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Int J Antimicrob Agents. 2019 May;53(5):694-697. doi: 10.1016/j.ijantimicag.2019.03.015. Epub 2019 Mar 14.

Novel staphylococcal cassette chromosome composite island (SCC-CI) with a new subtype of SCCmecVI cassette found in ST5 methicillin-resistant Staphylococcus aureus in France.

Author information

1
CHU de Limoges, Laboratoire de Bactériologie-Virologie-Hygiène, Limoges, France; Inserm, U1092, Limoges, France; University of Limoges, UMR-S1092, Limoges, France.
2
National Reference Center for Staphylococci, Hospices Civils de Lyon, Lyon, France; Department of Clinical Microbiology, Northern Hospital Group, Hospices Civils de Lyon, Lyon, France; International Centre for Research in Infectious diseases, INSERM U1111, University of Lyon, Lyon, France.
3
National Reference Center for Staphylococci, Hospices Civils de Lyon, Lyon, France.
4
National Reference Center for Staphylococci, Hospices Civils de Lyon, Lyon, France; Department of Clinical Microbiology, Northern Hospital Group, Hospices Civils de Lyon, Lyon, France.
5
National Reference Center for Staphylococci, Hospices Civils de Lyon, Lyon, France; Department of Clinical Microbiology, Northern Hospital Group, Hospices Civils de Lyon, Lyon, France; International Centre for Research in Infectious diseases, INSERM U1111, University of Lyon, Lyon, France. Electronic address: patricia.martins-simoes01@chu-lyon.fr.

Abstract

An emergent kanamycin-susceptible ST5 methicillin-resistant Staphylococcus aureus (MRSA) lineage has been identified in France. Whole-genome sequencing revealed a 40-kb staphylococcal cassette chromosome (SCC) composite island with a mosaic structure including three SCC elements: a ΨSCCcop/ars, a SCCLim88A with a ccrC recombinase, and a novel subtype of SCCmec type VI (VIb). This mosaic structure suggests a high recombination rate of SCC elements from distinct staphylococci species.

KEYWORDS:

Antimicrobial resistance; MRSA; Novel SCCmec; Staphylococcus aureus; mecA

[Indexed for MEDLINE]

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