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Items: 43


Structure-activity relationships in a series of antiplasmodial thieno[2,3-b]pyridines.

Masch A, Nasereddin A, Alder A, Bird MJ, Schweda SI, Preu L, Doerig C, Dzikowski R, Gilberger TW, Kunick C.

Malar J. 2019 Mar 21;18(1):89. doi: 10.1186/s12936-019-2725-y.


An upstream open reading frame (uORF) signals for cellular localization of the virulence factor implicated in pregnancy associated malaria.

Fastman Y, Assaraf S, Rose M, Milrot E, Basore K, Arasu BS, Desai SA, Elbaum M, Dzikowski R.

Nucleic Acids Res. 2018 Jun 1;46(10):4919-4932. doi: 10.1093/nar/gky178.


Variant Gene Expression and Antigenic Variation by Malaria Parasites.

Deitsch KW, Dzikowski R.

Annu Rev Microbiol. 2017 Sep 8;71:625-641. doi: 10.1146/annurev-micro-090816-093841. Epub 2017 Jul 11. Review.


Antiplasmodial dihetarylthioethers target the coenzyme A synthesis pathway in Plasmodium falciparum erythrocytic stages.

Weidner T, Lucantoni L, Nasereddin A, Preu L, Jones PG, Dzikowski R, Avery VM, Kunick C.

Malar J. 2017 May 15;16(1):192. doi: 10.1186/s12936-017-1839-3.


Controlled release of artemisone for the treatment of experimental cerebral malaria.

Golenser J, Buchholz V, Bagheri A, Nasereddin A, Dzikowski R, Guo J, Hunt NH, Eyal S, Vakruk N, Greiner A.

Parasit Vectors. 2017 Mar 1;10(1):117. doi: 10.1186/s13071-017-2018-7.


Adhesion of Plasmodium falciparum infected erythrocytes in ex vivo perfused placental tissue: a novel model of placental malaria.

Pehrson C, Mathiesen L, Heno KK, Salanti A, Resende M, Dzikowski R, Damm P, Hansson SR, King CL, Schneider H, Wang CW, Lavstsen T, Theander TG, Knudsen LE, Nielsen MA.

Malar J. 2016 May 26;15(1):292. doi: 10.1186/s12936-016-1342-2.


Novel 2-Phenoxyanilide Congeners Derived from a Hit Structure of the TCAMS: Synthesis and Evaluation of Their in Vitro Activity against Plasmodium falciparum.

Weidner T, Nasereddin A, Preu L, Grünefeld J, Dzikowski R, Kunick C.

Molecules. 2016 Feb 17;21(2). pii: E223. doi: 10.3390/molecules21020223.


Multiple Plasmodium falciparum Erythrocyte Membrane Protein 1 Variants per Genome Can Bind IgM via Its Fc Fragment Fcμ.

Jeppesen A, Ditlev SB, Soroka V, Stevenson L, Turner L, Dzikowski R, Hviid L, Barfod L.

Infect Immun. 2015 Oct;83(10):3972-81. doi: 10.1128/IAI.00337-15. Epub 2015 Jul 27.


PfSR1 controls alternative splicing and steady-state RNA levels in Plasmodium falciparum through preferential recognition of specific RNA motifs.

Eshar S, Altenhofen L, Rabner A, Ross P, Fastman Y, Mandel-Gutfreund Y, Karni R, Llinás M, Dzikowski R.

Mol Microbiol. 2015 Jun;96(6):1283-97. doi: 10.1111/mmi.13007. Epub 2015 Apr 16.


Functional analysis of sirtuin genes in multiple Plasmodium falciparum strains.

Merrick CJ, Jiang RH, Skillman KM, Samarakoon U, Moore RM, Dzikowski R, Ferdig MT, Duraisingh MT.

PLoS One. 2015 Mar 17;10(3):e0118865. doi: 10.1371/journal.pone.0118865. eCollection 2015.


Antisense long noncoding RNAs regulate var gene activation in the malaria parasite Plasmodium falciparum.

Amit-Avraham I, Pozner G, Eshar S, Fastman Y, Kolevzon N, Yavin E, Dzikowski R.

Proc Natl Acad Sci U S A. 2015 Mar 3;112(9):E982-91. doi: 10.1073/pnas.1420855112. Epub 2015 Feb 17.


Use of peptide nucleic acids to manipulate gene expression in the malaria parasite Plasmodium falciparum.

Kolevzon N, Nasereddin A, Naik S, Yavin E, Dzikowski R.

PLoS One. 2014 Jan 22;9(1):e86802. doi: 10.1371/journal.pone.0086802. eCollection 2014.


Recruitment of PfSET2 by RNA polymerase II to variant antigen encoding loci contributes to antigenic variation in P. falciparum.

Ukaegbu UE, Kishore SP, Kwiatkowski DL, Pandarinath C, Dahan-Pasternak N, Dzikowski R, Deitsch KW.

PLoS Pathog. 2014 Jan;10(1):e1003854. doi: 10.1371/journal.ppat.1003854. Epub 2014 Jan 2.


PfSec13 is an unusual chromatin-associated nucleoporin of Plasmodium falciparum that is essential for parasite proliferation in human erythrocytes.

Dahan-Pasternak N, Nasereddin A, Kolevzon N, Pe'er M, Wong W, Shinder V, Turnbull L, Whitchurch CB, Elbaum M, Gilberger TW, Yavin E, Baum J, Dzikowski R.

J Cell Sci. 2013 Jul 15;126(Pt 14):3055-69. doi: 10.1242/jcs.122119. Epub 2013 May 17.


P. falciparum cpn20 is a bona fide co-chaperonin that can replace GroES in E. coli.

Vitlin Gruber A, Nisemblat S, Zizelski G, Parnas A, Dzikowski R, Azem A, Weiss C.

PLoS One. 2013;8(1):e53909. doi: 10.1371/journal.pone.0053909. Epub 2013 Jan 10.


3,6-Diamino-4-(2-halophenyl)-2-benzoylthieno[2,3-b]pyridine-5-carbonitriles are selective inhibitors of Plasmodium falciparum glycogen synthase kinase-3.

Fugel W, Oberholzer AE, Gschloessl B, Dzikowski R, Pressburger N, Preu L, Pearl LH, Baratte B, Ratin M, Okun I, Doerig C, Kruggel S, Lemcke T, Meijer L, Kunick C.

J Med Chem. 2013 Jan 10;56(1):264-75. doi: 10.1021/jm301575n. Epub 2012 Dec 27.


Insulator-like pairing elements regulate silencing and mutually exclusive expression in the malaria parasite Plasmodium falciparum.

Avraham I, Schreier J, Dzikowski R.

Proc Natl Acad Sci U S A. 2012 Dec 26;109(52):E3678-86. doi: 10.1073/pnas.1214572109. Epub 2012 Nov 29.


A novel Plasmodium falciparum SR protein is an alternative splicing factor required for the parasites' proliferation in human erythrocytes.

Eshar S, Allemand E, Sebag A, Glaser F, Muchardt C, Mandel-Gutfreund Y, Karni R, Dzikowski R.

Nucleic Acids Res. 2012 Oct;40(19):9903-16. doi: 10.1093/nar/gks735. Epub 2012 Aug 9.


Oriented nucleation of hemozoin at the digestive vacuole membrane in Plasmodium falciparum.

Kapishnikov S, Weiner A, Shimoni E, Guttmann P, Schneider G, Dahan-Pasternak N, Dzikowski R, Leiserowitz L, Elbaum M.

Proc Natl Acad Sci U S A. 2012 Jul 10;109(28):11188-93. doi: 10.1073/pnas.1118120109. Epub 2012 Jun 28.


Erasing the epigenetic memory and beginning to switch--the onset of antigenic switching of var genes in Plasmodium falciparum.

Fastman Y, Noble R, Recker M, Dzikowski R.

PLoS One. 2012;7(3):e34168. doi: 10.1371/journal.pone.0034168. Epub 2012 Mar 26.


Var Gene promoter activation in clonal Plasmodium falciparum isolates follows a hierarchy and suggests a conserved switching program that is independent of genetic background.

Enderes C, Kombila D, Dal-Bianco M, Dzikowski R, Kremsner P, Frank M.

J Infect Dis. 2011 Nov 15;204(10):1620-31. doi: 10.1093/infdis/jir594. Epub 2011 Sep 16.


High resolution 3D perspective of Plasmodium biology: advancing into a new era.

Eshar S, Dahan-Pasternak N, Weiner A, Dzikowski R.

Trends Parasitol. 2011 Dec;27(12):548-54. doi: 10.1016/ Epub 2011 Sep 4. Review.


3D nuclear architecture reveals coupled cell cycle dynamics of chromatin and nuclear pores in the malaria parasite Plasmodium falciparum.

Weiner A, Dahan-Pasternak N, Shimoni E, Shinder V, von Huth P, Elbaum M, Dzikowski R.

Cell Microbiol. 2011 Jul;13(7):967-77. doi: 10.1111/j.1462-5822.2011.01592.x. Epub 2011 Apr 28.


Clonally variant gene families in Plasmodium falciparum share a common activation factor.

Howitt CA, Wilinski D, Llinás M, Templeton TJ, Dzikowski R, Deitsch KW.

Mol Microbiol. 2009 Sep;73(6):1171-85. doi: 10.1111/j.1365-2958.2009.06846.x. Epub 2009 Aug 24.


The effect of Plasmodium falciparum Sir2a histone deacetylase on clonal and longitudinal variation in expression of the var family of virulence genes.

Merrick CJ, Dzikowski R, Imamura H, Chuang J, Deitsch K, Duraisingh MT.

Int J Parasitol. 2010 Jan;40(1):35-43. doi: 10.1016/j.ijpara.2009.06.012. Epub 2009 Aug 8.


Genetics of antigenic variation in Plasmodium falciparum.

Dzikowski R, Deitsch KW.

Curr Genet. 2009 Apr;55(2):103-10. doi: 10.1007/s00294-009-0233-2. Epub 2009 Feb 26. Review.


PfEMP1: an antigen that plays a key role in the pathogenicity and immune evasion of the malaria parasite Plasmodium falciparum.

Pasternak ND, Dzikowski R.

Int J Biochem Cell Biol. 2009 Jul;41(7):1463-6. doi: 10.1016/j.biocel.2008.12.012. Epub 2008 Dec 25. Review.


Active transcription is required for maintenance of epigenetic memory in the malaria parasite Plasmodium falciparum.

Dzikowski R, Deitsch KW.

J Mol Biol. 2008 Oct 3;382(2):288-97. doi: 10.1016/j.jmb.2008.07.015. Epub 2008 Jul 16.


Mechanisms underlying mutually exclusive expression of virulence genes by malaria parasites.

Dzikowski R, Li F, Amulic B, Eisberg A, Frank M, Patel S, Wellems TE, Deitsch KW.

EMBO Rep. 2007 Oct;8(10):959-65. Epub 2007 Aug 31.


Mechanisms of gene regulation in Plasmodium.

Deitsch K, Duraisingh M, Dzikowski R, Gunasekera A, Khan S, Le Roch K, Llinás M, Mair G, McGovern V, Roos D, Shock J, Sims J, Wiegand R, Winzeler E.

Am J Trop Med Hyg. 2007 Aug;77(2):201-8. Review. No abstract available.


Variable switching rates of malaria virulence genes are associated with chromosomal position.

Frank M, Dzikowski R, Amulic B, Deitsch K.

Mol Microbiol. 2007 Jun;64(6):1486-98.


Epigenetic memory at malaria virulence genes.

Chookajorn T, Dzikowski R, Frank M, Li F, Jiwani AZ, Hartl DL, Deitsch KW.

Proc Natl Acad Sci U S A. 2007 Jan 16;104(3):899-902. Epub 2007 Jan 5.


Morphologic, Pathologic, and Genetic Investigations of Bolbophorus Species Affecting Cultured Channel Catfish in the Mississippi Delta.

Levy MG, Flowers JR, Poore MF, Mullen JE, Khoo LH, Pote LM, Paperna I, Dzikowski R, Litaker RW.

J Aquat Anim Health. 2006 Dec;18(4):235-46. doi: 10.1577/1548-8667(2002)014<0235:MPAGIO>2.0.CO;2.


Variant antigen gene expression in malaria.

Dzikowski R, Templeton TJ, Deitsch K.

Cell Microbiol. 2006 Sep;8(9):1371-81. Epub 2006 Jul 18. Review.


Strict pairing of var promoters and introns is required for var gene silencing in the malaria parasite Plasmodium falciparum.

Frank M, Dzikowski R, Costantini D, Amulic B, Berdougo E, Deitsch K.

J Biol Chem. 2006 Apr 14;281(15):9942-52. Epub 2006 Feb 2.


Antigenic variation by protozoan parasites: insights from Babesia bovis.

Dzikowski R, Deitsch K.

Mol Microbiol. 2006 Jan;59(2):364-6.


Inducible reproductive plasticity of the guppy Poecilia reticulata in response to predation cues.

Dzikowski R, Hulata G, Harpaz S, Karplus I.

J Exp Zool A Comp Exp Biol. 2004 Sep 1;301(9):776-82.


Use of rDNA polymorphism for identification of Heterophyidae infecting freshwater fishes.

Dzikowski R, Levy MG, Poore MF, Flowers JR, Paperna I.

Dis Aquat Organ. 2004 Apr 21;59(1):35-41.


Trematode metacercariae of fishes as sentinels for a changing limnological environment.

Dzikowski R, Diamant A, Paperna I.

Dis Aquat Organ. 2003 Jul 8;55(2):145-50.


Morphologic, Pathologic, and Genetic Investigations of Bolbophorus Species Affecting Cultured Channel Catfish in the Mississippi Delta.

Levy MG, Flowers JR, Poore MF, Mullen JE, Khoo LH, Pote LM, Paperna I, Dzikowski R, Litaker RW.

J Aquat Anim Health. 2002 Dec;14(4):235-246. doi: 10.1577/1548-8667(2002)014<0235:MPAGIO>2.0.CO;2.


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