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The relationship of age with the clinical phenotype in multiple sclerosis.

Scalfari A, Lederer C, Daumer M, Nicholas R, Ebers GC, Muraro PA.

Mult Scler. 2016 Nov;22(13):1750-1758. Epub 2016 Feb 11.


MRI measures should be a primary outcome endpoint in phase III randomized controlled trials in multiple sclerosis: no.

Ebers GC.

Mult Scler. 2014 Mar;20(3):282-3. doi: 10.1177/1352458513518264. No abstract available.


Multiple sclerosis in the Iranian immigrant population of BC, Canada: prevalence and risk factors.

Guimond C, Lee JD, Ramagopalan SV, Dyment DA, Hanwell H, Giovannoni G, Criscuoli M, Yee IM, Vorobeychik G, Ebers GC, Sadovnick AD.

Mult Scler. 2014 Aug;20(9):1182-8. doi: 10.1177/1352458513519179. Epub 2014 Jan 10.


Interactions of environment and genes in multiple sclerosis.

Ebers G.

J Neurol Sci. 2013 Nov 15;334(1-2):161-3. doi: 10.1016/j.jns.2013.08.018. Epub 2013 Aug 19.


Vitamin D receptor ChIP-seq in primary CD4+ cells: relationship to serum 25-hydroxyvitamin D levels and autoimmune disease.

Handel AE, Sandve GK, Disanto G, Berlanga-Taylor AJ, Gallone G, Hanwell H, Drabløs F, Giovannoni G, Ebers GC, Ramagopalan SV.

BMC Med. 2013 Jul 12;11:163. doi: 10.1186/1741-7015-11-163.


Mortality in patients with multiple sclerosis.

Scalfari A, Knappertz V, Cutter G, Goodin DS, Ashton R, Ebers GC.

Neurology. 2013 Jul 9;81(2):184-92. doi: 10.1212/WNL.0b013e31829a3388. Review.


DNA methylation in monozygotic quadruplets affected by type 1 diabetes.

Disanto G, Vcelakova J, Pakpoor J, Elangovan RI, Sumnik Z, Ulmannova T, Ebers GC, Ramagopalan SV, Stechová K.

Diabetologia. 2013 Sep;56(9):2093-5. doi: 10.1007/s00125-013-2972-3. Epub 2013 Jun 23. No abstract available.


Inactive or moderately active human promoters are enriched for inter-individual epialleles.

Gemma C, Ramagopalan SV, Down TA, Beyan H, Hawa MI, Holland ML, Hurd PJ, Giovannoni G, Leslie RD, Ebers GC, Rakyan VK.

Genome Biol. 2013 May 25;14(5):R43. doi: 10.1186/gb-2013-14-5-r43.


TRPV1 gates tissue access and sustains pathogenicity in autoimmune encephalitis.

Paltser G, Liu XJ, Yantha J, Winer S, Tsui H, Wu P, Maezawa Y, Cahill LS, Laliberté CL, Ramagopalan SV, DeLuca GC, Sadovnick AD, Astsaturov I, Ebers GC, Henkelman RM, Salter MW, Dosch HM.

Mol Med. 2013 Jul 24;19:149-59. doi: 10.2119/molmed.2012.00329.


Month of birth and thymic output.

Disanto G, Watson CT, Meier UC, Ebers GC, Giovannoni G, Ramagopalan SV.

JAMA Neurol. 2013 Apr;70(4):527-8. doi: 10.1001/jamaneurol.2013.2116. No abstract available.


Onset of secondary progressive phase and long-term evolution of multiple sclerosis.

Scalfari A, Neuhaus A, Daumer M, Muraro PA, Ebers GC.

J Neurol Neurosurg Psychiatry. 2014 Jan;85(1):67-75. doi: 10.1136/jnnp-2012-304333. Epub 2013 Mar 13.


Association of smoking with risk of multiple sclerosis: a population-based study.

Ramagopalan SV, Lee JD, Yee IM, Guimond C, Traboulsee AL, Ebers GC, Sadovnick AD.

J Neurol. 2013 Jul;260(7):1778-81. doi: 10.1007/s00415-013-6873-7. Epub 2013 Mar 2.


Early relapses, onset of progression, and late outcome in multiple sclerosis.

Scalfari A, Neuhaus A, Daumer M, Deluca GC, Muraro PA, Ebers GC.

JAMA Neurol. 2013 Feb;70(2):214-22. doi: 10.1001/jamaneurol.2013.599.


A web-based tool for personalized prediction of long-term disease course in patients with multiple sclerosis.

Galea I, Lederer C, Neuhaus A, Muraro PA, Scalfari A, Koch-Henriksen N, Heesen C, Koepke S, Stellmann P, Albrecht H, Winkelmann A, Weber F, Bahn E, Hauser M, Edan G, Ebers G, Daumer M.

Eur J Neurol. 2013 Jul;20(7):1107-9. doi: 10.1111/ene.12016. Epub 2012 Dec 7.


Review: the role of vitamin D in nervous system health and disease.

DeLuca GC, Kimball SM, Kolasinski J, Ramagopalan SV, Ebers GC.

Neuropathol Appl Neurobiol. 2013 Aug;39(5):458-84. doi: 10.1111/nan.12020. Review.


Cause of death in MS: long-term follow-up of a randomised cohort, 21 years after the start of the pivotal IFNβ-1b study.

Goodin DS, Ebers GC, Cutter G, Cook SD, O'Donnell T, Reder AT, Kremenchutzky M, Oger J, Rametta M, Beckmann K, Knappertz V.

BMJ Open. 2012 Nov 30;2(6). pii: e001972. doi: 10.1136/bmjopen-2012-001972. Print 2012.


Protein-protein interaction analysis highlights additional loci of interest for multiple sclerosis.

Ragnedda G, Disanto G, Giovannoni G, Ebers GC, Sotgiu S, Ramagopalan SV.

PLoS One. 2012;7(10):e46730. doi: 10.1371/journal.pone.0046730. Epub 2012 Oct 18.


Interferon β for secondary progressive multiple sclerosis: a systematic review.

La Mantia L, Vacchi L, Rovaris M, Di Pietrantonj C, Ebers G, Fredrikson S, Filippini G.

J Neurol Neurosurg Psychiatry. 2013 Apr;84(4):420-6. doi: 10.1136/jnnp-2012-303291. Epub 2012 Sep 5. Review.


Guthrie card methylomics identifies temporally stable epialleles that are present at birth in humans.

Beyan H, Down TA, Ramagopalan SV, Uvebrant K, Nilsson A, Holland ML, Gemma C, Giovannoni G, Boehm BO, Ebers GC, Lernmark Å, Cilio CM, Leslie RD, Rakyan VK.

Genome Res. 2012 Nov;22(11):2138-45. doi: 10.1101/gr.134304.111. Epub 2012 Aug 23.


Robert Whytt, Benjamin Franklin, and the first probable case of multiple sclerosis.

Lincoln MR, Ebers GC.

Ann Neurol. 2012 Sep;72(3):307-11. doi: 10.1002/ana.23605. Epub 2012 Aug 22. No abstract available.


Genetic, environmental and stochastic factors in monozygotic twin discordance with a focus on epigenetic differences.

Czyz W, Morahan JM, Ebers GC, Ramagopalan SV.

BMC Med. 2012 Aug 17;10:93. doi: 10.1186/1741-7015-10-93. Review.


Month of birth, vitamin D and risk of immune-mediated disease: a case control study.

Disanto G, Chaplin G, Morahan JM, Giovannoni G, Hyppönen E, Ebers GC, Ramagopalan SV.

BMC Med. 2012 Jul 6;10:69. doi: 10.1186/1741-7015-10-69.


High reprint orders in medical journals and pharmaceutical industry funding: case-control study.

Handel AE, Patel SV, Pakpoor J, Ebers GC, Goldacre B, Ramagopalan SV.

BMJ. 2012 Jun 28;344:e4212. doi: 10.1136/bmj.e4212.


Exome sequencing identifies a novel multiple sclerosis susceptibility variant in the TYK2 gene.

Dyment DA, Cader MZ, Chao MJ, Lincoln MR, Morrison KM, Disanto G, Morahan JM, De Luca GC, Sadovnick AD, Lepage P, Montpetit A, Ebers GC, Ramagopalan SV.

Neurology. 2012 Jul 31;79(5):406-11. doi: 10.1212/WNL.0b013e3182616fc4. Epub 2012 Jun 27.


Term pregnancies and the clinical characteristics of multiple sclerosis: a population based study.

Ramagopalan S, Yee I, Byrnes J, Guimond C, Ebers G, Sadovnick D.

J Neurol Neurosurg Psychiatry. 2012 Aug;83(8):793-5. doi: 10.1136/jnnp-2012-302848. Epub 2012 May 23.


Vitamin D receptor binding, chromatin states and association with multiple sclerosis.

Disanto G, Sandve GK, Berlanga-Taylor AJ, Ragnedda G, Morahan JM, Watson CT, Giovannoni G, Ebers GC, Ramagopalan SV.

Hum Mol Genet. 2012 Aug 15;21(16):3575-86. doi: 10.1093/hmg/dds189. Epub 2012 May 16.


Combined MRI lesions and relapses as a surrogate for disability in MS.

Ebers GC, Scalfari A, Daumer M, Lederer C.

Neurology. 2012 Apr 24;78(17):1367; author reply 1367. doi: 10.1212/WNL.0b013e318255b4fe. No abstract available.


fMRI and corpus callosum relationships in monozygotic twins discordant for handedness.

Gurd JM, Cowell PE, Lux S, Rezai R, Cherkas L, Ebers GC.

Brain Struct Funct. 2013 Mar;218(2):491-509. doi: 10.1007/s00429-012-0410-9. Epub 2012 Apr 21.


Seasonal distribution of psychiatric births in England.

Disanto G, Morahan JM, Lacey MV, DeLuca GC, Giovannoni G, Ebers GC, Ramagopalan SV.

PLoS One. 2012;7(4):e34866. doi: 10.1371/journal.pone.0034866. Epub 2012 Apr 4.


Survival in MS: a randomized cohort study 21 years after the start of the pivotal IFNβ-1b trial.

Goodin DS, Reder AT, Ebers GC, Cutter G, Kremenchutzky M, Oger J, Langdon D, Rametta M, Beckmann K, DeSimone TM, Knappertz V.

Neurology. 2012 Apr 24;78(17):1315-22. doi: 10.1212/WNL.0b013e3182535cf6. Epub 2012 Apr 11.


Functional analysis of missense variants in the TRESK (KCNK18) K channel.

Andres-Enguix I, Shang L, Stansfeld PJ, Morahan JM, Sansom MS, Lafrenière RG, Roy B, Griffiths LR, Rouleau GA, Ebers GC, Cader ZM, Tucker SJ.

Sci Rep. 2012;2:237. doi: 10.1038/srep00237. Epub 2012 Jan 27.


Interferon beta for secondary progressive multiple sclerosis.

La Mantia L, Vacchi L, Di Pietrantonj C, Ebers G, Rovaris M, Fredrikson S, Filippini G.

Cochrane Database Syst Rev. 2012 Jan 18;1:CD005181. doi: 10.1002/14651858.CD005181.pub3. Review.


Relationship between early clinical characteristics and long term disability outcomes: 16 year cohort study (follow-up) of the pivotal interferon β-1b trial in multiple sclerosis.

Goodin DS, Traboulsee A, Knappertz V, Reder AT, Li D, Langdon D, Wolf C, Beckmann K, Konieczny A, Ebers GC; 16-Year Long Term Follow-up Study Investigators.

J Neurol Neurosurg Psychiatry. 2012 Mar;83(3):282-7. doi: 10.1136/jnnp-2011-301178. Epub 2011 Dec 21.


Genome-wide meta-analysis identifies novel multiple sclerosis susceptibility loci.

Patsopoulos NA; Bayer Pharma MS Genetics Working Group; Steering Committees of Studies Evaluating IFNβ-1b and a CCR1-Antagonist; ANZgene Consortium; GeneMSA; International Multiple Sclerosis Genetics Consortium, Esposito F, Reischl J, Lehr S, Bauer D, Heubach J, Sandbrink R, Pohl C, Edan G, Kappos L, Miller D, Montalbán J, Polman CH, Freedman MS, Hartung HP, Arnason BG, Comi G, Cook S, Filippi M, Goodin DS, Jeffery D, O'Connor P, Ebers GC, Langdon D, Reder AT, Traboulsee A, Zipp F, Schimrigk S, Hillert J, Bahlo M, Booth DR, Broadley S, Brown MA, Browning BL, Browning SR, Butzkueven H, Carroll WM, Chapman C, Foote SJ, Griffiths L, Kermode AG, Kilpatrick TJ, Lechner-Scott J, Marriott M, Mason D, Moscato P, Heard RN, Pender MP, Perreau VM, Perera D, Rubio JP, Scott RJ, Slee M, Stankovich J, Stewart GJ, Taylor BV, Tubridy N, Willoughby E, Wiley J, Matthews P, Boneschi FM, Compston A, Haines J, Hauser SL, McCauley J, Ivinson A, Oksenberg JR, Pericak-Vance M, Sawcer SJ, De Jager PL, Hafler DA, de Bakker PI.

Ann Neurol. 2011 Dec;70(6):897-912. doi: 10.1002/ana.22609. Erratum in: Ann Neurol. 2013 Apr;73(4):561.


Rare variants in the CYP27B1 gene are associated with multiple sclerosis.

Ramagopalan SV, Dyment DA, Cader MZ, Morrison KM, Disanto G, Morahan JM, Berlanga-Taylor AJ, Handel A, De Luca GC, Sadovnick AD, Lepage P, Montpetit A, Ebers GC.

Ann Neurol. 2011 Dec;70(6):881-6. doi: 10.1002/ana.22678.


Relapses do not matter in relation to long-term disability: yes.

Casserly C, Ebers GC.

Mult Scler. 2011 Dec;17(12):1412-4. doi: 10.1177/1352458511427514. No abstract available.


Chromosome 1p36 in migraine with aura: association study of the 5HT(1D) locus.

Thompson MD, Noble-Topham S, Percy ME, Andrade DM, Ebers GC.

Neuroreport. 2012 Jan 4;23(1):45-8. doi: 10.1097/WNR.0b013e32834e5af3.


Determination of the real effect of genes identified in GWAS: the example of IL2RA in multiple sclerosis.

Babron MC, Perdry H, Handel AE, Ramagopalan SV, Damotte V, Fontaine B, Müller-Myhsok B, Ebers GC, Clerget-Darpoux F.

Eur J Hum Genet. 2012 Mar;20(3):321-5. doi: 10.1038/ejhg.2011.197. Epub 2011 Nov 16.


Vitamin D-gene interactions in multiple sclerosis.

Berlanga-Taylor AJ, Disanto G, Ebers GC, Ramagopalan SV.

J Neurol Sci. 2011 Dec 15;311(1-2):32-6. doi: 10.1016/j.jns.2011.08.041. Epub 2011 Oct 13. Review.


Age and disability accumulation in multiple sclerosis.

Scalfari A, Neuhaus A, Daumer M, Ebers GC, Muraro PA.

Neurology. 2011 Sep 27;77(13):1246-52. doi: 10.1212/WNL.0b013e318230a17d. Epub 2011 Sep 14.


HLA B*44: protective effects in MS susceptibility and MRI outcome measures.

Chao MJ, Lincoln MR, Dyment DA, Ramagopalan SV, Ebers GC.

Neurology. 2011 Aug 9;77(6):602; author reply 602-3. doi: 10.1212/WNL.0b013e318219a17e. No abstract available.


Seasonality of admissions with multiple sclerosis in Scotland.

Handel AE, Disanto G, Jarvis L, McLaughlin R, Fries A, Ebers GC, Ramagopalan SV.

Eur J Neurol. 2011 Aug;18(8):1109-11. doi: 10.1111/j.1468-1331.2010.03318.x. Epub 2010 Dec 29.


Vitamin D and multiple sclerosis hospital admissions in Scotland.

Disanto G, Handel AE, Morahan JM, Deluca GC, Kimball SM, Hypponen E, Giovannoni G, Ebers GC, Ramagopalan SV.

QJM. 2011 Nov;104(11):1001-3. doi: 10.1093/qjmed/hcr101. Epub 2011 Jun 29. No abstract available.


Early life child exposure and the risk of multiple sclerosis: a population based study.

Ramagopalan SV, Guimond C, Dyment DA, Yee IM, Ebers GC, Sadovnick AD.

J Neurol Sci. 2011 Aug 15;307(1-2):162-3. doi: 10.1016/j.jns.2011.04.014. Epub 2011 May 23.


Teaching NeuroImages: Headache with pulsatile tinnitus.

Armstrong RJ, Downer J, Evans N, Anslow P, Ebers GC.

Neurology. 2011 Apr 26;76(17):e82. doi: 10.1212/WNL.0b013e3182181067. No abstract available.


Relationship of UV exposure to prevalence of multiple sclerosis in England.

Ramagopalan SV, Handel AE, Giovannoni G, Rutherford Siegel S, Ebers GC, Chaplin G.

Neurology. 2011 Apr 19;76(16):1410-4. doi: 10.1212/WNL.0b013e318216715e. Erratum in: Neurology. 2011 May 17;76(20):1773.


Role of the HLA system in the association between multiple sclerosis and infectious mononucleosis.

Ramagopalan SV, Meier UC, Conacher M, Ebers GC, Giovannoni G, Crawford DH, McAulay KA.

Arch Neurol. 2011 Apr;68(4):469-72. doi: 10.1001/archneurol.2011.48.


Clinical, environmental, and genetic determinants of multiple sclerosis in children with acute demyelination: a prospective national cohort study.

Banwell B, Bar-Or A, Arnold DL, Sadovnick D, Narayanan S, McGowan M, O'Mahony J, Magalhaes S, Hanwell H, Vieth R, Tellier R, Vincent T, Disanto G, Ebers G, Wambera K, Connolly MB, Yager J, Mah JK, Booth F, Sebire G, Callen D, Meaney B, Dilenge ME, Lortie A, Pohl D, Doja A, Venketaswaran S, Levin S, Macdonald EA, Meek D, Wood E, Lowry N, Buckley D, Yim C, Awuku M, Cooper P, Grand'maison F, Baird JB, Bhan V, Marrie RA.

Lancet Neurol. 2011 May;10(5):436-45. doi: 10.1016/S1474-4422(11)70045-X. Epub 2011 Mar 31.


Epigenetic mechanisms in multiple sclerosis and the major histocompatibility complex (MHC).

Burrell AM, Handel AE, Ramagopalan SV, Ebers GC, Morahan JM.

Discov Med. 2011 Mar;11(58):187-96. Review.


Vitamin D metabolic pathway genes and risk of multiple sclerosis in Canadians.

Orton SM, Ramagopalan SV, Para AE, Lincoln MR, Handunnetthi L, Chao MJ, Morahan J, Morrison KM, Sadovnick AD, Ebers GC.

J Neurol Sci. 2011 Jun 15;305(1-2):116-20. doi: 10.1016/j.jns.2011.02.032. Epub 2011 Mar 26.


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