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Aldosterone Regulates Pendrin and Epithelial Sodium Channel Activity through Intercalated Cell Mineralocorticoid Receptor-Dependent and -Independent Mechanisms over a Wide Range in Serum Potassium.

Pham TD, Verlander JW, Wang Y, Romero CA, Yue Q, Chen C, Thumova M, Eaton DC, Lazo-Fernandez Y, Wall SM.

J Am Soc Nephrol. 2020 Feb 13. pii: ASN.2019050551. doi: 10.1681/ASN.2019050551. [Epub ahead of print]


Regulating ENaC's gate.

Kleyman TR, Eaton DC.

Am J Physiol Cell Physiol. 2020 Jan 1;318(1):C150-C162. doi: 10.1152/ajpcell.00418.2019. Epub 2019 Nov 13.


Mal protein stabilizes luminal membrane PLC-β3 and negatively regulates ENaC in mouse cortical collecting duct cells.

Tuna KM, Liu BC, Yue Q, Ghazi ZM, Ma HP, Eaton DC, Alli AA.

Am J Physiol Renal Physiol. 2019 Oct 1;317(4):F986-F995. doi: 10.1152/ajprenal.00446.2018. Epub 2019 Jul 31.


Loss of primary cilia increases polycystin-2 and TRPV4 and the appearance of a nonselective cation channel in the mouse cortical collecting duct.

Saigusa T, Yue Q, Bunni MA, Bell PD, Eaton DC.

Am J Physiol Renal Physiol. 2019 Sep 1;317(3):F632-F637. doi: 10.1152/ajprenal.00210.2019. Epub 2019 Jul 17.


The TNF-derived TIP peptide activates the epithelial sodium channel and ameliorates experimental nephrotoxic serum nephritis.

Madaio MP, Czikora I, Kvirkvelia N, McMenamin M, Yue Q, Liu T, Toque HA, Sridhar S, Covington K, Alaisami R, O'Connor PM, Caldwell RW, Chen JK, Clauss M, Brands MW, Eaton DC, Romero MJ, Lucas R.

Kidney Int. 2019 Jun;95(6):1359-1372. doi: 10.1016/j.kint.2018.12.022. Epub 2019 Mar 21.


Lack of urea transporters, UT-A1 and UT-A3, increases nitric oxide accumulation to dampen medullary sodium reabsorption through ENaC.

Rogers RT, Sun MA, Yue Q, Bao HF, Sands JM, Blount MA, Eaton DC.

Am J Physiol Renal Physiol. 2019 Mar 1;316(3):F539-F549. doi: 10.1152/ajprenal.00166.2018. Epub 2018 Dec 12.


Listeriolysin O Causes ENaC Dysfunction in Human Airway Epithelial Cells.

Yang G, Pillich H, White R, Czikora I, Pochic I, Yue Q, Hudel M, Gorshkov B, Verin A, Sridhar S, Isales CM, Eaton DC, Hamacher J, Chakraborty T, Lucas R.

Toxins (Basel). 2018 Feb 11;10(2). pii: E79. doi: 10.3390/toxins10020079.


A Model for Postdoctoral Education That Promotes Minority and Majority Success in the Biomedical Sciences.

Eisen A, Eaton DC.

CBE Life Sci Educ. 2017 Winter;16(4). pii: ar65. doi: 10.1187/cbe.17-03-0051.


Knockout of mitochondrial voltage-dependent anion channel type 3 increases reactive oxygen species (ROS) levels and alters renal sodium transport.

Zou L, Linck V, Zhai YJ, Galarza-Paez L, Li L, Yue Q, Al-Khalili O, Bao HF, Ma HP, Thai TL, Jiao J, Eaton DC.

J Biol Chem. 2018 Feb 2;293(5):1666-1675. doi: 10.1074/jbc.M117.798645. Epub 2017 Nov 27.


Current-direction/amplitude-dependent single channel gating kinetics of mouse pannexin 1 channel: a new concept for gating kinetics.

Nomura T, Taruno A, Shiraishi M, Nakahari T, Inui T, Sokabe M, Eaton DC, Marunaka Y.

Sci Rep. 2017 Sep 5;7(1):10512. doi: 10.1038/s41598-017-10921-x.


Regulation of Lung Epithelial Sodium Channels by Cytokines and Chemokines.

Wynne BM, Zou L, Linck V, Hoover RS, Ma HP, Eaton DC.

Front Immunol. 2017 Jul 25;8:766. doi: 10.3389/fimmu.2017.00766. eCollection 2017. Review.


Epithelial Sodium Channel-α Mediates the Protective Effect of the TNF-Derived TIP Peptide in Pneumolysin-Induced Endothelial Barrier Dysfunction.

Czikora I, Alli AA, Sridhar S, Matthay MA, Pillich H, Hudel M, Berisha B, Gorshkov B, Romero MJ, Gonzales J, Wu G, Huo Y, Su Y, Verin AD, Fulton D, Chakraborty T, Eaton DC, Lucas R.

Front Immunol. 2017 Jul 21;8:842. doi: 10.3389/fimmu.2017.00842. eCollection 2017.


Aldosterone Modulates the Association between NCC and ENaC.

Wynne BM, Mistry AC, Al-Khalili O, Mallick R, Theilig F, Eaton DC, Hoover RS.

Sci Rep. 2017 Jun 23;7(1):4149. doi: 10.1038/s41598-017-03510-5.


Analysis of Aprotinin, a Protease Inhibitor, Action on the Trafficking of Epithelial Na+ Channels (ENaC) in Renal Epithelial Cells Using a Mathematical Model.

Sasamoto K, Marunaka R, Niisato N, Sun H, Taruno A, Pezzotti G, Yamamoto T, Kanamura N, Zhu W, Nishio K, Inui T, Eaton DC, Marunaka Y.

Cell Physiol Biochem. 2017;41(5):1865-1880. doi: 10.1159/000471934. Epub 2017 Apr 4.


ENaC activity is regulated by calpain-2 proteolysis of MARCKS proteins.

Montgomery DS, Yu L, Ghazi ZM, Thai TL, Al-Khalili O, Ma HP, Eaton DC, Alli AA.

Am J Physiol Cell Physiol. 2017 Jul 1;313(1):C42-C53. doi: 10.1152/ajpcell.00244.2016. Epub 2017 May 3.


Alveolar nonselective channels are ASIC1a/α-ENaC channels and contribute to AFC.

Trac PT, Thai TL, Linck V, Zou L, Greenlee M, Yue Q, Al-Khalili O, Alli AA, Eaton AF, Eaton DC.

Am J Physiol Lung Cell Mol Physiol. 2017 Jun 1;312(6):L797-L811. doi: 10.1152/ajplung.00379.2016. Epub 2017 Mar 10.


Inhibition of TRPC6 reduces non-small cell lung cancer cell proliferation and invasion.

Yang LL, Liu BC, Lu XY, Yan Y, Zhai YJ, Bao Q, Doetsch PW, Deng X, Thai TL, Alli AA, Eaton DC, Shen BZ, Ma HP.

Oncotarget. 2017 Jan 17;8(3):5123-5134. doi: 10.18632/oncotarget.14034.


The Lectin-like Domain of TNF Increases ENaC Open Probability through a Novel Site at the Interface between the Second Transmembrane and C-terminal Domains of the α-Subunit.

Lucas R, Yue Q, Alli A, Duke BJ, Al-Khalili O, Thai TL, Hamacher J, Sridhar S, Lebedyeva I, Su H, Tzotzos S, Fischer B, Gameiro AF, Loose M, Chakraborty T, Shabbir W, Aufy M, Lemmens-Gruber R, Eaton DC, Czikora I.

J Biol Chem. 2016 Nov 4;291(45):23440-23451. Epub 2016 Sep 19.


The sodium chloride cotransporter (NCC) and epithelial sodium channel (ENaC) associate.

Mistry AC, Wynne BM, Yu L, Tomilin V, Yue Q, Zhou Y, Al-Khalili O, Mallick R, Cai H, Alli AA, Ko B, Mattheyses A, Bao HF, Pochynyuk O, Theilig F, Eaton DC, Hoover RS.

Biochem J. 2016 Oct 1;473(19):3237-52. doi: 10.1042/BCJ20160312. Epub 2016 Jul 15.


The Polarized Effect of Intracellular Calcium on the Renal Epithelial Sodium Channel Occurs as a Result of Subcellular Calcium Signaling Domains Maintained by Mitochondria.

Thai TL, Yu L, Galarza-Paez L, Wu MM, Lam HY, Bao HF, Duke BJ, Al-Khalili O, Ma HP, Liu B, Eaton DC.

J Biol Chem. 2015 Nov 27;290(48):28805-11. doi: 10.1074/jbc.M115.668293. Epub 2015 Oct 8.


Unoprostone activation of BK (KCa1.1) channel splice variants.

Yu L, Eaton AF, Yue Q, Bao HF, Ma HP, Cuppoletti J, Eaton DC.

Biochim Biophys Acta. 2015 Nov;1848(11 Pt A):2859-67. doi: 10.1016/j.bbamem.2015.08.005. Epub 2015 Aug 13.


Calmodulin and CaMKII modulate ENaC activity by regulating the association of MARCKS and the cytoskeleton with the apical membrane.

Alli AA, Bao HF, Liu BC, Yu L, Aldrugh S, Montgomery DS, Ma HP, Eaton DC.

Am J Physiol Renal Physiol. 2015 Sep 1;309(5):F456-63. doi: 10.1152/ajprenal.00631.2014. Epub 2015 Jul 1.


Pendrin gene ablation alters ENaC subcellular distribution and open probability.

Pech V, Wall SM, Nanami M, Bao HF, Kim YH, Lazo-Fernandez Y, Yue Q, Pham TD, Eaton DC, Verlander JW.

Am J Physiol Renal Physiol. 2015 Jul 15;309(2):F154-63. doi: 10.1152/ajprenal.00564.2014. Epub 2015 May 13.


Membrane transport: ionic environments, signal transduction, and development of therapeutic targets.

Tomoda A, Marunaka Y, Eaton DC, Dinudom A.

Biomed Res Int. 2015;2015:581626. doi: 10.1155/2015/581626. Epub 2015 Apr 12. No abstract available.


ENaC inhibition stimulates HCl secretion in the mouse cortical collecting duct. I. Stilbene-sensitive Cl- secretion.

Nanami M, Lazo-Fernandez Y, Pech V, Verlander JW, Agazatian D, Weinstein AM, Bao HF, Eaton DC, Wall SM.

Am J Physiol Renal Physiol. 2015 Aug 1;309(3):F251-8. doi: 10.1152/ajprenal.00471.2013. Epub 2015 Apr 29.


Acute ethanol induces apoptosis by stimulating TRPC6 via elevation of superoxide in oxygenated podocytes.

Lu XY, Liu BC, Wang LH, Yang LL, Bao Q, Zhai YJ, Alli AA, Thai TL, Eaton DC, Wang WZ, Ma HP.

Biochim Biophys Acta. 2015 May;1853(5):965-74. doi: 10.1016/j.bbamcr.2015.01.007. Epub 2015 Jan 17.


Prolactin stimulates sodium and chloride ion channels in A6 renal epithelial cells.

Greenlee MM, Mitzelfelt JD, Duke BJ, Al-Khalili O, Bao HF, Eaton DC.

Am J Physiol Renal Physiol. 2015 Apr 1;308(7):F697-705. doi: 10.1152/ajprenal.00270.2014. Epub 2015 Jan 13.


Lovastatin-Induced Phosphatidylinositol-4-Phosphate 5-Kinase Diffusion from Microvilli Stimulates ROMK Channels.

Liu BC, Yang LL, Lu XY, Song X, Li XC, Chen G, Li Y, Yao X, Humphrey DR, Eaton DC, Shen BZ, Ma HP.

J Am Soc Nephrol. 2015 Jul;26(7):1576-87. doi: 10.1681/ASN.2013121326. Epub 2014 Oct 27.


Contractile force is enhanced in Aortas from pendrin null mice due to stimulation of angiotensin II-dependent signaling.

Sutliff RL, Walp ER, Kim YH, Walker LA, El-Ali AM, Ma J, Bonsall R, Ramosevac S, Eaton DC, Verlander JW, Hansen L, Gleason RL Jr, Pham TD, Hong S, Pech V, Wall SM.

PLoS One. 2014 Aug 22;9(8):e105101. doi: 10.1371/journal.pone.0105101. eCollection 2014.


WNK1 activates large-conductance Ca2+-activated K+ channels through modulation of ERK1/2 signaling.

Liu Y, Song X, Shi Y, Shi Z, Niu W, Feng X, Gu D, Bao HF, Ma HP, Eaton DC, Zhuang J, Cai H.

J Am Soc Nephrol. 2015 Apr;26(4):844-54. doi: 10.1681/ASN.2014020186. Epub 2014 Aug 21.


Basolateral P2X₄channels stimulate ENaC activity in Xenopus cortical collecting duct A6 cells.

Thai TL, Yu L, Eaton DC, Duke BJ, Al-Khalili O, Lam HY, Ma H, Bao HF.

Am J Physiol Renal Physiol. 2014 Oct 1;307(7):F806-13. doi: 10.1152/ajprenal.00350.2013. Epub 2014 Aug 6.


A novel tumor necrosis factor-mediated mechanism of direct epithelial sodium channel activation.

Czikora I, Alli A, Bao HF, Kaftan D, Sridhar S, Apell HJ, Gorshkov B, White R, Zimmermann A, Wendel A, Pauly-Evers M, Hamacher J, Garcia-Gabay I, Fischer B, Verin A, Bagi Z, Pittet JF, Shabbir W, Lemmens-Gruber R, Chakraborty T, Lazrak A, Matthay MA, Eaton DC, Lucas R.

Am J Respir Crit Care Med. 2014 Sep 1;190(5):522-32. doi: 10.1164/rccm.201405-0833OC.


ENaC activity and expression is decreased in the lungs of protein kinase C-α knockout mice.

Eaton AF, Yue Q, Eaton DC, Bao HF.

Am J Physiol Lung Cell Mol Physiol. 2014 Sep 1;307(5):L374-85. doi: 10.1152/ajplung.00040.2014. Epub 2014 Jul 11.


Cytochalasin E alters the cytoskeleton and decreases ENaC activity in Xenopus 2F3 cells.

Reifenberger MS, Yu L, Bao HF, Duke BJ, Liu BC, Ma HP, Alli AA, Eaton DC, Alli AA.

Am J Physiol Renal Physiol. 2014 Jul 1;307(1):F86-95. doi: 10.1152/ajprenal.00251.2013. Epub 2014 May 14.


Chronic ethanol exposure alters the lung proteome and leads to mitochondrial dysfunction in alveolar type 2 cells.

Alli AA, Brewer EM, Montgomery DS, Ghant MS, Eaton DC, Brown LA, Helms MN.

Am J Physiol Lung Cell Mol Physiol. 2014 Jun 1;306(11):L1026-35. doi: 10.1152/ajplung.00287.2013. Epub 2014 Mar 28.


Lovastatin inhibits human B lymphoma cell proliferation by reducing intracellular ROS and TRPC6 expression.

Song X, Liu BC, Lu XY, Yang LL, Zhai YJ, Eaton AF, Thai TL, Eaton DC, Ma HP, Shen BZ.

Biochim Biophys Acta. 2014 May;1843(5):894-901. doi: 10.1016/j.bbamcr.2014.02.002. Epub 2014 Feb 8.


ENaC activity is increased in isolated, split-open cortical collecting ducts from protein kinase Cα knockout mice.

Bao HF, Thai TL, Yue Q, Ma HP, Eaton AF, Cai H, Klein JD, Sands JM, Eaton DC.

Am J Physiol Renal Physiol. 2014 Feb 1;306(3):F309-20. doi: 10.1152/ajprenal.00519.2013. Epub 2013 Dec 11.


Estradiol activates epithelial sodium channels in rat alveolar cells through the G protein-coupled estrogen receptor.

Greenlee MM, Mitzelfelt JD, Yu L, Yue Q, Duke BJ, Harrell CS, Neigh GN, Eaton DC.

Am J Physiol Lung Cell Mol Physiol. 2013 Dec;305(11):L878-89. doi: 10.1152/ajplung.00008.2013. Epub 2013 Oct 4.


The inhibitory effect of Gβγ and Gβ isoform specificity on ENaC activity.

Yu L, Al-Khalili O, Duke BJ, Stockand JD, Eaton DC, Bao HF.

Am J Physiol Renal Physiol. 2013 Nov 1;305(9):F1365-73. doi: 10.1152/ajprenal.00009.2013. Epub 2013 Jul 17.


Lovastatin attenuates effects of cyclosporine A on tight junctions and apoptosis in cultured cortical collecting duct principal cells.

Liu BC, Song X, Lu XY, Fang CZ, Wei SP, Alli AA, Eaton DC, Shen BZ, Li XQ, Ma HP.

Am J Physiol Renal Physiol. 2013 Aug 1;305(3):F304-13. doi: 10.1152/ajprenal.00074.2013. Epub 2013 May 29.


WNK4 inhibition of ENaC is independent of Nedd4-2-mediated ENaC ubiquitination.

Yu L, Cai H, Yue Q, Alli AA, Wang D, Al-Khalili O, Bao HF, Eaton DC.

Am J Physiol Renal Physiol. 2013 Jul 1;305(1):F31-41. doi: 10.1152/ajprenal.00652.2012. Epub 2013 Apr 17.


Estradiol stimulates an anti-translocation expression pattern of glucocorticoid co-regulators in a hippocampal cell model.

Malviya SA, Kelly SD, Greenlee MM, Eaton DC, Duke BJ, Bourke CH, Neigh GN.

Physiol Behav. 2013 Oct 2;122:187-92. doi: 10.1016/j.physbeh.2013.03.018. Epub 2013 Mar 26.


High glucose induces podocyte apoptosis by stimulating TRPC6 via elevation of reactive oxygen species.

Liu BC, Song X, Lu XY, Li DT, Eaton DC, Shen BZ, Li XQ, Ma HP.

Biochim Biophys Acta. 2013 Jun;1833(6):1434-42. doi: 10.1016/j.bbamcr.2013.02.031. Epub 2013 Mar 13.


Scanning ion conductance microscopy: a nanotechnology for biological studies in live cells.

Liu BC, Lu XY, Song X, Lei KY, Alli AA, Bao HF, Eaton DC, Ma HP.

Front Physiol. 2013 Jan 14;3:483. doi: 10.3389/fphys.2012.00483. eCollection 2012.


ENaC is regulated by natriuretic peptide receptor-dependent cGMP signaling.

Guo LJ, Alli AA, Eaton DC, Bao HF.

Am J Physiol Renal Physiol. 2013 Apr 1;304(7):F930-7. doi: 10.1152/ajprenal.00638.2012. Epub 2013 Jan 16.


Cholinergic regulation of epithelial sodium channels in rat alveolar type 2 epithelial cells.

Takemura Y, Helms MN, Eaton AF, Self J, Ramosevac S, Jain L, Bao HF, Eaton DC.

Am J Physiol Lung Cell Mol Physiol. 2013 Mar 15;304(6):L428-37. doi: 10.1152/ajplung.00129.2012. Epub 2013 Jan 4.


Ethanol stimulates epithelial sodium channels by elevating reactive oxygen species.

Bao HF, Song JZ, Duke BJ, Ma HP, Denson DD, Eaton DC.

Am J Physiol Cell Physiol. 2012 Dec 1;303(11):C1129-38. doi: 10.1152/ajpcell.00139.2012. Epub 2012 Aug 15.


Inhibition of αENaC expression and ENaC activity following blockade of the circadian clock-regulatory kinases CK1δ/ε.

Richards J, Greenlee MM, Jeffers LA, Cheng KY, Guo L, Eaton DC, Gumz ML.

Am J Physiol Renal Physiol. 2012 Oct;303(7):F918-27. doi: 10.1152/ajprenal.00678.2011. Epub 2012 Jul 25.


Phosphatidylinositol phosphate-dependent regulation of Xenopus ENaC by MARCKS protein.

Alli AA, Bao HF, Alli AA, Aldrugh Y, Song JZ, Ma HP, Yu L, Al-Khalili O, Eaton DC.

Am J Physiol Renal Physiol. 2012 Sep 15;303(6):F800-11. doi: 10.1152/ajprenal.00703.2011. Epub 2012 Jul 11.


Cathepsin B is secreted apically from Xenopus 2F3 cells and cleaves the epithelial sodium channel (ENaC) to increase its activity.

Alli AA, Song JZ, Al-Khalili O, Bao HF, Ma HP, Alli AA, Eaton DC.

J Biol Chem. 2012 Aug 31;287(36):30073-83. doi: 10.1074/jbc.M111.338574. Epub 2012 Jul 10.

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