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Items: 1 to 50 of 182

1.

Alosetron use in clinical practice: significant improvement in irritable bowel syndrome symptoms evaluated using the US Food and Drug Administration composite endpoint.

Lacy BE, Nicandro JP, Chuang E, Earnest DL.

Therap Adv Gastroenterol. 2018 May 8;11:1756284818771674. doi: 10.1177/1756284818771674. eCollection 2018.

2.

PER2 regulation of mammary gland development.

McQueen CM, Schmitt EE, Sarkar TR, Elswood J, Metz RP, Earnest D, Rijnkels M, Porter WW.

Development. 2018 Mar 14;145(6). pii: dev157966. doi: 10.1242/dev.157966.

3.

Shift work cycle-induced alterations of circadian rhythms potentiate the effects of high-fat diet on inflammation and metabolism.

Kim SM, Neuendorff N, Alaniz RC, Sun Y, Chapkin RS, Earnest DJ.

FASEB J. 2018 Jun;32(6):3085-3095. doi: 10.1096/fj.201700784R. Epub 2018 Feb 5.

PMID:
29405095
4.

Inhibition of p38 MAPK activity leads to cell type-specific effects on the molecular circadian clock and time-dependent reduction of glioma cell invasiveness.

Goldsmith CS, Kim SM, Karunarathna N, Neuendorff N, Gerard Toussaint L, Earnest DJ, Bell-Pedersen D.

BMC Cancer. 2018 Jan 10;18(1):43. doi: 10.1186/s12885-017-3896-y.

5.

Cadexomer iodine provides superior efficacy against bacterial wound biofilms in vitro and in vivo.

Fitzgerald DJ, Renick PJ, Forrest EC, Tetens SP, Earnest DN, McMillan J, Kiedaisch BM, Shi L, Roche ED.

Wound Repair Regen. 2017 Jan;25(1):13-24. doi: 10.1111/wrr.12497. Epub 2016 Dec 5.

PMID:
27859922
6.

Role of Inflammatory Signaling in the Differential Effects of Saturated and Poly-unsaturated Fatty Acids on Peripheral Circadian Clocks.

Kim SM, Neuendorff N, Chapkin RS, Earnest DJ.

EBioMedicine. 2016 May;7:100-11. doi: 10.1016/j.ebiom.2016.03.037. Epub 2016 Mar 31.

7.

Sex Differences in the Impact of Shift Work Schedules on Pathological Outcomes in an Animal Model of Ischemic Stroke.

Earnest DJ, Neuendorff N, Coffman J, Selvamani A, Sohrabji F.

Endocrinology. 2016 Jul;157(7):2836-43. doi: 10.1210/en.2016-1130. Epub 2016 Jun 2.

8.

Rifaximin and eluxadoline - newly approved treatments for diarrhea-predominant irritable bowel syndrome: what is their role in clinical practice alongside alosetron?

Cash BD, Lacy BE, Rao T, Earnest DL.

Expert Opin Pharmacother. 2016;17(3):311-22. doi: 10.1517/14656566.2016.1118052. Epub 2015 Dec 8. Review.

PMID:
26559529
9.

MicroRNAs function as cis- and trans-acting modulators of peripheral circadian clocks.

Shende VR, Kim SM, Neuendorff N, Earnest DJ.

FEBS Lett. 2014 Aug 25;588(17):3015-22. doi: 10.1016/j.febslet.2014.05.058. Epub 2014 Jun 10.

10.

Why do employees worry about their jobs? A meta-analytic review of predictors of job insecurity.

Keim AC, Landis RS, Pierce CA, Earnest DR.

J Occup Health Psychol. 2014 Jul;19(3):269-90. doi: 10.1037/a0036743. Epub 2014 May 5.

PMID:
24796228
11.

Myeloid cell-specific disruption of Period1 and Period2 exacerbates diet-induced inflammation and insulin resistance.

Xu H, Li H, Woo SL, Kim SM, Shende VR, Neuendorff N, Guo X, Guo T, Qi T, Pei Y, Zhao Y, Hu X, Zhao J, Chen L, Chen L, Ji JY, Alaniz RC, Earnest DJ, Wu C.

J Biol Chem. 2014 Jun 6;289(23):16374-88. doi: 10.1074/jbc.M113.539601. Epub 2014 Apr 25.

12.

Trabecular meshwork bradykinin receptors: mRNA levels, immunohistochemical visualization, signaling processes pharmacology, and linkage to IOP reduction.

Sharif NA, Katoli P, Kelly CR, Li L, Xu S, Wang Y, Klekar L, Earnest D, Yacoub S, Hamilton G, Jacobson N, Shepard AR, Ellis D.

J Ocul Pharmacol Ther. 2014 Feb;30(1):21-34. doi: 10.1089/jop.2013.0105. Epub 2013 Nov 16.

PMID:
24236827
13.

Role of miR-142-3p in the post-transcriptional regulation of the clock gene Bmal1 in the mouse SCN.

Shende VR, Neuendorff N, Earnest DJ.

PLoS One. 2013 Jun 5;8(6):e65300. doi: 10.1371/journal.pone.0065300. Print 2013.

14.

The Zelnorm epidemiologic study (ZEST): a cohort study evaluating incidence of abdominal and pelvic surgery related to tegaserod treatment.

Seeger JD, Quinn S, Earnest DL, Lembo A, Kuo B, Rivero E, Walker AM.

BMC Gastroenterol. 2012 Nov 30;12:171. doi: 10.1186/1471-230X-12-171.

15.

Diurnal rhythms in neurexins transcripts and inhibitory/excitatory synapse scaffold proteins in the biological clock.

Shapiro-Reznik M, Jilg A, Lerner H, Earnest DJ, Zisapel N.

PLoS One. 2012;7(5):e37894. doi: 10.1371/journal.pone.0037894. Epub 2012 May 25.

16.

Cardiac-specific mutation of Clock alters the quantitative measurements of physical activities without changing behavioral circadian rhythms.

Ko ML, Shi L, Tsai JY, Young ME, Neuendorff N, Earnest DJ, Ko GY.

J Biol Rhythms. 2011 Oct;26(5):412-22. doi: 10.1177/0748730411414170.

17.

Expression and rhythmic modulation of circulating microRNAs targeting the clock gene Bmal1 in mice.

Shende VR, Goldrick MM, Ramani S, Earnest DJ.

PLoS One. 2011;6(7):e22586. doi: 10.1371/journal.pone.0022586. Epub 2011 Jul 22.

18.

Mitochondrial calcium signaling mediates rhythmic extracellular ATP accumulation in suprachiasmatic nucleus astrocytes.

Burkeen JF, Womac AD, Earnest DJ, Zoran MJ.

J Neurosci. 2011 Jun 8;31(23):8432-40. doi: 10.1523/JNEUROSCI.6576-10.2011.

19.

Immortalized cell lines for real-time analysis of circadian pacemaker and peripheral oscillator properties.

Farnell YF, Shende VR, Neuendorff N, Allen GC, Earnest DJ.

Eur J Neurosci. 2011 Apr;33(8):1533-40. doi: 10.1111/j.1460-9568.2011.07629.x. Epub 2011 Mar 2.

PMID:
21366728
21.

The clock genes period 1 and period 2 mediate diurnal rhythms in dioxin-induced Cyp1A1 expression in the mouse mammary gland and liver.

Qu X, Metz RP, Porter WW, Neuendorff N, Earnest BJ, Earnest DJ.

Toxicol Lett. 2010 Jun 16;196(1):28-32. doi: 10.1016/j.toxlet.2010.03.020. Epub 2010 Apr 3.

22.

Tegaserod and the risk of cardiovascular ischemic events: an observational cohort study.

Loughlin J, Quinn S, Rivero E, Wong J, Huang J, Kralstein J, Earnest DL, Seeger JD.

J Cardiovasc Pharmacol Ther. 2010 Jun;15(2):151-7. doi: 10.1177/1074248409360357. Epub 2010 Mar 3.

PMID:
20200325
23.

Long-term tegaserod treatment for dysmotility-like functional dyspepsia: results of two identical 1-year cohort studies.

Chey WD, Howden CW, Tack J, Ligozio G, Earnest DL.

Dig Dis Sci. 2010 Mar;55(3):684-97. doi: 10.1007/s10620-009-1049-0. Epub 2009 Dec 3.

PMID:
19957035
24.

Circadian rhythms of extracellular ATP accumulation in suprachiasmatic nucleus cells and cultured astrocytes.

Womac AD, Burkeen JF, Neuendorff N, Earnest DJ, Zoran MJ.

Eur J Neurosci. 2009 Sep;30(5):869-76. doi: 10.1111/j.1460-9568.2009.06874.x. Epub 2009 Aug 27.

25.

Effects of neonatal alcohol exposure on vasoactive intestinal polypeptide neurons in the rat suprachiasmatic nucleus.

Farnell YZ, Allen GC, Neuendorff N, West JR, Wei-Jung AC, Earnest DJ.

Alcohol. 2009 Aug;43(5):387-96. doi: 10.1016/j.alcohol.2009.06.002.

26.

Increased colonic transit in rats produced by a combination of a cholinesterase inhibitor with a 5-HT4 receptor agonist.

Campbell-Dittmeyer K, Hicks GA, Earnest DL, Greenwood-Van Meerveld B.

Neurogastroenterol Motil. 2009 Nov;21(11):1197-e108. doi: 10.1111/j.1365-2982.2008.01238.x. Epub 2009 Jan 30.

PMID:
19210632
27.

Disruption of period gene expression alters the inductive effects of dioxin on the AhR signaling pathway in the mouse liver.

Qu X, Metz RP, Porter WW, Cassone VM, Earnest DJ.

Toxicol Appl Pharmacol. 2009 Feb 1;234(3):370-7. doi: 10.1016/j.taap.2008.10.016. Epub 2008 Nov 7.

28.

Tegaserod treatment for dysmotility-like functional dyspepsia: results of two randomized, controlled trials.

Vakil N, Laine L, Talley NJ, Zakko SF, Tack J, Chey WD, Kralstein J, Earnest DL, Ligozio G, Cohard-Radice M.

Am J Gastroenterol. 2008 Aug;103(8):1906-19. doi: 10.1111/j.1572-0241.2008.01953.x. Epub 2008 Jul 4.

29.

Neonatal alcohol exposure differentially alters clock gene oscillations within the suprachiasmatic nucleus, cerebellum, and liver of adult rats.

Farnell YZ, Allen GC, Nahm SS, Neuendorff N, West JR, Chen WJ, Earnest DJ.

Alcohol Clin Exp Res. 2008 Mar;32(3):544-52. doi: 10.1111/j.1530-0277.2007.00598.x. Epub 2008 Jan 22.

30.

Disruption of clock gene expression alters responses of the aryl hydrocarbon receptor signaling pathway in the mouse mammary gland.

Qu X, Metz RP, Porter WW, Cassone VM, Earnest DJ.

Mol Pharmacol. 2007 Nov;72(5):1349-58. Epub 2007 Aug 22.

31.

Circadian profiling of the transcriptome in NIH/3T3 fibroblasts: comparison with rhythmic gene expression in SCN2.2 cells and the rat SCN.

Menger GJ, Allen GC, Neuendorff N, Nahm SS, Thomas TL, Cassone VM, Earnest DJ.

Physiol Genomics. 2007 May 11;29(3):280-9. Epub 2007 Feb 6.

PMID:
17284666
32.

Safety, tolerability, and efficacy of tegaserod over 13 months in patients with chronic constipation.

Müller-Lissner S, Kamm MA, Musoglu A, Earnest DL, Dunger-Baldauf C, Shetzline MA.

Am J Gastroenterol. 2006 Nov;101(11):2558-69; quiz 2671.

PMID:
17090282
33.

Double-blind, randomized, placebo-controlled study to evaluate the effects of tegaserod on gastric motor, sensory and myoelectric function in healthy volunteers.

Talley NJ, Camilleri M, Burton D, Thomforde G, Koch K, Rucker MJ, Peterson J, Zinsmeister AR, Earnest DL.

Aliment Pharmacol Ther. 2006 Sep 1;24(5):859-67.

34.
35.

Safety and tolerability of tegaserod in patients with chronic constipation: pooled data from two phase III studies.

Quigley EM, Wald A, Fidelholtz J, Boivin M, Pecher E, Earnest D.

Clin Gastroenterol Hepatol. 2006 May;4(5):605-13.

PMID:
16678076
36.
37.

Predictors of the placebo response in functional dyspepsia.

Talley NJ, Locke GR, Lahr BD, Zinsmeister AR, Cohard-Radice M, D'Elia TV, Tack J, Earnest DL.

Aliment Pharmacol Ther. 2006 Apr 1;23(7):923-36.

38.

The incidence of abdominal and pelvic surgery among patients with irritable bowel syndrome.

Cole JA, Yeaw JM, Cutone JA, Kuo B, Huang Z, Earnest DL, Walker AM.

Dig Dis Sci. 2005 Dec;50(12):2268-75.

PMID:
16416174
39.
40.
41.

Circadian regulation and function of voltage-dependent calcium channels in the suprachiasmatic nucleus.

Nahm SS, Farnell YZ, Griffith W, Earnest DJ.

J Neurosci. 2005 Oct 5;25(40):9304-8.

42.

Omeprazole-induced slowing of gastrointestinal transit in mice can be countered with tegaserod.

Cowan A, Earnest DL, Ligozio G, Rojavin MA.

Eur J Pharmacol. 2005 Jul 4;517(1-2):127-31.

PMID:
15972210
43.

Omeprazole delays gastric emptying in healthy volunteers: an effect prevented by tegaserod.

Tougas G, Earnest DL, Chen Y, Vanderkoy C, Rojavin M.

Aliment Pharmacol Ther. 2005 Jul 1;22(1):59-65.

44.

Circadian rhythms from multiple oscillators: lessons from diverse organisms.

Bell-Pedersen D, Cassone VM, Earnest DJ, Golden SS, Hardin PE, Thomas TL, Zoran MJ.

Nat Rev Genet. 2005 Jul;6(7):544-56. Review.

45.
46.

TrkB-deficient mice show diminished phase shifts of the circadian activity rhythm in response to light.

Allen GC, Qu X, Earnest DJ.

Neurosci Lett. 2005 Apr 22;378(3):150-5. Epub 2005 Jan 8.

PMID:
15781149
47.

Circadian profiling of the transcriptome in immortalized rat SCN cells.

Menger GJ, Lu K, Thomas T, Cassone VM, Earnest DJ.

Physiol Genomics. 2005 May 11;21(3):370-81. Epub 2005 Mar 15.

PMID:
15769907
48.
49.

Melatonin desensitizes endogenous MT2 melatonin receptors in the rat suprachiasmatic nucleus: relevance for defining the periods of sensitivity of the mammalian circadian clock to melatonin.

Gerdin MJ, Masana MI, Rivera-Bermúdez MA, Hudson RL, Earnest DJ, Gillette MU, Dubocovich ML.

FASEB J. 2004 Nov;18(14):1646-56.

PMID:
15522910
50.

AL-12182, a novel 11-oxa prostaglandin analog with topical ocular hypotensive activity in the monkey.

Selliah RD, Hellberg MR, Sharif NA, McLaughlin MA, Williams GW, Scott DA, Earnest D, Haggard KS, Dean WD, Delgado P, Gaines MS, Conrow RE, Klimko PG.

Bioorg Med Chem Lett. 2004 Sep 6;14(17):4525-8.

PMID:
15357985

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