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Items: 38


Defining UHRF1 Domains that Support Maintenance of Human Colon Cancer DNA Methylation and Oncogenic Properties.

Kong X, Chen J, Xie W, Brown SM, Cai Y, Wu K, Fan D, Nie Y, Yegnasubramanian S, Tiedemann RL, Tao Y, Chiu Yen RW, Topper MJ, Zahnow CA, Easwaran H, Rothbart SB, Xia L, Baylin SB.

Cancer Cell. 2019 Apr 15;35(4):633-648.e7. doi: 10.1016/j.ccell.2019.03.003. Epub 2019 Apr 4.


DNA methylation in senescence, aging and cancer.

Xie W, Baylin SB, Easwaran H.

Oncoscience. 2019 Jan 31;6(1-2):291-293. doi: 10.18632/oncoscience.476. eCollection 2019 Jan. No abstract available.


Aging-like Spontaneous Epigenetic Silencing Facilitates Wnt Activation, Stemness, and BrafV600E-Induced Tumorigenesis.

Tao Y, Kang B, Petkovich DA, Bhandari YR, In J, Stein-O'Brien G, Kong X, Xie W, Zachos N, Maegawa S, Vaidya H, Brown S, Chiu Yen RW, Shao X, Thakor J, Lu Z, Cai Y, Zhang Y, Mallona I, Peinado MA, Zahnow CA, Ahuja N, Fertig E, Issa JP, Baylin SB, Easwaran H.

Cancer Cell. 2019 Feb 11;35(2):315-328.e6. doi: 10.1016/j.ccell.2019.01.005.


Integrated Genomic, Epigenomic, and Expression Analyses of Ovarian Cancer Cell Lines.

Papp E, Hallberg D, Konecny GE, Bruhm DC, Adleff V, Noë M, Kagiampakis I, Palsgrove D, Conklin D, Kinose Y, White JR, Press MF, Drapkin R, Easwaran H, Baylin SB, Slamon D, Velculescu VE, Scharpf RB.

Cell Rep. 2018 Nov 27;25(9):2617-2633. doi: 10.1016/j.celrep.2018.10.096.


DNA Methylation Patterns Separate Senescence from Transformation Potential and Indicate Cancer Risk.

Xie W, Kagiampakis I, Pan L, Zhang YW, Murphy L, Tao Y, Kong X, Kang B, Xia L, Carvalho FLF, Sen S, Chiu Yen RW, Zahnow CA, Ahuja N, Baylin SB, Easwaran H.

Cancer Cell. 2018 Feb 12;33(2):309-321.e5. doi: 10.1016/j.ccell.2018.01.008.


A KDM5 Inhibitor Increases Global H3K4 Trimethylation Occupancy and Enhances the Biological Efficacy of 5-Aza-2'-Deoxycytidine.

Leadem BR, Kagiampakis I, Wilson C, Cheung TK, Arnott D, Trojer P, Classon M, Easwaran H, Baylin SB.

Cancer Res. 2018 Mar 1;78(5):1127-1139. doi: 10.1158/0008-5472.CAN-17-1453. Epub 2017 Dec 27.


Epigenetic regulation of gene expression in cancer: techniques, resources and analysis.

Kagohara LT, Stein-O'Brien GL, Kelley D, Flam E, Wick HC, Danilova LV, Easwaran H, Favorov AV, Qian J, Gaykalova DA, Fertig EJ.

Brief Funct Genomics. 2018 Jan 1;17(1):49-63. doi: 10.1093/bfgp/elx018.


Chronic Cigarette Smoke-Induced Epigenomic Changes Precede Sensitization of Bronchial Epithelial Cells to Single-Step Transformation by KRAS Mutations.

Vaz M, Hwang SY, Kagiampakis I, Phallen J, Patil A, O'Hagan HM, Murphy L, Zahnow CA, Gabrielson E, Velculescu VE, Easwaran HP, Baylin SB.

Cancer Cell. 2017 Sep 11;32(3):360-376.e6. doi: 10.1016/j.ccell.2017.08.006.


Combination epigenetic therapy in metastatic colorectal cancer (mCRC) with subcutaneous 5-azacitidine and entinostat: a phase 2 consortium/stand up 2 cancer study.

Azad NS, El-Khoueiry A, Yin J, Oberg AL, Flynn P, Adkins D, Sharma A, Weisenberger DJ, Brown T, Medvari P, Jones PA, Easwaran H, Kamel I, Bahary N, Kim G, Picus J, Pitot HC, Erlichman C, Donehower R, Shen H, Laird PW, Piekarz R, Baylin S, Ahuja N.

Oncotarget. 2017 May 23;8(21):35326-35338. doi: 10.18632/oncotarget.15108.


Acetylation Enhances TET2 Function in Protecting against Abnormal DNA Methylation during Oxidative Stress.

Zhang YW, Wang Z, Xie W, Cai Y, Xia L, Easwaran H, Luo J, Yen RC, Li Y, Baylin SB.

Mol Cell. 2017 Jan 19;65(2):323-335. doi: 10.1016/j.molcel.2016.12.013.


Genome-wide positioning of bivalent mononucleosomes.

Sen S, Block KF, Pasini A, Baylin SB, Easwaran H.

BMC Med Genomics. 2016 Sep 15;9(1):60. doi: 10.1186/s12920-016-0221-6.


Evaluation of azacitidine and entinostat as sensitization agents to cytotoxic chemotherapy in preclinical models of non-small cell lung cancer.

Vendetti FP, Topper M, Huang P, Dobromilskaya I, Easwaran H, Wrangle J, Baylin SB, Poirier JT, Rudin CM.

Oncotarget. 2015 Jan 1;6(1):56-70.


Cancer epigenetics: tumor heterogeneity, plasticity of stem-like states, and drug resistance.

Easwaran H, Tsai HC, Baylin SB.

Mol Cell. 2014 Jun 5;54(5):716-27. doi: 10.1016/j.molcel.2014.05.015. Review.


Prognostic value of CpG island methylator phenotype among colorectal cancer patients: a systematic review and meta-analysis.

Juo YY, Johnston FM, Zhang DY, Juo HH, Wang H, Pappou EP, Yu T, Easwaran H, Baylin S, van Engeland M, Ahuja N.

Ann Oncol. 2014 Dec;25(12):2314-27. doi: 10.1093/annonc/mdu149. Epub 2014 Apr 8. Review.


Immune regulation by low doses of the DNA methyltransferase inhibitor 5-azacitidine in common human epithelial cancers.

Li H, Chiappinelli KB, Guzzetta AA, Easwaran H, Yen RW, Vatapalli R, Topper MJ, Luo J, Connolly RM, Azad NS, Stearns V, Pardoll DM, Davidson N, Jones PA, Slamon DJ, Baylin SB, Zahnow CA, Ahuja N.

Oncotarget. 2014 Feb 15;5(3):587-98.


Functional identification of cancer-specific methylation of CDO1, HOXA9, and TAC1 for the diagnosis of lung cancer.

Wrangle J, Machida EO, Danilova L, Hulbert A, Franco N, Zhang W, Glöckner SC, Tessema M, Van Neste L, Easwaran H, Schuebel KE, Licchesi J, Hooker CM, Ahuja N, Amano J, Belinsky SA, Baylin SB, Herman JG, Brock MV.

Clin Cancer Res. 2014 Apr 1;20(7):1856-64. doi: 10.1158/1078-0432.CCR-13-2109. Epub 2014 Jan 31.


Harnessing the potential of epigenetic therapy to target solid tumors.

Ahuja N, Easwaran H, Baylin SB.

J Clin Invest. 2014 Jan;124(1):56-63. doi: 10.1172/JCI69736. Epub 2014 Jan 2. Review.


Alterations of immune response of Non-Small Cell Lung Cancer with Azacytidine.

Wrangle J, Wang W, Koch A, Easwaran H, Mohammad HP, Vendetti F, Vancriekinge W, Demeyer T, Du Z, Parsana P, Rodgers K, Yen RW, Zahnow CA, Taube JM, Brahmer JR, Tykodi SS, Easton K, Carvajal RD, Jones PA, Laird PW, Weisenberger DJ, Tsai S, Juergens RA, Topalian SL, Rudin CM, Brock MV, Pardoll D, Baylin SB.

Oncotarget. 2013 Nov;4(11):2067-79.


Epigenetic abnormalities in cancer find a "home on the range".

Easwaran H, Baylin SB.

Cancer Cell. 2013 Jan 14;23(1):1-3. doi: 10.1016/j.ccr.2012.12.018.


A DNA hypermethylation module for the stem/progenitor cell signature of cancer.

Easwaran H, Johnstone SE, Van Neste L, Ohm J, Mosbruger T, Wang Q, Aryee MJ, Joyce P, Ahuja N, Weisenberger D, Collisson E, Zhu J, Yegnasubramanian S, Matsui W, Baylin SB.

Genome Res. 2012 May;22(5):837-49. doi: 10.1101/gr.131169.111. Epub 2012 Mar 5.


Biomarkers for EGFR-antagonist response: in the genes and on the genes!

Easwaran H, Baylin SB.

Clin Cancer Res. 2012 Apr 15;18(8):2121-3. doi: 10.1158/1078-0432.CCR-12-0157. Epub 2012 Feb 27.


DNMT1 modulates gene expression without its catalytic activity partially through its interactions with histone-modifying enzymes.

Clements EG, Mohammad HP, Leadem BR, Easwaran H, Cai Y, Van Neste L, Baylin SB.

Nucleic Acids Res. 2012 May;40(10):4334-46. doi: 10.1093/nar/gks031. Epub 2012 Jan 25.


Oxidative damage targets complexes containing DNA methyltransferases, SIRT1, and polycomb members to promoter CpG Islands.

O'Hagan HM, Wang W, Sen S, Destefano Shields C, Lee SS, Zhang YW, Clements EG, Cai Y, Van Neste L, Easwaran H, Casero RA, Sears CL, Baylin SB.

Cancer Cell. 2011 Nov 15;20(5):606-19. doi: 10.1016/j.ccr.2011.09.012.


Role of nuclear architecture in epigenetic alterations in cancer.

Easwaran HP, Baylin SB.

Cold Spring Harb Symp Quant Biol. 2010;75:507-15. doi: 10.1101/sqb.2010.75.031. Epub 2011 Mar 29.


Aberrant silencing of cancer-related genes by CpG hypermethylation occurs independently of their spatial organization in the nucleus.

Easwaran HP, Van Neste L, Cope L, Sen S, Mohammad HP, Pageau GJ, Lawrence JB, Herman JG, Schuebel KE, Baylin SB.

Cancer Res. 2010 Oct 15;70(20):8015-24. doi: 10.1158/0008-5472.CAN-10-0765. Epub 2010 Aug 24.


Enzymatic incorporation of multiple dyes for increased sensitivity in QD-FRET sensing for DNA methylation detection.

Bailey VJ, Keeley BP, Zhang Y, Ho YP, Easwaran H, Brock MV, Pelosky KL, Carraway HE, Baylin SB, Herman JG, Wang TH.

Chembiochem. 2010 Jan 4;11(1):71-4. doi: 10.1002/cbic.200900630. No abstract available.


Polycomb CBX7 promotes initiation of heritable repression of genes frequently silenced with cancer-specific DNA hypermethylation.

Mohammad HP, Cai Y, McGarvey KM, Easwaran H, Van Neste L, Ohm JE, O'Hagan HM, Baylin SB.

Cancer Res. 2009 Aug 1;69(15):6322-30. doi: 10.1158/0008-5472.CAN-09-0065. Epub 2009 Jul 14.


MS-qFRET: a quantum dot-based method for analysis of DNA methylation.

Bailey VJ, Easwaran H, Zhang Y, Griffiths E, Belinsky SA, Herman JG, Baylin SB, Carraway HE, Wang TH.

Genome Res. 2009 Aug;19(8):1455-61. doi: 10.1101/gr.088831.108. Epub 2009 May 14.


DNA methylation analysis on a droplet-in-oil PCR array.

Zhang Y, Bailey V, Puleo CM, Easwaran H, Griffiths E, Herman JG, Baylin SB, Wang TH.

Lab Chip. 2009 Apr 21;9(8):1059-64. doi: 10.1039/b821780g. Epub 2009 Mar 6.


Abnormal DNA methylation of CD133 in colorectal and glioblastoma tumors.

Yi JM, Tsai HC, Glöckner SC, Lin S, Ohm JE, Easwaran H, James CD, Costello JF, Riggins G, Eberhart CG, Laterra J, Vescovi AL, Ahuja N, Herman JG, Schuebel KE, Baylin SB.

Cancer Res. 2008 Oct 1;68(19):8094-103. doi: 10.1158/0008-5472.CAN-07-6208.


Epigenetic inactivation of the canonical Wnt antagonist SRY-box containing gene 17 in colorectal cancer.

Zhang W, Glöckner SC, Guo M, Machida EO, Wang DH, Easwaran H, Van Neste L, Herman JG, Schuebel KE, Watkins DN, Ahuja N, Baylin SB.

Cancer Res. 2008 Apr 15;68(8):2764-72. doi: 10.1158/0008-5472.CAN-07-6349. Erratum in: Cancer Res. 2008 Jul 15;68(14):6030.


Distribution of DNA replication proteins in Drosophila cells.

Easwaran HP, Leonhardt H, Cardoso MC.

BMC Cell Biol. 2007 Oct 15;8:42.


Trapped in action: direct visualization of DNA methyltransferase activity in living cells.

Schermelleh L, Spada F, Easwaran HP, Zolghadr K, Margot JB, Cardoso MC, Leonhardt H.

Nat Methods. 2005 Oct;2(10):751-6.


Methyl CpG-binding proteins induce large-scale chromatin reorganization during terminal differentiation.

Brero A, Easwaran HP, Nowak D, Grunewald I, Cremer T, Leonhardt H, Cardoso MC.

J Cell Biol. 2005 Jun 6;169(5):733-43.


Cell cycle markers for live cell analyses.

Easwaran HP, Leonhardt H, Cardoso MC.

Cell Cycle. 2005 Mar;4(3):453-5. Epub 2005 Mar 7.


Replication-independent chromatin loading of Dnmt1 during G2 and M phases.

Easwaran HP, Schermelleh L, Leonhardt H, Cardoso MC.

EMBO Rep. 2004 Dec;5(12):1181-6.


A novel approach to induce cell cycle reentry in terminally differentiated muscle cells.

Derer W, Easwaran HP, Leonhardt H, Cardoso MC.

FASEB J. 2002 Jan;16(1):132-3. Epub 2001 Nov 29.


Direct protein transfer to terminally differentiated muscle cells.

Derer W, Easwaran HP, Knopf CW, Leonhardt H, Cardoso MC.

J Mol Med (Berl). 1999 Aug;77(8):609-13.


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