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Items: 1 to 50 of 523

1.

Iminosugar antivirals: the therapeutic sweet spot.

Alonzi DS, Scott KA, Dwek RA, Zitzmann N.

Biochem Soc Trans. 2017 Apr 15;45(2):571-582. doi: 10.1042/BST20160182. Review.

2.

Minimal In Vivo Efficacy of Iminosugars in a Lethal Ebola Virus Guinea Pig Model.

Miller JL, Spiro SG, Dowall SD, Taylor I, Rule A, Alonzi DS, Sayce AC, Wright E, Bentley EM, Thom R, Hall G, Dwek RA, Hewson R, Zitzmann N.

PLoS One. 2016 Nov 23;11(11):e0167018. doi: 10.1371/journal.pone.0167018. eCollection 2016.

3.

Iminosugars Inhibit Dengue Virus Production via Inhibition of ER Alpha-Glucosidases--Not Glycolipid Processing Enzymes.

Sayce AC, Alonzi DS, Killingbeck SS, Tyrrell BE, Hill ML, Caputo AT, Iwaki R, Kinami K, Ide D, Kiappes JL, Beatty PR, Kato A, Harris E, Dwek RA, Miller JL, Zitzmann N.

PLoS Negl Trop Dis. 2016 Mar 14;10(3):e0004524. doi: 10.1371/journal.pntd.0004524. eCollection 2016 Mar.

4.

Inhibition of endoplasmic reticulum glucosidases is required for in vitro and in vivo dengue antiviral activity by the iminosugar UV-4.

Warfield KL, Plummer EM, Sayce AC, Alonzi DS, Tang W, Tyrrell BE, Hill ML, Caputo AT, Killingbeck SS, Beatty PR, Harris E, Iwaki R, Kinami K, Ide D, Kiappes JL, Kato A, Buck MD, King K, Eddy W, Khaliq M, Sampath A, Treston AM, Dwek RA, Enterlein SG, Miller JL, Zitzmann N, Ramstedt U, Shresta S.

Antiviral Res. 2016 May;129:93-98. doi: 10.1016/j.antiviral.2016.03.001. Epub 2016 Mar 3.

5.

Glycosphingolipid synthesis inhibition limits osteoclast activation and myeloma bone disease.

Ersek A, Xu K, Antonopoulos A, Butters TD, Santo AE, Vattakuzhi Y, Williams LM, Goudevenou K, Danks L, Freidin A, Spanoudakis E, Parry S, Papaioannou M, Hatjiharissi E, Chaidos A, Alonzi DS, Twigg G, Hu M, Dwek RA, Haslam SM, Roberts I, Dell A, Rahemtulla A, Horwood NJ, Karadimitris A.

J Clin Invest. 2015 Jun;125(6):2279-92. doi: 10.1172/JCI59987. Epub 2015 Apr 27.

6.

Soluble human TLR2 ectodomain binds diacylglycerol from microbial lipopeptides and glycolipids.

Jiménez-Dalmaroni MJ, Radcliffe CM, Harvey DJ, Wormald MR, Verdino P, Ainge GD, Larsen DS, Painter GF, Ulevitch R, Beutler B, Rudd PM, Dwek RA, Wilson IA.

Innate Immun. 2015 Feb;21(2):175-93. doi: 10.1177/1753425914524077. Epub 2014 Mar 3.

7.

Journeys in science: glycobiology and other paths.

Dwek RA.

Annu Rev Biochem. 2014;83:1-44. doi: 10.1146/annurev-biochem-041612-095236. Epub 2014 Jan 15.

PMID:
24437663
8.

Emerging principles for the therapeutic exploitation of glycosylation.

Dalziel M, Crispin M, Scanlan CN, Zitzmann N, Dwek RA.

Science. 2014 Jan 3;343(6166):1235681. doi: 10.1126/science.1235681. Review.

PMID:
24385630
9.

Directing stem cell differentiation with antibodies.

Dalziel M, Crispin M, Dwek RA.

Proc Natl Acad Sci U S A. 2013 Oct 29;110(44):17608-9. doi: 10.1073/pnas.1317614110. Epub 2013 Oct 18. No abstract available.

10.

Glycoprotein misfolding in the endoplasmic reticulum: identification of released oligosaccharides reveals a second ER-associated degradation pathway for Golgi-retrieved proteins.

Alonzi DS, Kukushkin NV, Allman SA, Hakki Z, Williams SJ, Pierce L, Dwek RA, Butters TD.

Cell Mol Life Sci. 2013 Aug;70(15):2799-814. doi: 10.1007/s00018-013-1304-6. Epub 2013 Mar 16.

PMID:
23503623
11.

An iminosugar with potent inhibition of dengue virus infection in vivo.

Perry ST, Buck MD, Plummer EM, Penmasta RA, Batra H, Stavale EJ, Warfield KL, Dwek RA, Butters TD, Alonzi DS, Lada SM, King K, Klose B, Ramstedt U, Shresta S.

Antiviral Res. 2013 Apr;98(1):35-43. doi: 10.1016/j.antiviral.2013.01.004. Epub 2013 Jan 31.

PMID:
23376501
12.

Liposome-mediated delivery of iminosugars enhances efficacy against dengue virus in vivo.

Miller JL, Lachica R, Sayce AC, Williams JP, Bapat M, Dwek R, Beatty PR, Harris E, Zitzmann N.

Antimicrob Agents Chemother. 2012 Dec;56(12):6379-86. doi: 10.1128/AAC.01554-12. Epub 2012 Oct 15.

13.

Discovery of novel biomarker candidates for liver fibrosis in hepatitis C patients: a preliminary study.

Gangadharan B, Bapat M, Rossa J, Antrobus R, Chittenden D, Kampa B, Barnes E, Klenerman P, Dwek RA, Zitzmann N.

PLoS One. 2012;7(6):e39603. doi: 10.1371/journal.pone.0039603. Epub 2012 Jun 26.

14.

Selective deactivation of serum IgG: a general strategy for the enhancement of monoclonal antibody receptor interactions.

Baruah K, Bowden TA, Krishna BA, Dwek RA, Crispin M, Scanlan CN.

J Mol Biol. 2012 Jun 29;420(1-2):1-7. doi: 10.1016/j.jmb.2012.04.002. Epub 2012 Apr 5.

15.

Cholesterol depletion of hepatoma cells impairs hepatitis B virus envelopment by altering the topology of the large envelope protein.

Dorobantu C, Macovei A, Lazar C, Dwek RA, Zitzmann N, Branza-Nichita N.

J Virol. 2011 Dec;85(24):13373-83. doi: 10.1128/JVI.05423-11. Epub 2011 Oct 12.

16.

The glycan shield of HIV is predominantly oligomannose independently of production system or viral clade.

Bonomelli C, Doores KJ, Dunlop DC, Thaney V, Dwek RA, Burton DR, Crispin M, Scanlan CN.

PLoS One. 2011;6(8):e23521. doi: 10.1371/journal.pone.0023521. Epub 2011 Aug 16.

17.

The influence of different lipid environments on the structure and function of the hepatitis C virus p7 ion channel protein.

Whitfield T, Miles AJ, Scheinost JC, Offer J, Wentworth P Jr, Dwek RA, Wallace BA, Biggin PC, Zitzmann N.

Mol Membr Biol. 2011 Aug;28(5):254-64. doi: 10.3109/09687688.2011.581253. Epub 2011 May 23.

PMID:
21604991
18.

Demonstration that endoplasmic reticulum-associated degradation of glycoproteins can occur downstream of processing by endomannosidase.

Kukushkin NV, Alonzi DS, Dwek RA, Butters TD.

Biochem J. 2011 Aug 15;438(1):133-42. doi: 10.1042/BJ20110186.

PMID:
21585340
19.

New approaches for biomarker discovery: the search for liver fibrosis markers in hepatitis C patients.

Gangadharan B, Antrobus R, Chittenden D, Rossa J, Bapat M, Klenerman P, Barnes E, Dwek RA, Zitzmann N.

J Proteome Res. 2011 May 6;10(5):2643-50. doi: 10.1021/pr101077c. Epub 2011 Mar 30.

20.

EUROCarbDB: An open-access platform for glycoinformatics.

von der Lieth CW, Freire AA, Blank D, Campbell MP, Ceroni A, Damerell DR, Dell A, Dwek RA, Ernst B, Fogh R, Frank M, Geyer H, Geyer R, Harrison MJ, Henrick K, Herget S, Hull WE, Ionides J, Joshi HJ, Kamerling JP, Leeflang BR, Lütteke T, Lundborg M, Maass K, Merry A, Ranzinger R, Rosen J, Royle L, Rudd PM, Schloissnig S, Stenutz R, Vranken WF, Widmalm G, Haslam SM.

Glycobiology. 2011 Apr;21(4):493-502. doi: 10.1093/glycob/cwq188. Epub 2010 Nov 23.

21.

Polyunsaturated liposomes are antiviral against hepatitis B and C viruses and HIV by decreasing cholesterol levels in infected cells.

Pollock S, Nichita NB, Böhmer A, Radulescu C, Dwek RA, Zitzmann N.

Proc Natl Acad Sci U S A. 2010 Oct 5;107(40):17176-81. doi: 10.1073/pnas.1009445107. Epub 2010 Sep 20.

22.

Envelope glycans of immunodeficiency virions are almost entirely oligomannose antigens.

Doores KJ, Bonomelli C, Harvey DJ, Vasiljevic S, Dwek RA, Burton DR, Crispin M, Scanlan CN.

Proc Natl Acad Sci U S A. 2010 Aug 3;107(31):13800-5. doi: 10.1073/pnas.1006498107. Epub 2010 Jul 19.

23.

The N-glycosylation of classical swine fever virus E2 glycoprotein extracellular domain expressed in the milk of goat.

Montesino R, Gil J, González LJ, Zamora Y, Royle L, Rudd PM, Dwek RA, Harvey DJ, Cremata JA.

Arch Biochem Biophys. 2010 Aug 15;500(2):169-80. doi: 10.1016/j.abb.2010.05.006. Epub 2010 May 10.

PMID:
20460099
24.

Fragmentation of negative ions from N-linked carbohydrates, part 4. Fragmentation of complex glycans lacking substitution on the 6-antenna.

Harvey DJ, Jaeken J, Butler M, Armitage AJ, Rudd PM, Dwek RA.

J Mass Spectrom. 2010 May;45(5):528-35. doi: 10.1002/jms.1736.

PMID:
20446311
25.

Lysosomal storage of oligosaccharide and glycosphingolipid in imino sugar treated cells.

Boomkamp SD, Rountree JS, Neville DC, Dwek RA, Fleet GW, Butters TD.

Glycoconj J. 2010 Apr;27(3):297-308. doi: 10.1007/s10719-010-9278-1. Epub 2010 Feb 26.

PMID:
20186478
26.

Polysaccharide mimicry of the epitope of the broadly neutralizing anti-HIV antibody, 2G12, induces enhanced antibody responses to self oligomannose glycans.

Dunlop DC, Bonomelli C, Mansab F, Vasiljevic S, Doores KJ, Wormald MR, Palma AS, Feizi T, Harvey DJ, Dwek RA, Crispin M, Scanlan CN.

Glycobiology. 2010 Jul;20(7):812-23. doi: 10.1093/glycob/cwq020. Epub 2010 Feb 24.

27.

Activation state and intracellular trafficking contribute to the repertoire of endogenous glycosphingolipids presented by CD1d [corrected].

Muindi K, Cernadas M, Watts GF, Royle L, Neville DC, Dwek RA, Besra GS, Rudd PM, Butters TD, Brenner MB.

Proc Natl Acad Sci U S A. 2010 Feb 16;107(7):3052-7. doi: 10.1073/pnas.0915056107. Epub 2010 Jan 28. Erratum in: Proc Natl Acad Sci U S A. 2010 Mar 30;107(13):6118.

28.

Identification of N-glycans from Ebola virus glycoproteins by matrix-assisted laser desorption/ionisation time-of-flight and negative ion electrospray tandem mass spectrometry.

Ritchie G, Harvey DJ, Stroeher U, Feldmann F, Feldmann H, Wahl-Jensen V, Royle L, Dwek RA, Rudd PM.

Rapid Commun Mass Spectrom. 2010 Mar 15;24(5):571-85. doi: 10.1002/rcm.4410.

29.

Identification of N-linked carbohydrates from severe acute respiratory syndrome (SARS) spike glycoprotein.

Ritchie G, Harvey DJ, Feldmann F, Stroeher U, Feldmann H, Royle L, Dwek RA, Rudd PM.

Virology. 2010 Apr 10;399(2):257-69. doi: 10.1016/j.virol.2009.12.020. Epub 2010 Feb 2.

30.

Chemical and enzymatic N-glycan release comparison for N-glycan profiling of monoclonal antibodies expressed in plants.

Triguero A, Cabrera G, Royle L, Harvey DJ, Rudd PM, Dwek RA, Bardor M, Lerouge P, Cremata JA.

Anal Biochem. 2010 May 15;400(2):173-83. doi: 10.1016/j.ab.2010.01.027. Epub 2010 Jan 28.

PMID:
20109437
31.

Uptake and trafficking of liposomes to the endoplasmic reticulum.

Pollock S, Antrobus R, Newton L, Kampa B, Rossa J, Latham S, Nichita NB, Dwek RA, Zitzmann N.

FASEB J. 2010 Jun;24(6):1866-78. doi: 10.1096/fj.09-145755. Epub 2010 Jan 22.

PMID:
20097877
32.

Soluble CD36 ectodomain binds negatively charged diacylglycerol ligands and acts as a co-receptor for TLR2.

Jimenez-Dalmaroni MJ, Xiao N, Corper AL, Verdino P, Ainge GD, Larsen DS, Painter GF, Rudd PM, Dwek RA, Hoebe K, Beutler B, Wilson IA.

PLoS One. 2009 Oct 22;4(10):e7411. doi: 10.1371/journal.pone.0007411.

33.

Hepatitis B virus requires intact caveolin-1 function for productive infection in HepaRG cells.

Macovei A, Radulescu C, Lazar C, Petrescu S, Durantel D, Dwek RA, Zitzmann N, Nichita NB.

J Virol. 2010 Jan;84(1):243-53. doi: 10.1128/JVI.01207-09.

34.

Proposal for a standard system for drawing structural diagrams of N- and O-linked carbohydrates and related compounds.

Harvey DJ, Merry AH, Royle L, Campbell MP, Dwek RA, Rudd PM.

Proteomics. 2009 Aug;9(15):3796-801. doi: 10.1002/pmic.200900096. Erratum in: Proteomics. 2009 Nov;9(21):5002.

PMID:
19670245
35.

The 3-dimensional structure of a hepatitis C virus p7 ion channel by electron microscopy.

Luik P, Chew C, Aittoniemi J, Chang J, Wentworth P Jr, Dwek RA, Biggin PC, Vénien-Bryan C, Zitzmann N.

Proc Natl Acad Sci U S A. 2009 Aug 4;106(31):12712-6. doi: 10.1073/pnas.0905966106. Epub 2009 Jul 9.

36.

A human embryonic kidney 293T cell line mutated at the Golgi alpha-mannosidase II locus.

Crispin M, Chang VT, Harvey DJ, Dwek RA, Evans EJ, Stuart DI, Jones EY, Lord JM, Spooner RA, Davis SJ.

J Biol Chem. 2009 Aug 7;284(32):21684-95. doi: 10.1074/jbc.M109.006254. Epub 2009 May 22.

37.

Detailed N-glycan analysis of mannose receptor purified from murine spleen indicates tissue specific sialylation.

Su Y, Royle L, Radcliffe CM, Harvey DJ, Dwek RA, Martinez-Pomares L, Rudd PM.

Biochem Biophys Res Commun. 2009 Jul 10;384(4):436-43. doi: 10.1016/j.bbrc.2009.04.159. Epub 2009 May 8.

PMID:
19427834
38.

The conformational properties of the Glc3Man unit suggest conformational biasing within the chaperone-assisted glycoprotein folding pathway.

Mackeen MM, Almond A, Deschamps M, Cumpstey I, Fairbanks AJ, Tsang C, Rudd PM, Butters TD, Dwek RA, Wormald MR.

J Mol Biol. 2009 Mar 27;387(2):335-47. doi: 10.1016/j.jmb.2009.01.043. Epub 2009 Jan 29.

PMID:
19356590
39.

Synthesis and biological characterisation of novel N-alkyl-deoxynojirimycin alpha-glucosidase inhibitors.

Rawlings AJ, Lomas H, Pilling AW, Lee MJ, Alonzi DS, Rountree JS, Jenkinson SF, Fleet GW, Dwek RA, Jones JH, Butters TD.

Chembiochem. 2009 Apr 17;10(6):1101-5. doi: 10.1002/cbic.200900025.

PMID:
19294724
40.

Antibodies and antigens: it's all about the numbers game.

Dwek R.

Proc Natl Acad Sci U S A. 2009 Feb 17;106(7):2087-8. doi: 10.1073/pnas.0900276106. Epub 2009 Feb 11. No abstract available.

41.

Identification of high-mannose and multiantennary complex-type N-linked glycans containing alpha-galactose epitopes from Nurse shark IgM heavy chain.

Harvey DJ, Crispin M, Moffatt BE, Smith SL, Sim RB, Rudd PM, Dwek RA.

Glycoconj J. 2009 Nov;26(8):1055-64. doi: 10.1007/s10719-008-9226-5.

PMID:
19156518
42.

Design, synthesis, and biological evaluation of enantiomeric beta-N-acetylhexosaminidase inhibitors LABNAc and DABNAc as potential agents against Tay-Sachs and Sandhoff disease.

Rountree JS, Butters TD, Wormald MR, Boomkamp SD, Dwek RA, Asano N, Ikeda K, Evinson EL, Nash RJ, Fleet GW.

ChemMedChem. 2009 Mar;4(3):378-92. doi: 10.1002/cmdc.200800350.

PMID:
19145603
43.

Glycosylation changes on serum glycoproteins in ovarian cancer may contribute to disease pathogenesis.

Saldova R, Wormald MR, Dwek RA, Rudd PM.

Dis Markers. 2008;25(4-5):219-32. Review.

44.

Development of a single column method for the separation of lipid- and protein-derived oligosaccharides.

Neville DC, Dwek RA, Butters TD.

J Proteome Res. 2009 Feb;8(2):681-7. doi: 10.1021/pr800704t.

PMID:
19099509
45.

N-glycosylation pattern of E2 glycoprotein from classical swine fever virus.

Montesino R, Toledo JR, Sanchez O, Zamora Y, Barrera M, Royle L, Rudd PM, Dwek RA, Harvey DJ, Cremata JA.

J Proteome Res. 2009 Feb;8(2):546-55. doi: 10.1021/pr800725v.

PMID:
19093875
46.

Proteomic analysis of HepaRG cells: a novel cell line that supports hepatitis B virus infection.

Narayan R, Gangadharan B, Hantz O, Antrobus R, García A, Dwek RA, Zitzmann N.

J Proteome Res. 2009 Jan;8(1):118-22. doi: 10.1021/pr800562j.

PMID:
19053806
47.

Antigenic mimicry of the HIV envelope by AIDS-associated pathogens.

Dunlop DC, Ulrich A, Appelmelk BJ, Burton DR, Dwek RA, Zitzmann N, Scanlan CN.

AIDS. 2008 Oct 18;22(16):2214-7. doi: 10.1097/QAD.0b013e328314b5df.

PMID:
18832887
48.

A strategy to reveal potential glycan markers from serum glycoproteins associated with breast cancer progression.

Abd Hamid UM, Royle L, Saldova R, Radcliffe CM, Harvey DJ, Storr SJ, Pardo M, Antrobus R, Chapman CJ, Zitzmann N, Robertson JF, Dwek RA, Rudd PM.

Glycobiology. 2008 Dec;18(12):1105-18. doi: 10.1093/glycob/cwn095. Epub 2008 Sep 25.

PMID:
18818422
49.

N-Butyldeoxynojirimycin is a broadly effective anti-HIV therapy significantly enhanced by targeted liposome delivery.

Pollock S, Dwek RA, Burton DR, Zitzmann N.

AIDS. 2008 Oct 1;22(15):1961-9. doi: 10.1097/QAD.0b013e32830efd96.

PMID:
18753929
50.

Structural characterization of the 1918 influenza virus H1N1 neuraminidase.

Xu X, Zhu X, Dwek RA, Stevens J, Wilson IA.

J Virol. 2008 Nov;82(21):10493-501. doi: 10.1128/JVI.00959-08. Epub 2008 Aug 20.

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