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Isolation of mitotic chromosomes from vertebrate cells and characterization of their proteome by mass spectrometry.

Samejima I, Earnshaw WC.

Methods Cell Biol. 2018;144:329-348. doi: 10.1016/bs.mcb.2018.03.021. Epub 2018 Apr 12.


Publisher Correction: A DHODH inhibitor increases p53 synthesis and enhances tumor cell killing by p53 degradation blockage.

Ladds MJGW, van Leeuwen IMM, Drummond CJ, Chu S, Healy AR, Popova G, Pastor Fernández A, Mollick T, Darekar S, Sedimbi SK, Nekulova M, Sachweh MCC, Campbell J, Higgins M, Tuck C, Popa M, Safont MM, Gelebart P, Fandalyuk Z, Thompson AM, Svensson R, Gustavsson AL, Johansson L, Färnegårdh K, Yngve U, Saleh A, Haraldsson M, D'Hollander ACA, Franco M, Zhao Y, Håkansson M, Walse B, Larsson K, Peat EM, Pelechano V, Lunec J, Vojtesek B, Carmena M, Earnshaw WC, McCarthy AR, Westwood NJ, Arsenian-Henriksson M, Lane DP, Bhatia R, McCormack E, Laín S.

Nat Commun. 2018 May 22;9(1):2071. doi: 10.1038/s41467-018-04198-5.


Seh1 targets GATOR2 and Nup153 to mitotic chromosomes.

Platani M, Samejima I, Samejima K, Kanemaki MT, Earnshaw WC.

J Cell Sci. 2018 May 1;131(9). pii: jcs213140. doi: 10.1242/jcs.213140.


Generation of a Synthetic Human Chromosome with Two Centromeric Domains for Advanced Epigenetic Engineering Studies.

Pesenti E, Kouprina N, Liskovykh M, Aurich-Costa J, Larionov V, Masumoto H, Earnshaw WC, Molina O.

ACS Synth Biol. 2018 Apr 20;7(4):1116-1130. doi: 10.1021/acssynbio.8b00018. Epub 2018 Mar 29.


A DHODH inhibitor increases p53 synthesis and enhances tumor cell killing by p53 degradation blockage.

Ladds MJGW, van Leeuwen IMM, Drummond CJ, Chu S, Healy AR, Popova G, Pastor Fernández A, Mollick T, Darekar S, Sedimbi SK, Nekulova M, Sachweh MCC, Campbell J, Higgins M, Tuck C, Popa M, Safont MM, Gelebart P, Fandalyuk Z, Thompson AM, Svensson R, Gustavsson AL, Johansson L, Färnegårdh K, Yngve U, Saleh A, Haraldsson M, D'Hollander ACA, Franco M, Zhao Y, Håkansson M, Walse B, Larsson K, Peat EM, Pelechano V, Lunec J, Vojtesek B, Carmena M, Earnshaw WC, McCarthy AR, Westwood NJ, Arsenian-Henriksson M, Lane DP, Bhatia R, McCormack E, Laín S.

Nat Commun. 2018 Mar 16;9(1):1107. doi: 10.1038/s41467-018-03441-3. Erratum in: Nat Commun. 2018 May 22;9(1):2071.


Mps1 Phosphorylates Its N-Terminal Extension to Relieve Autoinhibition and Activate the Spindle Assembly Checkpoint.

Combes G, Barysz H, Garand C, Gama Braga L, Alharbi I, Thebault P, Murakami L, Bryne DP, Stankovic S, Eyers PA, Bolanos-Garcia VM, Earnshaw WC, Maciejowski J, Jallepalli PV, Elowe S.

Curr Biol. 2018 Mar 19;28(6):872-883.e5. doi: 10.1016/j.cub.2018.02.002. Epub 2018 Mar 1.


HP1α targets the chromosomal passenger complex for activation at heterochromatin before mitotic entry.

Ruppert JG, Samejima K, Platani M, Molina O, Kimura H, Jeyaprakash AA, Ohta S, Earnshaw WC.

EMBO J. 2018 Mar 15;37(6). pii: e97677. doi: 10.15252/embj.201797677. Epub 2018 Feb 21.


Functional analysis after rapid degradation of condensins and 3D-EM reveals chromatin volume is uncoupled from chromosome architecture in mitosis.

Samejima K, Booth DG, Ogawa H, Paulson JR, Xie L, Watson CA, Platani M, Kanemaki MT, Earnshaw WC.

J Cell Sci. 2018 Feb 22;131(4). pii: jcs210187. doi: 10.1242/jcs.210187.


A pathway for mitotic chromosome formation.

Gibcus JH, Samejima K, Goloborodko A, Samejima I, Naumova N, Nuebler J, Kanemaki MT, Xie L, Paulson JR, Earnshaw WC, Mirny LA, Dekker J.

Science. 2018 Feb 9;359(6376). pii: eaao6135. doi: 10.1126/science.aao6135. Epub 2018 Jan 18.


Mitotic post-translational modifications of histones promote chromatin compaction in vitro.

Zhiteneva A, Bonfiglio JJ, Makarov A, Colby T, Vagnarelli P, Schirmer EC, Matic I, Earnshaw WC.

Open Biol. 2017 Sep;7(9). pii: 170076. doi: 10.1098/rsob.170076.


Use of Mass Spectrometry to Study the Centromere and Kinetochore.

Samejima I, Platani M, Earnshaw WC.

Prog Mol Subcell Biol. 2017;56:3-27. doi: 10.1007/978-3-319-58592-5_1.


Ki-67 and the Chromosome Periphery Compartment in Mitosis.

Booth DG, Earnshaw WC.

Trends Cell Biol. 2017 Dec;27(12):906-916. doi: 10.1016/j.tcb.2017.08.001. Epub 2017 Aug 23. Review.


Method to Assemble Genomic DNA Fragments or Genes on Human Artificial Chromosome with Regulated Kinetochore Using a Multi-Integrase System.

Lee NCO, Kim JH, Petrov NS, Lee HS, Masumoto H, Earnshaw WC, Larionov V, Kouprina N.

ACS Synth Biol. 2018 Jan 19;7(1):63-74. doi: 10.1021/acssynbio.7b00209. Epub 2017 Aug 24.


Using human artificial chromosomes to study centromere assembly and function.

Molina O, Kouprina N, Masumoto H, Larionov V, Earnshaw WC.

Chromosoma. 2017 Oct;126(5):559-575. doi: 10.1007/s00412-017-0633-x. Epub 2017 Jul 7. Review.


Molecular basis for Cdk1-regulated timing of Mis18 complex assembly and CENP-A deposition.

Spiller F, Medina-Pritchard B, Abad MA, Wear MA, Molina O, Earnshaw WC, Jeyaprakash AA.

EMBO Rep. 2017 Jun;18(6):894-905. doi: 10.15252/embr.201643564. Epub 2017 Apr 4.


Stepwise unfolding supports a subunit model for vertebrate kinetochores.

Vargiu G, Makarov AA, Allan J, Fukagawa T, Booth DG, Earnshaw WC.

Proc Natl Acad Sci U S A. 2017 Mar 21;114(12):3133-3138. doi: 10.1073/pnas.1614145114. Epub 2017 Mar 6.


Nano Random Forests to mine protein complexes and their relationships in quantitative proteomics data.

Montaño-Gutierrez LF, Ohta S, Kustatscher G, Earnshaw WC, Rappsilber J.

Mol Biol Cell. 2017 Mar 1;28(5):673-680. doi: 10.1091/mbc.E16-06-0370. Epub 2017 Jan 5.


PREditOR: a synthetic biology approach to removing heterochromatin from cells.

Molina O, Carmena M, Maudlin IE, Earnshaw WC.

Chromosome Res. 2016 Dec;24(4):495-509. Epub 2016 Dec 6.


Epigenetic engineering reveals a balance between histone modifications and transcription in kinetochore maintenance.

Molina O, Vargiu G, Abad MA, Zhiteneva A, Jeyaprakash AA, Masumoto H, Kouprina N, Larionov V, Earnshaw WC.

Nat Commun. 2016 Nov 14;7:13334. doi: 10.1038/ncomms13334.


3D-CLEM Reveals that a Major Portion of Mitotic Chromosomes Is Not Chromatin.

Booth DG, Beckett AJ, Molina O, Samejima I, Masumoto H, Kouprina N, Larionov V, Prior IA, Earnshaw WC.

Mol Cell. 2016 Nov 17;64(4):790-802. doi: 10.1016/j.molcel.2016.10.009. Epub 2016 Nov 10.


KAT7/HBO1/MYST2 Regulates CENP-A Chromatin Assembly by Antagonizing Suv39h1-Mediated Centromere Inactivation.

Ohzeki J, Shono N, Otake K, Martins NM, Kugou K, Kimura H, Nagase T, Larionov V, Earnshaw WC, Masumoto H.

Dev Cell. 2016 Jun 6;37(5):413-27. doi: 10.1016/j.devcel.2016.05.006.


Proteomics Analysis with a Nano Random Forest Approach Reveals Novel Functional Interactions Regulated by SMC Complexes on Mitotic Chromosomes.

Ohta S, Montaño-Gutierrez LF, de Lima Alves F, Ogawa H, Toramoto I, Sato N, Morrison CG, Takeda S, Hudson DF, Rappsilber J, Earnshaw WC.

Mol Cell Proteomics. 2016 Aug;15(8):2802-18. doi: 10.1074/mcp.M116.057885. Epub 2016 May 26.


Development of a novel HAC-based "gain of signal" quantitative assay for measuring chromosome instability (CIN) in cancer cells.

Kim JH, Lee HS, Lee NC, Goncharov NV, Kumeiko V, Masumoto H, Earnshaw WC, Kouprina N, Larionov V.

Oncotarget. 2016 Mar 22;7(12):14841-56. doi: 10.18632/oncotarget.7854.


Auxin/AID versus conventional knockouts: distinguishing the roles of CENP-T/W in mitotic kinetochore assembly and stability.

Wood L, Booth DG, Vargiu G, Ohta S, deLima Alves F, Samejima K, Fukagawa T, Rappsilber J, Earnshaw WC.

Open Biol. 2016 Jan;6(1):150230. doi: 10.1098/rsob.150230.


Whole-proteome genetic analysis of dependencies in assembly of a vertebrate kinetochore.

Samejima I, Spanos C, Alves Fde L, Hori T, Perpelescu M, Zou J, Rappsilber J, Fukagawa T, Earnshaw WC.

J Cell Biol. 2015 Dec 21;211(6):1141-56. doi: 10.1083/jcb.201508072. Epub 2015 Dec 14.


The Dawn of Aurora Kinase Research: From Fly Genetics to the Clinic.

Carmena M, Earnshaw WC, Glover DM.

Front Cell Dev Biol. 2015 Nov 17;3:73. doi: 10.3389/fcell.2015.00073. eCollection 2015. Review.


Epigenetic engineering shows that a human centromere resists silencing mediated by H3K27me3/K9me3.

Martins NM, Bergmann JH, Shono N, Kimura H, Larionov V, Masumoto H, Earnshaw WC.

Mol Biol Cell. 2016 Jan 1;27(1):177-96. doi: 10.1091/mbc.E15-08-0605. Epub 2015 Nov 12.


CENP-C and CENP-I are key connecting factors for kinetochore and CENP-A assembly.

Shono N, Ohzeki J, Otake K, Martins NM, Nagase T, Kimura H, Larionov V, Earnshaw WC, Masumoto H.

J Cell Sci. 2015 Dec 15;128(24):4572-87. doi: 10.1242/jcs.180786. Epub 2015 Nov 2.


Aurora B Overexpression Causes Aneuploidy and p21Cip1 Repression during Tumor Development.

González-Loyola A, Fernández-Miranda G, Trakala M, Partida D, Samejima K, Ogawa H, Cañamero M, de Martino A, Martínez-Ramírez Á, de Cárcer G, Pérez de Castro I, Earnshaw WC, Malumbres M.

Mol Cell Biol. 2015 Oct;35(20):3566-78. doi: 10.1128/MCB.01286-14. Epub 2015 Aug 3.


The Inner Centromere Protein (INCENP) Coil Is a Single α-Helix (SAH) Domain That Binds Directly to Microtubules and Is Important for Chromosome Passenger Complex (CPC) Localization and Function in Mitosis.

Samejima K, Platani M, Wolny M, Ogawa H, Vargiu G, Knight PJ, Peckham M, Earnshaw WC.

J Biol Chem. 2015 Aug 28;290(35):21460-72. doi: 10.1074/jbc.M115.645317. Epub 2015 Jul 14.


TD-60 links RalA GTPase function to the CPC in mitosis.

Papini D, Langemeyer L, Abad MA, Kerr A, Samejima I, Eyers PA, Jeyaprakash AA, Higgins JM, Barr FA, Earnshaw WC.

Nat Commun. 2015 Jul 9;6:7678. doi: 10.1038/ncomms8678.


Mio depletion links mTOR regulation to Aurora A and Plk1 activation at mitotic centrosomes.

Platani M, Trinkle-Mulcahy L, Porter M, Jeyaprakash AA, Earnshaw WC.

J Cell Biol. 2015 Jul 6;210(1):45-62. doi: 10.1083/jcb.201410001. Epub 2015 Jun 29.


Discovering centromere proteins: from cold white hands to the A, B, C of CENPs.

Earnshaw WC.

Nat Rev Mol Cell Biol. 2015 Jul;16(7):443-9. doi: 10.1038/nrm4001. Epub 2015 May 20.


Reed-Sternberg cells form by abscission failure in the presence of functional Aurora B kinase.

Xavier de Carvalho A, Maiato H, Maia AF, Ribeiro SA, Pontes P, Bickmore W, Earnshaw WC, Sambade C.

PLoS One. 2015 May 1;10(5):e0124629. doi: 10.1371/journal.pone.0124629. eCollection 2015.


Three-dimensional topology of the SMC2/SMC4 subcomplex from chicken condensin I revealed by cross-linking and molecular modelling.

Barysz H, Kim JH, Chen ZA, Hudson DF, Rappsilber J, Gerloff DL, Earnshaw WC.

Open Biol. 2015 Feb;5(2):150005. doi: 10.1098/rsob.150005.


Generation of a conditionally self-eliminating HAC gene delivery vector through incorporation of a tTAVP64 expression cassette.

Kononenko AV, Lee NC, Liskovykh M, Masumoto H, Earnshaw WC, Larionov V, Kouprina N.

Nucleic Acids Res. 2015 May 19;43(9):e57. doi: 10.1093/nar/gkv124. Epub 2015 Feb 20.


Genetic and epigenetic regulation of centromeres: a look at HAC formation.

Ohzeki J, Larionov V, Earnshaw WC, Masumoto H.

Chromosome Res. 2015 Feb;23(1):87-103. doi: 10.1007/s10577-015-9470-z. Review.


CENP-32 is required to maintain centrosomal dominance in bipolar spindle assembly.

Ohta S, Wood L, Toramoto I, Yagyu K, Fukagawa T, Earnshaw WC.

Mol Biol Cell. 2015 Apr 1;26(7):1225-37. doi: 10.1091/mbc.E14-09-1366. Epub 2015 Feb 5.


Panspecies small-molecule disruptors of heterochromatin-mediated transcriptional gene silencing.

Castonguay E, White SA, Kagansky A, St-Cyr DJ, Castillo AG, Brugger C, White R, Bonilla C, Spitzer M, Earnshaw WC, Schalch T, Ekwall K, Tyers M, Allshire RC.

Mol Cell Biol. 2015 Feb;35(4):662-74. doi: 10.1128/MCB.01102-14. Epub 2014 Dec 8.


Targeting the INCENP IN-box-Aurora B interaction to inhibit CPC activity in vivo.

Gohard FH, St-Cyr DJ, Tyers M, Earnshaw WC.

Open Biol. 2014 Nov;4(11):140163. doi: 10.1098/rsob.140163.


Polo kinase regulates the localization and activity of the chromosomal passenger complex in meiosis and mitosis in Drosophila melanogaster.

Carmena M, Lombardia MO, Ogawa H, Earnshaw WC.

Open Biol. 2014 Nov;4(11):140162. doi: 10.1098/rsob.140162.



Fukagawa T, Earnshaw WC.

Curr Biol. 2014 Oct 6;24(19):R946-7. doi: 10.1016/j.cub.2014.08.032. No abstract available.


A portable BRCA1-HAC (human artificial chromosome) module for analysis of BRCA1 tumor suppressor function.

Kononenko AV, Bansal R, Lee NC, Grimes BR, Masumoto H, Earnshaw WC, Larionov V, Kouprina N.

Nucleic Acids Res. 2014 Dec 1;42(21). doi: 10.1093/nar/gku870. Epub 2014 Sep 26.


Auxin-induced rapid degradation of inhibitor of caspase-activated DNase (ICAD) induces apoptotic DNA fragmentation, caspase activation, and cell death: a cell suicide module.

Samejima K, Ogawa H, Ageichik AV, Peterson KL, Kaufmann SH, Kanemaki MT, Earnshaw WC.

J Biol Chem. 2014 Nov 7;289(45):31617-23. doi: 10.1074/jbc.M114.583542. Epub 2014 Sep 23.


Replication of alpha-satellite DNA arrays in endogenous human centromeric regions and in human artificial chromosome.

Erliandri I, Fu H, Nakano M, Kim JH, Miga KH, Liskovykh M, Earnshaw WC, Masumoto H, Kouprina N, Aladjem MI, Larionov V.

Nucleic Acids Res. 2014 Oct;42(18):11502-16. doi: 10.1093/nar/gku835. Epub 2014 Sep 16.


The centromere: chromatin foundation for the kinetochore machinery.

Fukagawa T, Earnshaw WC.

Dev Cell. 2014 Sep 8;30(5):496-508. doi: 10.1016/j.devcel.2014.08.016. Review.


Histone H4 Lys 20 monomethylation of the CENP-A nucleosome is essential for kinetochore assembly.

Hori T, Shang WH, Toyoda A, Misu S, Monma N, Ikeo K, Molina O, Vargiu G, Fujiyama A, Kimura H, Earnshaw WC, Fukagawa T.

Dev Cell. 2014 Jun 23;29(6):740-9. doi: 10.1016/j.devcel.2014.05.001.


Ki-67 is a PP1-interacting protein that organises the mitotic chromosome periphery.

Booth DG, Takagi M, Sanchez-Pulido L, Petfalski E, Vargiu G, Samejima K, Imamoto N, Ponting CP, Tollervey D, Earnshaw WC, Vagnarelli P.

Elife. 2014 May 27;3:e01641. doi: 10.7554/eLife.01641.


DNA content of a functioning chicken kinetochore.

Ribeiro SA, Vagnarelli P, Earnshaw WC.

Chromosome Res. 2014 Apr;22(1):7-13. doi: 10.1007/s10577-014-9410-3.


Human artificial chromosome-based gene delivery vectors for biomedicine and biotechnology.

Kouprina N, Tomilin AN, Masumoto H, Earnshaw WC, Larionov V.

Expert Opin Drug Deliv. 2014 Apr;11(4):517-35. doi: 10.1517/17425247.2014.882314. Epub 2014 Jan 30. Review.


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