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Items: 1 to 50 of 51

1.

A Randomized Phase II Trial of Pioglitazone for Lung Cancer Chemoprevention in High-Risk Current and Former Smokers.

Keith RL, Blatchford PJ, Merrick DT, Bunn PA Jr, Bagwell B, Dwyer-Nield LD, Jackson MK, Geraci MW, Miller YE.

Cancer Prev Res (Phila). 2019 Oct;12(10):721-730. doi: 10.1158/1940-6207.CAPR-19-0006. Epub 2019 Jul 15.

PMID:
31308004
2.

Dysregulation of Gap Junction Function and Cytokine Production in Response to Non-Genotoxic Polycyclic Aromatic Hydrocarbons in an In Vitro Lung Cell Model.

Romo D, Velmurugan K, Upham BL, Dwyer-Nield LD, Bauer AK.

Cancers (Basel). 2019 Apr 23;11(4). pii: E572. doi: 10.3390/cancers11040572.

3.

Prostacyclin and EMT Pathway Markers for Monitoring Response to Lung Cancer Chemoprevention.

New ML, White CM, McGonigle P, McArthur DG, Dwyer-Nield LD, Merrick DT, Keith RL, Tennis MA.

Cancer Prev Res (Phila). 2018 Oct;11(10):643-654. doi: 10.1158/1940-6207.CAPR-18-0052. Epub 2018 Jul 25.

4.

Altered Cell-Cycle Control, Inflammation, and Adhesion in High-Risk Persistent Bronchial Dysplasia.

Merrick DT, Edwards MG, Franklin WA, Sugita M, Keith RL, Miller YE, Friedman MB, Dwyer-Nield LD, Tennis MA, O'Keefe MC, Donald EJ, Malloy JM, van Bokhoven A, Wilson S, Koch PJ, O'Shea C, Coldren C, Orlicky DJ, Lu X, Baron AE, Hickey G, Kennedy TC, Powell R, Heasley L, Bunn PA, Geraci M, Nemenoff RA.

Cancer Res. 2018 Sep 1;78(17):4971-4983. doi: 10.1158/0008-5472.CAN-17-3822. Epub 2018 Jul 11.

5.

Prostacyclin reverses the cigarette smoke-induced decrease in pulmonary Frizzled 9 expression through miR-31.

Tennis MA, New ML, McArthur DG, Merrick DT, Dwyer-Nield LD, Keith RL.

Sci Rep. 2016 Jun 24;6:28519. doi: 10.1038/srep28519.

6.

Tracheal dysplasia precedes bronchial dysplasia in mouse model of N-nitroso trischloroethylurea induced squamous cell lung cancer.

Ghosh M, Dwyer-Nield LD, Kwon JB, Barthel L, Janssen WJ, Merrick DT, Keith RL.

PLoS One. 2015 Apr 10;10(4):e0122823. doi: 10.1371/journal.pone.0122823. eCollection 2015.

7.

Corrigendum: depletion of tumor-associated macrophages slows the growth of chemically induced mouse lung adenocarcinomas.

Fritz JM, Tennis MA, Orlicky DJ, Yin H, Ju C, Redente EF, Choo KS, Staab TA, Bouchard RJ, Merrick DT, Malkinson AM, Dwyer-Nield LD.

Front Immunol. 2015 Mar 3;6:88. doi: 10.3389/fimmu.2015.00088. eCollection 2015.

8.

Depletion of tumor-associated macrophages slows the growth of chemically induced mouse lung adenocarcinomas.

Fritz JM, Tennis MA, Orlicky DJ, Lin H, Ju C, Redente EF, Choo KS, Staab TA, Bouchard RJ, Merrick DT, Malkinson AM, Dwyer-Nield LD.

Front Immunol. 2014 Nov 25;5:587. doi: 10.3389/fimmu.2014.00587. eCollection 2014. Erratum in: Front Immunol. 2015;6:88.

9.

Silibinin modulates TNF-α and IFN-γ mediated signaling to regulate COX2 and iNOS expression in tumorigenic mouse lung epithelial LM2 cells.

Tyagi A, Agarwal C, Dwyer-Nield LD, Singh RP, Malkinson AM, Agarwal R.

Mol Carcinog. 2012 Oct;51(10):832-42. doi: 10.1002/mc.20851. Epub 2011 Aug 31.

PMID:
21882257
10.
11.

Silibinin prevents lung tumorigenesis in wild-type but not in iNOS-/- mice: potential of real-time micro-CT in lung cancer chemoprevention studies.

Ramasamy K, Dwyer-Nield LD, Serkova NJ, Hasebroock KM, Tyagi A, Raina K, Singh RP, Malkinson AM, Agarwal R.

Clin Cancer Res. 2011 Feb 15;17(4):753-61. doi: 10.1158/1078-0432.CCR-10-2290. Epub 2010 Dec 10.

12.

Regulation of cytokine-induced prostanoid and nitric oxide synthesis by extracellular signal–regulated kinase 1/2 in lung epithelial cells.

Rice PL, Barrett BS, Fritz JM, Srebernak MC, Kisley LR, Malkinson AM, Dwyer-Nield LD.

Exp Lung Res. 2010 Nov;36(9):558-71. doi: 10.3109/01902148.2010.491891.

13.

Tumor progression stage and anatomical site regulate tumor-associated macrophage and bone marrow-derived monocyte polarization.

Redente EF, Dwyer-Nield LD, Merrick DT, Raina K, Agarwal R, Pao W, Rice PL, Shroyer KR, Malkinson AM.

Am J Pathol. 2010 Jun;176(6):2972-85. doi: 10.2353/ajpath.2010.090879. Epub 2010 Apr 29.

14.

Differential polarization of alveolar macrophages and bone marrow-derived monocytes following chemically and pathogen-induced chronic lung inflammation.

Redente EF, Higgins DM, Dwyer-Nield LD, Orme IM, Gonzalez-Juarrero M, Malkinson AM.

J Leukoc Biol. 2010 Jul;88(1):159-68. doi: 10.1189/jlb.0609378. Epub 2010 Apr 1.

15.

The Kras mutational spectra of chemically induced lung tumors in different inbred mice mimics the spectra of KRAS mutations in adenocarcinomas in smokers versus nonsmokers.

Fritz JM, Dwyer-Nield LD, Russell BM, Malkinson AM.

J Thorac Oncol. 2010 Feb;5(2):254-7. doi: 10.1097/JTO.0b013e3181c8ce04.

16.

Lung tumor growth is stimulated in IFN-gamma-/- mice and inhibited in IL-4Ralpha-/- mice.

Redente EF, Dwyer-Nield LD, Barrett BS, Riches DW, Malkinson AM.

Anticancer Res. 2009 Dec;29(12):5095-101.

17.

Epistatic interactions govern chemically-induced lung tumor susceptibility and Kras mutation site in murine C57BL/6J-ChrA/J chromosome substitution strains.

Dwyer-Nield LD, McQuillan J, Hill-Baskin A, Radcliffe RA, You M, Nadeau JH, Malkinson AM.

Int J Cancer. 2010 Jan 1;126(1):125-32. doi: 10.1002/ijc.24743.

18.

Growth inhibition and regression of lung tumors by silibinin: modulation of angiogenesis by macrophage-associated cytokines and nuclear factor-kappaB and signal transducers and activators of transcription 3.

Tyagi A, Singh RP, Ramasamy K, Raina K, Redente EF, Dwyer-Nield LD, Radcliffe RA, Malkinson AM, Agarwal R.

Cancer Prev Res (Phila). 2009 Jan;2(1):74-83. doi: 10.1158/1940-6207.CAPR-08-0095.

19.

Inhibition by erlotinib of primary lung adenocarcinoma at an early stage in male mice.

Zerbe LK, Dwyer-Nield LD, Fritz JM, Redente EF, Shroyer RJ, Conklin E, Kane S, Tucker C, Eckhardt SG, Gustafson DL, Iwata KK, Malkinson AM.

Cancer Chemother Pharmacol. 2008 Sep;62(4):605-20. Epub 2007 Nov 21.

PMID:
18030469
20.

Altered expression of splicing factor, heterogeneous nuclear ribonucleoprotein A2/B1, in mouse lung neoplasia.

Peebles KA, Dwyer-Nield LD, Malkinson AM.

Mol Carcinog. 2007 Nov;46(11):887-900.

PMID:
17477362
21.

Prostaglandin E2 receptor subtype 2 (EP2) null mice are protected against murine lung tumorigenesis.

Keith RL, Geraci MW, Nana-Sinkam SP, Breyer RM, Hudish TM, Meyer AM, Malkinson AM, Dwyer-Nield LD.

Anticancer Res. 2006 Jul-Aug;26(4B):2857-61.

22.

Effect of silibinin on the growth and progression of primary lung tumors in mice.

Singh RP, Deep G, Chittezhath M, Kaur M, Dwyer-Nield LD, Malkinson AM, Agarwal R.

J Natl Cancer Inst. 2006 Jun 21;98(12):846-55.

PMID:
16788158
23.

Attenuation of the pulmonary inflammatory response following butylated hydroxytoluene treatment of cytosolic phospholipase A2 null mice.

Meyer AM, Dwyer-Nield LD, Hurteau G, Keith RL, Ouyang Y, Freed BM, Kisley LR, Geraci MW, Bonventre JV, Nemenoff RA, Malkinson AM.

Am J Physiol Lung Cell Mol Physiol. 2006 Jun;290(6):L1260-6. Epub 2006 Jan 27.

24.

Quantitative analysis of early chemically-induced pulmonary lesions in mice of varying susceptibilities to lung tumorigenesis.

O'Donnell EP, Zerbe LK, Dwyer-Nield LD, Kisley LR, Malkinson AM.

Cancer Lett. 2006 Sep 28;241(2):197-202. Epub 2005 Dec 7.

PMID:
16337739
25.

Cytokines differentially regulate the synthesis of prostanoid and nitric oxide mediators in tumorigenic versus non-tumorigenic mouse lung epithelial cell lines.

Dwyer-Nield LD, Srebernak MC, Barrett BS, Ahn J, Cosper P, Meyer AM, Kisley LR, Bauer AK, Thompson DC, Malkinson AM.

Carcinogenesis. 2005 Jul;26(7):1196-206. Epub 2005 Mar 3.

PMID:
15746162
26.

Relative amounts of antagonistic splicing factors, hnRNP A1 and ASF/SF2, change during neoplastic lung growth: implications for pre-mRNA processing.

Zerbe LK, Pino I, Pio R, Cosper PF, Dwyer-Nield LD, Meyer AM, Port JD, Montuenga LM, Malkinson AM.

Mol Carcinog. 2004 Dec;41(4):187-96.

PMID:
15390079
27.

Mutation-selective tumor remission with Ras-targeted, whole yeast-based immunotherapy.

Lu Y, Bellgrau D, Dwyer-Nield LD, Malkinson AM, Duke RC, Rodell TC, Franzusoff A.

Cancer Res. 2004 Aug 1;64(15):5084-8.

28.

Serum levels of surfactant protein D are increased in mice with lung tumors.

Zhang F, Pao W, Umphress S, Jakowlew S, Meyer AM, Dwyer-Nield LD, Takeda K, Gelfand EW, Fisher J, Malkinson AM, Mason RJ.

Chest. 2004 May;125(5 Suppl):109S. No abstract available.

PMID:
15136449
29.

Decreased lung tumorigenesis in mice genetically deficient in cytosolic phospholipase A2.

Meyer AM, Dwyer-Nield LD, Hurteau GJ, Keith RL, O'Leary E, You M, Bonventre JV, Nemenoff RA, Malkinson AM.

Carcinogenesis. 2004 Aug;25(8):1517-24. Epub 2004 Mar 19.

PMID:
15033900
30.

Serum levels of surfactant protein D are increased in mice with lung tumors.

Zhang F, Pao W, Umphress SM, Jakowlew SB, Meyer AM, Dwyer-Nield LD, Nielsen LD, Takeda K, Gelfand EW, Fisher JH, Zhang L, Malkinson AM, Mason RJ.

Cancer Res. 2003 Sep 15;63(18):5889-94.

31.

Induction of a high incidence of lung tumors in C57BL/6 mice with multiple ethyl carbamate injections.

Miller YE, Dwyer-Nield LD, Keith RL, Le M, Franklin WA, Malkinson AM.

Cancer Lett. 2003 Aug 20;198(2):139-44.

PMID:
12957351
32.

Responses of tumorigenic and non-tumorigenic mouse lung epithelial cell lines to electrophilic metabolites of the tumor promoter butylated hydroxytoluene.

Sun Y, Dwyer-Nield LD, Malkinson AM, Zhang YL, Thompson JA.

Chem Biol Interact. 2003 Mar 6;145(1):41-51.

PMID:
12606153
33.

Genetic ablation of inducible nitric oxide synthase decreases mouse lung tumorigenesis.

Kisley LR, Barrett BS, Bauer AK, Dwyer-Nield LD, Barthel B, Meyer AM, Thompson DC, Malkinson AM.

Cancer Res. 2002 Dec 1;62(23):6850-6.

34.

Morphological assessment of apoptosis in human lung cells.

Dwyer-Nield LD, Dinsdale D, Cohen JJ, Squier MK, Malkinson AM.

Methods Mol Med. 2003;74:283-97. No abstract available.

PMID:
12415703
35.

Celecoxib reduces pulmonary inflammation but not lung tumorigenesis in mice.

Kisley LR, Barrett BS, Dwyer-Nield LD, Bauer AK, Thompson DC, Malkinson AM.

Carcinogenesis. 2002 Oct;23(10):1653-60.

PMID:
12376474
37.

The lung tumor promoter, butylated hydroxytoluene (BHT), causes chronic inflammation in promotion-sensitive BALB/cByJ mice but not in promotion-resistant CXB4 mice.

Bauer AK, Dwyer-Nield LD, Hankin JA, Murphy RC, Malkinson AM.

Toxicology. 2001 Dec 1;169(1):1-15. Erratum in: Toxicology 2002 Jul 1;176(1-2):159-61.

PMID:
11696405
38.

Cyclin D1 as a proliferative marker regulating retinoblastoma phosphorylation in mouse lung epithelial cells.

Mamay CL, Schauer IE, Rice PL, McDoniels-Silvers A, Dwyer-Nield LD, You M, Sclafani RA, Malkinson AM.

Cancer Lett. 2001 Jul 26;168(2):165-72. Erratum in: Cancer Lett 2002 Jun 28;180(2):223.

PMID:
11403921
39.

Regulation of lung epithelial cell morphology by cAMP-dependent protein kinase type I isozyme.

Porter SE, Dwyer-Nield LD, Malkinson AM.

Am J Physiol Lung Cell Mol Physiol. 2001 Jun;280(6):L1282-9.

40.

Defective gap junctional intercellular communication in lung cancer: loss of an important mediator of tissue homeostasis and phenotypic regulation.

Ruch RJ, Porter S, Koffler LD, Dwyer-Nield LD, Malkinson AM.

Exp Lung Res. 2001 Apr-May;27(3):231-43.

PMID:
11293326
41.

Butylated hydroxytoluene (BHT) induction of pulmonary inflammation: a role in tumor promotion.

Bauer AK, Dwyer-Nield LD, Keil K, Koski K, Malkinson AM.

Exp Lung Res. 2001 Apr-May;27(3):197-216.

PMID:
11293324
42.
43.

Growth inhibition in G(1) and altered expression of cyclin D1 and p27(kip-1 )after forced connexin expression in lung and liver carcinoma cells.

Koffler L, Roshong S, Kyu Park I, Cesen-Cummings K, Thompson DC, Dwyer-Nield LD, Rice P, Mamay C, Malkinson AM, Ruch RJ.

J Cell Biochem. 2000 Sep 7;79(3):347-54.

PMID:
10972973
44.

Quantitative trait locus mapping of genes regulating pulmonary PKC activity and PKC-alpha content.

Dwyer-Nield LD, Paigen B, Porter SE, Malkinson AM.

Am J Physiol Lung Cell Mol Physiol. 2000 Aug;279(2):L326-32.

45.

Differential expression and localization of the mRNA binding proteins, AU-rich element mRNA binding protein (AUF1) and Hu antigen R (HuR), in neoplastic lung tissue.

Blaxall BC, Dwyer-Nield LD, Bauer AK, Bohlmeyer TJ, Malkinson AM, Port JD.

Mol Carcinog. 2000 Jun;28(2):76-83.

PMID:
10900464
46.

High cyclooxygenase 1 (COX-1) and cyclooxygenase 2 (COX-2) contents in mouse lung tumors.

Bauer AK, Dwyer-Nield LD, Malkinson AM.

Carcinogenesis. 2000 Apr;21(4):543-50.

PMID:
10753183
47.

Selective induction of apoptosis in mouse and human lung epithelial cell lines by the tert-butyl hydroxylated metabolite of butylated hydroxytoluene: a proposed role in tumor promotion.

Dwyer-Nield LD, Thompson JA, Peljak G, Squier MK, Barker TD, Parkinson A, Cohen JJ, Dinsdale D, Malkinson AM.

Toxicology. 1998 Sep 15;130(2-3):115-27.

PMID:
9865479
48.

Inhibition of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone-induced mouse lung tumor formation by FGN-1 (sulindac sulfone).

Malkinson AM, Koski KM, Dwyer-Nield LD, Rice PL, Rioux N, Castonguay A, Ahnen DJ, Thompson H, Pamukcu R, Piazza GA.

Carcinogenesis. 1998 Aug;19(8):1353-6.

PMID:
9744528
49.

Mouse lung epithelial cell lines--tools for the study of differentiation and the neoplastic phenotype.

Malkinson AM, Dwyer-Nield LD, Rice PL, Dinsdale D.

Toxicology. 1997 Nov 21;123(1-2):53-100. Review.

PMID:
9347924
50.

Cytoskeletal architecture in mouse lung epithelial cells is regulated by protein-kinase C-alpha and calpain II.

Dwyer-Nield LD, Miller AC, Neighbors BW, Dinsdale D, Malkinson AM.

Am J Physiol. 1996 Apr;270(4 Pt 1):L526-34.

PMID:
8928811

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