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Items: 1 to 50 of 182

1.

Junior doctor-designed induction booklet to improve future junior doctor experience in a new post.

Thomas N, McGrann E, Zammit L, Eaton P, White W, Lingam C, Thompson C, Morgan C, William L, Davie P, Shellien R, O'Neill R.

Future Healthc J. 2019 Jun;6(Suppl 2):17. doi: 10.7861/futurehosp.6-2s-s17. No abstract available.

2.

Long-lasting blood pressure lowering effects of nitrite are NO-independent and mediated by hydrogen peroxide, persulfides and oxidation of protein kinase G 1α redox signaling.

Feelisch M, Akaike T, Griffiths K, Ida T, Prysyahna O, Goodwin JJ, Gollop ND, Fernandez BO, Minnion M, Cortese-Krott MM, Borgognone A, Hayes RM, Eaton P, Frenneaux MP, Madhani M.

Cardiovasc Res. 2019 Jul 31. pii: cvz202. doi: 10.1093/cvr/cvz202. [Epub ahead of print]

PMID:
31372656
3.

Intragenic Antimicrobial Peptide Hs02 Hampers the Proliferation of Single- and Dual-Species Biofilms of P. aeruginosa and S. aureus: A Promising Agent for Mitigation of Biofilm-Associated Infections.

Bessa LJ, Manickchand JR, Eaton P, Leite JRSA, Brand GD, Gameiro P.

Int J Mol Sci. 2019 Jul 23;20(14). pii: E3604. doi: 10.3390/ijms20143604.

4.

Oxidation of PKGIα mediates an endogenous adaptation to pulmonary hypertension.

Rudyk O, Rowan A, Prysyazhna O, Krasemann S, Hartmann K, Zhang M, Shah AM, Ruppert C, Weiss A, Schermuly RT, Ida T, Akaike T, Zhao L, Eaton P.

Proc Natl Acad Sci U S A. 2019 Jun 25;116(26):13016-13025. doi: 10.1073/pnas.1904064116. Epub 2019 Jun 11.

5.

Silver nanoparticle stabilized by hydrolyzed collagen and natural polymers: Synthesis, characterization and antibacterial-antifungal evaluation.

Nogueira SS, de Araujo-Nobre AR, Mafud AC, Guimarães MA, Alves MMM, Plácido A, Carvalho FAA, Arcanjo DDR, Mascarenhas Y, Costa FG, Albuquerque P, Eaton P, de Souza de Almeida Leite JR, da Silva DA, Cardoso VS.

Int J Biol Macromol. 2019 Aug 15;135:808-814. doi: 10.1016/j.ijbiomac.2019.05.214. Epub 2019 May 31.

PMID:
31158421
6.

15-deoxy-Δ12,14-Prostaglandin J2 inhibits human soluble epoxide hydrolase by a dual orthosteric and allosteric mechanism.

Abis G, Charles RL, Kopec J, Yue WW, Atkinson RA, Bui TTT, Lynham S, Popova S, Sun YB, Fraternali F, Eaton P, Conte MR.

Commun Biol. 2019 May 17;2:188. doi: 10.1038/s42003-019-0426-2. eCollection 2019.

7.

Blood Pressure-Lowering by the Antioxidant Resveratrol Is Counterintuitively Mediated by Oxidation of cGMP-Dependent Protein Kinase.

Prysyazhna O, Wolhuter K, Switzer C, Santos C, Yang X, Lynham S, Shah AM, Eaton P, Burgoyne JR.

Circulation. 2019 Jul 9;140(2):126-137. doi: 10.1161/CIRCULATIONAHA.118.037398. Epub 2019 May 22.

8.

A multiparametric study of gold nanoparticles cytotoxicity, internalization and permeability using an in vitro model of blood-brain barrier. Influence of size, shape and capping agent.

Enea M, Peixoto de Almeida M, Eaton P, Dias da Silva D, Pereira E, Soares ME, Bastos ML, Carmo H.

Nanotoxicology. 2019 Sep;13(7):990-1004. doi: 10.1080/17435390.2019.1621398. Epub 2019 Jun 8.

PMID:
31106633
9.

Antifungal and anti-inflammatory potential of eschweilenol C-rich fraction derived from Terminalia fagifolia Mart.

Rodrigues de Araújo A, Iles B, de Melo Nogueira K, Dias JDN, Plácido A, Rodrigues A, Albuquerque P, Silva-Pereira I, Socodatto R, Portugal CC, Relvas JB, Costa Véras LM, Dalmatti Alves Lima FC, Batagin-Neto A, Rolim Medeiros JV, Moreira Nunes PH, Eaton P, de Souza de Almeida Leite JR.

J Ethnopharmacol. 2019 Aug 10;240:111941. doi: 10.1016/j.jep.2019.111941. Epub 2019 May 15.

PMID:
31100435
10.

Copper nanoparticles stabilized with cashew gum: Antimicrobial activity and cytotoxicity against 4T1 mouse mammary tumor cell line.

Amorim A, Mafud AC, Nogueira S, Jesus JR, Araújo AR, Plácido A, Brito Neta M, Alves MMM, Carvalho FAA, Rufino Arcanjo DD, Braun S, López MS, López-Ruiz B, Delerue-Matos C, Mascarenhas Y, Silva D, Eaton P, Almeida Leite JRS.

J Biomater Appl. 2019 Aug;34(2):188-197. doi: 10.1177/0885328219845964. Epub 2019 May 1. No abstract available.

PMID:
31042123
11.

Ndufs2, a Core Subunit of Mitochondrial Complex I, Is Essential for Acute Oxygen-Sensing and Hypoxic Pulmonary Vasoconstriction.

Dunham-Snary KJ, Wu D, Potus F, Sykes EA, Mewburn JD, Charles RL, Eaton P, Sultanian RA, Archer SL.

Circ Res. 2019 Jun 7;124(12):1727-1746. doi: 10.1161/CIRCRESAHA.118.314284. Epub 2019 Mar 29.

PMID:
30922174
12.

Singlet molecular oxygen regulates vascular tone and blood pressure in inflammation.

Stanley CP, Maghzal GJ, Ayer A, Talib J, Giltrap AM, Shengule S, Wolhuter K, Wang Y, Chadha P, Suarna C, Prysyazhna O, Scotcher J, Dunn LL, Prado FM, Nguyen N, Odiba JO, Baell JB, Stasch JP, Yamamoto Y, Di Mascio P, Eaton P, Payne RJ, Stocker R.

Nature. 2019 Feb;566(7745):548-552. doi: 10.1038/s41586-019-0947-3. Epub 2019 Feb 13.

PMID:
30760924
13.

Acetylated cashew gum-based nanoparticles for the incorporation of alkaloid epiisopiloturine.

do Amaral Rodrigues J, de Araújo AR, Pitombeira NA, Plácido A, de Almeida MP, Veras LMC, Delerue-Matos C, Lima FCDA, Neto AB, de Paula RCM, Feitosa JPA, Eaton P, Leite JRSA, da Silva DA.

Int J Biol Macromol. 2019 May 1;128:965-972. doi: 10.1016/j.ijbiomac.2019.01.206. Epub 2019 Jan 31.

PMID:
30711562
14.

PKG1α oxidation negatively regulates food seeking behaviour and reward.

Duraffourd C, Huckstepp RTR, Braren I, Fernandes C, Brock O, Delogu A, Prysyazhna O, Burgoyne J, Eaton P.

Redox Biol. 2019 Feb;21:101077. doi: 10.1016/j.redox.2018.101077. Epub 2018 Dec 18.

15.

Artifacts and Practical Issues in Atomic Force Microscopy.

Eaton P, Batziou K.

Methods Mol Biol. 2019;1886:3-28. doi: 10.1007/978-1-4939-8894-5_1. Review.

PMID:
30374859
16.

Expression, purification, and characterisation of human soluble Epoxide Hydrolase (hsEH) and of its functional C-terminal domain.

Abis G, Charles RL, Eaton P, Conte MR.

Protein Expr Purif. 2019 Jan;153:105-113. doi: 10.1016/j.pep.2018.09.001. Epub 2018 Sep 12.

17.

Cysteine-Based Redox Sensing and Its Role in Signaling by Cyclic Nucleotide-Dependent Kinases in the Cardiovascular System.

Cuello F, Eaton P.

Annu Rev Physiol. 2019 Feb 10;81:63-87. doi: 10.1146/annurev-physiol-020518-114417. Epub 2018 Sep 14.

PMID:
30216743
18.

The TAB1-p38α complex aggravates myocardial injury and can be targeted by small molecules.

De Nicola GF, Bassi R, Nichols C, Fernandez-Caggiano M, Golforoush PA, Thapa D, Anderson R, Martin ED, Verma S, Kleinjung J, Laing A, Hutchinson JP, Eaton P, Clark J, Marber MS.

JCI Insight. 2018 Aug 23;3(16). pii: 121144. doi: 10.1172/jci.insight.121144. eCollection 2018 Aug 23.

19.

Oxidation of cardiac myofilament proteins: Priming for dysfunction?

Cuello F, Wittig I, Lorenz K, Eaton P.

Mol Aspects Med. 2018 Oct;63:47-58. doi: 10.1016/j.mam.2018.08.003. Epub 2018 Aug 23. Review.

PMID:
30130564
20.

Multidisciplinary Prerounding Meeting as a Continuous Quality Improvement Tool: Leveraging to Reduce Continuous Benzodiazepine Use at an Academic Medical Center.

Flannery AH, Thompson Bastin ML, Montgomery-Yates A, Hook C, Cassity E, Eaton PM, Morris PE.

J Intensive Care Med. 2019 Sep;34(9):707-713. doi: 10.1177/0885066618769015. Epub 2018 Apr 22.

PMID:
29683053
21.

Evidence against Stable Protein S-Nitrosylation as a Widespread Mechanism of Post-translational Regulation.

Wolhuter K, Whitwell HJ, Switzer CH, Burgoyne JR, Timms JF, Eaton P.

Mol Cell. 2018 Feb 1;69(3):438-450.e5. doi: 10.1016/j.molcel.2017.12.019. Epub 2018 Jan 18.

22.

Synergistic and antibiofilm properties of ocellatin peptides against multidrug-resistant Pseudomonas aeruginosa.

Bessa LJ, Eaton P, Dematei A, Plácido A, Vale N, Gomes P, Delerue-Matos C, Sa Leite JR, Gameiro P.

Future Microbiol. 2018 Feb;13:151-163. doi: 10.2217/fmb-2017-0175. Epub 2018 Jan 8.

PMID:
29308671
23.

In Situ Synthesis of Silver Nanoparticles in a Hydrogel of Carboxymethyl Cellulose with Phthalated-Cashew Gum as a Promising Antibacterial and Healing Agent.

Lustosa AKMF, de Jesus Oliveira AC, Quelemes PV, Plácido A, da Silva FV, Oliveira IS, de Almeida MP, Amorim ADGN, Delerue-Matos C, de Oliveira RCM, da Silva DA, Eaton P, de Almeida Leite JRS.

Int J Mol Sci. 2017 Nov 12;18(11). pii: E2399. doi: 10.3390/ijms18112399.

24.

Oxidant sensor in the cGMP-binding pocket of PKGIα regulates nitroxyl-mediated kinase activity.

Donzelli S, Goetz M, Schmidt K, Wolters M, Stathopoulou K, Diering S, Prysyazhna O, Polat V, Scotcher J, Dees C, Subramanian H, Butt E, Kamynina A, Schobesberger S, King SB, Nikolaev VO, de Wit C, Leichert LI, Feil R, Eaton P, Cuello F.

Sci Rep. 2017 Aug 30;7(1):9938. doi: 10.1038/s41598-017-09275-1.

25.

Redox-dependent dimerization of p38α mitogen-activated protein kinase with mitogen-activated protein kinase kinase 3.

Bassi R, Burgoyne JR, DeNicola GF, Rudyk O, DeSantis V, Charles RL, Eaton P, Marber MS.

J Biol Chem. 2017 Sep 29;292(39):16161-16173. doi: 10.1074/jbc.M117.785410. Epub 2017 Jul 24.

26.

Proof of Principle for a Novel Class of Antihypertensives That Target the Oxidative Activation of PKG Iα (Protein Kinase G Iα).

Burgoyne JR, Prysyazhna O, Richards DA, Eaton P.

Hypertension. 2017 Sep;70(3):577-586. doi: 10.1161/HYPERTENSIONAHA.117.09670. Epub 2017 Jul 17.

27.

A direct comparison of experimental methods to measure dimensions of synthetic nanoparticles.

Eaton P, Quaresma P, Soares C, Neves C, de Almeida MP, Pereira E, West P.

Ultramicroscopy. 2017 Nov;182:179-190. doi: 10.1016/j.ultramic.2017.07.001. Epub 2017 Jul 5.

PMID:
28692935
28.

Examining a role for PKG Iα oxidation in the pathogenesis of cardiovascular dysfunction during diet-induced obesity.

Rudyk O, Eaton P.

Free Radic Biol Med. 2017 Sep;110:390-398. doi: 10.1016/j.freeradbiomed.2017.07.007. Epub 2017 Jul 6.

29.

Antibacterial activity of novel peptide derived from Cry1Ab16 toxin and development of LbL films for foodborne pathogens control.

Plácido A, Bragança I, Marani M, de Araujo AR, Vasconcelos AG, Batziou K, Domingues VF, Eaton P, Almeida Leite JRSA, Delerue-Matos C.

Mater Sci Eng C Mater Biol Appl. 2017 Jun 1;75:503-509. doi: 10.1016/j.msec.2017.02.027. Epub 2017 Feb 10.

PMID:
28415492
30.

Distinct Regulatory Effects of Myeloid Cell and Endothelial Cell NAPDH Oxidase 2 on Blood Pressure.

Sag CM, Schnelle M, Zhang J, Murdoch CE, Kossmann S, Protti A, Santos CXC, Sawyer G, Zhang X, Mongue-Din H, Richards DA, Brewer AC, Prysyazhna O, Maier LS, Wenzel P, Eaton PJ, Shah AM.

Circulation. 2017 May 30;135(22):2163-2177. doi: 10.1161/CIRCULATIONAHA.116.023877. Epub 2017 Mar 15.

31.

How widespread is stable protein S-nitrosylation as an end-effector of protein regulation?

Wolhuter K, Eaton P.

Free Radic Biol Med. 2017 Aug;109:156-166. doi: 10.1016/j.freeradbiomed.2017.02.013. Epub 2017 Feb 9. Review.

PMID:
28189849
32.

Synergistic effects of in vitro combinations of piplartine, epiisopiloturine and praziquantel against Schistosoma mansoni.

Campelo YDM, Mafud AC, Véras LMC, Guimarães MA, Yamaguchi LF, Lima DF, Arcanjo DDR, Kato MJ, Mendonça RZ, Pinto PLS, Mascarenhas YP, Silva MPN, de Moraes J, Eaton P, de Souza de Almeida Leite JR.

Biomed Pharmacother. 2017 Apr;88:488-499. doi: 10.1016/j.biopha.2016.12.057. Epub 2017 Jan 23.

PMID:
28126674
33.

Anthelmintic, Antibacterial and Cytotoxicity Activity of Imidazole Alkaloids from Pilocarpus microphyllus Leaves.

Rocha JA, Andrade IM, Véras LM, Quelemes PV, Lima DF, Soares MJ, Pinto PL, Mayo SJ, Ivanova G, Rangel M, Correia M, Mafud AC, Mascarenhas YP, Delerue-Matos C, de Moraes J, Eaton P, Leite JR.

Phytother Res. 2017 Apr;31(4):624-630. doi: 10.1002/ptr.5771. Epub 2017 Jan 23.

PMID:
28111828
34.

Thaulin-1: The first antimicrobial peptide isolated from the skin of a Patagonian frog Pleurodema thaul (Anura: Leptodactylidae: Leiuperinae) with activity against Escherichia coli.

Marani MM, Perez LO, de Araujo AR, Plácido A, Sousa CF, Quelemes PV, Oliveira M, Gomes-Alves AG, Pueta M, Gameiro P, Tomás AM, Delerue-Matos C, Eaton P, Camperi SA, Basso NG, de Souza de Almeida Leite JR.

Gene. 2017 Mar 20;605:70-80. doi: 10.1016/j.gene.2016.12.020. Epub 2016 Dec 23.

PMID:
28025119
35.

Quaternized cashew gum: An anti-staphylococcal and biocompatible cationic polymer for biotechnological applications.

Quelemes PV, de Araújo AR, Plácido A, Delerue-Matos C, Maciel JS, Bessa LJ, Ombredane AS, Joanitti GA, Soares MJDS, Eaton P, da Silva DA, Leite JRSA.

Carbohydr Polym. 2017 Feb 10;157:567-575. doi: 10.1016/j.carbpol.2016.10.026. Epub 2016 Oct 12.

PMID:
27987963
36.

Redox-guided axonal regrowth requires cyclic GMP dependent protein kinase 1: Implication for neuropathic pain.

Valek L, Häussler A, Dröse S, Eaton P, Schröder K, Tegeder I.

Redox Biol. 2017 Apr;11:176-191. doi: 10.1016/j.redox.2016.12.004. Epub 2016 Dec 7.

37.

Disulfide-activated protein kinase G Iα regulates cardiac diastolic relaxation and fine-tunes the Frank-Starling response.

Scotcher J, Prysyazhna O, Boguslavskyi A, Kistamas K, Hadgraft N, Martin ED, Worthington J, Rudyk O, Rodriguez Cutillas P, Cuello F, Shattock MJ, Marber MS, Conte MR, Greenstein A, Greensmith DJ, Venetucci L, Timms JF, Eaton P.

Nat Commun. 2016 Oct 26;7:13187. doi: 10.1038/ncomms13187.

38.

Pressure-induced oxidative activation of PKG enables vasoregulation by Ca2+ sparks and BK channels.

Khavandi K, Baylie RA, Sugden SA, Ahmed M, Csato V, Eaton P, Hill-Eubanks DC, Bonev AD, Nelson MT, Greenstein AS.

Sci Signal. 2016 Oct 11;9(449):ra100. doi: 10.1126/scisignal.aaf6625.

39.

Ocellatin-PT antimicrobial peptides: High-resolution microscopy studies in antileishmania models and interactions with mimetic membrane systems.

Oliveira M, Gomes-Alves AG, Sousa C, Mirta Marani M, Plácido A, Vale N, Delerue-Matos C, Gameiro P, Kückelhaus SA, Tomas AM, S A Leite JR, Eaton P.

Biopolymers. 2016 Dec;105(12):873-86. doi: 10.1002/bip.22925.

PMID:
27463422
40.

Phosphodiesterase 5 Inhibition Limits Doxorubicin-induced Heart Failure by Attenuating Protein Kinase G Iα Oxidation.

Prysyazhna O, Burgoyne JR, Scotcher J, Grover S, Kass D, Eaton P.

J Biol Chem. 2016 Aug 12;291(33):17427-36. doi: 10.1074/jbc.M116.724070. Epub 2016 Jun 24.

41.

Oxidant-induced Interprotein Disulfide Formation in Cardiac Protein DJ-1 Occurs via an Interaction with Peroxiredoxin 2.

Fernandez-Caggiano M, Schröder E, Cho HJ, Burgoyne J, Barallobre-Barreiro J, Mayr M, Eaton P.

J Biol Chem. 2016 May 6;291(19):10399-410. doi: 10.1074/jbc.M115.699850. Epub 2016 Mar 4.

42.

S-glutathiolation impairs phosphoregulation and function of cardiac myosin-binding protein C in human heart failure.

Stathopoulou K, Wittig I, Heidler J, Piasecki A, Richter F, Diering S, van der Velden J, Buck F, Donzelli S, Schröder E, Wijnker PJ, Voigt N, Dobrev D, Sadayappan S, Eschenhagen T, Carrier L, Eaton P, Cuello F.

FASEB J. 2016 May;30(5):1849-64. doi: 10.1096/fj.201500048. Epub 2016 Feb 2.

43.

Persistent Activation of cGMP-Dependent Protein Kinase by a Nitrated Cyclic Nucleotide via Site Specific Protein S-Guanylation.

Akashi S, Ahmed KA, Sawa T, Ono K, Tsutsuki H, Burgoyne JR, Ida T, Horio E, Prysyazhna O, Oike Y, Rahaman MM, Eaton P, Fujii S, Akaike T.

Biochemistry. 2016 Feb 9;55(5):751-61. doi: 10.1021/acs.biochem.5b00774. Epub 2016 Jan 29.

PMID:
26784639
44.

Intensity matters: Ryanodine receptor regulation during exercise.

Kohl T, Weninger G, Zalk R, Eaton P, Lehnart SE.

Proc Natl Acad Sci U S A. 2015 Dec 15;112(50):15271-2. doi: 10.1073/pnas.1521051112. Epub 2015 Dec 2. No abstract available.

45.

Transcriptional Regulation of Cystathionine-γ-Lyase in Endothelial Cells by NADPH Oxidase 4-Dependent Signaling.

Mistry RK, Murray TV, Prysyazhna O, Martin D, Burgoyne JR, Santos C, Eaton P, Shah AM, Brewer AC.

J Biol Chem. 2016 Jan 22;291(4):1774-88. doi: 10.1074/jbc.M115.685578. Epub 2015 Nov 30.

46.

Analysis of Mitochondrial Proteins in the Surviving Myocardium after Ischemia Identifies Mitochondrial Pyruvate Carrier Expression as Possible Mediator of Tissue Viability.

Fernández-Caggiano M, Prysyazhna O, Barallobre-Barreiro J, CalviñoSantos R, Aldama López G, Generosa Crespo-Leiro M, Eaton P, Doménech N.

Mol Cell Proteomics. 2016 Jan;15(1):246-55. doi: 10.1074/mcp.M115.051862. Epub 2015 Nov 18.

47.

Characterization and optimization of the haemozoin-like crystal (HLC) assay to determine Hz inhibiting effects of anti-malarial compounds.

Tempera C, Franco R, Caro C, André V, Eaton P, Burke P, Hänscheid T.

Malar J. 2015 Oct 12;14:403. doi: 10.1186/s12936-015-0913-y.

48.

Effect of neem (Azadirachta indica A. Juss) leaf extract on resistant Staphylococcus aureus biofilm formation and Schistosoma mansoni worms.

Quelemes PV, Perfeito ML, Guimarães MA, dos Santos RC, Lima DF, Nascimento C, Silva MP, Soares MJ, Ropke CD, Eaton P, de Moraes J, Leite JR.

J Ethnopharmacol. 2015 Dec 4;175:287-94. doi: 10.1016/j.jep.2015.09.026. Epub 2015 Sep 25.

49.

Deficient angiogenesis in redox-dead Cys17Ser PKARIα knock-in mice.

Burgoyne JR, Rudyk O, Cho HJ, Prysyazhna O, Hathaway N, Weeks A, Evans R, Ng T, Schröder K, Brandes RP, Shah AM, Eaton P.

Nat Commun. 2015 Aug 10;6:7920. doi: 10.1038/ncomms8920.

PMID:
26258640
50.

Redox regulation of cGMP-dependent protein kinase Iα in the cardiovascular system.

Prysyazhna O, Eaton P.

Front Pharmacol. 2015 Jul 17;6:139. doi: 10.3389/fphar.2015.00139. eCollection 2015. Review.

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