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Selective covalent targeting of GPX4 using masked nitrile-oxide electrophiles.

Eaton JK, Furst L, Ruberto RA, Moosmayer D, Hilpmann A, Ryan MJ, Zimmermann K, Cai LL, Niehues M, Badock V, Kramm A, Chen S, Hillig RC, Clemons PA, Gradl S, Montagnon C, Lazarski KE, Christian S, Bajrami B, Neuhaus R, Eheim AL, Viswanathan VS, Schreiber SL.

Nat Chem Biol. 2020 Mar 30. doi: 10.1038/s41589-020-0501-5. [Epub ahead of print]


The relationship between mental health conditions and hearing loss in low- and middle-income countries.

Jiang F, Kubwimana C, Eaton J, Kuper H, Bright T.

Trop Med Int Health. 2020 Mar 27. doi: 10.1111/tmi.13393. [Epub ahead of print] Review.


Partnership for the implementation of mental health policy in Nigeria: a case study of the Comprehensive Community Mental Health Programme in Benue State.

Ryan GK, Nwefoh E, Aguocha C, Ode PO, Okpoju SO, Ocheche P, Woyengikuro A, Abdulmalik J, Eaton J.

Int J Ment Health Syst. 2020 Feb 21;14:10. doi: 10.1186/s13033-020-00344-z. eCollection 2020.


Biallelic mutations in NRROS cause an early onset lethal microgliopathy.

Smith C, McColl BW, Patir A, Barrington J, Armishaw J, Clarke A, Eaton J, Hobbs V, Mansour S, Nolan M, Rice GI, Rodero MP, Seabra L, Uggenti C, Livingston JH, Bridges LR, Jeffrey IJM, Crow YJ.

Acta Neuropathol. 2020 Feb 25. doi: 10.1007/s00401-020-02137-7. [Epub ahead of print] No abstract available.


Survival and Functional Outcomes at Discharge After Traumatic Brain Injury in Children versus Adults in Resource-Poor Setting.

Purcell LN, Reiss R, Eaton J, Kumwenda KK, Quinsey C, Charles A.

World Neurosurg. 2020 Feb 19. pii: S1878-8750(20)30337-5. doi: 10.1016/j.wneu.2020.02.062. [Epub ahead of print]


Cytochrome P450 oxidoreductase contributes to phospholipid peroxidation in ferroptosis.

Zou Y, Li H, Graham ET, Deik AA, Eaton JK, Wang W, Sandoval-Gomez G, Clish CB, Doench JG, Schreiber SL.

Nat Chem Biol. 2020 Mar;16(3):302-309. doi: 10.1038/s41589-020-0472-6. Epub 2020 Feb 17.


Prevalence of a Good Perinatal Outcome With Cryopreserved Compared With Fresh Donor Oocytes.

Eaton JL, Truong T, Li YJ, Polotsky AJ.

Obstet Gynecol. 2020 Mar;135(3):709-716. doi: 10.1097/AOG.0000000000003695.


Nursing Management of Patients Requiring Acute Mechanical Circulatory Support Devices.

Asber SR, Shanahan KP, Lussier L, Didomenico D, Davis M, Eaton J, Esposito M, Kapur NK.

Crit Care Nurse. 2020 Feb 1;40(1):e1-e11. doi: 10.4037/ccn2020764.


Efficacy of psychosocial interventions for mental health outcomes in low-income and middle-income countries: an umbrella review.

Barbui C, Purgato M, Abdulmalik J, Acarturk C, Eaton J, Gastaldon C, Gureje O, Hanlon C, Jordans M, Lund C, Nosè M, Ostuzzi G, Papola D, Tedeschi F, Tol W, Turrini G, Patel V, Thornicroft G.

Lancet Psychiatry. 2020 Feb;7(2):162-172. doi: 10.1016/S2215-0366(19)30511-5. Epub 2020 Jan 13.


An update on primary sclerosing cholangitis epidemiology, outcomes and quantification of alkaline phosphatase variability in a population-based cohort.

Bakhshi Z, Hilscher MB, Gores GJ, Harmsen WS, Viehman JK, LaRusso NF, Gossard AA, Lazaridis KN, Lindor KD, Eaton JE.

J Gastroenterol. 2020 Jan 13. doi: 10.1007/s00535-020-01663-1. [Epub ahead of print]


Comparison of liver stiffness measurement with MRE and liver and spleen volumetry for prediction of disease severity and hepatic decompensation in patients with primary sclerosing cholangitis.

Idilman IS, Low HM, Bakhshi Z, Eaton J, Venkatesh SK.

Abdom Radiol (NY). 2020 Mar;45(3):701-709. doi: 10.1007/s00261-019-02387-4.


Diacylfuroxans Are Masked Nitrile Oxides That Inhibit GPX4 Covalently.

Eaton JK, Ruberto RA, Kramm A, Viswanathan VS, Schreiber SL.

J Am Chem Soc. 2019 Dec 26;141(51):20407-20415. doi: 10.1021/jacs.9b10769. Epub 2019 Dec 16.


Whipworm Found During a Colonoscopy.

Wang XJ, Eaton JE.

ACG Case Rep J. 2019 Oct 22;6(10):e00259. doi: 10.14309/crj.0000000000000259. eCollection 2019 Oct. No abstract available.


Structural and Dynamical Signatures of Local DNA Damage in Live Cells.

Eaton JA, Zidovska A.

Biophys J. 2019 Nov 13. pii: S0006-3495(19)30906-3. doi: 10.1016/j.bpj.2019.10.042. [Epub ahead of print]


Dynamic rodent behavioral response to predation risk: implications for disease ecology.

Moll RJ, Eaton JT, Cepek JD, Lorch PD, Dennis PM, Robison T, Tsao J, Montgomery RA.

Oecologia. 2020 Jan;192(1):67-78. doi: 10.1007/s00442-019-04565-z. Epub 2019 Dec 7.


A unified allosteric/torpedo mechanism for transcriptional termination on human protein-coding genes.

Eaton JD, Francis L, Davidson L, West S.

Genes Dev. 2020 Jan 1;34(1-2):132-145. doi: 10.1101/gad.332833.119. Epub 2019 Dec 5.


HIV surveillance based on routine testing data from antenatal clinics in Malawi (2011-2018): measuring and adjusting for bias from imperfect testing coverage.

Maheu-Giroux M, Jahn A, Kalua T, Mganga A, Eaton JW.

AIDS. 2019 Dec 15;33 Suppl 3:S295-S302. doi: 10.1097/QAD.0000000000002356.


Global variations in mortality in adults after initiating antiretroviral treatment: an updated analysis of the International epidemiology Databases to Evaluate AIDS cohort collaboration.

Johnson LF, Anderegg N, Zaniewski E, Eaton JW, Rebeiro PF, Carriquiry G, Nash D, Yotebieng M, Ekouevi DK, Holmes CB, Choi JY, Jiamsakul A, Bakoyannis G, Althoff KN, Sohn AH, Yiannoutsos C, Egger M; International epidemiology Databases to Evaluate AIDS (IeDEA) Collaboration.

AIDS. 2019 Dec 15;33 Suppl 3:S283-S294. doi: 10.1097/QAD.0000000000002358.


The Estimation and Projection Package Age-Sex Model and the r-hybrid model: new tools for estimating HIV incidence trends in sub-Saharan Africa.

Eaton JW, Brown T, Puckett R, Glaubius R, Mutai K, Bao L, Salomon JA, Stover J, Mahy M, Hallett TB.

AIDS. 2019 Dec 15;33 Suppl 3:S235-S244. doi: 10.1097/QAD.0000000000002437.


National HIV testing and diagnosis coverage in sub-Saharan Africa: a new modeling tool for estimating the 'first 90' from program and survey data.

Maheu-Giroux M, Marsh K, Doyle CM, Godin A, Lanièce Delaunay C, Johnson LF, Jahn A, Abo K, Mbofana F, Boily MC, Buckeridge DL, Hankins CA, Eaton JW.

AIDS. 2019 Dec 15;33 Suppl 3:S255-S269. doi: 10.1097/QAD.0000000000002386.


A Compendium of Genetic Modifiers of Mitochondrial Dysfunction Reveals Intra-organelle Buffering.

To TL, Cuadros AM, Shah H, Hung WHW, Li Y, Kim SH, Rubin DHF, Boe RH, Rath S, Eaton JK, Piccioni F, Goodale A, Kalani Z, Doench JG, Root DE, Schreiber SL, Vafai SB, Mootha VK.

Cell. 2019 Nov 14;179(5):1222-1238.e17. doi: 10.1016/j.cell.2019.10.032.


EPP-ASM and the r-hybrid model: new tools for estimating HIV incidence trends in sub-Saharan Africa.

Eaton JW, Brown T, Puckett R, Glaubius R, Mutai K, Bao L, Salomon JA, Stover J, Mahy M, Hallett TB.

AIDS. 2019 Nov 12. doi: 10.1097/QAD.0000000000002437. [Epub ahead of print]


Summarizing the results and methods of the 2019 Joint United Nations Programme on HIV/AIDS HIV estimates.

Case KK, Johnson LF, Mahy M, Marsh K, Supervie V, Eaton JW.

AIDS. 2019 Dec 15;33 Suppl 3:S197-S201. doi: 10.1097/QAD.0000000000002440.


Avoiding anaesthetics after multiple failed drug-induced comas: an unorthodox approach to management of new-onset refractory status epilepticus (NORSE).

Eaton JE, Meriweather MT, Abou-Khalil BW, Sonmezturk HH.

Epileptic Disord. 2019 Oct 1;21(5):483-491. doi: 10.1684/epd.2019.1104.


Dataset for dose and time-dependent transcriptional response to ionizing radiation exposure.

Rouchka EC, Flight RM, Fasciotto BH, Estrada R, Eaton JW, Patibandla PK, Waigel SJ, Li D, Kirtley JK, Sethu P, Keynton RS.

Data Brief. 2019 Oct 5;27:104624. doi: 10.1016/j.dib.2019.104624. eCollection 2019 Dec.


Changes in Liver Stiffness, Measured by Magnetic Resonance Elastography, Associated With Hepatic Decompensation in Patients With Primary Sclerosing Cholangitis.

Eaton JE, Sen A, Hoodeshenas S, Schleck CD, Harmsen WS, Gores GJ, LaRusso NF, Gossard AA, Lazaridis KN, Venkatesh SK.

Clin Gastroenterol Hepatol. 2019 Nov 1. pii: S1542-3565(19)31243-1. doi: 10.1016/j.cgh.2019.10.041. [Epub ahead of print]


Liver Injury in Patients With Cholestatic Liver Disease Treated With Obeticholic Acid.

Eaton JE, Vuppalanchi R, Reddy R, Sathapathy S, Ali B, Kamath PS.

Hepatology. 2019 Nov 4. doi: 10.1002/hep.31017. [Epub ahead of print] No abstract available.


Evasins: Tick Salivary Proteins that Inhibit Mammalian Chemokines.

Bhusal RP, Eaton JRO, Chowdhury ST, Power CA, Proudfoot AEI, Stone MJ, Bhattacharya S.

Trends Biochem Sci. 2020 Feb;45(2):108-122. doi: 10.1016/j.tibs.2019.10.003. Epub 2019 Nov 1. Review.


Portrait of a Caregiver: Ethnodrama Development and Its Influence on Caregiver Well-Being.

Eaton J.

Gerontologist. 2019 Oct 19. pii: gnz137. doi: 10.1093/geront/gnz137. [Epub ahead of print]


Toward a standard definition of polycystic ovarian morphology.

Eaton JL.

Fertil Steril. 2019 Nov;112(5):823-824. doi: 10.1016/j.fertnstert.2019.07.009. Epub 2019 Oct 6. No abstract available.


Certified nursing assistants as agents of creative caregiving in long-term care.

Eaton J, Cloyes K, Paulsen B, Madden C, Ellington L.

Int J Older People Nurs. 2020 Mar;15(1):e12280. doi: 10.1111/opn.12280. Epub 2019 Oct 7.


Development of a Gerontology Graduate Certificate in Post-Acute and Long-Term Care.

Dassel KB, Flattes V, Eaton J, Towsley G, Moyers L, Edelman L.

J Gerontol Nurs. 2019 Oct 1;45(10):47-52. doi: 10.3928/00989134-20190825-02.


Homelessness and severe mental illness in low- and middle-income countries: scoping review.

Smartt C, Prince M, Frissa S, Eaton J, Fekadu A, Hanlon C.

BJPsych Open. 2019 Jun 24;5(4):e57. doi: 10.1192/bjo.2019.32.


Global, regional and country-level 90-90-90 estimates for 2018: assessing progress towards the 2020 target.

Marsh K, Eaton JW, Mahy M, Sabin K, Autenrieth CS, Wanyeki I, Daher J, Ghys PD.

AIDS. 2019 Dec 15;33 Suppl 3:S213-S226. doi: 10.1097/QAD.0000000000002355.


Estimating and projecting the number of new HIV diagnoses and incidence in Spectrum's case surveillance and vital registration tool.

Mahiane SG, Marsh K, Glaubius R, Eaton JW.

AIDS. 2019 Dec 15;33 Suppl 3:S245-S253. doi: 10.1097/QAD.0000000000002324.


Cost-per-diagnosis as a metric for monitoring cost-effectiveness of HIV testing programmes in low-income settings in southern Africa: health economic and modelling analysis.

Phillips AN, Cambiano V, Nakagawa F, Bansi-Matharu L, Wilson D, Jani I, Apollo T, Sculpher M, Hallett T, Kerr C, van Oosterhout JJ, Eaton JW, Estill J, Williams B, Doi N, Cowan F, Keiser O, Ford D, Hatzold K, Barnabas R, Ayles H, Meyer-Rath G, Nelson L, Johnson C, Baggaley R, Fakoya A, Jahn A, Revill P.

J Int AIDS Soc. 2019 Jul;22(7):e25325. doi: 10.1002/jia2.25325.


Effects of motion on MRI signal decay from micron-scale particles.

Borup DD, Elkins CJ, Eaton JK.

J Magn Reson. 2019 Aug;305:152-161. doi: 10.1016/j.jmr.2019.06.014. Epub 2019 Jun 28.


A knottin scaffold directs the CXC-chemokine-binding specificity of tick evasins.

Lee AW, Deruaz M, Lynch C, Davies G, Singh K, Alenazi Y, Eaton JRO, Kawamura A, Shaw J, Proudfoot AEI, Dias JM, Bhattacharya S.

J Biol Chem. 2019 Jul 19;294(29):11199-11212. doi: 10.1074/jbc.RA119.008817. Epub 2019 Jun 5.


CD4 count recovery and associated factors among individuals enrolled in the South African antiretroviral therapy programme: An analysis of national laboratory based data.

Kufa T, Shubber Z, MacLeod W, Takuva S, Carmona S, Bor J, Gorgens M, Pillay Y, Puren A, Eaton JW, Fraser-Hurt N.

PLoS One. 2019 May 31;14(5):e0217742. doi: 10.1371/journal.pone.0217742. eCollection 2019.


Human rights-based approaches to mental health legislation and global mental health.

Eaton J.

BJPsych Int. 2019 May;16(2):37-40. doi: 10.1192/bji.2018.5.


Efficacy and safety of curcumin in primary sclerosing cholangitis: an open label pilot study.

Eaton JE, Nelson KM, Gossard AA, Carey EJ, Tabibian JH, Lindor KD, LaRusso NF.

Scand J Gastroenterol. 2019 May;54(5):633-639. doi: 10.1080/00365521.2019.1611917. Epub 2019 May 26.


Population-level adult mortality following the expansion of antiretroviral therapy in Rakai, Uganda.

Nabukalu D, Reniers G, Risher KA, Blom S, Slaymaker E, Kabudula C, Zaba B, Nalugoda F, Kigozi G, Makumbi F, Serwadda D, Reynolds SJ, Marston M, Eaton JW, Gray R, Wawer M, Sewankambo N, Lutalo T.

Popul Stud (Camb). 2020 Mar;74(1):93-102. doi: 10.1080/00324728.2019.1595099. Epub 2019 May 23.


Mapping HIV prevalence in sub-Saharan Africa between 2000 and 2017.

Dwyer-Lindgren L, Cork MA, Sligar A, Steuben KM, Wilson KF, Provost NR, Mayala BK, VanderHeide JD, Collison ML, Hall JB, Biehl MH, Carter A, Frank T, Douwes-Schultz D, Burstein R, Casey DC, Deshpande A, Earl L, El Bcheraoui C, Farag TH, Henry NJ, Kinyoki D, Marczak LB, Nixon MR, Osgood-Zimmerman A, Pigott D, Reiner RC Jr, Ross JM, Schaeffer LE, Smith DL, Davis Weaver N, Wiens KE, Eaton JW, Justman JE, Opio A, Sartorius B, Tanser F, Wabiri N, Piot P, Murray CJL, Hay SI.

Nature. 2019 Jun;570(7760):189-193. doi: 10.1038/s41586-019-1200-9. Epub 2019 May 15.


Heavy metal concentrations in drinking water in a country heavily reliant on desalination.

Barnett-Itzhaki Z, Eaton J, Hen I, Berman T.

Environ Sci Pollut Res Int. 2019 Jul;26(19):19991-19996. doi: 10.1007/s11356-019-05358-w. Epub 2019 May 14.


Magnetic Resonance Imaging in Primary Sclerosing Cholangitis-Current State and Future Directions.

Zenouzi R, Welle CL, Venkatesh SK, Schramm C, Eaton JE.

Semin Liver Dis. 2019 Jul;39(3):369-380. doi: 10.1055/s-0039-1687853. Epub 2019 Apr 30.


A GPX4-dependent cancer cell state underlies the clear-cell morphology and confers sensitivity to ferroptosis.

Zou Y, Palte MJ, Deik AA, Li H, Eaton JK, Wang W, Tseng YY, Deasy R, Kost-Alimova M, Dančík V, Leshchiner ES, Viswanathan VS, Signoretti S, Choueiri TK, Boehm JS, Wagner BK, Doench JG, Clish CB, Clemons PA, Schreiber SL.

Nat Commun. 2019 Apr 8;10(1):1617. doi: 10.1038/s41467-019-09277-9.


Long-term outcomes with obeticholic acid in primary biliary cholangitis: reassuring, but still an itch we need to scratch.

Eaton JE, Gores GJ.

Lancet Gastroenterol Hepatol. 2019 Jun;4(6):417-418. doi: 10.1016/S2468-1253(19)30084-6. Epub 2019 Mar 26. No abstract available.


Optimizing HIV testing services in sub-Saharan Africa: cost and performance of verification testing with HIV self-tests and tests for triage.

Eaton JW, Terris-Prestholt F, Cambiano V, Sands A, Baggaley RC, Hatzold K, Corbett EL, Kalua T, Jahn A, Johnson CC.

J Int AIDS Soc. 2019 Mar;22 Suppl 1:e25237. doi: 10.1002/jia2.25237.


Magnetic Resonance Elastography in Primary Sclerosing Cholangitis: Interobserver Agreement for Liver Stiffness Measurement with Manual and Automated Methods.

Hoodeshenas S, Welle CL, Navin PJ, Dzyubak B, Eaton JE, Ehman RL, Venkatesh SK.

Acad Radiol. 2019 Dec;26(12):1625-1632. doi: 10.1016/j.acra.2019.02.004. Epub 2019 Mar 14.


Rapid Depletion of DIS3, EXOSC10, or XRN2 Reveals the Immediate Impact of Exoribonucleolysis on Nuclear RNA Metabolism and Transcriptional Control.

Davidson L, Francis L, Cordiner RA, Eaton JD, Estell C, Macias S, Cáceres JF, West S.

Cell Rep. 2019 Mar 5;26(10):2779-2791.e5. doi: 10.1016/j.celrep.2019.02.012.

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