Format
Sort by
Items per page

Send to

Choose Destination

Search results

Items: 1 to 50 of 55

1.

Human genetic variation in GLS2 is associated with development of complicated Staphylococcus aureus bacteremia.

Scott WK, Medie FM, Ruffin F, Sharma-Kuinkel BK, Cyr DD, Guo S, Dykxhoorn DM, Skov RL, Bruun NE, Dahl A, Lerche CJ, Petersen A, Larsen AR, Lauridsen TK, Johansen HK, Ullum H, Sørensen E, Hassager C, Bundgaard H, Schønheyder HC, Torp-Pedersen C, Østergaard LB, Arpi M, Rosenvinge F, Erikstrup LT, Chehri M, Søgaard P, Andersen PS, Fowler VG Jr.

PLoS Genet. 2018 Oct 5;14(10):e1007667. doi: 10.1371/journal.pgen.1007667. eCollection 2018 Oct.

2.

Convergent Pathways in Idiopathic Autism Revealed by Time Course Transcriptomic Analysis of Patient-Derived Neurons.

DeRosa BA, El Hokayem J, Artimovich E, Garcia-Serje C, Phillips AW, Van Booven D, Nestor JE, Wang L, Cuccaro ML, Vance JM, Pericak-Vance MA, Cukier HN, Nestor MW, Dykxhoorn DM.

Sci Rep. 2018 May 30;8(1):8423. doi: 10.1038/s41598-018-26495-1.

3.

Differentiation of hepatocyte-like cells from human pluripotent stem cells using small molecules.

Asumda FZ, Hatzistergos KE, Dykxhoorn DM, Jakubski S, Edwards J, Thomas E, Schiff ER.

Differentiation. 2018 May - Jun;101:16-24. doi: 10.1016/j.diff.2018.03.002. Epub 2018 Mar 27.

PMID:
29626713
4.

Cocaine Exposure Increases Blood Pressure and Aortic Stiffness via the miR-30c-5p-Malic Enzyme 1-Reactive Oxygen Species Pathway.

Zhu W, Wang H, Wei J, Sartor GC, Bao MM, Pierce CT, Wahlestedt CR, Dykxhoorn DM, Dong C.

Hypertension. 2018 Apr;71(4):752-760. doi: 10.1161/HYPERTENSIONAHA.117.10213. Epub 2018 Feb 26.

PMID:
29483230
5.

Novel Regulatory Mechanisms for the SoxC Transcriptional Network Required for Visual Pathway Development.

Chang KC, Hertz J, Zhang X, Jin XL, Shaw P, Derosa BA, Li JY, Venugopalan P, Valenzuela DA, Patel RD, Russano KR, Alshamekh SA, Sun C, Tenerelli K, Li C, Velmeshev D, Cheng Y, Boyce TM, Dreyfuss A, Uddin MS, Muller KJ, Dykxhoorn DM, Goldberg JL.

J Neurosci. 2017 May 10;37(19):4967-4981. doi: 10.1523/JNEUROSCI.3430-13.2017. Epub 2017 Apr 14.

6.

Evaluating genetic susceptibility to Staphylococcus aureus bacteremia in African Americans using admixture mapping.

Cyr DD, Allen AS, Du GJ, Ruffin F, Adams C, Thaden JT, Maskarinec SA, Souli M, Guo S, Dykxhoorn DM, Scott WK, Fowler VG Jr.

Genes Immun. 2017 Mar;18(2):95-99. doi: 10.1038/gene.2017.6. Epub 2017 Mar 23.

7.

MicroRNA-146a Induces Lineage-Negative Bone Marrow Cell Apoptosis and Senescence by Targeting Polo-Like Kinase 2 Expression.

Deng S, Wang H, Jia C, Zhu S, Chu X, Ma Q, Wei J, Chen E, Zhu W, Macon CJ, Jayaweera DT, Dykxhoorn DM, Dong C.

Arterioscler Thromb Vasc Biol. 2017 Feb;37(2):280-290. doi: 10.1161/ATVBAHA.116.308378. Epub 2016 Dec 1.

8.

Blood Derived Induced Pluripotent Stem Cells (iPSCs): Benefits, Challenges and the Road Ahead.

El Hokayem J, Cukier HN, Dykxhoorn DM.

J Alzheimers Dis Parkinsonism. 2016 Oct;6(5). pii: 275. doi: 10.4172/2161-0460.1000275. Epub 2016 Oct 25.

9.

Generation of disease-specific autopsy-confirmed iPSCs lines from postmortem isolated Peripheral Blood Mononuclear Cells.

Belle K, Shabazz FS, Nuytemans K, Davis DA, Ali A, Young JL, Scott WK, Mash DC, Vance JM, Dykxhoorn DM.

Neurosci Lett. 2017 Jan 10;637:201-206. doi: 10.1016/j.neulet.2016.10.065. Epub 2016 Nov 5.

PMID:
27826014
10.

Corrigendum: Distinct Transcriptomic Features Are Associated with Transitional and Mature B-Cell Populations in the Mouse Spleen.

Kleiman E, Salyakina D, De Heusch M, Hoek KL, Llanes JM, Castro I, Wright JA, Clark ES, Dykxhoorn DM, Capobianco E, Takeda A, McCormack RM, Podack ER, Renauld JC, Khan WN.

Front Immunol. 2016 Jul 4;7:267. doi: 10.3389/fimmu.2016.00267. eCollection 2016.

11.

ABCA7 frameshift deletion associated with Alzheimer disease in African Americans.

Cukier HN, Kunkle BW, Vardarajan BN, Rolati S, Hamilton-Nelson KL, Kohli MA, Whitehead PL, Dombroski BA, Van Booven D, Lang R, Dykxhoorn DM, Farrer LA, Cuccaro ML, Vance JM, Gilbert JR, Beecham GW, Martin ER, Carney RM, Mayeux R, Schellenberg GD, Byrd GS, Haines JL, Pericak-Vance MA; Alzheimer's Disease Genetics Consortium.

Neurol Genet. 2016 May 17;2(3):e79. doi: 10.1212/NXG.0000000000000079. eCollection 2016 Jun.

12.

The microRNA-23b/-27b cluster suppresses prostate cancer metastasis via Huntingtin-interacting protein 1-related.

Rice MA, Ishteiwy RA, Magani F, Udayakumar T, Reiner T, Yates TJ, Miller P, Perez-Stable C, Rai P, Verdun R, Dykxhoorn DM, Burnstein KL.

Oncogene. 2016 Sep 8;35(36):4752-61. doi: 10.1038/onc.2016.6. Epub 2016 Feb 22.

13.

C9orf72 promoter hypermethylation is reduced while hydroxymethylation is acquired during reprogramming of ALS patient cells.

Esanov R, Belle KC, van Blitterswijk M, Belzil VV, Rademakers R, Dickson DW, Petrucelli L, Boylan KB, Dykxhoorn DM, Wuu J, Benatar M, Wahlestedt C, Zeier Z.

Exp Neurol. 2016 Mar;277:171-177. doi: 10.1016/j.expneurol.2015.12.022. Epub 2015 Dec 31.

14.

hVGAT-mCherry: A novel molecular tool for analysis of GABAergic neurons derived from human pluripotent stem cells.

DeRosa BA, Belle KC, Thomas BJ, Cukier HN, Pericak-Vance MA, Vance JM, Dykxhoorn DM.

Mol Cell Neurosci. 2015 Sep;68:244-57. doi: 10.1016/j.mcn.2015.08.007. Epub 2015 Aug 16.

15.

Bromodomain inhibitors regulate the C9ORF72 locus in ALS.

Zeier Z, Esanov R, Belle KC, Volmar CH, Johnstone AL, Halley P, DeRosa BA, Khoury N, van Blitterswijk M, Rademakers R, Albert J, Brothers SP, Wuu J, Dykxhoorn DM, Benatar M, Wahlestedt C.

Exp Neurol. 2015 Sep;271:241-50. doi: 10.1016/j.expneurol.2015.06.017. Epub 2015 Jun 20.

16.

Systemic Gene Silencing in Primary T Lymphocytes Using Targeted Lipid Nanoparticles.

Ramishetti S, Kedmi R, Goldsmith M, Leonard F, Sprague AG, Godin B, Gozin M, Cullis PR, Dykxhoorn DM, Peer D.

ACS Nano. 2015 Jul 28;9(7):6706-16. doi: 10.1021/acsnano.5b02796. Epub 2015 Jun 10.

PMID:
26042619
17.

Distinct Transcriptomic Features are Associated with Transitional and Mature B-Cell Populations in the Mouse Spleen.

Kleiman E, Salyakina D, De Heusch M, Hoek KL, Llanes JM, Castro I, Wright JA, Clark ES, Dykxhoorn DM, Capobianco E, Takeda A, Renauld JC, Khan WN.

Front Immunol. 2015 Feb 11;6:30. doi: 10.3389/fimmu.2015.00030. eCollection 2015. Erratum in: Front Immunol. 2016;7:267.

18.

PARK10 is a major locus for sporadic neuropathologically confirmed Parkinson disease.

Beecham GW, Dickson DW, Scott WK, Martin ER, Schellenberg G, Nuytemans K, Larson EB, Buxbaum JD, Trojanowski JQ, Van Deerlin VM, Hurtig HI, Mash DC, Beach TG, Troncoso JC, Pletnikova O, Frosch MP, Ghetti B, Foroud TM, Honig LS, Marder K, Vonsattel JP, Goldman SM, Vinters HV, Ross OA, Wszolek ZK, Wang L, Dykxhoorn DM, Pericak-Vance MA, Montine TJ, Leverenz JB, Dawson TM, Vance JM.

Neurology. 2015 Mar 10;84(10):972-80. doi: 10.1212/WNL.0000000000001332. Epub 2015 Feb 6.

19.

Target silencing of components of the conserved oligomeric Golgi complex impairs HIV-1 replication.

Liu S, Dominska-Ngowe M, Dykxhoorn DM.

Virus Res. 2014 Nov 4;192:92-102. doi: 10.1016/j.virusres.2014.08.015. Epub 2014 Aug 30.

20.

The microRNA -23b/-27b cluster suppresses the metastatic phenotype of castration-resistant prostate cancer cells.

Ishteiwy RA, Ward TM, Dykxhoorn DM, Burnstein KL.

PLoS One. 2012;7(12):e52106. doi: 10.1371/journal.pone.0052106. Epub 2012 Dec 26.

21.

Genomic signatures of a global fitness index in a multi-ethnic cohort of women.

Rampersaud E, Nathanson L, Farmer J, Meshbane K, Belton RL, Dressen A, Cuccaro M, Musto A, Daunert S, Deo S, Hudson N, Vance JM, Seo D, Mendez A, Dykxhoorn DM, Pericak-Vance MA, Goldschmidt-Clermont PJ.

Ann Hum Genet. 2013 Mar;77(2):147-57. doi: 10.1111/ahg.12006. Epub 2013 Jan 7.

22.

MicroRNA-10A* and MicroRNA-21 modulate endothelial progenitor cell senescence via suppressing high-mobility group A2.

Zhu S, Deng S, Ma Q, Zhang T, Jia C, Zhuo D, Yang F, Wei J, Wang L, Dykxhoorn DM, Hare JM, Goldschmidt-Clermont PJ, Dong C.

Circ Res. 2013 Jan 4;112(1):152-64. doi: 10.1161/CIRCRESAHA.112.280016. Epub 2012 Oct 16.

23.

Derivation of autism spectrum disorder-specific induced pluripotent stem cells from peripheral blood mononuclear cells.

DeRosa BA, Van Baaren JM, Dubey GK, Lee JM, Cuccaro ML, Vance JM, Pericak-Vance MA, Dykxhoorn DM.

Neurosci Lett. 2012 May 10;516(1):9-14. doi: 10.1016/j.neulet.2012.02.086. Epub 2012 Mar 7.

24.

Inhibition of HIV transmission in human cervicovaginal explants and humanized mice using CD4 aptamer-siRNA chimeras.

Wheeler LA, Trifonova R, Vrbanac V, Basar E, McKernan S, Xu Z, Seung E, Deruaz M, Dudek T, Einarsson JI, Yang L, Allen TM, Luster AD, Tager AM, Dykxhoorn DM, Lieberman J.

J Clin Invest. 2011 Jun;121(6):2401-12. doi: 10.1172/JCI45876. Epub 2011 May 16.

25.

MicroRNAs and metastasis: little RNAs go a long way.

Dykxhoorn DM.

Cancer Res. 2010 Aug 15;70(16):6401-6. doi: 10.1158/0008-5472.CAN-10-1346. Epub 2010 Jul 27. Review.

26.

Advances in synthetic siRNA delivery.

Manjunath N, Dykxhoorn DM.

Discov Med. 2010 May;9(48):418-30. Review.

27.

Advances in cell-type specific delivery of RNAi-based therapeutics.

Dykxhoorn DM.

IDrugs. 2010 May;13(5):325-31. Review.

PMID:
20432190
28.

Breaking down the barriers: siRNA delivery and endosome escape.

Dominska M, Dykxhoorn DM.

J Cell Sci. 2010 Apr 15;123(Pt 8):1183-9. doi: 10.1242/jcs.066399.

29.

miR-200 enhances mouse breast cancer cell colonization to form distant metastases.

Dykxhoorn DM, Wu Y, Xie H, Yu F, Lal A, Petrocca F, Martinvalet D, Song E, Lim B, Lieberman J.

PLoS One. 2009 Sep 29;4(9):e7181. doi: 10.1371/journal.pone.0007181.

30.

miR-24 Inhibits cell proliferation by targeting E2F2, MYC, and other cell-cycle genes via binding to "seedless" 3'UTR microRNA recognition elements.

Lal A, Navarro F, Maher CA, Maliszewski LE, Yan N, O'Day E, Chowdhury D, Dykxhoorn DM, Tsai P, Hofmann O, Becker KG, Gorospe M, Hide W, Lieberman J.

Mol Cell. 2009 Sep 11;35(5):610-25. doi: 10.1016/j.molcel.2009.08.020.

31.

RNA interference as an anticancer therapy: a patent perspective.

Dykxhoorn DM.

Expert Opin Ther Pat. 2009 Apr;19(4):475-91. doi: 10.1517/13543770902838008. Review.

PMID:
19441927
32.

miR-24-mediated downregulation of H2AX suppresses DNA repair in terminally differentiated blood cells.

Lal A, Pan Y, Navarro F, Dykxhoorn DM, Moreau L, Meire E, Bentwich Z, Lieberman J, Chowdhury D.

Nat Struct Mol Biol. 2009 May;16(5):492-8. doi: 10.1038/nsmb.1589. Epub 2009 Apr 19.

33.

A PP4-phosphatase complex dephosphorylates gamma-H2AX generated during DNA replication.

Chowdhury D, Xu X, Zhong X, Ahmed F, Zhong J, Liao J, Dykxhoorn DM, Weinstock DM, Pfeifer GP, Lieberman J.

Mol Cell. 2008 Jul 11;31(1):33-46. doi: 10.1016/j.molcel.2008.05.016.

34.

Granzyme A cleaves a mitochondrial complex I protein to initiate caspase-independent cell death.

Martinvalet D, Dykxhoorn DM, Ferrini R, Lieberman J.

Cell. 2008 May 16;133(4):681-92. doi: 10.1016/j.cell.2008.03.032.

35.

RNA interference and cancer: endogenous pathways and therapeutic approaches.

Dykxhoorn DM, Chowdhury D, Lieberman J.

Adv Exp Med Biol. 2008;615:299-329. doi: 10.1007/978-1-4020-6554-5_14. Review.

PMID:
18437900
36.

Identification of host proteins required for HIV infection through a functional genomic screen.

Brass AL, Dykxhoorn DM, Benita Y, Yan N, Engelman A, Xavier RJ, Lieberman J, Elledge SJ.

Science. 2008 Feb 15;319(5865):921-6. doi: 10.1126/science.1152725. Epub 2008 Jan 10.

37.

Focal adhesion kinase is required for CXCL12-induced chemotactic and pro-adhesive responses in hematopoietic precursor cells.

Glodek AM, Le Y, Dykxhoorn DM, Park SY, Mostoslavsky G, Mulligan R, Lieberman J, Beggs HE, Honczarenko M, Silberstein LE.

Leukemia. 2007 Aug;21(8):1723-32. Epub 2007 Jun 14.

PMID:
17568820
38.

MicroRNAs in viral replication and pathogenesis.

Dykxhoorn DM.

DNA Cell Biol. 2007 Apr;26(4):239-49. Review.

PMID:
17465890
39.

Knocking down disease with siRNAs.

Dykxhoorn DM, Lieberman J.

Cell. 2006 Jul 28;126(2):231-5.

40.

Silencing viral infection.

Dykxhoorn DM, Lieberman J.

PLoS Med. 2006 Jul;3(7):e242. Epub 2006 Jul 25. Review. No abstract available.

41.

Running interference: prospects and obstacles to using small interfering RNAs as small molecule drugs.

Dykxhoorn DM, Lieberman J.

Annu Rev Biomed Eng. 2006;8:377-402. Review.

PMID:
16834561
42.

Determinants of specific RNA interference-mediated silencing of human beta-globin alleles differing by a single nucleotide polymorphism.

Dykxhoorn DM, Schlehuber LD, London IM, Lieberman J.

Proc Natl Acad Sci U S A. 2006 Apr 11;103(15):5953-8. Epub 2006 Apr 3.

43.

The silent treatment: siRNAs as small molecule drugs.

Dykxhoorn DM, Palliser D, Lieberman J.

Gene Ther. 2006 Mar;13(6):541-52. Review.

PMID:
16397510
44.

Genetic analysis of the subunit organization and function of the conserved oligomeric golgi (COG) complex: studies of COG5- and COG7-deficient mammalian cells.

Oka T, Vasile E, Penman M, Novina CD, Dykxhoorn DM, Ungar D, Hughson FM, Krieger M.

J Biol Chem. 2005 Sep 23;280(38):32736-45. Epub 2005 Jul 28.

45.

Antibody mediated in vivo delivery of small interfering RNAs via cell-surface receptors.

Song E, Zhu P, Lee SK, Chowdhury D, Kussman S, Dykxhoorn DM, Feng Y, Palliser D, Weiner DB, Shankar P, Marasco WA, Lieberman J.

Nat Biotechnol. 2005 Jun;23(6):709-17. Epub 2005 May 22.

46.

Lentiviral delivery of short hairpin RNAs protects CD4 T cells from multiple clades and primary isolates of HIV.

Lee SK, Dykxhoorn DM, Kumar P, Ranjbar S, Song E, Maliszewski LE, François-Bongarçon V, Goldfeld A, Swamy NM, Lieberman J, Shankar P.

Blood. 2005 Aug 1;106(3):818-26. Epub 2005 Apr 14.

47.

The silent revolution: RNA interference as basic biology, research tool, and therapeutic.

Dykxhoorn DM, Lieberman J.

Annu Rev Med. 2005;56:401-23. Review.

PMID:
15660519
48.

P-bodies and RNAi: The missing link?

Dykxhoorn DM.

J RNAi Gene Silencing. 2005 Dec 16;2(1):105-6. No abstract available.

49.

Sustained small interfering RNA-mediated human immunodeficiency virus type 1 inhibition in primary macrophages.

Song E, Lee SK, Dykxhoorn DM, Novina C, Zhang D, Crawford K, Cerny J, Sharp PA, Lieberman J, Manjunath N, Shankar P.

J Virol. 2003 Jul;77(13):7174-81.

50.

Killing the messenger: short RNAs that silence gene expression.

Dykxhoorn DM, Novina CD, Sharp PA.

Nat Rev Mol Cell Biol. 2003 Jun;4(6):457-67. Review.

PMID:
12778125

Supplemental Content

Loading ...
Support Center