Format
Sort by
Items per page

Send to

Choose Destination

Search results

Items: 1 to 50 of 114

1.

Biological plasticity rescues target activity in CRISPR knock outs.

Smits AH, Ziebell F, Joberty G, Zinn N, Mueller WF, Clauder-Münster S, Eberhard D, Fälth Savitski M, Grandi P, Jakob P, Michon AM, Sun H, Tessmer K, Bürckstümmer T, Bantscheff M, Steinmetz LM, Drewes G, Huber W.

Nat Methods. 2019 Oct 28. doi: 10.1038/s41592-019-0614-5. [Epub ahead of print]

PMID:
31659326
2.

Correction: Dexamethasone Treatment Induces the Reprogramming of Pancreatic Acinar Cells to Hepatocytes and Ductal Cells.

Al-Adsani A, Burke ZD, Eberhard D, Lawrence KL, Shen CN, Rustgi AK, Sakaue H, Mark Farrant J, Tosh D.

PLoS One. 2019 Jul 2;14(7):e0219419. doi: 10.1371/journal.pone.0219419. eCollection 2019.

3.

Mechanosensing by β1 integrin induces angiocrine signals for liver growth and survival.

Lorenz L, Axnick J, Buschmann T, Henning C, Urner S, Fang S, Nurmi H, Eichhorst N, Holtmeier R, Bódis K, Hwang JH, Müssig K, Eberhard D, Stypmann J, Kuss O, Roden M, Alitalo K, Häussinger D, Lammert E.

Nature. 2018 Oct;562(7725):128-132. doi: 10.1038/s41586-018-0522-3. Epub 2018 Sep 26.

PMID:
30258227
4.

Improved Tumor Purity Metrics in Next-generation Sequencing for Clinical Practice: The Integrated Interpretation of Neoplastic Cellularity and Sequencing Results (IINCaSe) Approach.

Patel NM, Jo H, Eberhard DA, Yin X, Hayward MC, Stein MK, Hayes DN, Grilley-Olson JE.

Appl Immunohistochem Mol Morphol. 2019 Nov/Dec;27(10):764-772. doi: 10.1097/PAI.0000000000000684.

PMID:
30102605
5.

Loss of angiopoietin-like 4 (ANGPTL4) in mice with diet-induced obesity uncouples visceral obesity from glucose intolerance partly via the gut microbiota.

Janssen AWF, Katiraei S, Bartosinska B, Eberhard D, Willems van Dijk K, Kersten S.

Diabetologia. 2018 Jun;61(6):1447-1458. doi: 10.1007/s00125-018-4583-5. Epub 2018 Mar 3.

6.

Diagnostic accuracy and prediction increment of markers of epithelial-mesenchymal transition to assess cancer cell detachment from primary tumors.

Busch EL, Don PK, Chu H, Richardson DB, Keku TO, Eberhard DA, Avery CL, Sandler RS.

BMC Cancer. 2018 Jan 16;18(1):82. doi: 10.1186/s12885-017-3964-3.

7.

Enhancing Next-Generation Sequencing-Guided Cancer Care Through Cognitive Computing.

Patel NM, Michelini VV, Snell JM, Balu S, Hoyle AP, Parker JS, Hayward MC, Eberhard DA, Salazar AH, McNeillie P, Xu J, Huettner CS, Koyama T, Utro F, Rhrissorrakrai K, Norel R, Bilal E, Royyuru A, Parida L, Earp HS, Grilley-Olson JE, Hayes DN, Harvey SJ, Sharpless NE, Kim WY.

Oncologist. 2018 Feb;23(2):179-185. doi: 10.1634/theoncologist.2017-0170. Epub 2017 Nov 20.

8.

The Role of the Antioxidant Protein DJ-1 in Type 2 Diabetes Mellitus.

Eberhard D, Lammert E.

Adv Exp Med Biol. 2017;1037:173-186. doi: 10.1007/978-981-10-6583-5_11. Review.

PMID:
29147909
9.

NMDAR antagonists for the treatment of diabetes mellitus-Current status and future directions.

Welters A, Klüppel C, Mrugala J, Wörmeyer L, Meissner T, Mayatepek E, Heiss C, Eberhard D, Lammert E.

Diabetes Obes Metab. 2017 Sep;19 Suppl 1:95-106. doi: 10.1111/dom.13017. Review.

PMID:
28880473
10.

A Phase 2/3 Multicenter, Randomized, Open-Label Study to Compare the Efficacy and Safety of Lenalidomide Versus Investigator's Choice in Patients with Relapsed or Refractory Diffuse Large B-Cell Lymphoma.

Czuczman MS, Trněný M, Davies A, Rule S, Linton KM, Wagner-Johnston N, Gascoyne RD, Slack GW, Brousset P, Eberhard DA, Hernandez-Ilizaliturri FJ, Salles G, Witzig TE, Zinzani PL, Wright GW, Staudt LM, Yang Y, Williams PM, Lih CJ, Russo J, Thakurta A, Hagner P, Fustier P, Song D, Lewis ID.

Clin Cancer Res. 2017 Aug 1;23(15):4127-4137. doi: 10.1158/1078-0432.CCR-16-2818. Epub 2017 Apr 5.

11.

Collaborating to Compete: Blood Profiling Atlas in Cancer (BloodPAC) Consortium.

Grossman RL, Abel B, Angiuoli S, Barrett JC, Bassett D, Bramlett K, Blumenthal GM, Carlsson A, Cortese R, DiGiovanna J, Davis-Dusenbery B, Dittamore R, Eberhard DA, Febbo P, Fitzsimons M, Flamig Z, Godsey J, Goswami J, Gruen A, Ortuño F, Han J, Hayes D, Hicks J, Holloway D, Hovelson D, Johnson J, Juhl H, Kalamegham R, Kamal R, Kang Q, Kelloff GJ, Klozenbuecher M, Kolatkar A, Kuhn P, Langone K, Leary R, Loverso P, Manmathan H, Martin AM, Martini J, Miller D, Mitchell M, Morgan T, Mulpuri R, Nguyen T, Otto G, Pathak A, Peters E, Philip R, Posadas E, Reese D, Reese MG, Robinson D, Dei Rossi A, Sakul H, Schageman J, Singh S, Scher HI, Schmitt K, Silvestro A, Simmons J, Simmons T, Sislow J, Talasaz A, Tang P, Tewari M, Tomlins S, Toukhy H, Tseng HR, Tuck M, Tzou A, Vinson J, Wang Y, Wells W, Welsh A, Wilbanks J, Wolf J, Young L, Lee J, Leiman LC.

Clin Pharmacol Ther. 2017 May;101(5):589-592. doi: 10.1002/cpt.666. Epub 2017 Apr 12. Review.

12.

The biomechanical properties of an epithelial tissue determine the location of its vasculature.

Kragl M, Schubert R, Karsjens H, Otter S, Bartosinska B, Jeruschke K, Weiss J, Chen C, Alsteens D, Kuss O, Speier S, Eberhard D, Müller DJ, Lammert E.

Nat Commun. 2016 Dec 20;7:13560. doi: 10.1038/ncomms13560.

13.

The molecular basis of breast cancer pathological phenotypes.

Heng YJ, Lester SC, Tse GM, Factor RE, Allison KH, Collins LC, Chen YY, Jensen KC, Johnson NB, Jeong JC, Punjabi R, Shin SJ, Singh K, Krings G, Eberhard DA, Tan PH, Korski K, Waldman FM, Gutman DA, Sanders M, Reis-Filho JS, Flanagan SR, Gendoo DM, Chen GM, Haibe-Kains B, Ciriello G, Hoadley KA, Perou CM, Beck AH.

J Pathol. 2017 Feb;241(3):375-391. doi: 10.1002/path.4847. Epub 2016 Dec 29.

14.

Interrogating the Druggability of the 2-Oxoglutarate-Dependent Dioxygenase Target Class by Chemical Proteomics.

Joberty G, Boesche M, Brown JA, Eberhard D, Garton NS, Humphreys PG, Mathieson T, Muelbaier M, Ramsden NG, Reader V, Rueger A, Sheppard RJ, Westaway SM, Bantscheff M, Lee K, Wilson DM, Prinjha RK, Drewes G.

ACS Chem Biol. 2016 Jul 15;11(7):2002-10. doi: 10.1021/acschembio.6b00080. Epub 2016 May 19.

PMID:
27197014
15.

Thermal proteome profiling monitors ligand interactions with cellular membrane proteins.

Reinhard FB, Eberhard D, Werner T, Franken H, Childs D, Doce C, Savitski MF, Huber W, Bantscheff M, Savitski MM, Drewes G.

Nat Methods. 2015 Dec;12(12):1129-31. doi: 10.1038/nmeth.3652. Epub 2015 Nov 2.

PMID:
26524241
16.

Evaluating markers of epithelial-mesenchymal transition to identify cancer patients at risk for metastatic disease.

Busch EL, Keku TO, Richardson DB, Cohen SM, Eberhard DA, Avery CL, Sandler RS.

Clin Exp Metastasis. 2016 Jan;33(1):53-62. doi: 10.1007/s10585-015-9757-7. Epub 2015 Oct 27.

17.

DJ-1 Protects Pancreatic Beta Cells from Cytokine- and Streptozotocin-Mediated Cell Death.

Jain D, Weber G, Eberhard D, Mehana AE, Eglinger J, Welters A, Bartosinska B, Jeruschke K, Weiss J, Päth G, Ariga H, Seufert J, Lammert E.

PLoS One. 2015 Sep 30;10(9):e0138535. doi: 10.1371/journal.pone.0138535. eCollection 2015.

18.

Identification of Human Papillomavirus Infection in Cancer Tissue by Targeted Next-generation Sequencing.

Montgomery ND, Parker JS, Eberhard DA, Patel NM, Weck KE, Sharpless NE, Hu Z, Hayes DN, Gulley ML.

Appl Immunohistochem Mol Morphol. 2016 Aug;24(7):490-5. doi: 10.1097/PAI.0000000000000215.

19.

Combined Targeted DNA Sequencing in Non-Small Cell Lung Cancer (NSCLC) Using UNCseq and NGScopy, and RNA Sequencing Using UNCqeR for the Detection of Genetic Aberrations in NSCLC.

Zhao X, Wang A, Walter V, Patel NM, Eberhard DA, Hayward MC, Salazar AH, Jo H, Soloway MG, Wilkerson MD, Parker JS, Yin X, Zhang G, Siegel MB, Rosson GB, Earp HS 3rd, Sharpless NE, Gulley ML, Weck KE, Hayes DN, Moschos SJ.

PLoS One. 2015 Jun 15;10(6):e0129280. doi: 10.1371/journal.pone.0129280. eCollection 2015.

20.

Characterization of pancreatic NMDA receptors as possible drug targets for diabetes treatment.

Marquard J, Otter S, Welters A, Stirban A, Fischer A, Eglinger J, Herebian D, Kletke O, Klemen MS, Stožer A, Wnendt S, Piemonti L, Köhler M, Ferrer J, Thorens B, Schliess F, Rupnik MS, Heise T, Berggren PO, Klöcker N, Meissner T, Mayatepek E, Eberhard D, Kragl M, Lammert E.

Nat Med. 2015 Apr;21(4):363-72. doi: 10.1038/nm.3822. Epub 2015 Mar 16.

PMID:
25774850
21.

Inhibition of PAD4 activity is sufficient to disrupt mouse and human NET formation.

Lewis HD, Liddle J, Coote JE, Atkinson SJ, Barker MD, Bax BD, Bicker KL, Bingham RP, Campbell M, Chen YH, Chung CW, Craggs PD, Davis RP, Eberhard D, Joberty G, Lind KE, Locke K, Maller C, Martinod K, Patten C, Polyakova O, Rise CE, Rüdiger M, Sheppard RJ, Slade DJ, Thomas P, Thorpe J, Yao G, Drewes G, Wagner DD, Thompson PR, Prinjha RK, Wilson DM.

Nat Chem Biol. 2015 Mar;11(3):189-91. doi: 10.1038/nchembio.1735. Epub 2015 Jan 26.

22.

Kruidenier et al. reply.

Kruidenier L, Chung CW, Cheng Z, Liddle J, Che K, Joberty G, Bantscheff M, Bountra C, Bridges A, Diallo H, Eberhard D, Hutchinson S, Jones E, Katso R, Leveridge M, Mander PK, Mosley J, Ramirez-Molina C, Rowland P, Schofield CJ, Sheppard RJ, Smith JE, Swales C, Tanner R, Thomas P, Tumber A, Drewes G, Oppermann U, Patel DJ, Lee K, Wilson DM.

Nature. 2014 Oct 2;514(7520):E2. doi: 10.1038/nature13689. No abstract available.

PMID:
25279927
23.

Tracking cancer drugs in living cells by thermal profiling of the proteome.

Savitski MM, Reinhard FB, Franken H, Werner T, Savitski MF, Eberhard D, Martinez Molina D, Jafari R, Dovega RB, Klaeger S, Kuster B, Nordlund P, Bantscheff M, Drewes G.

Science. 2014 Oct 3;346(6205):1255784. doi: 10.1126/science.1255784. Epub 2014 Oct 2.

24.

Hepatocyte-ductal transdifferentiation is mediated by reciprocal repression of SOX9 and C/EBPα.

O'Neill KE, Thowfeequ S, Li WC, Eberhard D, Dutton JR, Tosh D, Slack JM.

Cell Reprogram. 2014 Oct;16(5):314-23. doi: 10.1089/cell.2014.0032. Epub 2014 Aug 25.

25.

FTO is a relevant factor for the development of the metabolic syndrome in mice.

Ikels K, Kuschel S, Fischer J, Kaisers W, Eberhard D, Rüther U.

PLoS One. 2014 Aug 21;9(8):e105349. doi: 10.1371/journal.pone.0105349. eCollection 2014.

26.

Targeted next generation sequencing identifies clinically actionable mutations in patients with melanoma.

Jeck WR, Parker J, Carson CC, Shields JM, Sambade MJ, Peters EC, Burd CE, Thomas NE, Chiang DY, Liu W, Eberhard DA, Ollila D, Grilley-Olson J, Moschos S, Neil Hayes D, Sharpless NE.

Pigment Cell Melanoma Res. 2014 Jul;27(4):653-63. doi: 10.1111/pcmr.12238. Epub 2014 Apr 7.

27.

Reprogramming of various cell types to a beta-like state by Pdx1, Ngn3 and MafA.

Akinci E, Banga A, Tungatt K, Segal J, Eberhard D, Dutton JR, Slack JM.

PLoS One. 2013 Nov 29;8(11):e82424. doi: 10.1371/journal.pone.0082424. eCollection 2013.

28.

Criteria for the use of omics-based predictors in clinical trials: explanation and elaboration.

McShane LM, Cavenagh MM, Lively TG, Eberhard DA, Bigbee WL, Williams PM, Mesirov JP, Polley MY, Kim KY, Tricoli JV, Taylor JM, Shuman DJ, Simon RM, Doroshow JH, Conley BA.

BMC Med. 2013 Oct 17;11:220. doi: 10.1186/1741-7015-11-220.

29.

Criteria for the use of omics-based predictors in clinical trials.

McShane LM, Cavenagh MM, Lively TG, Eberhard DA, Bigbee WL, Williams PM, Mesirov JP, Polley MY, Kim KY, Tricoli JV, Taylor JM, Shuman DJ, Simon RM, Doroshow JH, Conley BA.

Nature. 2013 Oct 17;502(7471):317-20. doi: 10.1038/nature12564.

30.

Neuron and beta-cell evolution: learning about neurons is learning about beta-cells.

Eberhard D.

Bioessays. 2013 Jul;35(7):584. doi: 10.1002/bies.201300035. Epub 2013 Apr 11. No abstract available.

PMID:
23575922
31.

Deletion of CD73 promotes dyslipidemia and intramyocellular lipid accumulation in muscle of mice.

Burghoff S, Flögel U, Bongardt S, Burkart V, Sell H, Tucci S, Ikels K, Eberhard D, Kern M, Klöting N, Eckel J, Schrader J.

Arch Physiol Biochem. 2013 May;119(2):39-51. doi: 10.3109/13813455.2012.755547. Epub 2013 Feb 11.

PMID:
23398498
32.

Chemical proteomic analysis reveals the drugability of the kinome of Trypanosoma brucei.

Urbaniak MD, Mathieson T, Bantscheff M, Eberhard D, Grimaldi R, Miranda-Saavedra D, Wyatt P, Ferguson MA, Frearson J, Drewes G.

ACS Chem Biol. 2012 Nov 16;7(11):1858-65. doi: 10.1021/cb300326z. Epub 2012 Aug 23.

33.

A selective jumonji H3K27 demethylase inhibitor modulates the proinflammatory macrophage response.

Kruidenier L, Chung CW, Cheng Z, Liddle J, Che K, Joberty G, Bantscheff M, Bountra C, Bridges A, Diallo H, Eberhard D, Hutchinson S, Jones E, Katso R, Leveridge M, Mander PK, Mosley J, Ramirez-Molina C, Rowland P, Schofield CJ, Sheppard RJ, Smith JE, Swales C, Tanner R, Thomas P, Tumber A, Drewes G, Oppermann U, Patel DJ, Lee K, Wilson DM.

Nature. 2012 Aug 16;488(7411):404-8. doi: 10.1038/nature11262.

34.

Tissue pattern recognition error rates and tumor heterogeneity in gastric cancer.

Potts SJ, Huff SE, Lange H, Zakharov V, Eberhard DA, Krueger JS, Hicks DG, Young GD, Johnson T, Whitney-Miller CL.

Appl Immunohistochem Mol Morphol. 2013 Jan;21(1):21-30. doi: 10.1097/PAI.0b013e31825552a3.

PMID:
22820657
35.

Evaluating tumor heterogeneity in immunohistochemistry-stained breast cancer tissue.

Potts SJ, Krueger JS, Landis ND, Eberhard DA, Young GD, Schmechel SC, Lange H.

Lab Invest. 2012 Sep;92(9):1342-57. doi: 10.1038/labinvest.2012.91. Epub 2012 Jul 16.

36.

Age- and diet-dependent requirement of DJ-1 for glucose homeostasis in mice with implications for human type 2 diabetes.

Jain D, Jain R, Eberhard D, Eglinger J, Bugliani M, Piemonti L, Marchetti P, Lammert E.

J Mol Cell Biol. 2012 Aug;4(4):221-30. doi: 10.1093/jmcb/mjs025. Epub 2012 May 19.

PMID:
22611253
37.

Determination of kinase inhibitor potencies in cell extracts by competition binding assays and isobaric mass tags.

Hopf C, Eberhard D, Boesche M, Bastuck S, Dümpelfeld B, Bantscheff M.

Methods Mol Biol. 2012;803:141-55. doi: 10.1007/978-1-61779-364-6_10.

PMID:
22065223
38.

Chemoproteomics profiling of HDAC inhibitors reveals selective targeting of HDAC complexes.

Bantscheff M, Hopf C, Savitski MM, Dittmann A, Grandi P, Michon AM, Schlegl J, Abraham Y, Becher I, Bergamini G, Boesche M, Delling M, Dümpelfeld B, Eberhard D, Huthmacher C, Mathieson T, Poeckel D, Reader V, Strunk K, Sweetman G, Kruse U, Neubauer G, Ramsden NG, Drewes G.

Nat Biotechnol. 2011 Mar;29(3):255-65. doi: 10.1038/nbt.1759. Epub 2011 Jan 23.

PMID:
21258344
39.

Dexamethasone treatment induces the reprogramming of pancreatic acinar cells to hepatocytes and ductal cells.

Al-Adsani A, Burke ZD, Eberhard D, Lawrence KL, Shen CN, Rustgi AK, Sakaue H, Farrant JM, Tosh D.

PLoS One. 2010 Oct 27;5(10):e13650. doi: 10.1371/journal.pone.0013650. Erratum in: PLoS One. 2019 Jul 2;14(7):e0219419.

40.

Chemoproteomics-based kinome profiling and target deconvolution of clinical multi-kinase inhibitors in primary chronic lymphocytic leukemia cells.

Kruse U, Pallasch CP, Bantscheff M, Eberhard D, Frenzel L, Ghidelli S, Maier SK, Werner T, Wendtner CM, Drewes G.

Leukemia. 2011 Jan;25(1):89-100. doi: 10.1038/leu.2010.233. Epub 2010 Oct 14.

PMID:
20944678
41.

Clonal and territorial development of the pancreas as revealed by eGFP-labelled mouse chimeras.

Eberhard D, Jockusch H.

Cell Tissue Res. 2010 Oct;342(1):31-8. doi: 10.1007/s00441-010-1028-y. Epub 2010 Aug 29.

PMID:
20803297
42.

Diverse somatic mutation patterns and pathway alterations in human cancers.

Kan Z, Jaiswal BS, Stinson J, Janakiraman V, Bhatt D, Stern HM, Yue P, Haverty PM, Bourgon R, Zheng J, Moorhead M, Chaudhuri S, Tomsho LP, Peters BA, Pujara K, Cordes S, Davis DP, Carlton VE, Yuan W, Li L, Wang W, Eigenbrot C, Kaminker JS, Eberhard DA, Waring P, Schuster SC, Modrusan Z, Zhang Z, Stokoe D, de Sauvage FJ, Faham M, Seshagiri S.

Nature. 2010 Aug 12;466(7308):869-73. doi: 10.1038/nature09208. Epub 2010 Jul 28.

PMID:
20668451
43.

'Giving and taking': endothelial and beta-cells in the islets of Langerhans.

Eberhard D, Kragl M, Lammert E.

Trends Endocrinol Metab. 2010 Aug;21(8):457-63. doi: 10.1016/j.tem.2010.03.003. Epub 2010 Mar 31. Review.

PMID:
20359908
44.

In vitro reprogramming of pancreatic cells to hepatocytes.

Eberhard D, O'Neill K, Burke ZD, Tosh D.

Methods Mol Biol. 2010;636:285-92. doi: 10.1007/978-1-60761-691-7_17.

PMID:
20336529
45.

EGFR fluorescence in situ hybridisation assay: guidelines for application to non-small-cell lung cancer.

Varella-Garcia M, Diebold J, Eberhard DA, Geenen K, Hirschmann A, Kockx M, Nagelmeier I, Rüschoff J, Schmitt M, Arbogast S, Cappuzzo F.

J Clin Pathol. 2009 Nov;62(11):970-7. doi: 10.1136/jcp.2009.066548.

46.

The pancreatic beta-cell in the islet and organ community.

Eberhard D, Lammert E.

Curr Opin Genet Dev. 2009 Oct;19(5):469-75. doi: 10.1016/j.gde.2009.07.003. Epub 2009 Aug 25. Review.

PMID:
19713099
47.

A tumor sorting protocol that enables enrichment of pancreatic adenocarcinoma cells and facilitation of genetic analyses.

Boyd ZS, Raja R, Johnson S, Eberhard DA, Lackner MR.

J Mol Diagn. 2009 Jul;11(4):290-7. doi: 10.2353/jmoldx.2009.080124. Epub 2009 May 21.

48.

The western corn rootworm (Diabrotica virgifera virgifera) and its first appearance in Germany 2007.

Hummel HE, Deuker A, Eberhard D, Glas M, Leithold G.

Commun Agric Appl Biol Sci. 2008;73(3):481-91.

PMID:
19226788
49.

Origin of pancreatic endocrine cells from biliary duct epithelium.

Eberhard D, Tosh D, Slack JM.

Cell Mol Life Sci. 2008 Nov;65(21):3467-80. doi: 10.1007/s00018-008-8427-1.

PMID:
18810318
50.

Origin of beta-cells in regenerating pancreas.

O'Neill KE, Eberhard D, Tosh D.

Bioessays. 2008 Jul;30(7):617-20. doi: 10.1002/bies.20779.

PMID:
18536025

Supplemental Content

Loading ...
Support Center