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Items: 27

1.

Mitochondrial dysfunction in macrophages: a key to defective bacterial phagocytosis in COPD.

Eapen MS, Sharma P, Sohal SS.

Eur Respir J. 2019 Oct 10;54(4). pii: 1901641. doi: 10.1183/13993003.01641-2019. Print 2019 Oct. No abstract available.

PMID:
31601722
2.

Epithelial-mesenchymal transition is driven by transcriptional and post transcriptional modulations in COPD: implications for disease progression and new therapeutics.

Eapen MS, Sharma P, Gaikwad AV, Lu W, Myers S, Hansbro PM, Sohal SS.

Int J Chron Obstruct Pulmon Dis. 2019 Jul 18;14:1603-1610. doi: 10.2147/COPD.S208428. eCollection 2019.

3.

New therapeutic targets for the prevention of infectious acute exacerbations of COPD: role of epithelial adhesion molecules and inflammatory pathways.

Atto B, Eapen MS, Sharma P, Frey U, Ammit AJ, Markos J, Chia C, Larby J, Haug G, Weber HC, Mabeza G, Tristram S, Myers S, Geraghty DP, Flanagan KL, Hansbro PM, Sohal SS.

Clin Sci (Lond). 2019 Jul 25;133(14):1663-1703. doi: 10.1042/CS20181009. Print 2019 Jul 31. Review.

PMID:
31346069
4.

Inhaled corticosteroids attenuate epithelial mesenchymal transition: implications for COPD and lung cancer prophylaxis.

Lu W, Sharma P, Eapen MS, Sohal SS.

Eur Respir J. 2019 Jul 11;54(1). pii: 1900778. doi: 10.1183/13993003.00778-2019. Print 2019 Jul. No abstract available.

PMID:
31296782
5.

The effectiveness of immunosuppressive cyclosporin in attenuating the progression of interstitial lung diseases.

Eapen MS, Gaikwad AV, Thompson IE, Lu W, Myers S, Sharma P, Sohal SS.

J Thorac Dis. 2019 May;11(Suppl 9):S1139-S1142. doi: 10.21037/jtd.2019.04.44. No abstract available.

6.

Investigations into the physical and chemical stability of concentrated co-trimoxazole intravenous infusions.

Khaleel I, Zaidi STR, Shastri MD, Eapen MS, Ming LC, Wanandy T, Patel RP.

Eur J Hosp Pharm. 2018 Oct;25(e2):e102-e108. doi: 10.1136/ejhpharm-2017-001225. Epub 2017 Jul 19.

7.

IQOS exposure impairs human airway cell homeostasis: direct comparison with traditional cigarette and e-cigarette.

Sohal SS, Eapen MS, Naidu VGM, Sharma P.

ERJ Open Res. 2019 Feb 11;5(1). pii: 00159-2018. doi: 10.1183/23120541.00159-2018. eCollection 2019 Feb.

8.

Impact of Maternal Air Pollution Exposure on Children's Lung Health: An Indian Perspective.

Saha P, Johny E, Dangi A, Shinde S, Brake S, Eapen MS, Sohal SS, Naidu V, Sharma P.

Toxics. 2018 Nov 16;6(4). pii: E68. doi: 10.3390/toxics6040068. Review.

9.

Heparin-binding epidermal growth factor (HB-EGF) drives EMT in patients with COPD: implications for disease pathogenesis and novel therapies.

Eapen MS, Sharma P, Thompson IE, Lu W, Myers S, Hansbro PM, Sohal SS.

Lab Invest. 2019 Feb;99(2):150-157. doi: 10.1038/s41374-018-0146-0. Epub 2018 Nov 19. Review.

PMID:
30451982
10.

Chronic Obstructive Pulmonary Disease and Lung Cancer: Underlying Pathophysiology and New Therapeutic Modalities.

Eapen MS, Hansbro PM, Larsson-Callerfelt AK, Jolly MK, Myers S, Sharma P, Jones B, Rahman MA, Markos J, Chia C, Larby J, Haug G, Hardikar A, Weber HC, Mabeza G, Cavalheri V, Khor YH, McDonald CF, Sohal SS.

Drugs. 2018 Nov;78(16):1717-1740. doi: 10.1007/s40265-018-1001-8. Review.

PMID:
30392114
11.

Dysfunctional Immunity and Microbial Adhesion Molecules in Smoking-induced Pneumonia.

Eapen MS, Sharma P, Moodley YP, Hansbro PM, Sohal SS.

Am J Respir Crit Care Med. 2019 Jan 15;199(2):250-251. doi: 10.1164/rccm.201808-1553LE. No abstract available.

PMID:
30290125
12.

Apoptosis signal-regulating kinase 1 inhibition attenuates human airway smooth muscle growth and migration in chronic obstructive pulmonary disease.

Eapen MS, Kota A, Vindin H, McAlinden KD, Xenaki D, Oliver BG, Deshpande DA, Sohal SS, Sharma P.

Clin Sci (Lond). 2018 Jul 31;132(14):1615-1627. doi: 10.1042/CS20180398. Print 2018 Jul 31.

13.

sE-cadherin and sVE-cadherin indicate active epithelial/endothelial to mesenchymal transition (EMT and EndoMT) in smokers and COPD: implications for new biomarkers and therapeutics.

Eapen MS, Myers S, Lu W, Tanghe C, Sharma P, Sohal SS.

Biomarkers. 2018 Nov;23(7):709-711. doi: 10.1080/1354750X.2018.1479772. Epub 2018 Jun 19. No abstract available.

PMID:
29781727
14.

Understanding novel mechanisms of microbial pathogenesis in chronic lung disease: implications for new therapeutic targets.

Eapen MS, Sohal SS.

Clin Sci (Lond). 2018 Feb 8;132(3):375-379. doi: 10.1042/CS20171261. Print 2018 Feb 14. Review.

PMID:
29439118
15.

Abnormal M1/M2 macrophage phenotype profiles in the small airway wall and lumen in smokers and chronic obstructive pulmonary disease (COPD).

Eapen MS, Hansbro PM, McAlinden K, Kim RY, Ward C, Hackett TL, Walters EH, Sohal SS.

Sci Rep. 2017 Oct 17;7(1):13392. doi: 10.1038/s41598-017-13888-x.

16.

Potential Mechanisms of Microbial Pathogens in Idiopathic Interstitial Lung Disease.

Sohal SS, Hansbro PM, Shukla SD, Eapen MS, Walters EH.

Chest. 2017 Oct;152(4):899-900. doi: 10.1016/j.chest.2017.05.024. No abstract available.

PMID:
28991543
17.

Airway inflammation in chronic obstructive pulmonary disease (COPD): a true paradox.

Eapen MS, Myers S, Walters EH, Sohal SS.

Expert Rev Respir Med. 2017 Oct;11(10):827-839. doi: 10.1080/17476348.2017.1360769. Epub 2017 Aug 2. Review.

PMID:
28743228
18.

Epithelial-mesenchymal transition, a spectrum of states: Role in lung development, homeostasis, and disease.

Jolly MK, Ward C, Eapen MS, Myers S, Hallgren O, Levine H, Sohal SS.

Dev Dyn. 2018 Mar;247(3):346-358. doi: 10.1002/dvdy.24541. Epub 2017 Jul 21. Review.

19.

Epithelial-Mesenchymal Transition: A Necessary New Therapeutic Target in Chronic Obstructive Pulmonary Disease?

Sohal SS, Eapen MS, Ward C, Walters EH.

Am J Respir Crit Care Med. 2017 Aug 1;196(3):393-394. doi: 10.1164/rccm.201704-0771LE. No abstract available.

PMID:
28640653
20.

Airway inflammation and inhaled corticosteroids in COPD.

Sohal SS, Eapen MS, Ward C, Walters EH.

Eur Respir J. 2017 Jun 15;49(6). pii: 1700289. doi: 10.1183/13993003.00289-2017. Print 2017 Jun. No abstract available.

21.

Vitamin D both facilitates and attenuates the cellular response to lipopolysaccharide.

Chen L, Eapen MS, Zosky GR.

Sci Rep. 2017 Mar 27;7:45172. doi: 10.1038/srep45172.

22.

Profiling cellular and inflammatory changes in the airway wall of mild to moderate COPD.

Eapen MS, McAlinden K, Tan D, Weston S, Ward C, Muller HK, Walters EH, Sohal SS.

Respirology. 2017 Aug;22(6):1125-1132. doi: 10.1111/resp.13021. Epub 2017 Mar 22.

PMID:
28326668
23.

Ventilatory efficiency slope as a predictor of suitability for surgery in chronic obstructive pulmonary disease patients with lung cancer.

Eapen MS, Grover R, Ahuja K, Williams A, Sohal SS.

Ann Transl Med. 2016 Aug;4(15):296. doi: 10.21037/atm.2016.07.20. No abstract available.

24.

Platelet activating factor receptor: gateway for bacterial chronic airway infection in chronic obstructive pulmonary disease and potential therapeutic target.

Shukla SD, Sohal SS, O'Toole RF, Eapen MS, Walters EH.

Expert Rev Respir Med. 2015 Aug;9(4):473-85. doi: 10.1586/17476348.2015.1070673. Review.

PMID:
26207607
25.

Evaluation of nonradioactive cell-free cAMP assays for measuring in vitro phosphodiesterase activity.

Eapen MS, Sodhi R, Balakrishnan G, Dastidar S, Ray A, Vijayakrishnan L.

Pharmacology. 2010;85(5):280-5. doi: 10.1159/000290641. Epub 2010 Apr 24.

PMID:
20424496
26.

Purification of recombinant human phosphodiesterase 7A expressed in Dictyostelium discoideum.

Arya R, Gupta S, Aslam S, Kaur NJ, Seth A, Eapen MS, Malik R, Vijayakrishnan L, Saini KS.

Protein Expr Purif. 2008 Oct;61(2):149-54. doi: 10.1016/j.pep.2008.05.002. Epub 2008 May 14.

PMID:
18547817
27.

Small-molecule inhibitors of PDE-IV and -VII in the treatment of respiratory diseases and chronic inflammation.

Vijayakrishnan L, Rudra S, Eapen MS, Dastidar S, Ray A.

Expert Opin Investig Drugs. 2007 Oct;16(10):1585-99. Review.

PMID:
17922623

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