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Response to Comment on "PP2A inhibition sensitizes cancer stem cells to ABL tyrosine kinase inhibitors in BCR-ABL+ human leukemia".

Lai D, Chen M, Su J, Liu X, Rothe K, Hu K, Forrest DL, Eaves CJ, Morin GB, Jiang X.

Sci Transl Med. 2019 Jul 17;11(501). pii: eaav0819. doi: 10.1126/scitranslmed.aav0819.


Transcriptional regulation of normal human mammary cell heterogeneity and its perturbation in breast cancer.

Pellacani D, Tan S, Lefort S, Eaves CJ.

EMBO J. 2019 Jul 15;38(14):e100330. doi: 10.15252/embj.2018100330. Epub 2019 Jan 11. Review.


Synthetic modeling reveals HOXB genes are critical for the initiation and maintenance of human leukemia.

Kusakabe M, Sun AC, Tyshchenko K, Wong R, Nanda A, Shanna C, Gusscott S, Chavez EA, Lorzadeh A, Zhu A, Hill A, Hung S, Brown S, Babaian A, Wang X, Holt RA, Steidl C, Karsan A, Humphries RK, Eaves CJ, Hirst M, Weng AP.

Nat Commun. 2019 Jul 2;10(1):2913. doi: 10.1038/s41467-019-10510-8.


Transcriptional regulation of normal human mammary cell heterogeneity and its perturbation in breast cancer.

Pellacani D, Tan S, Lefort S, Eaves CJ.

EMBO J. 2019 Jan 11. pii: e100330. doi: 10.15252/embj.2018100330. [Epub ahead of print] Review.


A topological view of human CD34+ cell state trajectories from integrated single-cell output and proteomic data.

Knapp DJHF, Hammond CA, Wang F, Aghaeepour N, Miller PH, Beer PA, Pellacani D, VanInsberghe M, Hansen C, Bendall SC, Nolan GP, Eaves CJ.

Blood. 2019 Feb 28;133(9):927-939. doi: 10.1182/blood-2018-10-878025. Epub 2019 Jan 8.


Clonal Analysis of Mouse Mammary Luminal Epithelial Cell Transplants.

Nguyen LV, Makarem M, Kannan N, Carles A, Balani S, Moksa M, Hirst M, Eaves CJ.

Stem Cells Dev. 2019 Mar 1;28(5):353-355. doi: 10.1089/scd.2018.0158. Epub 2019 Jan 31. No abstract available.


A Prospective Analysis of Human Leukemogenesis.

Eaves CJ.

Stem Cell Reports. 2018 Nov 13;11(5):1034-1039. doi: 10.1016/j.stemcr.2018.10.016. Review.


Phenotype-independent DNA methylation changes in prostate cancer.

Pellacani D, Droop AP, Frame FM, Simms MS, Mann VM, Collins AT, Eaves CJ, Maitland NJ.

Br J Cancer. 2018 Oct;119(9):1133-1143. doi: 10.1038/s41416-018-0236-1. Epub 2018 Oct 15.


Epigenetic Restoration of Fetal-like IGF1 Signaling Inhibits Leukemia Stem Cell Activity.

Giambra V, Gusscott S, Gracias D, Song R, Lam SH, Panelli P, Tyshchenko K, Jenkins CE, Hoofd C, Lorzadeh A, Carles A, Hirst M, Eaves CJ, Weng AP.

Cell Stem Cell. 2018 Nov 1;23(5):714-726.e7. doi: 10.1016/j.stem.2018.08.018. Epub 2018 Sep 27.


High-Resolution Single-Cell DNA Methylation Measurements Reveal Epigenetically Distinct Hematopoietic Stem Cell Subpopulations.

Hui T, Cao Q, Wegrzyn-Woltosz J, O'Neill K, Hammond CA, Knapp DJHF, Laks E, Moksa M, Aparicio S, Eaves CJ, Karsan A, Hirst M.

Stem Cell Reports. 2018 Aug 14;11(2):578-592. doi: 10.1016/j.stemcr.2018.07.003. Epub 2018 Aug 2.


Macrophages stimulate mammary stem cells.

Kannan N, Eaves CJ.

Science. 2018 Jun 29;360(6396):1401-1402. doi: 10.1126/science.aau1394. No abstract available.


Basal-like Breast Cancers: From Pathology to Biology and Back Again.

Gusterson B, Eaves CJ.

Stem Cell Reports. 2018 Jun 5;10(6):1676-1686. doi: 10.1016/j.stemcr.2018.04.023. Review.


GateFinder: projection-based gating strategy optimization for flow and mass cytometry.

Aghaeepour N, Simonds EF, Knapp DJHF, Bruggner RV, Sachs K, Culos A, Gherardini PF, Samusik N, Fragiadakis GK, Bendall SC, Gaudilliere B, Angst MS, Eaves CJ, Weiss WA, Fantl WJ, Nolan GP.

Bioinformatics. 2018 Dec 1;34(23):4131-4133. doi: 10.1093/bioinformatics/bty430.


Single-cell analysis identifies a CD33+ subset of human cord blood cells with high regenerative potential.

Knapp DJHF, Hammond CA, Hui T, van Loenhout MTJ, Wang F, Aghaeepour N, Miller PH, Moksa M, Rabu GM, Beer PA, Pellacani D, Humphries RK, Hansen C, Hirst M, Eaves CJ.

Nat Cell Biol. 2018 Jun;20(6):710-720. doi: 10.1038/s41556-018-0104-5. Epub 2018 May 25.


Plerixafor effectively mobilizes CD56bright NK cells in blood, providing an allograft predicted to protect against GVHD.

Wong PPC, Kariminia A, Jones D, Eaves CJ, Foley R, Ivison S, Couban S, Schultz KR.

Blood. 2018 Jun 21;131(25):2863-2866. doi: 10.1182/blood-2018-03-836700. Epub 2018 May 4. No abstract available.


PP2A inhibition sensitizes cancer stem cells to ABL tyrosine kinase inhibitors in BCR-ABL+ human leukemia.

Lai D, Chen M, Su J, Liu X, Rothe K, Hu K, Forrest DL, Eaves CJ, Morin GB, Jiang X.

Sci Transl Med. 2018 Feb 7;10(427). pii: eaan8735. doi: 10.1126/scitranslmed.aan8735.


Breast Cancers Activate Stromal Fibroblast-Induced Suppression of Progenitors in Adjacent Normal Tissue.

Chatterjee S, Basak P, Buchel E, Safneck J, Murphy LC, Mowat M, Kung SK, Eirew P, Eaves CJ, Raouf A.

Stem Cell Reports. 2018 Jan 9;10(1):196-211. doi: 10.1016/j.stemcr.2017.11.002. Epub 2017 Dec 7.


Mass Cytometric Analysis Reveals Viable Activated Caspase-3+ Luminal Progenitors in the Normal Adult Human Mammary Gland.

Knapp DJHF, Kannan N, Pellacani D, Eaves CJ.

Cell Rep. 2017 Oct 24;21(4):1116-1126. doi: 10.1016/j.celrep.2017.09.096.


Fate mapping of human glioblastoma reveals an invariant stem cell hierarchy.

Lan X, Jörg DJ, Cavalli FMG, Richards LM, Nguyen LV, Vanner RJ, Guilhamon P, Lee L, Kushida MM, Pellacani D, Park NI, Coutinho FJ, Whetstone H, Selvadurai HJ, Che C, Luu B, Carles A, Moksa M, Rastegar N, Head R, Dolma S, Prinos P, Cusimano MD, Das S, Bernstein M, Arrowsmith CH, Mungall AJ, Moore RA, Ma Y, Gallo M, Lupien M, Pugh TJ, Taylor MD, Hirst M, Eaves CJ, Simons BD, Dirks PB.

Nature. 2017 Sep 14;549(7671):227-232. doi: 10.1038/nature23666. Epub 2017 Aug 30.


Whole-genome analysis reveals unexpected dynamics of mutant subclone development in a patient with JAK2-V617F-positive chronic myeloid leukemia.

Sloma I, Mitjavila-Garcia MT, Feraud O, Griscelli F, Oudrhiri N, El Marsafy S, Gobbo E, Divers D, Proust A, Smadja DM, Desterke C, Carles A, Ma Y, Hirst M, Marra MA, Eaves CJ, Bennaceur-Griscelli A, Turhan AG.

Exp Hematol. 2017 Sep;53:48-58. doi: 10.1016/j.exphem.2017.05.007. Epub 2017 Jun 8.


Modeling the process of human tumorigenesis.

Balani S, Nguyen LV, Eaves CJ.

Nat Commun. 2017 May 25;8:15422. doi: 10.1038/ncomms15422. Review. No abstract available.


Stability of patient-specific features of altered DNA replication timing in xenografts of primary human acute lymphoblastic leukemia.

Sasaki T, Rivera-Mulia JC, Vera D, Zimmerman J, Das S, Padget M, Nakamichi N, Chang BH, Tyner J, Druker BJ, Weng AP, Civin CI, Eaves CJ, Gilbert DM.

Exp Hematol. 2017 Jul;51:71-82.e3. doi: 10.1016/j.exphem.2017.04.004. Epub 2017 Apr 19.


BRCA1 controls the cell division axis and governs ploidy and phenotype in human mammary cells.

He Z, Kannan N, Nemirovsky O, Chen H, Connell M, Taylor B, Jiang J, Pilarski LM, Fleisch MC, Niederacher D, Pujana MA, Eaves CJ, Maxwell CA.

Oncotarget. 2017 May 16;8(20):32461-32475. doi: 10.18632/oncotarget.15688.


Analysis of parameters that affect human hematopoietic cell outputs in mutant c-kit-immunodeficient mice.

Miller PH, Rabu G, MacAldaz M, Knapp DJ, Cheung AM, Dhillon K, Nakamichi N, Beer PA, Shultz LD, Humphries RK, Eaves CJ.

Exp Hematol. 2017 Apr;48:41-49. doi: 10.1016/j.exphem.2016.12.012. Epub 2017 Jan 11.


Dissociation of Survival, Proliferation, and State Control in Human Hematopoietic Stem Cells.

Knapp DJ, Hammond CA, Miller PH, Rabu GM, Beer PA, Ricicova M, Lecault V, Da Costa D, VanInsberghe M, Cheung AM, Pellacani D, Piret J, Hansen C, Eaves CJ.

Stem Cell Reports. 2017 Jan 10;8(1):152-162. doi: 10.1016/j.stemcr.2016.12.003.


Nucleosome Density ChIP-Seq Identifies Distinct Chromatin Modification Signatures Associated with MNase Accessibility.

Lorzadeh A, Bilenky M, Hammond C, Knapp DJHF, Li L, Miller PH, Carles A, Heravi-Moussavi A, Gakkhar S, Moksa M, Eaves CJ, Hirst M.

Cell Rep. 2016 Nov 15;17(8):2112-2124. doi: 10.1016/j.celrep.2016.10.055.


Analysis of Normal Human Mammary Epigenomes Reveals Cell-Specific Active Enhancer States and Associated Transcription Factor Networks.

Pellacani D, Bilenky M, Kannan N, Heravi-Moussavi A, Knapp DJHF, Gakkhar S, Moksa M, Carles A, Moore R, Mungall AJ, Marra MA, Jones SJM, Aparicio S, Hirst M, Eaves CJ.

Cell Rep. 2016 Nov 15;17(8):2060-2074. doi: 10.1016/j.celrep.2016.10.058.


Distinct signaling programs control human hematopoietic stem cell survival and proliferation.

Knapp DJ, Hammond CA, Aghaeepour N, Miller PH, Pellacani D, Beer PA, Sachs K, Qiao W, Wang W, Humphries RK, Sauvageau G, Zandstra PW, Bendall SC, Nolan GP, Hansen C, Eaves CJ.

Blood. 2017 Jan 19;129(3):307-318. doi: 10.1182/blood-2016-09-740654. Epub 2016 Nov 8.


Hematopoietic Stem Cells Are the Major Source of Multilineage Hematopoiesis in Adult Animals.

Sawai CM, Babovic S, Upadhaya S, Knapp DJHF, Lavin Y, Lau CM, Goloborodko A, Feng J, Fujisaki J, Ding L, Mirny LA, Merad M, Eaves CJ, Reizis B.

Immunity. 2016 Sep 20;45(3):597-609. doi: 10.1016/j.immuni.2016.08.007. Epub 2016 Aug 30.


Isolation and Assessment of Single Long-Term Reconstituting Hematopoietic Stem Cells from Adult Mouse Bone Marrow.

Kent DG, Dykstra BJ, Eaves CJ.

Curr Protoc Stem Cell Biol. 2016 Aug 17;38:2A.4.1-2A.4.24. doi: 10.1002/cpsc.10.


Quantitation of Human Cells that Produce Neutrophils and Platelets in Vivo Obtained from Normal Donors Treated with Granulocyte Colony-Stimulating Factor and/or Plerixafor.

Miller PH, Nakamichi N, Knapp DJHF, Rabu G, Schultz KR, Jones DM, Couban S, Eaves CJ.

Biol Blood Marrow Transplant. 2016 Nov;22(11):1945-1952. doi: 10.1016/j.bbmt.2016.07.023. Epub 2016 Aug 2.


Early production of human neutrophils and platelets posttransplant is severely compromised by growth factor exposure.

Miller PH, Knapp DJ, Beer PA, MacAldaz M, Rabu G, Cheung AM, Wei L, Eaves CJ.

Exp Hematol. 2016 Jul;44(7):635-40. doi: 10.1016/j.exphem.2016.04.003. Epub 2016 Apr 16.


Barcoding reveals complex clonal dynamics of de novo transformed human mammary cells.

Nguyen LV, Pellacani D, Lefort S, Kannan N, Osako T, Makarem M, Cox CL, Kennedy W, Beer P, Carles A, Moksa M, Bilenky M, Balani S, Babovic S, Sun I, Rosin M, Aparicio S, Hirst M, Eaves CJ.

Nature. 2015 Dec 10;528(7581):267-71. doi: 10.1038/nature15742. Epub 2015 Dec 2.


Characterization of Epithelial Progenitors in Normal Human Palatine Tonsils and Their HPV16 E6/E7-Induced Perturbation.

Kang SYC, Kannan N, Zhang L, Martinez V, Rosin MP, Eaves CJ.

Stem Cell Reports. 2015 Dec 8;5(6):1210-1225. doi: 10.1016/j.stemcr.2015.09.020. Epub 2015 Oct 29.


Modeling Normal and Disordered Human Hematopoiesis.

Beer PA, Eaves CJ.

Trends Cancer. 2015 Nov;1(3):199-210. doi: 10.1016/j.trecan.2015.09.002. Epub 2015 Oct 2. Review.


A novel population of local pericyte precursor cells in tumor stroma that require Notch signaling for differentiation.

Patenaude A, Woerher S, Umlandt P, Wong F, Ibrahim R, Kyle A, Unger S, Fuller M, Parker J, Minchinton A, Eaves CJ, Karsan A.

Microvasc Res. 2015 Sep;101:38-47. doi: 10.1016/j.mvr.2015.05.004. Epub 2015 Jun 17.


Clonal analysis of individual human embryonic stem cell differentiation patterns in microfluidic cultures.

Sikorski DJ, Caron NJ, VanInsberghe M, Zahn H, Eaves CJ, Piret JM, Hansen CL.

Biotechnol J. 2015 Oct;10(10):1546-54. doi: 10.1002/biot.201500035. Epub 2015 Jul 16.


Inhibition of the Mitochondrial Protease ClpP as a Therapeutic Strategy for Human Acute Myeloid Leukemia.

Cole A, Wang Z, Coyaud E, Voisin V, Gronda M, Jitkova Y, Mattson R, Hurren R, Babovic S, Maclean N, Restall I, Wang X, Jeyaraju DV, Sukhai MA, Prabha S, Bashir S, Ramakrishnan A, Leung E, Qia YH, Zhang N, Combes KR, Ketela T, Lin F, Houry WA, Aman A, Al-Awar R, Zheng W, Wienholds E, Xu CJ, Dick J, Wang JC, Moffat J, Minden MD, Eaves CJ, Bader GD, Hao Z, Kornblau SM, Raught B, Schimmer AD.

Cancer Cell. 2015 Jun 8;27(6):864-76. doi: 10.1016/j.ccell.2015.05.004.


Dominant-negative IKAROS enhances IL-3-stimulated signaling in wild-type but not BCR-ABL1(+) mouse BA/F3 cells.

von Palffy S, Bulaeva E, Babovic S, Kannan N, Knapp DJ, Wei L, Eaves CJ, Beer PA.

Exp Hematol. 2015 Jul;43(7):514-23.e1-2. doi: 10.1016/j.exphem.2015.04.004. Epub 2015 May 4.


Hematopoietic stem cells: concepts, definitions, and the new reality.

Eaves CJ.

Blood. 2015 Apr 23;125(17):2605-13. doi: 10.1182/blood-2014-12-570200. Epub 2015 Mar 11. Review.


DNA barcoding reveals diverse growth kinetics of human breast tumour subclones in serially passaged xenografts.

Nguyen LV, Cox CL, Eirew P, Knapp DJ, Pellacani D, Kannan N, Carles A, Moksa M, Balani S, Shah S, Hirst M, Aparicio S, Eaves CJ.

Nat Commun. 2014 Dec 23;5:5871. doi: 10.1038/ncomms6871.


Dynamics of genomic clones in breast cancer patient xenografts at single-cell resolution.

Eirew P, Steif A, Khattra J, Ha G, Yap D, Farahani H, Gelmon K, Chia S, Mar C, Wan A, Laks E, Biele J, Shumansky K, Rosner J, McPherson A, Nielsen C, Roth AJ, Lefebvre C, Bashashati A, de Souza C, Siu C, Aniba R, Brimhall J, Oloumi A, Osako T, Bruna A, Sandoval JL, Algara T, Greenwood W, Leung K, Cheng H, Xue H, Wang Y, Lin D, Mungall AJ, Moore R, Zhao Y, Lorette J, Nguyen L, Huntsman D, Eaves CJ, Hansen C, Marra MA, Caldas C, Shah SP, Aparicio S.

Nature. 2015 Feb 19;518(7539):422-6. doi: 10.1038/nature13952. Epub 2014 Nov 26.


A dominant-negative isoform of IKAROS expands primitive normal human hematopoietic cells.

Beer PA, Knapp DJ, Kannan N, Miller PH, Babovic S, Bulaeva E, Aghaeepour N, Rabu G, Rostamirad S, Shih K, Wei L, Eaves CJ.

Stem Cell Reports. 2014 Nov 11;3(5):841-57. doi: 10.1016/j.stemcr.2014.09.006. Epub 2014 Oct 11.


Cell fate decisions in malignant hematopoiesis: leukemia phenotype is determined by distinct functional domains of the MN1 oncogene.

Lai CK, Moon Y, Kuchenbauer F, Starzcynowski DT, Argiropoulos B, Yung E, Beer P, Schwarzer A, Sharma A, Park G, Leung M, Lin G, Vollett S, Fung S, Eaves CJ, Karsan A, Weng AP, Humphries RK, Heuser M.

PLoS One. 2014 Nov 17;9(11):e112671. doi: 10.1371/journal.pone.0112671. eCollection 2014.


Disruption of IKAROS activity in primitive chronic-phase CML cells mimics myeloid disease progression.

Beer PA, Knapp DJ, Miller PH, Kannan N, Sloma I, Heel K, Babovic S, Bulaeva E, Rabu G, Terry J, Druker BJ, Loriaux MM, Loeb KR, Radich JP, Erber WN, Eaves CJ.

Blood. 2015 Jan 15;125(3):504-15. doi: 10.1182/blood-2014-06-581173. Epub 2014 Nov 4.


Modeling de novo leukemogenesis from human cord blood with MN1 and NUP98HOXD13.

Imren S, Heuser M, Gasparetto M, Beer PA, Norddahl GL, Xiang P, Chen L, Berg T, Rhyasen GW, Rosten P, Park G, Moon Y, Weng AP, Eaves CJ, Humphries RK.

Blood. 2014 Dec 4;124(24):3608-12. doi: 10.1182/blood-2014-04-564666. Epub 2014 Oct 22.


ΔNp63 promotes stem cell activity in mammary gland development and basal-like breast cancer by enhancing Fzd7 expression and Wnt signalling.

Chakrabarti R, Wei Y, Hwang J, Hang X, Andres Blanco M, Choudhury A, Tiede B, Romano RA, DeCoste C, Mercatali L, Ibrahim T, Amadori D, Kannan N, Eaves CJ, Sinha S, Kang Y.

Nat Cell Biol. 2014 Oct;16(10):1004-15, 1-13. doi: 10.1038/ncb3040. Epub 2014 Sep 21.


Cord blood expansion. Pyrimidoindole derivatives are agonists of human hematopoietic stem cell self-renewal.

Fares I, Chagraoui J, Gareau Y, Gingras S, Ruel R, Mayotte N, Csaszar E, Knapp DJ, Miller P, Ngom M, Imren S, Roy DC, Watts KL, Kiem HP, Herrington R, Iscove NN, Humphries RK, Eaves CJ, Cohen S, Marinier A, Zandstra PW, Sauvageau G.

Science. 2014 Sep 19;345(6203):1509-12. doi: 10.1126/science.1256337.


Hierarchical organization of fetal and adult hematopoietic stem cells.

Babovic S, Eaves CJ.

Exp Cell Res. 2014 Dec 10;329(2):185-91. doi: 10.1016/j.yexcr.2014.08.005. Epub 2014 Aug 13. Review.


Tipping the balance: MTDH-SND1 curbs oncogene-induced apoptosis and promotes tumorigenesis.

Kannan N, Eaves CJ.

Cell Stem Cell. 2014 Aug 7;15(2):118-20. doi: 10.1016/j.stem.2014.07.010.

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