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Items: 15


Characterization of ML-IAP protein stability and physiological role in vivo.

Varfolomeev E, Moradi E, Dynek JN, Zha J, Fedorova AV, Deshayes K, Fairbrother WJ, Newton K, Le Couter J, Vucic D.

Biochem J. 2012 Nov 1;447(3):427-36. doi: 10.1042/BJ20121103.


c-IAP1 and UbcH5 promote K11-linked polyubiquitination of RIP1 in TNF signalling.

Dynek JN, Goncharov T, Dueber EC, Fedorova AV, Izrael-Tomasevic A, Phu L, Helgason E, Fairbrother WJ, Deshayes K, Kirkpatrick DS, Vucic D.

EMBO J. 2010 Dec 15;29(24):4198-209. doi: 10.1038/emboj.2010.300. Epub 2010 Nov 26.


Improved quantitative mass spectrometry methods for characterizing complex ubiquitin signals.

Phu L, Izrael-Tomasevic A, Matsumoto ML, Bustos D, Dynek JN, Fedorova AV, Bakalarski CE, Arnott D, Deshayes K, Dixit VM, Kelley RF, Vucic D, Kirkpatrick DS.

Mol Cell Proteomics. 2011 May;10(5):M110.003756. doi: 10.1074/mcp.M110.003756. Epub 2010 Nov 3.


Antagonists of IAP proteins as cancer therapeutics.

Dynek JN, Vucic D.

Cancer Lett. 2013 May 28;332(2):206-14. doi: 10.1016/j.canlet.2010.06.013. Epub 2010 Aug 3. Review.


Antagonism of c-IAP and XIAP proteins is required for efficient induction of cell death by small-molecule IAP antagonists.

Ndubaku C, Varfolomeev E, Wang L, Zobel K, Lau K, Elliott LO, Maurer B, Fedorova AV, Dynek JN, Koehler M, Hymowitz SG, Tsui V, Deshayes K, Fairbrother WJ, Flygare JA, Vucic D.

ACS Chem Biol. 2009 Jul 17;4(7):557-66. doi: 10.1021/cb900083m.


c-IAP1 and c-IAP2 are critical mediators of tumor necrosis factor alpha (TNFalpha)-induced NF-kappaB activation.

Varfolomeev E, Goncharov T, Fedorova AV, Dynek JN, Zobel K, Deshayes K, Fairbrother WJ, Vucic D.

J Biol Chem. 2008 Sep 5;283(36):24295-9. doi: 10.1074/jbc.C800128200. Epub 2008 Jul 11.


Microphthalmia-associated transcription factor is a critical transcriptional regulator of melanoma inhibitor of apoptosis in melanomas.

Dynek JN, Chan SM, Liu J, Zha J, Fairbrother WJ, Vucic D.

Cancer Res. 2008 May 1;68(9):3124-32. doi: 10.1158/0008-5472.CAN-07-6622.


IAP antagonists induce autoubiquitination of c-IAPs, NF-kappaB activation, and TNFalpha-dependent apoptosis.

Varfolomeev E, Blankenship JW, Wayson SM, Fedorova AV, Kayagaki N, Garg P, Zobel K, Dynek JN, Elliott LO, Wallweber HJ, Flygare JA, Fairbrother WJ, Deshayes K, Dixit VM, Vucic D.

Cell. 2007 Nov 16;131(4):669-81.


Protein requirements for sister telomere association in human cells.

Canudas S, Houghtaling BR, Kim JY, Dynek JN, Chang WG, Smith S.

EMBO J. 2007 Nov 28;26(23):4867-78. Epub 2007 Oct 25.


Diversity of viruses in Cryphonectria parasitica and C. nitschkei in Japan and China, and partial characterization of a new chrysovirus species.

Liu YC, Dynek JN, Hillman BI, Milgroom MG.

Mycol Res. 2007 Apr;111(Pt 4):433-42. Epub 2007 Feb 4.


NuMA is a major acceptor of poly(ADP-ribosyl)ation by tankyrase 1 in mitosis.

Chang W, Dynek JN, Smith S.

Biochem J. 2005 Oct 15;391(Pt 2):177-84.


Genome analysis of Cryphonectria hypovirus 4, the most common hypovirus species in North America.

Linder-Basso D, Dynek JN, Hillman BI.

Virology. 2005 Jun 20;337(1):192-203.


TRF1 is degraded by ubiquitin-mediated proteolysis after release from telomeres.

Chang W, Dynek JN, Smith S.

Genes Dev. 2003 Jun 1;17(11):1328-33.


Role for the related poly(ADP-Ribose) polymerases tankyrase 1 and 2 at human telomeres.

Cook BD, Dynek JN, Chang W, Shostak G, Smith S.

Mol Cell Biol. 2002 Jan;22(1):332-42.

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