Format
Sort by
Items per page

Send to

Choose Destination

Search results

Items: 1 to 50 of 184

1.

Crystal structure of a chimaeric bacterial glutamate dehydrogenase.

Oliveira T, Sharkey MA, Engel PC, Khan AR.

Acta Crystallogr F Struct Biol Commun. 2016 Jun;72(Pt 6):462-6. doi: 10.1107/S2053230X16007305. Epub 2016 May 23.

3.

Structure of NADP(+)-dependent glutamate dehydrogenase from Escherichia coli--reflections on the basis of coenzyme specificity in the family of glutamate dehydrogenases.

Sharkey MA, Oliveira TF, Engel PC, Khan AR.

FEBS J. 2013 Sep;280(18):4681-92. doi: 10.1111/febs.12439. Epub 2013 Aug 20.

4.

Glutamate dehydrogenases: the why and how of coenzyme specificity.

Engel PC.

Neurochem Res. 2014;39(3):426-32. doi: 10.1007/s11064-013-1089-x. Epub 2013 Jun 13. Review.

PMID:
23761034
5.

Prospects for robust biocatalysis: engineering of novel specificity in a halophilic amino acid dehydrogenase.

Munawar N, Engel PC.

Extremophiles. 2013 Jan;17(1):43-51. doi: 10.1007/s00792-012-0491-7. Epub 2012 Oct 27.

PMID:
23104166
6.

Development of a satisfactory and general continuous assay for aminotransferases by coupling with (R)-2-hydroxyglutarate dehydrogenase.

Yu X, Bresser J, Schall I, Djurdjevic I, Buckel W, Wang X, Engel PC.

Anal Biochem. 2012 Dec 15;431(2):127-31. doi: 10.1016/j.ab.2012.09.009. Epub 2012 Sep 19.

PMID:
23000002
7.

Reversal of the extreme coenzyme selectivity of Clostridium symbiosum glutamate dehydrogenase.

Sharkey MA, Gori A, Capone M, Engel PC.

FEBS J. 2012 Sep;279(17):3003-9. doi: 10.1111/j.1742-4658.2012.08681.x. Epub 2012 Jul 31.

8.

Overexpression in a non-native halophilic host and biotechnological potential of NAD+-dependent glutamate dehydrogenase from Halobacterium salinarum strain NRC-36014.

Munawar N, Engel PC.

Extremophiles. 2012 May;16(3):463-76. doi: 10.1007/s00792-012-0446-z. Epub 2012 Apr 19.

PMID:
22527040
9.

Crystal structure of NAD+-dependent Peptoniphilus asaccharolyticus glutamate dehydrogenase reveals determinants of cofactor specificity.

Oliveira T, Panjikar S, Carrigan JB, Hamza M, Sharkey MA, Engel PC, Khan AR.

J Struct Biol. 2012 Feb;177(2):543-52. doi: 10.1016/j.jsb.2011.10.006. Epub 2011 Oct 31.

PMID:
22068154
11.

Molecular recruitment as a basis for negative dominant inheritance? propagation of misfolding in oligomers of IMPDH1, the mutated enzyme in the RP10 form of retinitis pigmentosa.

Wang XT, Mion B, Aherne A, Engel PC.

Biochim Biophys Acta. 2011 Nov;1812(11):1472-6. doi: 10.1016/j.bbadis.2011.07.006. Epub 2011 Jul 21.

12.

Plasmodium falciparum glutamate dehydrogenase a is dispensable and not a drug target during erythrocytic development.

Storm J, Perner J, Aparicio I, Patzewitz EM, Olszewski K, Llinas M, Engel PC, Müller S.

Malar J. 2011 Jul 14;10:193. doi: 10.1186/1475-2875-10-193.

13.

Kinetic characterisation of recombinant Corynebacterium glutamicum NAD+-dependent LDH over-expressed in E. coli and its rescue of an lldD- phenotype in C. glutamicum: the issue of reversibility re-examined.

Sharkey MA, Maher MA, Guyonvarch A, Engel PC.

Arch Microbiol. 2011 Oct;193(10):731-40. doi: 10.1007/s00203-011-0711-z. Epub 2011 May 13.

PMID:
21567176
14.
15.

Making biochemistry count: life among the amino acid dehydrogenases.

Engel PC.

Biochem Soc Trans. 2011 Apr;39(2):425-9. doi: 10.1042/BST0390425.

PMID:
21428913
16.

A marriage full of surprises: forty-five years living with glutamate dehydrogenase.

Engel PC.

Neurochem Int. 2011 Sep;59(4):489-94. doi: 10.1016/j.neuint.2011.03.014. Epub 2011 Mar 17. Review.

PMID:
21419817
17.

Analysis of specific pre-operative model to valve surgery and relationship with the length of stay in intensive care unit.

Pena FM, Soares Jda S, Peixoto RS, Pires Júnior HR, Paiva BT, Moraes FV, Engel PC, Gomes NC, Pena Gde S.

Rev Bras Ter Intensiva. 2010 Dec;22(4):339-45. English, Portuguese.

PMID:
25302509
19.

Crystallization and preliminary structural analyses of glutamate dehydrogenase from Peptoniphilus asaccharolyticus.

Oliveira TF, Carrigan JB, Hamza MA, Sharkey MA, Engel PC, Khan AR.

Acta Crystallogr Sect F Struct Biol Cryst Commun. 2010 May 1;66(Pt 5):523-6. doi: 10.1107/S1744309110010006. Epub 2010 Apr 29.

20.

Susceptibility of Plasmodium falciparum to glutamate dehydrogenase inhibitors--a possible new antimalarial target.

Aparicio IM, Marín-Menéndez A, Bell A, Engel PC.

Mol Biochem Parasitol. 2010 Aug;172(2):152-5. doi: 10.1016/j.molbiopara.2010.04.002. Epub 2010 Apr 23.

PMID:
20399810
21.

An NSAID-like compound, FT-9, preferentially inhibits gamma-secretase cleavage of the amyloid precursor protein compared to its effect on amyloid precursor-like protein 1.

Sala Frigerio C, Kukar TL, Fauq A, Engel PC, Golde TE, Walsh DM.

Biochemistry. 2009 Nov 24;48(46):10894-904. doi: 10.1021/bi901237k.

22.
23.

Clinical mutants of human glucose 6-phosphate dehydrogenase: impairment of NADP(+) binding affects both folding and stability.

Wang XT, Engel PC.

Biochim Biophys Acta. 2009 Aug;1792(8):804-9. doi: 10.1016/j.bbadis.2009.05.003. Epub 2009 May 22.

24.

Modular coenzyme specificity: a domain-swopped chimera of glutamate dehydrogenase.

Sharkey MA, Engel PC.

Proteins. 2009 Nov 1;77(2):268-78. doi: 10.1002/prot.22433.

PMID:
19425107
25.

An optimised system for refolding of human glucose 6-phosphate dehydrogenase.

Wang XT, Engel PC.

BMC Biotechnol. 2009 Mar 11;9:19. doi: 10.1186/1472-6750-9-19.

26.

Engineered dehydrogenase biocatalysts for non-natural amino acids: efficient isolation of the D-enantiomer from racemic mixtures.

Paradisi F, Conway PA, Maguire AR, Engel PC.

Org Biomol Chem. 2008 Oct 7;6(19):3611-5. doi: 10.1039/b809147a. Epub 2008 Aug 5.

PMID:
19082164
27.

What is the role of the second "structural" NADP+-binding site in human glucose 6-phosphate dehydrogenase?

Wang XT, Chan TF, Lam VM, Engel PC.

Protein Sci. 2008 Aug;17(8):1403-11. doi: 10.1110/ps.035352.108. Epub 2008 May 20.

28.

Homotropic allosteric control in clostridial glutamate dehydrogenase: different mechanisms for glutamate and NAD+?

Hamza MA, Engel PC.

FEBS Lett. 2008 Jun 11;582(13):1816-20. doi: 10.1016/j.febslet.2008.04.049. Epub 2008 May 8.

29.

The structural basis of proteolytic activation of bovine glutamate dehydrogenase.

Carrigan JB, Engel PC.

Protein Sci. 2008 Aug;17(8):1346-53. doi: 10.1110/ps.034785.108. Epub 2008 May 8.

30.

Apparent negative co-operativity and substrate inhibition in overexpressed glutamate dehydrogenase from Escherichia coli.

Sharkey MA, Engel PC.

FEMS Microbiol Lett. 2008 Apr;281(2):132-9. doi: 10.1111/j.1574-6968.2008.01086.x. Epub 2008 Feb 21.

34.

Phenylalanine dehydrogenase mutants: efficient biocatalysts for synthesis of non-natural phenylalanine derivatives.

Paradisi F, Collins S, Maguire AR, Engel PC.

J Biotechnol. 2007 Feb 1;128(2):408-11. Epub 2006 Sep 25.

PMID:
16996633
36.

Engineered phenylalanine dehydrogenase in organic solvents: homogeneous and biphasic enzymatic reactions.

Cainelli G, Engel PC, Galletti P, Giacomini D, Gualandi A, Paradisi F.

Org Biomol Chem. 2005 Dec 21;3(24):4316-20. Epub 2005 Nov 14.

PMID:
16327891
39.

Identification of the residue responsible for catalysing regeneration of activity in the inactive glutamate dehydrogenase mutant D165N.

Paradisi F, Woolfson R, Geoghegan KF, Engel PC.

FEBS Lett. 2005 May 23;579(13):2830-2. Epub 2005 Apr 25.

40.

The discovery of four distinct glutamate dehydrogenase genes in a strain of Halobacterium salinarum.

Ingoldsby LM, Geoghegan KF, Hayden BM, Engel PC.

Gene. 2005 Apr 11;349:237-44.

PMID:
15780999
41.
43.

The Y42H mutation in medium-chain acyl-CoA dehydrogenase, which is prevalent in babies identified by MS/MS-based newborn screening, is temperature sensitive.

O'Reilly L, Bross P, Corydon TJ, Olpin SE, Hansen J, Kenney JM, McCandless SE, Frazier DM, Winter V, Gregersen N, Engel PC, Andresen BS.

Eur J Biochem. 2004 Oct;271(20):4053-63.

44.

Enantioselective synthesis of non-natural amino acids using phenylalanine dehydrogenases modified by site-directed mutagenesis.

Busca P, Paradisi F, Moynihan E, Maguire AR, Engel PC.

Org Biomol Chem. 2004 Sep 21;2(18):2684-91. Epub 2004 Aug 25.

PMID:
15351834
45.

On the molecular pathology of neurodegeneration in IMPDH1-based retinitis pigmentosa.

Aherne A, Kennan A, Kenna PF, McNally N, Lloyd DG, Alberts IL, Kiang AS, Humphries MM, Ayuso C, Engel PC, Gu JJ, Mitchell BS, Farrar GJ, Humphries P.

Hum Mol Genet. 2004 Mar 15;13(6):641-50.

PMID:
14981049
46.
47.

Alanine dehydrogenase from the psychrophilic bacterium strain PA-43: overexpression, molecular characterization, and sequence analysis.

Irwin JA, Lynch SV, Coughlan S, Baker PJ, Gudmundsson HM, Alfredsson GA, Rice DW, Engel PC.

Extremophiles. 2003 Apr;7(2):135-43. Epub 2003 Feb 4.

PMID:
12664266
48.

A thermally sensitive loop in clostridial glutamate dehydrogenase detected by limited proteolysis.

Aghajanian S, Hovsepyan M, Geoghegan KF, Chrunyk BA, Engel PC.

J Biol Chem. 2003 Jan 10;278(2):1067-74. Epub 2002 Oct 31.

49.
50.

Supplemental Content

Loading ...
Support Center