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Items: 1 to 50 of 144

1.

Urinary excretion of parathyroid hormone-related protein correlates with renal function in control rats and rats with cisplatin nephrotoxicity.

Ortega A, Olea-Herrero N, Arenas MI, Vélez-Vélez E, Moreno-Gómez-Toledano R, Muñoz-Moreno C, Lázaro A, Esbrit P, Tejedor A, Bosch RJ.

Am J Physiol Renal Physiol. 2019 Oct 1;317(4):F874-F880. doi: 10.1152/ajprenal.00091.2019. Epub 2019 Aug 7.

PMID:
31390230
2.

Osteostatin potentiates the bioactivity of mesoporous glass scaffolds containing Zn2+ ions in human mesenchymal stem cells.

Heras C, Sanchez-Salcedo S, Lozano D, Peña J, Esbrit P, Vallet-Regi M, Salinas AJ.

Acta Biomater. 2019 Apr 15;89:359-371. doi: 10.1016/j.actbio.2019.03.033. Epub 2019 Mar 16.

PMID:
30890462
3.

Molecular evidence of field cancerization initiated by diabetes in colon cancer patients.

Del Puerto-Nevado L, Minguez P, Corton M, Solanes-Casado S, Prieto I, Mas S, Sanz AB, Gonzalez-Alonso P, Villaverde C, Portal-Nuñez S, Aguilera O, Gomez-Guerrero C, Esbrit P, Vivanco F, Gonzalez N, Ayuso C, Ortiz A, Rojo F, Egido J, Alvarez-Llamas G, Garcia-Foncillas J; DiabetesCancerConnect Consortium.

Mol Oncol. 2019 Apr;13(4):857-872. doi: 10.1002/1878-0261.12438. Epub 2019 Feb 16.

4.

Osteogenic Effect of ZnO-Mesoporous Glasses Loaded with Osteostatin.

Pérez R, Sanchez-Salcedo S, Lozano D, Heras C, Esbrit P, Vallet-Regí M, Salinas AJ.

Nanomaterials (Basel). 2018 Aug 4;8(8). pii: E592. doi: 10.3390/nano8080592.

5.

Parathyroid hormone-related protein exhibits antioxidant features in osteoblastic cells through its N-terminal and osteostatin domains.

Portal-Núñez S, Ardura JA, Lozano D, Martínez de Toda I, De la Fuente M, Herrero-Beaumont G, Largo R, Esbrit P.

Bone Joint Res. 2018 Jan;7(1):58-68. doi: 10.1302/2046-3758.71.BJR-2016-0242.R2.

6.

Impact of Chiropractic Manipulation on Bone and Skeletal Muscle of Ovariectomized Rats.

López-Herradón A, Fujikawa R, Gómez-Marín M, Stedile-Lovatel JP, Mulero F, Ardura JA, Ruiz P, Muñoz I, Esbrit P, Mahíllo-Fernández I, Ortega-de Mues A.

Calcif Tissue Int. 2017 Nov;101(5):519-529. doi: 10.1007/s00223-017-0304-1. Epub 2017 Jul 28.

PMID:
28755011
7.

Unexpected Bone Formation Produced by RANKL Blockade.

Portal-Núñez S, Mediero A, Esbrit P, Sánchez-Pernaute O, Largo R, Herrero-Beaumont G.

Trends Endocrinol Metab. 2017 Oct;28(10):695-704. doi: 10.1016/j.tem.2017.06.003. Epub 2017 Jul 19. Review.

PMID:
28733136
8.

Evaluation of bacterial adherence of clinical isolates of Staphylococcus sp. using a competitive model: An in vitro approach to the "race for the surface" theory.

Martinez-Perez M, Perez-Jorge C, Lozano D, Portal-Nuñez S, Perez-Tanoira R, Conde A, Arenas MA, Hernandez-Lopez JM, de Damborenea JJ, Gomez-Barrena E, Esbrit P, Esteban J.

Bone Joint Res. 2017 May;6(5):315-322. doi: 10.1302/2046-3758.65.BJR-2016-0226.R2.

9.

Colon cancer modulation by a diabetic environment: A single institutional experience.

Prieto I, Del Puerto-Nevado L, Gonzalez N, Portal-Nuñez S, Zazo S, Corton M, Minguez P, Gomez-Guerrero C, Arce JM, Sanz AB, Mas S, Aguilera O, Alvarez-Llamas G, Esbrit P, Ortiz A, Ayuso C, Egido J, Rojo F, Garcia-Foncillas J; DiabetesCancerConnect Consortium.

PLoS One. 2017 Mar 2;12(3):e0172300. doi: 10.1371/journal.pone.0172300. eCollection 2017.

10.

High glucose alters the secretome of mechanically stimulated osteocyte-like cells affecting osteoclast precursor recruitment and differentiation.

Maycas M, Portolés MT, Matesanz MC, Buendía I, Linares J, Feito MJ, Arcos D, Vallet-Regí M, Plotkin LI, Esbrit P, Gortázar AR.

J Cell Physiol. 2017 Dec;232(12):3611-3621. doi: 10.1002/jcp.25829. Epub 2017 Apr 25.

11.

2017 update on the relationship between diabetes and colorectal cancer: epidemiology, potential molecular mechanisms and therapeutic implications.

González N, Prieto I, Del Puerto-Nevado L, Portal-Nuñez S, Ardura JA, Corton M, Fernández-Fernández B, Aguilera O, Gomez-Guerrero C, Mas S, Moreno JA, Ruiz-Ortega M, Sanz AB, Sanchez-Niño MD, Rojo F, Vivanco F, Esbrit P, Ayuso C, Alvarez-Llamas G, Egido J, García-Foncillas J, Ortiz A; DiabetesCancerConnect Consortium.

Oncotarget. 2017 Mar 14;8(11):18456-18485. doi: 10.18632/oncotarget.14472. Review.

12.

Molecular mechanisms in bone mechanotransduction.

Maycas M, Esbrit P, Gortázar AR.

Histol Histopathol. 2017 Aug;32(8):751-760. doi: 10.14670/HH-11-858. Epub 2016 Dec 16. Review.

PMID:
27981526
13.

Oxidation inhibits PTH receptor signaling and trafficking.

Ardura JA, Alonso V, Esbrit P, Friedman PA.

Biochem Biophys Res Commun. 2017 Jan 22;482(4):1019-1024. doi: 10.1016/j.bbrc.2016.11.150. Epub 2016 Nov 28.

14.

PTHrP-Derived Peptides Restore Bone Mass and Strength in Diabetic Mice: Additive Effect of Mechanical Loading.

Maycas M, McAndrews KA, Sato AY, Pellegrini GG, Brown DM, Allen MR, Plotkin LI, Gortazar AR, Esbrit P, Bellido T.

J Bone Miner Res. 2017 Mar;32(3):486-497. doi: 10.1002/jbmr.3007. Epub 2016 Oct 24.

15.

Parathyroid Hormone-Related Protein Protects Osteoblastic Cells From Oxidative Stress by Activation of MKP1 Phosphatase.

Ardura JA, Portal-Núñez S, Castelbón-Calvo I, Martínez de Toda I, De la Fuente M, Esbrit P.

J Cell Physiol. 2017 Apr;232(4):785-796. doi: 10.1002/jcp.25473. Epub 2016 Jul 12.

PMID:
27357344
16.

Anti-senescence and Anti-inflammatory Effects of the C-terminal Moiety of PTHrP Peptides in OA Osteoblasts.

Platas J, Guillén MI, Gomar F, Castejón MA, Esbrit P, Alcaraz MJ.

J Gerontol A Biol Sci Med Sci. 2017 May 1;72(5):624-631. doi: 10.1093/gerona/glw100.

PMID:
27271252
17.

Local delivery of parathyroid hormone-related protein-derived peptides coated onto a hydroxyapatite-based implant enhances bone regeneration in old and diabetic rats.

Ardura JA, Portal-Núñez S, Lozano D, Gutiérrez-Rojas I, Sánchez-Salcedo S, López-Herradón A, Mulero F, Villanueva-Peñacarrillo ML, Vallet-Regí M, Esbrit P.

J Biomed Mater Res A. 2016 Aug;104(8):2060-70. doi: 10.1002/jbm.a.35742. Epub 2016 Apr 24.

PMID:
27086979
18.

Oxidative stress, autophagy, epigenetic changes and regulation by miRNAs as potential therapeutic targets in osteoarthritis.

Portal-Núñez S, Esbrit P, Alcaraz MJ, Largo R.

Biochem Pharmacol. 2016 May 15;108:1-10. doi: 10.1016/j.bcp.2015.12.012. Epub 2015 Dec 19. Review.

PMID:
26711691
19.

Effects of bleaching on osteoclast activity and their modulation by osteostatin and fibroblast growth factor 2.

Torres-Rodríguez C, Portolés MT, Matesanz MC, Linares J, Feito MJ, Izquierdo-Barba I, Esbrit P, Vallet-Regí M.

J Colloid Interface Sci. 2016 Jan 1;461:285-291. doi: 10.1016/j.jcis.2015.09.035. Epub 2015 Sep 12.

PMID:
26407056
20.

Adverse Effects of Diabetes Mellitus on the Skeleton of Aging Mice.

Portal-Núñez S, Ardura JA, Lozano D, Bolívar OH, López-Herradón A, Gutiérrez-Rojas I, Proctor A, van der Eerden B, Schreuders-Koedam M, van Leeuwen J, Alcaraz MJ, Mulero F, de la Fuente M, Esbrit P.

J Gerontol A Biol Sci Med Sci. 2016 Mar;71(3):290-9. doi: 10.1093/gerona/glv160. Epub 2015 Sep 18.

PMID:
26386012
21.

Parathyroid Hormone-Related Protein Analogs as Osteoporosis Therapies.

Esbrit P, Herrera S, Portal-Núñez S, Nogués X, Díez-Pérez A.

Calcif Tissue Int. 2016 Apr;98(4):359-69. doi: 10.1007/s00223-015-0050-1. Epub 2015 Aug 11. Review.

PMID:
26259869
22.

Osteostatin-coated porous titanium can improve early bone regeneration of cortical bone defects in rats.

van der Stok J, Lozano D, Chai YC, Amin Yavari S, Bastidas Coral AP, Verhaar JA, Gómez-Barrena E, Schrooten J, Jahr H, Zadpoor AA, Esbrit P, Weinans H.

Tissue Eng Part A. 2015 May;21(9-10):1495-506. doi: 10.1089/ten.TEA.2014.0476. Epub 2015 Mar 10.

PMID:
25627039
23.

Role of the Parathyroid Hormone Type 1 Receptor (PTH1R) as a Mechanosensor in Osteocyte Survival.

Maycas M, Ardura JA, de Castro LF, Bravo B, Gortázar AR, Esbrit P.

J Bone Miner Res. 2015 Jul;30(7):1231-44. doi: 10.1002/jbmr.2439.

24.

Influence of the nanostructure of F-doped TiO2 films on osteoblast growth and function.

Lozano D, Hernández-López JM, Esbrit P, Arenas MA, Gómez-Barrena E, de Damborenea J, Esteban J, Pérez-Jorge C, Pérez-Tanoira R, Conde A.

J Biomed Mater Res A. 2015 Jun;103(6):1985-90. doi: 10.1002/jbm.a.35337. Epub 2014 Sep 25.

PMID:
25230841
25.

VEGF Receptor 2 (VEGFR2) Activation Is Essential for Osteocyte Survival Induced by Mechanotransduction.

de Castro LF, Maycas M, Bravo B, Esbrit P, Gortazar A.

J Cell Physiol. 2015 Feb;230(2):278-85. doi: 10.1002/jcp.24734.

PMID:
25102966
26.

Characterization of Hybrid Bioactive Glass-polyvinyl Alcohol Scaffolds Containing a PTHrP-derived Pentapeptide as Implants for Tissue Engineering Applications.

Coletta DJ, Lozano D, Rocha-Oliveira AA, Mortarino P, Bumaguin GE, Vitelli E, Vena R, Missana L, Jammal MV, Portal-Núñez S, Pereira M, Esbrit P, Feldman S.

Open Biomed Eng J. 2014 Mar 7;8:20-7. doi: 10.2174/1874120701408010020. eCollection 2014.

27.

Functional roles of the nuclear localization signal of parathyroid hormone-related protein (PTHrP) in osteoblastic cells.

García-Martín A, Ardura JA, Maycas M, Lozano D, López-Herradón A, Portal-Núñez S, García-Ocaña A, Esbrit P.

Mol Endocrinol. 2014 Jun;28(6):925-34. doi: 10.1210/me.2013-1225. Epub 2014 Apr 11.

28.

Parathyroid hormone-related protein (107-111) improves the bone regeneration potential of gelatin-glutaraldehyde biopolymer-coated hydroxyapatite.

Lozano D, Sánchez-Salcedo S, Portal-Núñez S, Vila M, López-Herradón A, Ardura JA, Mulero F, Gómez-Barrena E, Vallet-Regí M, Esbrit P.

Acta Biomater. 2014 Jul;10(7):3307-16. doi: 10.1016/j.actbio.2014.03.025. Epub 2014 Apr 2.

PMID:
24704694
29.

Treatment with N- and C-terminal peptides of parathyroid hormone-related protein partly compensate the skeletal abnormalities in IGF-I deficient mice.

Rodríguez-de la Rosa L, López-Herradón A, Portal-Núñez S, Murillo-Cuesta S, Lozano D, Cediel R, Varela-Nieto I, Esbrit P.

PLoS One. 2014 Feb 4;9(2):e87536. doi: 10.1371/journal.pone.0087536. eCollection 2014.

30.

Novel role of parathyroid hormone-related protein in the pathophysiology of the diabetic kidney: evidence from experimental and human diabetic nephropathy.

Romero M, Ortega A, Olea N, Arenas MI, Izquierdo A, Bover J, Esbrit P, Bosch RJ.

J Diabetes Res. 2013;2013:162846. doi: 10.1155/2013/162846. Epub 2013 Jul 31. Review.

31.

Autophagy impairment aggravates the inhibitory effects of high glucose on osteoblast viability and function.

Bartolomé A, López-Herradón A, Portal-Núñez S, García-Aguilar A, Esbrit P, Benito M, Guillén C.

Biochem J. 2013 Nov 1;455(3):329-37. doi: 10.1042/BJ20130562.

PMID:
23981124
32.

The vertebrae of prematurely aging mice as a skeletal model of involutional osteoporosis.

Portal-Núñez S, Cruces J, Gutiérrez-Rojas I, Lozano D, Ardura JA, Villanueva-Peñacarrillo ML, De la Fuente M, Esbrit P.

Histol Histopathol. 2013 Nov;28(11):1473-81. doi: 10.14670/HH-28.1473. Epub 2013 May 15.

PMID:
23673876
33.

Current perspectives on parathyroid hormone (PTH) and PTH-related protein (PTHrP) as bone anabolic therapies.

Esbrit P, Alcaraz MJ.

Biochem Pharmacol. 2013 May 15;85(10):1417-23. doi: 10.1016/j.bcp.2013.03.002. Epub 2013 Mar 13. Review.

PMID:
23500550
34.

Inhibition of the canonical Wnt pathway by high glucose can be reversed by parathyroid hormone-related protein in osteoblastic cells.

López-Herradón A, Portal-Núñez S, García-Martín A, Lozano D, Pérez-Martínez FC, Ceña V, Esbrit P.

J Cell Biochem. 2013 Aug;114(8):1908-16. doi: 10.1002/jcb.24535.

PMID:
23494914
35.

Src kinases mediate VEGFR2 transactivation by the osteostatin domain of PTHrP to modulate osteoblastic function.

García-Martín A, Acitores A, Maycas M, Villanueva-Peñacarrillo ML, Esbrit P.

J Cell Biochem. 2013 Jun;114(6):1404-13. doi: 10.1002/jcb.24482.

PMID:
23444047
36.

Parathyroid hormone-related protein protects renal tubuloepithelial cells from apoptosis by activating transcription factor Runx2.

Ardura JA, Sanz AB, Ortiz A, Esbrit P.

Kidney Int. 2013 May;83(5):825-34. doi: 10.1038/ki.2012.476. Epub 2013 Jan 30.

37.

Amylin exerts osteogenic actions with different efficacy depending on the diabetic status.

Gutiérrez-Rojas I, Lozano D, Nuche-Berenguer B, Moreno P, Acitores A, Ramos-Álvarez I, Rovira A, Novials A, Martín-Crespo E, Villanueva-Peñacarrillo ML, Esbrit P.

Mol Cell Endocrinol. 2013 Jan 30;365(2):309-15. doi: 10.1016/j.mce.2012.11.013. Epub 2012 Nov 21.

PMID:
23178165
38.

Osteostatin improves the osteogenic activity of fibroblast growth factor-2 immobilized in Si-doped hydroxyapatite in osteoblastic cells.

Lozano D, Feito MJ, Portal-Núñez S, Lozano RM, Matesanz MC, Serrano MC, Vallet-Regí M, Portolés MT, Esbrit P.

Acta Biomater. 2012 Jul;8(7):2770-7. doi: 10.1016/j.actbio.2012.04.002. Epub 2012 Apr 6.

PMID:
22487933
39.

Role of angiogenesis on bone formation.

Portal-Núñez S, Lozano D, Esbrit P.

Histol Histopathol. 2012 May;27(5):559-66. doi: 10.14670/HH-27.559. Review.

PMID:
22419020
40.

Osteostatin-loaded onto mesoporous ceramics improves the early phase of bone regeneration in a rabbit osteopenia model.

Lozano D, Trejo CG, Gómez-Barrena E, Manzano M, Doadrio JC, Salinas AJ, Vallet-Regí M, García-Honduvilla N, Esbrit P, Buján J.

Acta Biomater. 2012 Jul;8(6):2317-23. doi: 10.1016/j.actbio.2012.03.014. Epub 2012 Mar 10.

PMID:
22414621
41.

Characterization of skeletal alterations in a model of prematurely aging mice.

Portal-Núñez S, Manassra R, Lozano D, Acitores A, Mulero F, Villanueva-Peñacarrillo ML, De la Fuente M, Esbrit P.

Age (Dordr). 2013 Apr;35(2):383-93. doi: 10.1007/s11357-011-9372-8. Epub 2012 Jan 11.

42.

[Pathophysiology of aging bone].

Portal-Núñez S, Lozano D, de la Fuente M, Esbrit P.

Rev Esp Geriatr Gerontol. 2012 May-Jun;47(3):125-31. doi: 10.1016/j.regg.2011.09.003. Epub 2011 Dec 14. Review. Spanish.

PMID:
22172573
43.

Parathyroid hormone-related protein is a hypertrophy factor for human mesangial cells: Implications for diabetic nephropathy.

Ortega A, Romero M, Izquierdo A, Troyano N, Arce Y, Ardura JA, Arenas MI, Bover J, Esbrit P, Bosch RJ.

J Cell Physiol. 2012 May;227(5):1980-7. doi: 10.1002/jcp.22926.

PMID:
21732369
44.

Comparison of the skeletal effects induced by daily administration of PTHrP (1-36) and PTHrP (107-139) to ovariectomized mice.

de Castro LF, Lozano D, Portal-Núñez S, Maycas M, De la Fuente M, Caeiro JR, Esbrit P.

J Cell Physiol. 2012 Apr;227(4):1752-60. doi: 10.1002/jcp.22902.

PMID:
21702049
45.

Comparison of the osteoblastic activity conferred on Si-doped hydroxyapatite scaffolds by different osteostatin coatings.

Manzano M, Lozano D, Arcos D, Portal-Núñez S, Orden CL, Esbrit P, Vallet-Regí M.

Acta Biomater. 2011 Oct;7(10):3555-62. doi: 10.1016/j.actbio.2011.06.004. Epub 2011 Jun 14.

PMID:
21693201
46.

GLP-1 and exendin-4 can reverse hyperlipidic-related osteopenia.

Nuche-Berenguer B, Lozano D, Gutiérrez-Rojas I, Moreno P, Mariñoso ML, Esbrit P, Villanueva-Peñacarrillo ML.

J Endocrinol. 2011 May;209(2):203-10. doi: 10.1530/JOE-11-0015. Epub 2011 Mar 3.

PMID:
21372151
47.

The C-terminal fragment of parathyroid hormone-related peptide promotes bone formation in diabetic mice with low-turnover osteopaenia.

Lozano D, Fernández-de-Castro L, Portal-Núñez S, López-Herradón A, Dapía S, Gómez-Barrena E, Esbrit P.

Br J Pharmacol. 2011 Mar;162(6):1424-38. doi: 10.1111/j.1476-5381.2010.01155.x.

48.

A transgenic mouse model for studying the role of the parathyroid hormone-related protein system in renal injury.

Bosch RJ, Ortega A, Izquierdo A, Arribas I, Bover J, Esbrit P.

J Biomed Biotechnol. 2011;2011:290874. doi: 10.1155/2011/290874. Epub 2010 Oct 31. Review.

49.

The osteoinductive properties of mesoporous silicate coated with osteostatin in a rabbit femur cavity defect model.

Trejo CG, Lozano D, Manzano M, Doadrio JC, Salinas AJ, Dapía S, Gómez-Barrena E, Vallet-Regí M, García-Honduvilla N, Buján J, Esbrit P.

Biomaterials. 2010 Nov;31(33):8564-73. doi: 10.1016/j.biomaterials.2010.07.103. Epub 2010 Aug 19.

PMID:
20727584
50.

Alterations of the Wnt/beta-catenin pathway and its target genes for the N- and C-terminal domains of parathyroid hormone-related protein in bone from diabetic mice.

Portal-Núñez S, Lozano D, de Castro LF, de Gortázar AR, Nogués X, Esbrit P.

FEBS Lett. 2010 Jul 16;584(14):3095-100. doi: 10.1016/j.febslet.2010.05.047. Epub 2010 Jun 1.

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