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Detection of G Protein-Coupled Receptor Complexes in Postmortem Human Brain by Proximity Ligation Assay.

Zhu Y, Dwork AJ, Trifilieff P, Javitch JA.

Curr Protoc Neurosci. 2020 Mar;91(1):e86. doi: 10.1002/cpns.86.


Detecting G protein-coupled receptor complexes in postmortem human brain with proximity ligation assay and a Bayesian classifier.

Zhu Y, Mészáros J, Walle R, Fan R, Sun Z, Dwork AJ, Trifilieff P, Javitch JA.

Biotechniques. 2020 Mar;68(3):122-129. doi: 10.2144/btn-2019-0083. Epub 2019 Dec 20.


Measurement-oriented deep-learning workflow for improved segmentation of myelin and axons in high-resolution images of human cerebral white matter.

Janjic P, Petrovski K, Dolgoski B, Smiley J, Zdravkovski P, Pavlovski G, Jakjovski Z, Davceva N, Poposka V, Stankov A, Rosoklija G, Petrushevska G, Kocarev L, Dwork AJ.

J Neurosci Methods. 2019 Oct 1;326:108373. doi: 10.1016/j.jneumeth.2019.108373. Epub 2019 Aug 1.


GAD mRNA in Orbital Prefrontal Cortex and Anterior Cingulate Cortex in Alcoholics Compared with Nonpsychiatric Controls: A Negative Postmortem Study.

Underwood MD, Bakalian MJ, Dwork AJ, Min E, Mann JJ, Arango V.

J Psychiatr Brain Sci. 2019;4(2). pii: e190007. doi: 10.20900/jpbs.20190007. Epub 2019 Apr 3.


Resilience Is Associated With Larger Dentate Gyrus, While Suicide Decedents With Major Depressive Disorder Have Fewer Granule Neurons.

Boldrini M, Galfalvy H, Dwork AJ, Rosoklija GB, Trencevska-Ivanovska I, Pavlovski G, Hen R, Arango V, Mann JJ.

Biol Psychiatry. 2019 May 15;85(10):850-862. doi: 10.1016/j.biopsych.2018.12.022. Epub 2019 Jan 17.


The SNAP25 Interactome in Ventromedial Caudate in Schizophrenia Includes the Mitochondrial Protein ARF1.

Ramos-Miguel A, Barakauskas V, Alamri J, Miyauchi M, Barr AM, Beasley CL, Rosoklija G, Mann JJ, Dwork AJ, Moradian A, Morin GB, Honer WG.

Neuroscience. 2019 Nov 10;420:97-111. doi: 10.1016/j.neuroscience.2018.12.045. Epub 2019 Jan 2.


Reduced SNAP25 Protein Fragmentation Contributes to SNARE Complex Dysregulation in Schizophrenia Postmortem Brain.

Ramos-Miguel A, Gicas K, Alamri J, Beasley CL, Dwork AJ, Mann JJ, Rosoklija G, Cai F, Song W, Barr AM, Honer WG.

Neuroscience. 2019 Nov 10;420:112-128. doi: 10.1016/j.neuroscience.2018.12.015. Epub 2018 Dec 21.


Serotonin receptors and suicide, major depression, alcohol use disorder and reported early life adversity.

Underwood MD, Kassir SA, Bakalian MJ, Galfalvy H, Dwork AJ, Mann JJ, Arango V.

Transl Psychiatry. 2018 Dec 14;8(1):279. doi: 10.1038/s41398-018-0309-1.


Considerations for Assessing the Extent of Hippocampal Neurogenesis in the Adult and Aging Human Brain.

Tartt AN, Fulmore CA, Liu Y, Rosoklija GB, Dwork AJ, Arango V, Hen R, Mann JJ, Boldrini M.

Cell Stem Cell. 2018 Dec 6;23(6):782-783. doi: 10.1016/j.stem.2018.10.025. No abstract available.


Blood Vessels and Perivascular Phagocytes of Prefrontal White and Gray Matter in Suicide.

Schnieder TP, Zhou Qin ID, Trencevska-Ivanovska I, Rosoklija G, Stankov A, Pavlovski G, Mann JJ, Dwork AJ.

J Neuropathol Exp Neurol. 2019 Jan 1;78(1):15-30. doi: 10.1093/jnen/nly103.


Targeting Kruppel-like Factor 9 in Excitatory Neurons Protects against Chronic Stress-Induced Impairments in Dendritic Spines and Fear Responses.

Besnard A, Langberg T, Levinson S, Chu D, Vicidomini C, Scobie KN, Dwork AJ, Arango V, Rosoklija GB, Mann JJ, Hen R, Leonardo ED, Boldrini M, Sahay A.

Cell Rep. 2018 Jun 12;23(11):3183-3196. doi: 10.1016/j.celrep.2018.05.040.


Human Hippocampal Neurogenesis Persists throughout Aging.

Boldrini M, Fulmore CA, Tartt AN, Simeon LR, Pavlova I, Poposka V, Rosoklija GB, Stankov A, Arango V, Dwork AJ, Hen R, Mann JJ.

Cell Stem Cell. 2018 Apr 5;22(4):589-599.e5. doi: 10.1016/j.stem.2018.03.015.


Association of BDNF Val66Met Polymorphism and Brain BDNF Levels with Major Depression and Suicide.

Youssef MM, Underwood MD, Huang YY, Hsiung SC, Liu Y, Simpson NR, Bakalian MJ, Rosoklija GB, Dwork AJ, Arango V, Mann JJ.

Int J Neuropsychopharmacol. 2018 Jun 1;21(6):528-538. doi: 10.1093/ijnp/pyy008.


In utero exposure to maternal smoking is associated with DNA methylation alterations and reduced neuronal content in the developing fetal brain.

Chatterton Z, Hartley BJ, Seok MH, Mendelev N, Chen S, Milekic M, Rosoklija G, Stankov A, Trencevsja-Ivanovska I, Brennand K, Ge Y, Dwork AJ, Haghighi F.

Epigenetics Chromatin. 2017 Jan 26;10:4. doi: 10.1186/s13072-017-0111-y. eCollection 2017.


Metalloproteinases and Brain Arterial Remodeling Among Individuals With and Those Without HIV Infection.

Gutierrez J, Menshawy K, Goldman J, Dwork AJ, Elkind MS, Marshall RS, Morgello S.

J Infect Dis. 2016 Nov 1;214(9):1329-1335. Epub 2016 Aug 22.


Whole-transcriptome brain expression and exon-usage profiling in major depression and suicide: evidence for altered glial, endothelial and ATPase activity.

Pantazatos SP, Huang YY, Rosoklija GB, Dwork AJ, Arango V, Mann JJ.

Mol Psychiatry. 2017 May;22(5):760-773. doi: 10.1038/mp.2016.130. Epub 2016 Aug 16.



Yin H, Galfalvy H, Pantazatos SP, Huang YY, Rosoklija GB, Dwork AJ, Burke A, Arango V, Oquendo MA, Mann JJ.

Depress Anxiety. 2016 Jun;33(6):531-540. doi: 10.1002/da.22499. Epub 2016 Mar 31.


Brain arterial aging and its relationship to Alzheimer dementia.

Gutierrez J, Honig L, Elkind MS, Mohr JP, Goldman J, Dwork AJ, Morgello S, Marshall RS.

Neurology. 2016 Apr 19;86(16):1507-15. doi: 10.1212/WNL.0000000000002590. Epub 2016 Mar 16.


Quantitative mass spectrometry reveals changes in SNAP-25 isoforms in schizophrenia.

Barakauskas VE, Moradian A, Barr AM, Beasley CL, Rosoklija G, Mann JJ, Ilievski B, Stankov A, Dwork AJ, Falkai P, Morin GB, Honer WG.

Schizophr Res. 2016 Nov;177(1-3):44-51. doi: 10.1016/j.schres.2016.03.002. Epub 2016 Mar 9.


Cigarette Smoking and Tryptophan Hydroxylase 2 mRNA in the Dorsal Raphe Nucleus in Suicides.

Bach H, Arango V, Kassir SA, Dwork AJ, Mann JJ, Underwood MD.

Arch Suicide Res. 2016 Jul 2;20(3):451-62. doi: 10.1080/13811118.2015.1048398. Epub 2016 Mar 8.


Proteomics Research in Schizophrenia.

Davalieva K, Maleva Kostovska I, Dwork AJ.

Front Cell Neurosci. 2016 Feb 16;10:18. doi: 10.3389/fncel.2016.00018. eCollection 2016. Review.


A pilot integrative genomics study of GABA and glutamate neurotransmitter systems in suicide, suicidal behavior, and major depressive disorder.

Yin H, Pantazatos SP, Galfalvy H, Huang YY, Rosoklija GB, Dwork AJ, Burke A, Arango V, Oquendo MA, Mann JJ.

Am J Med Genet B Neuropsychiatr Genet. 2016 Apr;171B(3):414-426. doi: 10.1002/ajmg.b.32423. Epub 2016 Feb 19.


Reduced GABA neuron density in auditory cerebral cortex of subjects with major depressive disorder.

Smiley JF, Hackett TA, Bleiwas C, Petkova E, Stankov A, Mann JJ, Rosoklija G, Dwork AJ.

J Chem Neuroanat. 2016 Oct;76(Pt B):108-121. doi: 10.1016/j.jchemneu.2015.10.008. Epub 2015 Dec 12.


Substantial DNA methylation differences between two major neuronal subtypes in human brain.

Kozlenkov A, Wang M, Roussos P, Rudchenko S, Barbu M, Bibikova M, Klotzle B, Dwork AJ, Zhang B, Hurd YL, Koonin EV, Wegner M, Dracheva S.

Nucleic Acids Res. 2016 Apr 7;44(6):2593-612. doi: 10.1093/nar/gkv1304. Epub 2015 Nov 26.


Brain arterial remodeling contribution to nonembolic brain infarcts in patients with HIV.

Gutierrez J, Goldman J, Dwork AJ, Elkind MS, Marshall RS, Morgello S.

Neurology. 2015 Sep 29;85(13):1139-45. doi: 10.1212/WNL.0000000000001976. Epub 2015 Aug 28.


Increased SNARE Protein-Protein Interactions in Orbitofrontal and Anterior Cingulate Cortices in Schizophrenia.

Ramos-Miguel A, Beasley CL, Dwork AJ, Mann JJ, Rosoklija G, Barr AM, Honer WG.

Biol Psychiatry. 2015 Sep 15;78(6):361-73. doi: 10.1016/j.biopsych.2014.12.012. Epub 2014 Dec 19.


Elevated cerebrospinal fluid 5-hydroxyindoleacetic acid in macaques following early life stress and inverse association with hippocampal volume: preliminary implications for serotonin-related function in mood and anxiety disorders.

Coplan JD, Fulton SL, Reiner W, Jackowski A, Panthangi V, Perera TD, Gorman JM, Huang YY, Tang CY, Hof PR, Kaffman A, Dwork AJ, Mathew SJ, Kaufman J, Mann JJ.

Front Behav Neurosci. 2014 Dec 23;8:440. doi: 10.3389/fnbeh.2014.00440. eCollection 2014.


Glucagon-like peptide-1 as predictor of body mass index and dentate gyrus neurogenesis: neuroplasticity and the metabolic milieu.

Coplan JD, Syed S, Perera TD, Fulton SL, Banerji MA, Dwork AJ, Kral JG.

Neural Plast. 2014;2014:917981. doi: 10.1155/2014/917981. Epub 2014 Nov 23.


Increased DNA methylation in the suicide brain.

Haghighi F, Xin Y, Chanrion B, O'Donnell AH, Ge Y, Dwork AJ, Arango V, Mann JJ.

Dialogues Clin Neurosci. 2014 Sep;16(3):430-8.


Early life stress and macaque amygdala hypertrophy: preliminary evidence for a role for the serotonin transporter gene.

Coplan JD, Fathy HM, Jackowski AP, Tang CY, Perera TD, Mathew SJ, Martinez J, Abdallah CG, Dwork AJ, Pantol G, Carpenter D, Gorman JM, Nemeroff CB, Owens MJ, Kaffman A, Kaufman J.

Front Behav Neurosci. 2014 Oct 6;8:342. doi: 10.3389/fnbeh.2014.00342. eCollection 2014.


Postnatal day 2 to 11 constitutes a 5-HT-sensitive period impacting adult mPFC function.

Rebello TJ, Yu Q, Goodfellow NM, Caffrey Cagliostro MK, Teissier A, Morelli E, Demireva EY, Chemiakine A, Rosoklija GB, Dwork AJ, Lambe EK, Gingrich JA, Ansorge MS.

J Neurosci. 2014 Sep 10;34(37):12379-93. doi: 10.1523/JNEUROSCI.1020-13.2014.


Loss of mTOR-dependent macroautophagy causes autistic-like synaptic pruning deficits.

Tang G, Gudsnuk K, Kuo SH, Cotrina ML, Rosoklija G, Sosunov A, Sonders MS, Kanter E, Castagna C, Yamamoto A, Yue Z, Arancio O, Peterson BS, Champagne F, Dwork AJ, Goldman J, Sulzer D.

Neuron. 2014 Sep 3;83(5):1131-43. doi: 10.1016/j.neuron.2014.07.040. Epub 2014 Aug 21. Erratum in: Neuron. 2014 Sep 17;83(6):1482.


Microglia of prefrontal white matter in suicide.

Schnieder TP, Trencevska I, Rosoklija G, Stankov A, Mann JJ, Smiley J, Dwork AJ.

J Neuropathol Exp Neurol. 2014 Sep;73(9):880-90. doi: 10.1097/NEN.0000000000000107.


Benzodiazepines and the potential trophic effect of antidepressants on dentate gyrus cells in mood disorders.

Boldrini M, Butt TH, Santiago AN, Tamir H, Dwork AJ, Rosoklija GB, Arango V, Hen R, Mann JJ.

Int J Neuropsychopharmacol. 2014 Dec;17(12):1923-33. doi: 10.1017/S1461145714000844. Epub 2014 Jun 27.


Alcoholics have more tryptophan hydroxylase 2 mRNA and protein in the dorsal and median raphe nuclei.

Bach H, Arango V, Kassir SA, Tsaava T, Dwork AJ, Mann JJ, Underwood MD.

Alcohol Clin Exp Res. 2014 Jul;38(7):1894-901. doi: 10.1111/acer.12414. Epub 2014 Jun 18.


Reliable and durable Golgi staining of brain tissue from human autopsies and experimental animals.

Rosoklija GB, Petrushevski VM, Stankov A, Dika A, Jakovski Z, Pavlovski G, Davcheva N, Lipkin R, Schnieder T, Scobie K, Duma A, Dwork AJ.

J Neurosci Methods. 2014 Jun 15;230:20-9. doi: 10.1016/j.jneumeth.2014.04.006. Epub 2014 Apr 18.


A quantitative perspective to the study of brain arterial remodeling of donors with and without HIV in the Brain Arterial Remodeling Study (BARS).

Gutierrez J, Rosoklija G, Murray J, Chon C, Elkind MS, Goldman J, Honig LS, Dwork AJ, Morgello S, Marshall RS.

Front Physiol. 2014 Feb 19;5:56. doi: 10.3389/fphys.2014.00056. eCollection 2014.


Increased stability of microtubules in cultured olfactory neuroepithelial cells from individuals with schizophrenia.

Brown AS, Borgmann-Winter K, Hahn CG, Role L, Talmage D, Gur R, Chow J, Prado P, McCloskey T, Bao Y, Bulinski JC, Dwork AJ.

Prog Neuropsychopharmacol Biol Psychiatry. 2014 Jan 3;48:252-258. doi: 10.1016/j.pnpbp.2013.10.015. Epub 2013 Oct 24.


Hemispheric asymmetry of primary auditory cortex and Heschl's gyrus in schizophrenia and nonpsychiatric brains.

Smiley JF, Hackett TA, Preuss TM, Bleiwas C, Figarsky K, Mann JJ, Rosoklija G, Javitt DC, Dwork AJ.

Psychiatry Res. 2013 Dec 30;214(3):435-43. doi: 10.1016/j.pscychresns.2013.08.009. Epub 2013 Oct 19.


Psychiatric brain collection in Macedonia: general lessons for scientific collaboration among countries of differing wealth.

Rosoklija G, Duma A, Dwork AJ.

Pril (Makedon Akad Nauk Umet Odd Med Nauki). 2013;34(1):95-8.


Global epigenomic reconfiguration during mammalian brain development.

Lister R, Mukamel EA, Nery JR, Urich M, Puddifoot CA, Johnson ND, Lucero J, Huang Y, Dwork AJ, Schultz MD, Yu M, Tonti-Filippini J, Heyn H, Hu S, Wu JC, Rao A, Esteller M, He C, Haghighi FG, Sejnowski TJ, Behrens MM, Ecker JR.

Science. 2013 Aug 9;341(6146):1237905. doi: 10.1126/science.1237905. Epub 2013 Jul 4.


Elevated serotonin and 5-HIAA in the brainstem and lower serotonin turnover in the prefrontal cortex of suicides.

Bach H, Huang YY, Underwood MD, Dwork AJ, Mann JJ, Arango V.

Synapse. 2014 Mar;68(3):127-30. doi: 10.1002/syn.21695. Epub 2013 Jul 23.


Role of hippocampal neurogenesis in mnemonic segregation: implications for human mood disorders.

Perera TD, Thirumangalakudi L, Glennon E, Park S, Insanally M, Persky M, Fonseka J, Dwork AJ, Sackeim HA, Coplan JD, Fenton AA.

World J Biol Psychiatry. 2013 Dec;14(8):602-10. doi: 10.3109/15622975.2013.768356. Epub 2013 Feb 11.


Hippocampal granule neuron number and dentate gyrus volume in antidepressant-treated and untreated major depression.

Boldrini M, Santiago AN, Hen R, Dwork AJ, Rosoklija GB, Tamir H, Arango V, John Mann J.

Neuropsychopharmacology. 2013 May;38(6):1068-77. doi: 10.1038/npp.2013.5. Epub 2013 Jan 7.


A large-scale candidate gene analysis of mood disorders: evidence of neurotrophic tyrosine kinase receptor and opioid receptor signaling dysfunction.

Deo AJ, Huang YY, Hodgkinson CA, Xin Y, Oquendo MA, Dwork AJ, Arango V, Brent DA, Goldman D, Mann JJ, Haghighi F.

Psychiatr Genet. 2013 Apr;23(2):47-55. doi: 10.1097/YPG.0b013e32835d7028.


The contribution of HIV infection to intracranial arterial remodeling: a pilot study.

Gutierrez J, Elkind MS, Petito C, Chung DY, Dwork AJ, Marshall RS.

Neuropathology. 2013 Jun;33(3):256-63. doi: 10.1111/j.1440-1789.2012.01358.x. Epub 2012 Oct 15.


Air gun injury with deadly aftermath--case report.

Stankov A, Jakovski Z, Pavlovski G, Muric N, Dwork AJ, Cakar Z.

Leg Med (Tokyo). 2013 Jan;15(1):35-7. doi: 10.1016/j.legalmed.2012.08.004. Epub 2012 Sep 25.


Hippocampal angiogenesis and progenitor cell proliferation are increased with antidepressant use in major depression.

Boldrini M, Hen R, Underwood MD, Rosoklija GB, Dwork AJ, Mann JJ, Arango V.

Biol Psychiatry. 2012 Oct 1;72(7):562-71. doi: 10.1016/j.biopsych.2012.04.024. Epub 2012 May 30.


Serotonin 2c receptor RNA editing in major depression and suicide.

Lyddon R, Dwork AJ, Keddache M, Siever LJ, Dracheva S.

World J Biol Psychiatry. 2013 Dec;14(8):590-601. doi: 10.3109/15622975.2011.630406. Epub 2012 Mar 9.


A pilot genome wide association and gene expression array study of suicide with and without major depression.

Galfalvy H, Zalsman G, Huang YY, Murphy L, Rosoklija G, Dwork AJ, Haghighi F, Arango V, Mann JJ.

World J Biol Psychiatry. 2013 Dec;14(8):574-82. doi: 10.3109/15622975.2011.597875. Epub 2011 Nov 7.

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