T, Itoh T, Wakimoto T, Kushiro T, Fujii I, Ebizuka Y, Abe I.

Chembiochem. 2012 Aug 13;13(12):1738-41. doi: 10.1002/cbic.201200369. Epub 2012 Jul 10. No abstract available.

PMID:
22782788
5.

Identification of a key prenyltransferase involved in biosynthesis of the most abundant fungal meroterpenoids derived from 3,5-dimethylorsellinic acid.

Itoh T, Tokunaga K, Radhakrishnan EK, Fujii I, Abe I, Ebizuka Y, Kushiro T.

Chembiochem. 2012 May 29;13(8):1132-5. doi: 10.1002/cbic.201200124. Epub 2012 Apr 30.

PMID:
22549923
6.

Benzophenone synthase from Garcinia mangostana L. pericarps.

Nualkaew N, Morita H, Shimokawa Y, Kinjo K, Kushiro T, De-Eknamkul W, Ebizuka Y, Abe I.

Phytochemistry. 2012 May;77:60-9. doi: 10.1016/j.phytochem.2012.02.002. Epub 2012 Mar 3.

PMID:
22390826
7.

Linking genotype and phenotype of Saccharomyces cerevisiae strains reveals metabolic engineering targets and leads to triterpene hyper-producers.

Madsen KM, Udatha GD, Semba S, Otero JM, Koetter P, Nielsen J, Ebizuka Y, Kushiro T, Panagiotou G.

PLoS One. 2011 Mar 18;6(3):e14763. doi: 10.1371/journal.pone.0014763.

8.

Reconstitution of a fungal meroterpenoid biosynthesis reveals the involvement of a novel family of terpene cyclases.

Itoh T, Tokunaga K, Matsuda Y, Fujii I, Abe I, Ebizuka Y, Kushiro T.

Nat Chem. 2010 Oct;2(10):858-64. doi: 10.1038/nchem.764. Epub 2010 Aug 1.

PMID:
20861902
9.

Aspergillus oryzae type III polyketide synthase CsyA is involved in the biosynthesis of 3,5-dihydroxybenzoic acid.

Seshime Y, Juvvadi PR, Kitamoto K, Ebizuka Y, Nonaka T, Fujii I.

Bioorg Med Chem Lett. 2010 Aug 15;20(16):4785-8. doi: 10.1016/j.bmcl.2010.06.119. Epub 2010 Jun 25.

PMID:
20630753
10.

Solanapyrone synthase, a possible Diels-Alderase and iterative type I polyketide synthase encoded in a biosynthetic gene cluster from Alternaria solani.

Kasahara K, Miyamoto T, Fujimoto T, Oguri H, Tokiwano T, Oikawa H, Ebizuka Y, Fujii I.

Chembiochem. 2010 Jun 14;11(9):1245-52. doi: 10.1002/cbic.201000173.

PMID:
20486243
11.

Identification of csypyrone B1 as the novel product of Aspergillus oryzae type III polyketide synthase CsyB.

Seshime Y, Juvvadi PR, Kitamoto K, Ebizuka Y, Fujii I.

Bioorg Med Chem. 2010 Jun 15;18(12):4542-6. doi: 10.1016/j.bmc.2010.04.058. Epub 2010 Apr 27.

PMID:
20471846
12.

Identification and characterization of glycosyltransferases involved in the biosynthesis of soyasaponin I in Glycine max.

Shibuya M, Nishimura K, Yasuyama N, Ebizuka Y.

FEBS Lett. 2010 Jun 3;584(11):2258-64. doi: 10.1016/j.febslet.2010.03.037. Epub 2010 Mar 27.

13.

Hidden function of catalytic domain in 6-methylsalicylic acid synthase for product release.

Moriguchi T, Kezuka Y, Nonaka T, Ebizuka Y, Fujii I.

J Biol Chem. 2010 May 14;285(20):15637-43. doi: 10.1074/jbc.M110.107391. Epub 2010 Mar 19.

14.

Molecular evolution of fern squalene cyclases.

Shinozaki J, Shibuya M, Takahata Y, Masuda K, Ebizuka Y.

Chembiochem. 2010 Feb 15;11(3):426-33. doi: 10.1002/cbic.200900672.

PMID:
20082400
15.

Protostadienol synthase from Aspergillus fumigatus: functional conversion into lanosterol synthase.

Kimura M, Kushiro T, Shibuya M, Ebizuka Y, Abe I.

Biochem Biophys Res Commun. 2010 Jan 1;391(1):899-902. doi: 10.1016/j.bbrc.2009.11.160. Epub 2009 Nov 29.

PMID:
19951700
16.

Cloning and expression of 1-deoxy-d-xylulose 5-phosphate synthase cDNA from Croton stellatopilosus and expression of 2C-methyl-d-erythritol 4-phosphate synthase and geranylgeranyl diphosphate synthase, key enzymes of plaunotol biosynthesis.

Sitthithaworn W, Wungsintaweekul J, Sirisuntipong T, Charoonratana T, Ebizuka Y, De-Eknamkul W.

J Plant Physiol. 2010 Mar 1;167(4):292-300. doi: 10.1016/j.jplph.2009.09.001. Epub 2009 Sep 25.

PMID:
19782428
17.

Biosynthesis of steroidal antibiotic fusidanes: functional analysis of oxidosqualene cyclase and subsequent tailoring enzymes from Aspergillus fumigatus.

Mitsuguchi H, Seshime Y, Fujii I, Shibuya M, Ebizuka Y, Kushiro T.

J Am Chem Soc. 2009 May 13;131(18):6402-11. doi: 10.1021/ja8095976.

PMID:
19415934
18.

Functional expression of the Aspergillus flavus PKS-NRPS hybrid CpaA involved in the biosynthesis of cyclopiazonic acid.

Seshime Y, Juvvadi PR, Tokuoka M, Koyama Y, Kitamoto K, Ebizuka Y, Fujii I.

Bioorg Med Chem Lett. 2009 Jun 15;19(12):3288-92. doi: 10.1016/j.bmcl.2009.04.073. Epub 2009 Apr 22.

PMID:
19410456
19.

Identification of a product specific beta-amyrin synthase from Arabidopsis thaliana.

Shibuya M, Katsube Y, Otsuka M, Zhang H, Tansakul P, Xiang T, Ebizuka Y.

Plant Physiol Biochem. 2009 Jan;47(1):26-30. doi: 10.1016/j.plaphy.2008.09.007. Epub 2008 Oct 7.

PMID:
18977664
20.

Biosynthesis of baccharis oxide, a triterpene with a 3,10-oxide bridge in the A-ring.

Shibuya M, Sagara A, Saitoh A, Kushiro T, Ebizuka Y.

Org Lett. 2008 Nov 6;10(21):5071-4. doi: 10.1021/ol802072y. Epub 2008 Oct 14.

PMID:
18850716
21.

Dammaradiene synthase, a squalene cyclase, from Dryopteris crassirhizoma Nakai.

Shinozaki J, Shibuya M, Masuda K, Ebizuka Y.

Phytochemistry. 2008 Oct;69(14):2559-64. doi: 10.1016/j.phytochem.2008.07.017. Epub 2008 Sep 13.

PMID:
18790509
22.

New biosynthetic step in the melanin pathway of Wangiella (Exophiala) dermatitidis: evidence for 2-acetyl-1,3,6,8-Tetrahydroxynaphthalene as a novel precursor.

Wheeler MH, Abramczyk D, Puckhaber LS, Naruse M, Ebizuka Y, Fujii I, Szaniszlo PJ.

Eukaryot Cell. 2008 Oct;7(10):1699-711. doi: 10.1128/EC.00179-08. Epub 2008 Aug 1.

23.

Domain-domain interactions in the iterative type I polyketide synthase ATX from Aspergillus terreus.

Moriguchi T, Ebizuka Y, Fujii I.

Chembiochem. 2008 May 23;9(8):1207-12. doi: 10.1002/cbic.200700691. No abstract available.

PMID:
18412189
24.

Squalene cyclase and oxidosqualene cyclase from a fern.

Shinozaki J, Shibuya M, Masuda K, Ebizuka Y.

FEBS Lett. 2008 Jan 23;582(2):310-8. Epub 2007 Dec 26.

25.

[Bioorganic chemistry of plant triterpene biosynthesis].

Kushiro T, Ebizuka Y.

Tanpakushitsu Kakusan Koso. 2007 Oct;52(13 Suppl):1730-5. Review. Japanese. No abstract available.

PMID:
18051408
26.

Differential accumulation of hyperforin and secohyperforin in Hypericum perforatum tissue cultures.

Charchoglyan A, Abrahamyan A, Fujii I, Boubakir Z, Gulder TA, Kutchan TM, Vardapetyan H, Bringmann G, Ebizuka Y, Beerhues L.

Phytochemistry. 2007 Nov;68(21):2670-7. Epub 2007 Jul 23.

PMID:
17643455
27.

Actinorhodin biosynthesis: structural requirements for post-PKS tailoring intermediates revealed by functional analysis of ActVI-ORF1 reductase.

Itoh T, Taguchi T, Kimberley MR, Booker-Milburn KI, Stephenson GR, Ebizuka Y, Ichinose K.

Biochemistry. 2007 Jul 10;46(27):8181-8. Epub 2007 Jun 19.

PMID:
17579485
28.

Production of triterpene acids by cell suspension cultures of Olea europaea.

Saimaru H, Orihara Y, Tansakul P, Kang YH, Shibuya M, Ebizuka Y.

Chem Pharm Bull (Tokyo). 2007 May;55(5):784-8.

29.

Origin of structural diversity in natural triterpenes: direct synthesis of seco-triterpene skeletons by oxidosqualene cyclase.

Shibuya M, Xiang T, Katsube Y, Otsuka M, Zhang H, Ebizuka Y.

J Am Chem Soc. 2007 Feb 7;129(5):1450-5.

PMID:
17263431
30.

Possible involvement of ActVI-ORFA in transcriptional regulation of actVI tailoring-step genes for actinorhodin biosynthesis.

Taguchi T, Okamoto S, Lezhava A, Li A, Ochi K, Ebizuka Y, Ichinose K.

FEMS Microbiol Lett. 2007 Apr;269(2):234-9. Epub 2007 Jan 15.

31.

Two new 9,10-seco-cycloartanes from the seeds of Sphaerophysa salsula.

Ma ZJ, Wang N, Fujii I, Ebizuka Y, Li X.

J Asian Nat Prod Res. 2006 Oct-Nov;8(7):657-61.

PMID:
17135053
32.

Stereochemical course in water addition during LUP1-catalyzed triterpene cyclization.

Kushiro T, Hoshino M, Tsutsumi T, Kawai K, Shiro M, Shibuya M, Ebizuka Y.

Org Lett. 2006 Nov 23;8(24):5589-92.

PMID:
17107079
33.

Molecular cloning and functional expression of a multifunctional triterpene synthase cDNA from a mangrove species Kandelia candel (L.) Druce.

Basyuni M, Oku H, Inafuku M, Baba S, Iwasaki H, Oshiro K, Okabe T, Shibuya M, Ebizuka Y.

Phytochemistry. 2006 Dec;67(23):2517-24. Epub 2006 Oct 31.

PMID:
17078982
34.

Analysis of subunit interactions in the iterative type I polyketide synthase ATX from Aspergillus terreus.

Moriguchi T, Ebizuka Y, Fujii I.

Chembiochem. 2006 Dec;7(12):1869-74. No abstract available.

PMID:
17004275
35.

Dammarenediol-II synthase, the first dedicated enzyme for ginsenoside biosynthesis, in Panax ginseng.

Tansakul P, Shibuya M, Kushiro T, Ebizuka Y.

FEBS Lett. 2006 Oct 2;580(22):5143-9. Epub 2006 Sep 1.

36.

A new triterpene synthase from Arabidopsis thaliana produces a tricyclic triterpene with two hydroxyl groups.

Xiang T, Shibuya M, Katsube Y, Tsutsumi T, Otsuka M, Zhang H, Masuda K, Ebizuka Y.

Org Lett. 2006 Jun 22;8(13):2835-8.

PMID:
16774269
37.

Expression of Alternaria solani PKSF generates a set of complex reduced-type polyketides with different carbon-lengths and cyclization.

Kasahara K, Fujii I, Oikawa H, Ebizuka Y.

Chembiochem. 2006 Jun;7(6):920-4. No abstract available.

PMID:
16642517
38.

Lanosterol synthase in dicotyledonous plants.

Suzuki M, Xiang T, Ohyama K, Seki H, Saito K, Muranaka T, Hayashi H, Katsube Y, Kushiro T, Shibuya M, Ebizuka Y.

Plant Cell Physiol. 2006 May;47(5):565-71. Epub 2006 Mar 10.

PMID:
16531458
39.

Identification of beta-amyrin and sophoradiol 24-hydroxylase by expressed sequence tag mining and functional expression assay.

Shibuya M, Hoshino M, Katsube Y, Hayashi H, Kushiro T, Ebizuka Y.

FEBS J. 2006 Mar;273(5):948-59.

40.
41.

Revised structures of epohelmins A and B isolated as lanosterol synthase inhibitors from a fungal strain FKI-0929.

Shibuya M, Snider BB, Sakano Y, Tomoda H, Omura S, Ebizuka Y.

J Antibiot (Tokyo). 2005 Sep;58(9):599-601.

PMID:
16320765
42.

Two O-methyltransferases isolated from flower petals of Rosa chinensis var. spontanea involved in scent biosynthesis.

Wu S, Watanabe N, Mita S, Ueda Y, Shibuya M, Ebizuka Y.

J Biosci Bioeng. 2003;96(2):119-28.

PMID:
16233496
43.

Functional studies on a ketoreductase gene from Streptomyces sp. AM-7161 to control the stereochemistry in medermycin biosynthesis.

Li A, Itoh T, Taguchi T, Xiang T, Ebizuka Y, Ichinose K.

Bioorg Med Chem. 2005 Dec 15;13(24):6856-63. Epub 2005 Sep 19.

PMID:
16169737
44.

Inhibition of human lanosterol synthase by the constituents of Colocasia esculenta (taro).

Sakano Y, Mutsuga M, Tanaka R, Suganuma H, Inakuma T, Toyoda M, Goda Y, Shibuya M, Ebizuka Y.

Biol Pharm Bull. 2005 Feb;28(2):299-304.

45.

Enantioselective reduction of beta-keto acids with engineered Streptomyces coelicolor.

Booker-Milburn KI, Gillan R, Kimberley M, Taguchi T, Ichinose K, Stephenson GR, Ebizuka Y, Hopwood DA.

Angew Chem Int Ed Engl. 2005 Feb 4;44(7):1121-5. No abstract available.

PMID:
15645472
46.

A new lignan from the seeds of Sphaerophysa salsula.

Ma ZJ, Fujii I, Ebizuka Y, Li X.

J Asian Nat Prod Res. 2004 Dec;6(4):265-9.

PMID:
15621585
47.

Cycloartane-type triterpenoids from Sphaerophysa salsula.

Ma ZJ, Li X, Wang JH, Lu Y, Li W, Zheng QT, Wang C, Wang YX, Fujii I, Ebizuka Y.

J Asian Nat Prod Res. 2004 Dec;6(4):259-64.

PMID:
15621584
48.

Synthesis of digalactosyl diacylglycerols and their structure-inhibitory activity on human lanosterol synthase.

Tanaka R, Sakano Y, Nagatsu A, Shibuya M, Ebizuka Y, Goda Y.

Bioorg Med Chem Lett. 2005 Jan 3;15(1):159-62.

PMID:
15582431
49.

Epohelmins A and B, novel lanosterol synthase inhibitors from a fungal strain FKI-0929.

Sakano Y, Shibuya M, Yamaguchi Y, Masuma R, Tomoda H, Omura S, Ebizuka Y.

J Antibiot (Tokyo). 2004 Sep;57(9):564-8.

50.

Remarkably different structures and reaction mechanisms of ketoreductases for the opposite stereochemical control in the biosynthesis of BIQ antibiotics.

Taguchi T, Kunieda K, Takeda-Shitaka M, Takaya D, Kawano N, Kimberley MR, Booker-Milburn KI, Stephenson GR, Umeyama H, Ebizuka Y, Ichinose K.

Bioorg Med Chem. 2004 Nov 15;12(22):5917-27.

PMID:
15498668

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