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Items: 29


Transduction of rat pancreatic islets with pseudotyped adeno-associated virus vectors.

Craig AT, Gavrilova O, Dwyer NK, Jou W, Pack S, Liu E, Pechhold K, Schmidt M, McAlister VJ, Chiorini JA, Blanchette-Mackie EJ, Harlan DM, Owens RA.

Virol J. 2009 May 18;6:61. doi: 10.1186/1743-422X-6-61.


Differential trafficking of the Niemann-Pick C1 and 2 proteins highlights distinct roles in late endocytic lipid trafficking.

Zhang M, Sun M, Dwyer NK, Comly ME, Patel SC, Sundaram R, Hanover JA, Blanchette-Mackie EJ.

Acta Paediatr Suppl. 2003 Dec;92(443):63-73; discussion 45.


Targeted mutation of the MLN64 START domain causes only modest alterations in cellular sterol metabolism.

Kishida T, Kostetskii I, Zhang Z, Martinez F, Liu P, Walkley SU, Dwyer NK, Blanchette-Mackie EJ, Radice GL, Strauss JF 3rd.

J Biol Chem. 2004 Apr 30;279(18):19276-85. Epub 2004 Feb 12.


MLN64 mediates mobilization of lysosomal cholesterol to steroidogenic mitochondria.

Zhang M, Liu P, Dwyer NK, Christenson LK, Fujimoto T, Martinez F, Comly M, Hanover JA, Blanchette-Mackie EJ, Strauss JF 3rd.

J Biol Chem. 2002 Sep 6;277(36):33300-10. Epub 2002 Jun 17.


Cellular localization and trafficking of the human ABCA1 transporter.

Neufeld EB, Remaley AT, Demosky SJ, Stonik JA, Cooney AM, Comly M, Dwyer NK, Zhang M, Blanchette-Mackie J, Santamarina-Fojo S, Brewer HB Jr.

J Biol Chem. 2001 Jul 20;276(29):27584-90. Epub 2001 May 10.


Cessation of rapid late endosomal tubulovesicular trafficking in Niemann-Pick type C1 disease.

Zhang M, Dwyer NK, Love DC, Cooney A, Comly M, Neufeld E, Pentchev PG, Blanchette-Mackie EJ, Hanover JA.

Proc Natl Acad Sci U S A. 2001 Apr 10;98(8):4466-71.


Sterol-modulated glycolipid sorting occurs in niemann-pick C1 late endosomes.

Zhang M, Dwyer NK, Neufeld EB, Love DC, Cooney A, Comly M, Patel S, Watari H, Strauss JF 3rd, Pentchev PG, Hanover JA, Blanchette-Mackie EJ.

J Biol Chem. 2001 Feb 2;276(5):3417-25. Epub 2000 Oct 13.


Determinants of NPC1 expression and action: key promoter regions, posttranscriptional control, and the importance of a "cysteine-rich" loop.

Watari H, Blanchette-Mackie EJ, Dwyer NK, Watari M, Burd CG, Patel S, Pentchev PG, Strauss JF 3rd.

Exp Cell Res. 2000 Aug 25;259(1):247-56.


NPC1-containing compartment of human granulosa-lutein cells: a role in the intracellular trafficking of cholesterol supporting steroidogenesis.

Watari H, Blanchette-Mackie EJ, Dwyer NK, Sun G, Glick JM, Patel S, Neufeld EB, Pentchev PG, Strauss JF 3rd.

Exp Cell Res. 2000 Feb 25;255(1):56-66.


Mutations in the leucine zipper motif and sterol-sensing domain inactivate the Niemann-Pick C1 glycoprotein.

Watari H, Blanchette-Mackie EJ, Dwyer NK, Watari M, Neufeld EB, Patel S, Pentchev PG, Strauss JF 3rd.

J Biol Chem. 1999 Jul 30;274(31):21861-6.


The Niemann-Pick C1 protein resides in a vesicular compartment linked to retrograde transport of multiple lysosomal cargo.

Neufeld EB, Wastney M, Patel S, Suresh S, Cooney AM, Dwyer NK, Roff CF, Ohno K, Morris JA, Carstea ED, Incardona JP, Strauss JF 3rd, Vanier MT, Patterson MC, Brady RO, Pentchev PG, Blanchette-Mackie EJ.

J Biol Chem. 1999 Apr 2;274(14):9627-35.


Niemann-Pick C1 protein: obligatory roles for N-terminal domains and lysosomal targeting in cholesterol mobilization.

Watari H, Blanchette-Mackie EJ, Dwyer NK, Glick JM, Patel S, Neufeld EB, Brady RO, Pentchev PG, Strauss JF 3rd.

Proc Natl Acad Sci U S A. 1999 Feb 2;96(3):805-10.


Constitutive achlorhydria in mucolipidosis type IV.

Schiffmann R, Dwyer NK, Lubensky IA, Tsokos M, Sutliff VE, Latimer JS, Frei KP, Brady RO, Barton NW, Blanchette-Mackie EJ, Goldin E.

Proc Natl Acad Sci U S A. 1998 Feb 3;95(3):1207-12.


Niemann-Pick C1 disease gene: homology to mediators of cholesterol homeostasis.

Carstea ED, Morris JA, Coleman KG, Loftus SK, Zhang D, Cummings C, Gu J, Rosenfeld MA, Pavan WJ, Krizman DB, Nagle J, Polymeropoulos MH, Sturley SL, Ioannou YA, Higgins ME, Comly M, Cooney A, Brown A, Kaneski CR, Blanchette-Mackie EJ, Dwyer NK, Neufeld EB, Chang TY, Liscum L, Strauss JF 3rd, Ohno K, Zeigler M, Carmi R, Sokol J, Markie D, O'Neill RR, van Diggelen OP, Elleder M, Patterson MC, Brady RO, Vanier MT, Pentchev PG, Tagle DA.

Science. 1997 Jul 11;277(5323):228-31.


Effect of human milk or formula on gastric function and fat digestion in the premature infant.

Armand M, Hamosh M, Mehta NR, Angelus PA, Philpott JR, Henderson TR, Dwyer NK, Lairon D, Hamosh P.

Pediatr Res. 1996 Sep;40(3):429-37.


Intracellular trafficking of cholesterol monitored with a cyclodextrin.

Neufeld EB, Cooney AM, Pitha J, Dawidowicz EA, Dwyer NK, Pentchev PG, Blanchette-Mackie EJ.

J Biol Chem. 1996 Aug 30;271(35):21604-13.


Perilipin: possible roles in structure and metabolism of intracellular neutral lipids in adipocytes and steroidogenic cells.

Londos C, Gruia-Gray J, Brasaemle DL, Rondinone CM, Takeda T, Dwyer NK, Barber T, Kimmel AR, Blanchette-Mackie EJ.

Int J Obes Relat Metab Disord. 1996 Mar;20 Suppl 3:S97-101. Review.


Perilipin is located on the surface layer of intracellular lipid droplets in adipocytes.

Blanchette-Mackie EJ, Dwyer NK, Barber T, Coxey RA, Takeda T, Rondinone CM, Theodorakis JL, Greenberg AS, Londos C.

J Lipid Res. 1995 Jun;36(6):1211-26.


Cultured skin fibroblasts derived from patients with mucolipidosis 4 are auto-fluorescent.

Goldin E, Blanchette-Mackie EJ, Dwyer NK, Pentchev PG, Brady RO.

Pediatr Res. 1995 Jun;37(6):687-92.


Microtubules are not required for glucocorticoid receptor mediated gene induction.

Szapary D, Barber T, Dwyer NK, Blanchette-Mackie EJ, Simons SS Jr.

J Steroid Biochem Mol Biol. 1994 Nov;51(3-4):143-8.


Type C Niemann-Pick disease: documentation of abnormal LDL processing in lymphocytes.

Argoff CE, Kaneski CR, Blanchette-Mackie EJ, Comly M, Dwyer NK, Brown A, Brady RO, Pentchev PG.

Biochem Biophys Res Commun. 1990 Aug 31;171(1):38-45.


Type C Niemann-Pick disease: dimethyl sulfoxide moderates abnormal LDL-cholesterol processing in mutant fibroblasts.

Blanchette Mackie EJ, Dwyer NK, Vanier MT, Sokol J, Merrick HF, Comly ME, Argoff CE, Pentchev PG.

Biochim Biophys Acta. 1989 Nov 28;1006(2):219-26.


Lipoprotein lipase in myocytes and capillary endothelium of heart: immunocytochemical study.

Blanchette-Mackie EJ, Masuno H, Dwyer NK, Olivecrona T, Scow RO.

Am J Physiol. 1989 Jun;256(6 Pt 1):E818-28.


Cytochemical studies of lipid metabolism: immunogold probes for lipoprotein lipase and cholesterol.

Blanchette-Mackie EJ, Dwyer NK, Amende LA.

Am J Anat. 1989 Jun-Jul;185(2-3):255-63. Review.


Type-C Niemann-Pick disease: low density lipoprotein uptake is associated with premature cholesterol accumulation in the Golgi complex and excessive cholesterol storage in lysosomes.

Blanchette-Mackie EJ, Dwyer NK, Amende LM, Kruth HS, Butler JD, Sokol J, Comly ME, Vanier MT, August JT, Brady RO, et al.

Proc Natl Acad Sci U S A. 1988 Nov;85(21):8022-6.


Type C Niemann-Pick disease. Lysosomal accumulation and defective intracellular mobilization of low density lipoprotein cholesterol.

Sokol J, Blanchette-Mackie J, Kruth HS, Dwyer NK, Amende LM, Butler JD, Robinson E, Patel S, Brady RO, Comly ME, et al.

J Biol Chem. 1988 Mar 5;263(7):3411-7.


Evidence for a polysaccharide surface coat in the developmental stages of Leishmania donovani: a fine structure-cytochemical study.

Dwyer DM, Langreth SG, Dwyer NK.

Z Parasitenkd. 1974 Jun 21;43(4):227-49. No abstract available.


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