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Items: 36

1.

Plasmodium vivax chloroquine resistance links to pvcrt transcription in a genetic cross.

Sá JM, Kaslow SR, Moraes Barros RR, Brazeau NF, Parobek CM, Tao D, Salzman RE, Gibson TJ, Velmurugan S, Krause MA, Melendez-Muniz V, Kite WA, Han PK, Eastman RT, Kim A, Kessler EG, Abebe Y, James ER, Chakravarty S, Orr-Gonzalez S, Lambert LE, Engels T, Thomas ML, Fasinu PS, Serre D, Gwadz RW, Walker L, DeConti DK, Mu J, Bailey JA, Sim BKL, Hoffman SL, Fay MP, Dinglasan RR, Juliano JJ, Wellems TE.

Nat Commun. 2019 Sep 20;10(1):4300. doi: 10.1038/s41467-019-12256-9.

2.

Canvass: A Crowd-Sourced, Natural-Product Screening Library for Exploring Biological Space.

Kearney SE, Zahoránszky-Kőhalmi G, Brimacombe KR, Henderson MJ, Lynch C, Zhao T, Wan KK, Itkin Z, Dillon C, Shen M, Cheff DM, Lee TD, Bougie D, Cheng K, Coussens NP, Dorjsuren D, Eastman RT, Huang R, Iannotti MJ, Karavadhi S, Klumpp-Thomas C, Roth JS, Sakamuru S, Sun W, Titus SA, Yasgar A, Zhang YQ, Zhao J, Andrade RB, Brown MK, Burns NZ, Cha JK, Mevers EE, Clardy J, Clement JA, Crooks PA, Cuny GD, Ganor J, Moreno J, Morrill LA, Picazo E, Susick RB, Garg NK, Goess BC, Grossman RB, Hughes CC, Johnston JN, Joullie MM, Kinghorn AD, Kingston DGI, Krische MJ, Kwon O, Maimone TJ, Majumdar S, Maloney KN, Mohamed E, Murphy BT, Nagorny P, Olson DE, Overman LE, Brown LE, Snyder JK, Porco JA Jr, Rivas F, Ross SA, Sarpong R, Sharma I, Shaw JT, Xu Z, Shen B, Shi W, Stephenson CRJ, Verano AL, Tan DS, Tang Y, Taylor RE, Thomson RJ, Vosburg DA, Wu J, Wuest WM, Zakarian A, Zhang Y, Ren T, Zuo Z, Inglese J, Michael S, Simeonov A, Zheng W, Shinn P, Jadhav A, Boxer MB, Hall MD, Xia M, Guha R, Rohde JM.

ACS Cent Sci. 2018 Dec 26;4(12):1727-1741. doi: 10.1021/acscentsci.8b00747. Epub 2018 Dec 5.

3.

Artemisinin resistance phenotypes and K13 inheritance in a Plasmodium falciparum cross and Aotus model.

Sá JM, Kaslow SR, Krause MA, Melendez-Muniz VA, Salzman RE, Kite WA, Zhang M, Moraes Barros RR, Mu J, Han PK, Mershon JP, Figan CE, Caleon RL, Rahman RS, Gibson TJ, Amaratunga C, Nishiguchi EP, Breglio KF, Engels TM, Velmurugan S, Ricklefs S, Straimer J, Gnädig NF, Deng B, Liu A, Diouf A, Miura K, Tullo GS, Eastman RT, Chakravarty S, James ER, Udenze K, Li S, Sturdevant DE, Gwadz RW, Porcella SF, Long CA, Fidock DA, Thomas ML, Fay MP, Sim BKL, Hoffman SL, Adams JH, Fairhurst RM, Su XZ, Wellems TE.

Proc Natl Acad Sci U S A. 2018 Dec 4;115(49):12513-12518. doi: 10.1073/pnas.1813386115. Epub 2018 Nov 19.

4.

Using Machine Learning to Predict Synergistic Antimalarial Compound Combinations With Novel Structures.

Mason DJ, Eastman RT, Lewis RPI, Stott IP, Guha R, Bender A.

Front Pharmacol. 2018 Oct 2;9:1096. doi: 10.3389/fphar.2018.01096. eCollection 2018.

5.

Screening the Pathogen Box for Molecules Active against Plasmodium Sexual Stages Using a New Nanoluciferase-Based Transgenic Line of P. berghei Identifies Transmission-Blocking Compounds.

Calit J, Dobrescu I, Gaitán XA, Borges MH, Ramos MS, Eastman RT, Bargieri DY.

Antimicrob Agents Chemother. 2018 Oct 24;62(11). pii: e01053-18. doi: 10.1128/AAC.01053-18. Print 2018 Nov.

6.

Sulfamethoxazole Levels in HIV-Exposed Uninfected Ugandan Children.

Kasule J, Gabriel EE, Anok A, Neal J, Eastman RT, Penzak S, Newell K, Serwadda D, Duffy PE, Reynolds SJ, Hobbs CV.

Am J Trop Med Hyg. 2018 Jun;98(6):1718-1721. doi: 10.4269/ajtmh.17-0933. Epub 2018 Apr 19.

7.

A systematic and prospectively validated approach for identifying synergistic drug combinations against malaria.

KalantarMotamedi Y, Eastman RT, Guha R, Bender A.

Malar J. 2018 Apr 11;17(1):160. doi: 10.1186/s12936-018-2294-5.

8.

New WS9326A Derivatives and One New Annimycin Derivative with Antimalarial Activity are Produced by Streptomyces asterosporus DSM 41452 and Its Mutant.

Zhang S, Zhu J, Zechel DL, Jessen-Trefzer C, Eastman RT, Paululat T, Bechthold A.

Chembiochem. 2018 Feb 2;19(3):272-279. doi: 10.1002/cbic.201700428. Epub 2017 Dec 18.

9.

Mechanism of splenic cell death and host mortality in a Plasmodium yoelii malaria model.

Lacerda-Queiroz N, Riteau N, Eastman RT, Bock KW, Orandle MS, Moore IN, Sher A, Long CA, Jankovic D, Su XZ.

Sci Rep. 2017 Sep 5;7(1):10438. doi: 10.1038/s41598-017-10776-2.

10.

A Plasmodium yoelii HECT-like E3 ubiquitin ligase regulates parasite growth and virulence.

Nair SC, Xu R, Pattaradilokrat S, Wu J, Qi Y, Zilversmit M, Ganesan S, Nagarajan V, Eastman RT, Orandle MS, Tan JC, Myers TG, Liu S, Long CA, Li J, Su XZ.

Nat Commun. 2017 Aug 9;8(1):223. doi: 10.1038/s41467-017-00267-3.

11.

PfCRT and PfMDR1 modulate interactions of artemisinin derivatives and ion channel blockers.

Eastman RT, Khine P, Huang R, Thomas CJ, Su XZ.

Sci Rep. 2016 May 5;6:25379. doi: 10.1038/srep25379.

12.

Actinoramide A Identified as a Potent Antimalarial from Titration-Based Screening of Marine Natural Product Extracts.

Cheng KC, Cao S, Raveh A, MacArthur R, Dranchak P, Chlipala G, Okoneski MT, Guha R, Eastman RT, Yuan J, Schultz PJ, Su XZ, Tamayo-Castillo G, Matainaho T, Clardy J, Sherman DH, Inglese J.

J Nat Prod. 2015 Oct 23;78(10):2411-22. doi: 10.1021/acs.jnatprod.5b00489. Epub 2015 Oct 14.

13.

High-throughput matrix screening identifies synergistic and antagonistic antimalarial drug combinations.

Mott BT, Eastman RT, Guha R, Sherlach KS, Siriwardana A, Shinn P, McKnight C, Michael S, Lacerda-Queiroz N, Patel PR, Khine P, Sun H, Kasbekar M, Aghdam N, Fontaine SD, Liu D, Mierzwa T, Mathews-Griner LA, Ferrer M, Renslo AR, Inglese J, Yuan J, Roepe PD, Su XZ, Thomas CJ.

Sci Rep. 2015 Sep 25;5:13891. doi: 10.1038/srep13891.

14.

Regulation of Plasmodium yoelii oocyst development by strain- and stage-specific small-subunit rRNA.

Qi Y, Zhu F, Eastman RT, Fu Y, Zilversmit M, Pattaradilokrat S, Hong L, Liu S, McCutchan TF, Pan W, Xu W, Li J, Huang F, Su XZ.

MBio. 2015 Mar 10;6(2):e00117. doi: 10.1128/mBio.00117-15.

15.

Supergenomic network compression and the discovery of EXP1 as a glutathione transferase inhibited by artesunate.

Lisewski AM, Quiros JP, Ng CL, Adikesavan AK, Miura K, Putluri N, Eastman RT, Scanfeld D, Regenbogen SJ, Altenhofen L, Llinás M, Sreekumar A, Long C, Fidock DA, Lichtarge O.

Cell. 2014 Aug 14;158(4):916-928. doi: 10.1016/j.cell.2014.07.011.

16.

Plasmodium genetic loci linked to host cytokine and chemokine responses.

Pattaradilokrat S, Li J, Wu J, Qi Y, Eastman RT, Zilversmit M, Nair SC, Huaman MC, Quinones M, Jiang H, Li N, Zhu J, Zhao K, Kaneko O, Long CA, Su XZ.

Genes Immun. 2014 Apr-May;15(3):145-52. doi: 10.1038/gene.2013.74. Epub 2014 Jan 23.

17.

A specific inhibitor of PfCDPK4 blocks malaria transmission: chemical-genetic validation.

Ojo KK, Eastman RT, Vidadala R, Zhang Z, Rivas KL, Choi R, Lutz JD, Reid MC, Fox AM, Hulverson MA, Kennedy M, Isoherranen N, Kim LM, Comess KM, Kempf DJ, Verlinde CL, Su XZ, Kappe SH, Maly DJ, Fan E, Van Voorhis WC.

J Infect Dis. 2014 Jan 15;209(2):275-84. doi: 10.1093/infdis/jit522. Epub 2013 Oct 10.

18.

Genome-wide profiling of chromosome interactions in Plasmodium falciparum characterizes nuclear architecture and reconfigurations associated with antigenic variation.

Lemieux JE, Kyes SA, Otto TD, Feller AI, Eastman RT, Pinches RA, Berriman M, Su XZ, Newbold CI.

Mol Microbiol. 2013 Nov;90(3):519-37. doi: 10.1111/mmi.12381. Epub 2013 Sep 30.

19.

Ex vivo susceptibility of Plasmodium falciparum to antimalarial drugs in western, northern, and eastern Cambodia, 2011-2012: association with molecular markers.

Lim P, Dek D, Try V, Eastman RT, Chy S, Sreng S, Suon S, Mao S, Sopha C, Sam B, Ashley EA, Miotto O, Dondorp AM, White NJ, Su XZ, Char MC, Anderson JM, Amaratunga C, Menard D, Fairhurst RM.

Antimicrob Agents Chemother. 2013 Nov;57(11):5277-83. doi: 10.1128/AAC.00687-13. Epub 2013 Aug 12.

20.

A class of tricyclic compounds blocking malaria parasite oocyst development and transmission.

Eastman RT, Pattaradilokrat S, Raj DK, Dixit S, Deng B, Miura K, Yuan J, Tanaka TQ, Johnson RL, Jiang H, Huang R, Williamson KC, Lambert LE, Long C, Austin CP, Wu Y, Su XZ.

Antimicrob Agents Chemother. 2013 Jan;57(1):425-35. doi: 10.1128/AAC.00920-12. Epub 2012 Nov 5.

21.

Quantitative assessment of Plasmodium falciparum sexual development reveals potent transmission-blocking activity by methylene blue.

Adjalley SH, Johnston GL, Li T, Eastman RT, Ekland EH, Eappen AG, Richman A, Sim BK, Lee MC, Hoffman SL, Fidock DA.

Proc Natl Acad Sci U S A. 2011 Nov 22;108(47):E1214-23. doi: 10.1073/pnas.1112037108. Epub 2011 Oct 31.

22.

Piperaquine resistance is associated with a copy number variation on chromosome 5 in drug-pressured Plasmodium falciparum parasites.

Eastman RT, Dharia NV, Winzeler EA, Fidock DA.

Antimicrob Agents Chemother. 2011 Aug;55(8):3908-16. doi: 10.1128/AAC.01793-10. Epub 2011 May 16.

23.

Artemisinin-based combination therapies: a vital tool in efforts to eliminate malaria.

Eastman RT, Fidock DA.

Nat Rev Microbiol. 2009 Dec;7(12):864-74. doi: 10.1038/nrmicro2239. Epub 2009 Nov 2. Review.

24.

Use of high-density tiling microarrays to identify mutations globally and elucidate mechanisms of drug resistance in Plasmodium falciparum.

Dharia NV, Sidhu AB, Cassera MB, Westenberger SJ, Bopp SE, Eastman RT, Plouffe D, Batalov S, Park DJ, Volkman SK, Wirth DF, Zhou Y, Fidock DA, Winzeler EA.

Genome Biol. 2009 Feb 13;10(2):R21. doi: 10.1186/gb-2009-10-2-r21.

25.

Recent highlights in antimalarial drug resistance and chemotherapy research.

Fidock DA, Eastman RT, Ward SA, Meshnick SR.

Trends Parasitol. 2008 Dec;24(12):537-44. doi: 10.1016/j.pt.2008.09.005. Epub 2008 Oct 18. Review.

26.

C-terminal proteolysis of prenylated proteins in trypanosomatids and RNA interference of enzymes required for the post-translational processing pathway of farnesylated proteins.

Gillespie JR, Yokoyama K, Lu K, Eastman RT, Bollinger JG, Van Voorhis WC, Gelb MH, Buckner FS.

Mol Biochem Parasitol. 2007 Jun;153(2):115-24. Epub 2007 Mar 1.

PMID:
17397944
27.

Resistance mutations at the lipid substrate binding site of Plasmodium falciparum protein farnesyltransferase.

Eastman RT, White J, Hucke O, Yokoyama K, Verlinde CL, Hast MA, Beese LS, Gelb MH, Rathod PK, Van Voorhis WC.

Mol Biochem Parasitol. 2007 Mar;152(1):66-71. Epub 2006 Dec 22.

28.

Thematic review series: lipid posttranslational modifications. Fighting parasitic disease by blocking protein farnesylation.

Eastman RT, Buckner FS, Yokoyama K, Gelb MH, Van Voorhis WC.

J Lipid Res. 2006 Feb;47(2):233-40. Epub 2005 Dec 7. Review.

29.

Leishmania inactivation in human pheresis platelets by a psoralen (amotosalen HCl) and long-wavelength ultraviolet irradiation.

Eastman RT, Barrett LK, Dupuis K, Buckner FS, Van Voorhis WC.

Transfusion. 2005 Sep;45(9):1459-63.

PMID:
16131378
30.

Protein farnesyl transferase inhibitors for the treatment of malaria and African trypanosomiasis.

Buckner FS, Eastman RT, Yokoyama K, Gelb MH, Van Voorhis WC.

Curr Opin Investig Drugs. 2005 Aug;6(8):791-7. Review.

PMID:
16121685
31.

Resistance to a protein farnesyltransferase inhibitor in Plasmodium falciparum.

Eastman RT, White J, Hucke O, Bauer K, Yokoyama K, Nallan L, Chakrabarti D, Verlinde CL, Gelb MH, Rathod PK, Van Voorhis WC.

J Biol Chem. 2005 Apr 8;280(14):13554-9. Epub 2005 Jan 20.

32.

The Candida albicans lanosterol 14-alpha-demethylase (ERG11) gene promoter is maximally induced after prolonged growth with antifungal drugs.

Song JL, Harry JB, Eastman RT, Oliver BG, White TC.

Antimicrob Agents Chemother. 2004 Apr;48(4):1136-44.

33.

Cloning and analysis of Trypanosoma cruzi lanosterol 14alpha-demethylase.

Buckner FS, Joubert BM, Boyle SM, Eastman RT, Verlinde CL, Matsuda SP.

Mol Biochem Parasitol. 2003 Dec;132(2):75-81.

PMID:
14599667
34.

Oxidosqualene cyclase inhibitors as antimicrobial agents.

Hinshaw JC, Suh DY, Garnier P, Buckner FS, Eastman RT, Matsuda SP, Joubert BM, Coppens I, Joiner KA, Merali S, Nash TE, Prestwich GD.

J Med Chem. 2003 Sep 25;46(20):4240-3.

PMID:
13678402
35.

Trypanosoma cruzi inactivation in human platelet concentrates and plasma by a psoralen (amotosalen HCl) and long-wavelength UV.

Van Voorhis WC, Barrett LK, Eastman RT, Alfonso R, Dupuis K.

Antimicrob Agents Chemother. 2003 Feb;47(2):475-9.

36.

Cloning, heterologous expression, and substrate specificities of protein farnesyltransferases from Trypanosoma cruzi and Leishmania major.

Buckner FS, Eastman RT, Nepomuceno-Silva JL, Speelmon EC, Myler PJ, Van Voorhis WC, Yokoyama K.

Mol Biochem Parasitol. 2002 Jul;122(2):181-8.

PMID:
12106872

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