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Items: 1 to 50 of 79

1.

Combination Olaparib and Temozolomide in Relapsed Small-Cell Lung Cancer.

Farago AF, Yeap BY, Stanzione M, Hung YP, Heist RS, Marcoux JP, Zhong J, Rangachari D, Barbie DA, Phat S, Myers DT, Morris R, Kem M, Dubash TD, Kennedy EA, Digumarthy SR, Sequist LV, Hata AN, Maheswaran S, Haber DA, Lawrence MS, Shaw AT, Mino-Kenudson M, Dyson NJ, Drapkin BJ.

Cancer Discov. 2019 Aug 15. doi: 10.1158/2159-8290.CD-19-0582. [Epub ahead of print]

PMID:
31416802
2.

Visualizing Engrafted Human Cancer and Therapy Responses in Immunodeficient Zebrafish.

Yan C, Brunson DC, Tang Q, Do D, Iftimia NA, Moore JC, Hayes MN, Welker AM, Garcia EG, Dubash TD, Hong X, Drapkin BJ, Myers DT, Phat S, Volorio A, Marvin DL, Ligorio M, Dershowitz L, McCarthy KM, Karabacak MN, Fletcher JA, Sgroi DC, Iafrate JA, Maheswaran S, Dyson NJ, Haber DA, Rawls JF, Langenau DM.

Cell. 2019 Jun 13;177(7):1903-1914.e14. doi: 10.1016/j.cell.2019.04.004. Epub 2019 Apr 25.

PMID:
31031007
3.

A Code of Mono-phosphorylation Modulates the Function of RB.

Sanidas I, Morris R, Fella KA, Rumde PH, Boukhali M, Tai EC, Ting DT, Lawrence MS, Haas W, Dyson NJ.

Mol Cell. 2019 Mar 7;73(5):985-1000.e6. doi: 10.1016/j.molcel.2019.01.004. Epub 2019 Jan 30.

PMID:
30711375
4.

Non-canonical functions of the RB protein in cancer.

Dick FA, Goodrich DW, Sage J, Dyson NJ.

Nat Rev Cancer. 2018 Jul;18(7):442-451. doi: 10.1038/s41568-018-0008-5. Review.

5.

E2F/DP Prevents Cell-Cycle Progression in Endocycling Fat Body Cells by Suppressing dATM Expression.

Guarner A, Morris R, Korenjak M, Boukhali M, Zappia MP, Van Rechem C, Whetstine JR, Ramaswamy S, Zou L, Frolov MV, Haas W, Dyson NJ.

Dev Cell. 2017 Dec 18;43(6):689-703.e5. doi: 10.1016/j.devcel.2017.11.008. Epub 2017 Dec 7.

6.

The metabolic function of cyclin D3-CDK6 kinase in cancer cell survival.

Wang H, Nicolay BN, Chick JM, Gao X, Geng Y, Ren H, Gao H, Yang G, Williams JA, Suski JM, Keibler MA, Sicinska E, Gerdemann U, Haining WN, Roberts TM, Polyak K, Gygi SP, Dyson NJ, Sicinski P.

Nature. 2017 Jun 15;546(7658):426-430. doi: 10.1038/nature22797. Epub 2017 Jun 7.

7.

pRB Takes an EZ Path to a Repetitive Task.

Sanidas I, Dyson NJ.

Mol Cell. 2016 Dec 15;64(6):1015-1017. doi: 10.1016/j.molcel.2016.11.035.

8.

LKB1 loss links serine metabolism to DNA methylation and tumorigenesis.

Kottakis F, Nicolay BN, Roumane A, Karnik R, Gu H, Nagle JM, Boukhali M, Hayward MC, Li YY, Chen T, Liesa M, Hammerman PS, Wong KK, Hayes DN, Shirihai OS, Dyson NJ, Haas W, Meissner A, Bardeesy N.

Nature. 2016 Nov 17;539(7629):390-395. doi: 10.1038/nature20132. Epub 2016 Oct 31.

9.

RB1: a prototype tumor suppressor and an enigma.

Dyson NJ.

Genes Dev. 2016 Jul 1;30(13):1492-502. doi: 10.1101/gad.282145.116. Review.

10.

E2F1 mediates sustained lipogenesis and contributes to hepatic steatosis.

Denechaud PD, Lopez-Mejia IC, Giralt A, Lai Q, Blanchet E, Delacuisine B, Nicolay BN, Dyson NJ, Bonner C, Pattou F, Annicotte JS, Fajas L.

J Clin Invest. 2016 Jan;126(1):137-50. doi: 10.1172/JCI81542. Epub 2015 Nov 30.

11.

The LSD1 Family of Histone Demethylases and the Pumilio Posttranscriptional Repressor Function in a Complex Regulatory Feedback Loop.

Miles WO, Lepesant JM, Bourdeaux J, Texier M, Kerenyi MA, Nakakido M, Hamamoto R, Orkin SH, Dyson NJ, Di Stefano L.

Mol Cell Biol. 2015 Dec;35(24):4199-211. doi: 10.1128/MCB.00755-15. Epub 2015 Oct 5.

12.

Proteomic analysis of pRb loss highlights a signature of decreased mitochondrial oxidative phosphorylation.

Nicolay BN, Danielian PS, Kottakis F, Lapek JD Jr, Sanidas I, Miles WO, Dehnad M, Tschöp K, Gierut JJ, Manning AL, Morris R, Haigis K, Bardeesy N, Lees JA, Haas W, Dyson NJ.

Genes Dev. 2015 Sep 1;29(17):1875-89. doi: 10.1101/gad.264127.115. Epub 2015 Aug 27.

13.

RB-loss puts focus on Myc.

Miles WO, Dyson NJ.

Nat Cell Biol. 2015 Aug;17(8):968-9. doi: 10.1038/ncb3213.

PMID:
26239529
14.

Transcriptional control of autophagy-lysosome function drives pancreatic cancer metabolism.

Perera RM, Stoykova S, Nicolay BN, Ross KN, Fitamant J, Boukhali M, Lengrand J, Deshpande V, Selig MK, Ferrone CR, Settleman J, Stephanopoulos G, Dyson NJ, Zoncu R, Ramaswamy S, Haas W, Bardeesy N.

Nature. 2015 Aug 20;524(7565):361-5. doi: 10.1038/nature14587. Epub 2015 Jul 13.

15.

Pumilio and nanos RNA-binding proteins counterbalance the transcriptional consequences of RB1 inactivation.

Miles WO, Dyson NJ.

Mol Cell Oncol. 2014 Dec 31;1(4):e968074. doi: 10.4161/23723548.2014.968074. eCollection 2014 Oct-Dec.

16.

Post-transcriptional gene expression control by NANOS is up-regulated and functionally important in pRb-deficient cells.

Miles WO, Korenjak M, Griffiths LM, Dyer MA, Provero P, Dyson NJ.

EMBO J. 2014 Oct 1;33(19):2201-15. doi: 10.15252/embj.201488057. Epub 2014 Aug 6.

17.

dREAM co-operates with insulator-binding proteins and regulates expression at divergently paired genes.

Korenjak M, Kwon E, Morris RT, Anderssen E, Amzallag A, Ramaswamy S, Dyson NJ.

Nucleic Acids Res. 2014 Aug;42(14):8939-53. doi: 10.1093/nar/gku609. Epub 2014 Jul 22.

18.

CDK4/6 and IGF1 receptor inhibitors synergize to suppress the growth of p16INK4A-deficient pancreatic cancers.

Heilmann AM, Perera RM, Ecker V, Nicolay BN, Bardeesy N, Benes CH, Dyson NJ.

Cancer Res. 2014 Jul 15;74(14):3947-58. doi: 10.1158/0008-5472.CAN-13-2923. Epub 2014 Jul 1.

19.

Suppression of genome instability in pRB-deficient cells by enhancement of chromosome cohesion.

Manning AL, Yazinski SA, Nicolay B, Bryll A, Zou L, Dyson NJ.

Mol Cell. 2014 Mar 20;53(6):993-1004. doi: 10.1016/j.molcel.2014.01.032. Epub 2014 Mar 6.

20.

H4K20 methylation regulates quiescence and chromatin compaction.

Evertts AG, Manning AL, Wang X, Dyson NJ, Garcia BA, Coller HA.

Mol Biol Cell. 2013 Oct;24(19):3025-37. doi: 10.1091/mbc.E12-07-0529. Epub 2013 Aug 7.

21.

The multiple connections between pRB and cell metabolism.

Nicolay BN, Dyson NJ.

Curr Opin Cell Biol. 2013 Dec;25(6):735-40. doi: 10.1016/j.ceb.2013.07.012. Epub 2013 Aug 3. Review.

22.

KDM4A lysine demethylase induces site-specific copy gain and rereplication of regions amplified in tumors.

Black JC, Manning AL, Van Rechem C, Kim J, Ladd B, Cho J, Pineda CM, Murphy N, Daniels DL, Montagna C, Lewis PW, Glass K, Allis CD, Dyson NJ, Getz G, Whetstine JR.

Cell. 2013 Aug 1;154(3):541-55. doi: 10.1016/j.cell.2013.06.051. Epub 2013 Jul 18.

23.

Whole chromosome instability resulting from the synergistic effects of pRB and p53 inactivation.

Manning AL, Benes C, Dyson NJ.

Oncogene. 2014 May 8;33(19):2487-94. doi: 10.1038/onc.2013.201. Epub 2013 Jun 24.

24.

The emerging roles for histone demethylases in the modulation of signaling pathways.

Di Stefano L, Dyson NJ.

Biomol Concepts. 2013 Feb;4(1):13-27. doi: 10.1515/bmc-2012-0031. Review.

PMID:
25436562
25.

Loss of RBF1 changes glutamine catabolism.

Nicolay BN, Gameiro PA, Tschöp K, Korenjak M, Heilmann AM, Asara JM, Stephanopoulos G, Iliopoulos O, Dyson NJ.

Genes Dev. 2013 Jan 15;27(2):182-96. doi: 10.1101/gad.206227.112. Epub 2013 Jan 15.

26.

In vivo regulation of E2F1 by Polycomb group genes in Drosophila.

Ji JY, Miles WO, Korenjak M, Zheng Y, Dyson NJ.

G3 (Bethesda). 2012 Dec;2(12):1651-60. doi: 10.1534/g3.112.004333. Epub 2012 Dec 1.

27.

Identification of E2F target genes that are rate limiting for dE2F1-dependent cell proliferation.

Herr A, Longworth M, Ji JY, Korenjak M, Macalpine DM, Dyson NJ.

Dev Dyn. 2012 Nov;241(11):1695-707. doi: 10.1002/dvdy.23857. Epub 2012 Sep 17.

28.

RBF binding to both canonical E2F targets and noncanonical targets depends on functional dE2F/dDP complexes.

Korenjak M, Anderssen E, Ramaswamy S, Whetstine JR, Dyson NJ.

Mol Cell Biol. 2012 Nov;32(21):4375-87. doi: 10.1128/MCB.00536-12. Epub 2012 Aug 27.

29.

It's all in the timing: too much E2F is a bad thing.

Nicolay BN, Dyson NJ.

PLoS Genet. 2012;8(8):e1002909. doi: 10.1371/journal.pgen.1002909. Epub 2012 Aug 16. No abstract available.

30.

Phosphorylation puts the pRb tumor suppressor into shape.

Heilmann AM, Dyson NJ.

Genes Dev. 2012 Jun 1;26(11):1128-30. doi: 10.1101/gad.195552.112.

31.

A shared role for RBF1 and dCAP-D3 in the regulation of transcription with consequences for innate immunity.

Longworth MS, Walker JA, Anderssen E, Moon NS, Gladden A, Heck MM, Ramaswamy S, Dyson NJ.

PLoS Genet. 2012;8(4):e1002618. doi: 10.1371/journal.pgen.1002618. Epub 2012 Apr 5.

32.

Pumilio facilitates miRNA regulation of the E2F3 oncogene.

Miles WO, Tschöp K, Herr A, Ji JY, Dyson NJ.

Genes Dev. 2012 Feb 15;26(4):356-68. doi: 10.1101/gad.182568.111.

33.

RB: mitotic implications of a tumour suppressor.

Manning AL, Dyson NJ.

Nat Rev Cancer. 2012 Feb 9;12(3):220-6. doi: 10.1038/nrc3216. Review.

34.

A novel retinoblastoma therapy from genomic and epigenetic analyses.

Zhang J, Benavente CA, McEvoy J, Flores-Otero J, Ding L, Chen X, Ulyanov A, Wu G, Wilson M, Wang J, Brennan R, Rusch M, Manning AL, Ma J, Easton J, Shurtleff S, Mullighan C, Pounds S, Mukatira S, Gupta P, Neale G, Zhao D, Lu C, Fulton RS, Fulton LL, Hong X, Dooling DJ, Ochoa K, Naeve C, Dyson NJ, Mardis ER, Bahrami A, Ellison D, Wilson RK, Downing JR, Dyer MA.

Nature. 2012 Jan 11;481(7381):329-34. doi: 10.1038/nature10733.

35.

Rb deficiency during Drosophila eye development deregulates EMC, causing defects in the development of photoreceptors and cone cells.

Popova MK, He W, Korenjak M, Dyson NJ, Moon NS.

J Cell Sci. 2011 Dec 15;124(Pt 24):4203-12. doi: 10.1242/jcs.088773. Epub 2011 Dec 22.

36.

Modeling tumor invasion and metastasis in Drosophila.

Miles WO, Dyson NJ, Walker JA.

Dis Model Mech. 2011 Nov;4(6):753-61. doi: 10.1242/dmm.006908. Epub 2011 Oct 6. Review.

37.

pRB, a tumor suppressor with a stabilizing presence.

Manning AL, Dyson NJ.

Trends Cell Biol. 2011 Aug;21(8):433-41. doi: 10.1016/j.tcb.2011.05.003. Epub 2011 Jun 12. Review.

38.

The complex roles of histone demethylases in vivo.

Di Stefano L, Dyson NJ.

Cell Cycle. 2011 Jul 1;10(13):2049-50. No abstract available.

39.

A SIRT1-LSD1 corepressor complex regulates Notch target gene expression and development.

Mulligan P, Yang F, Di Stefano L, Ji JY, Ouyang J, Nishikawa JL, Toiber D, Kulkarni M, Wang Q, Najafi-Shoushtari SH, Mostoslavsky R, Gygi SP, Gill G, Dyson NJ, Näär AM.

Mol Cell. 2011 Jun 10;42(5):689-99. doi: 10.1016/j.molcel.2011.04.020. Epub 2011 May 19.

40.

Functional antagonism between histone H3K4 demethylases in vivo.

Di Stefano L, Walker JA, Burgio G, Corona DF, Mulligan P, Näär AM, Dyson NJ.

Genes Dev. 2011 Jan 1;25(1):17-28. doi: 10.1101/gad.1983711.

41.

Conserved antagonism between JMJD2A/KDM4A and HP1γ during cell cycle progression.

Black JC, Allen A, Van Rechem C, Forbes E, Longworth M, Tschöp K, Rinehart C, Quiton J, Walsh R, Smallwood A, Dyson NJ, Whetstine JR.

Mol Cell. 2010 Dec 10;40(5):736-48. doi: 10.1016/j.molcel.2010.11.008.

42.

CRL4(Cdt2)-mediated destruction of the histone methyltransferase Set8 prevents premature chromatin compaction in S phase.

Centore RC, Havens CG, Manning AL, Li JM, Flynn RL, Tse A, Jin J, Dyson NJ, Walter JC, Zou L.

Mol Cell. 2010 Oct 8;40(1):22-33. doi: 10.1016/j.molcel.2010.09.015.

43.

Conserved role of SIRT1 orthologs in fasting-dependent inhibition of the lipid/cholesterol regulator SREBP.

Walker AK, Yang F, Jiang K, Ji JY, Watts JL, Purushotham A, Boss O, Hirsch ML, Ribich S, Smith JJ, Israelian K, Westphal CH, Rodgers JT, Shioda T, Elson SL, Mulligan P, Najafi-Shoushtari H, Black JC, Thakur JK, Kadyk LC, Whetstine JR, Mostoslavsky R, Puigserver P, Li X, Dyson NJ, Hart AC, Näär AM.

Genes Dev. 2010 Jul 1;24(13):1403-17. doi: 10.1101/gad.1901210.

44.

Loss of pRB causes centromere dysfunction and chromosomal instability.

Manning AL, Longworth MS, Dyson NJ.

Genes Dev. 2010 Jul 1;24(13):1364-76. doi: 10.1101/gad.1917310. Epub 2010 Jun 15.

45.

YAP-dependent induction of amphiregulin identifies a non-cell-autonomous component of the Hippo pathway.

Zhang J, Ji JY, Yu M, Overholtzer M, Smolen GA, Wang R, Brugge JS, Dyson NJ, Haber DA.

Nat Cell Biol. 2009 Dec;11(12):1444-50. doi: 10.1038/ncb1993. Epub 2009 Nov 22.

46.

pRb, a local chromatin organizer with global possibilities.

Longworth MS, Dyson NJ.

Chromosoma. 2010 Feb;119(1):1-11. doi: 10.1007/s00412-009-0238-0. Epub 2009 Aug 28. Review.

47.

E2F1 represses beta-catenin transcription and is antagonized by both pRB and CDK8.

Morris EJ, Ji JY, Yang F, Di Stefano L, Herr A, Moon NS, Kwon EJ, Haigis KM, Näär AM, Dyson NJ.

Nature. 2008 Sep 25;455(7212):552-6. doi: 10.1038/nature07310. Epub 2008 Sep 14.

48.

Conserved functions of the pRB and E2F families.

van den Heuvel S, Dyson NJ.

Nat Rev Mol Cell Biol. 2008 Sep;9(9):713-24. doi: 10.1038/nrm2469. Review.

PMID:
18719710
49.

E2F and p53 induce apoptosis independently during Drosophila development but intersect in the context of DNA damage.

Moon NS, Di Stefano L, Morris EJ, Patel R, White K, Dyson NJ.

PLoS Genet. 2008 Aug 8;4(8):e1000153. doi: 10.1371/journal.pgen.1000153.

50.

The Drosophila homolog of human tumor suppressor TSC-22 promotes cellular growth, proliferation, and survival.

Wu X, Yamada-Mabuchi M, Morris EJ, Tanwar PS, Dobens L, Gluderer S, Khan S, Cao J, Stocker H, Hafen E, Dyson NJ, Raftery LA.

Proc Natl Acad Sci U S A. 2008 Apr 8;105(14):5414-9. doi: 10.1073/pnas.0800945105. Epub 2008 Mar 28.

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