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Items: 34


Protein Misfolding and Endoplasmic Reticulum Stress in Chronic Lung Disease: Will Cell-Specific Targeting Be the Key to the Cure?

Naiel S, Tat V, Padwal M, Vierhout M, Mekhael O, Yousof T, Ayoub A, Abed S, Dvorkin-Gheva A, Ask K.

Chest. 2019 Nov 26. pii: S0012-3692(19)34282-5. doi: 10.1016/j.chest.2019.11.009. [Epub ahead of print] Review.


Monoamine oxidase-A activity is required for clonal tumorsphere formation by human breast tumor cells.

Gwynne WD, Shakeel MS, Wu J, Hallett RM, Girgis-Gabardo A, Dvorkin-Gheva A, Hassell JA.

Cell Mol Biol Lett. 2019 Nov 12;24:59. doi: 10.1186/s11658-019-0183-8. eCollection 2019.


Transcriptomic and functional analyses of 3D placental extravillous trophoblast spheroids.

Wong MK, Wahed M, Shawky SA, Dvorkin-Gheva A, Raha S.

Sci Rep. 2019 Aug 30;9(1):12607. doi: 10.1038/s41598-019-48816-8.


Bmi1 regulates human glioblastoma stem cells through activation of differential gene networks in CD133+ brain tumor initiating cells.

Vora P, Seyfrid M, Venugopal C, Qazi MA, Salim S, Isserlin R, Subapanditha M, O'Farrell E, Mahendram S, Singh M, Bakhshinyan D, Chokshi C, McFarlane N, Dvorkin-Gheva A, Brown KR, Murty N, Moffat J, Bader GD, Singh SK.

J Neurooncol. 2019 Jul;143(3):417-428. doi: 10.1007/s11060-019-03192-1. Epub 2019 May 21.


Intraductal Adaptation of the 4T1 Mouse Model of Breast Cancer Reveals Effects of the Epithelial Microenvironment on Tumor Progression and Metastasis.

Atiya HI, Dvorkin-Gheva A, Hassell J, Patel S, Parker RL, Hartstone-Rose A, Hodge J, Fan D, Ramsdell AF.

Anticancer Res. 2019 May;39(5):2277-2287. doi: 10.21873/anticanres.13344.


Prostaglandin E2 inhibits profibrotic function of human pulmonary fibroblasts by disrupting Ca2+ signaling.

Mukherjee S, Sheng W, Michkov A, Sriarm K, Sun R, Dvorkin-Gheva A, Insel PA, Janssen LJ.

Am J Physiol Lung Cell Mol Physiol. 2019 May 1;316(5):L810-L821. doi: 10.1152/ajplung.00403.2018. Epub 2019 Feb 13.


The impact of cigarette smoke exposure, COPD, or asthma status on ABC transporter gene expression in human airway epithelial cells.

Aguiar JA, Tamminga A, Lobb B, Huff RD, Nguyen JP, Kim Y, Dvorkin-Gheva A, Stampfli MR, Doxey AC, Hirota JA.

Sci Rep. 2019 Jan 17;9(1):153. doi: 10.1038/s41598-018-36248-9.


Induction of Autonomous Memory Alveolar Macrophages Requires T Cell Help and Is Critical to Trained Immunity.

Yao Y, Jeyanathan M, Haddadi S, Barra NG, Vaseghi-Shanjani M, Damjanovic D, Lai R, Afkhami S, Chen Y, Dvorkin-Gheva A, Robbins CS, Schertzer JD, Xing Z.

Cell. 2018 Nov 29;175(6):1634-1650.e17. doi: 10.1016/j.cell.2018.09.042. Epub 2018 Oct 25.


IL-6 mediates ER expansion during hyperpolarization of alternatively activated macrophages.

Ayaub EA, Tandon K, Padwal M, Imani J, Patel H, Dubey A, Mekhael O, Upagupta C, Ayoub A, Dvorkin-Gheva A, Murphy J, Kolb PS, Lhotak S, Dickhout JG, Austin RC, Kolb MRJ, Richards CD, Ask K.

Immunol Cell Biol. 2019 Feb;97(2):203-217. doi: 10.1111/imcb.12212. Epub 2018 Nov 14.


Sputum Antineutrophil Cytoplasmic Antibodies in Serum Antineutrophil Cytoplasmic Antibody-Negative Eosinophilic Granulomatosis with Polyangiitis.

Mukherjee M, Thomas SR, Radford K, Dvorkin-Gheva A, Davydchenko S, Kjarsgaard M, Svenningsen S, Almas S, Felix LC, Stearns J, Li QZ, Khalidi N, Lacy P, Nair PK.

Am J Respir Crit Care Med. 2019 Jan 15;199(2):158-170. doi: 10.1164/rccm.201804-0809OC.


The Overlap of Lung Tissue Transcriptome of Smoke Exposed Mice with Human Smoking and COPD.

Obeidat M, Dvorkin-Gheva A, Li X, Bossé Y, Brandsma CA, Nickle DC, Hansbro PM, Faner R, Agusti A, Paré PD, Stampfli MR, Sin DD.

Sci Rep. 2018 Aug 8;8(1):11881. doi: 10.1038/s41598-018-30313-z.


Transforming the prostatic tumor microenvironment with oncolytic virotherapy.

Atherton MJ, Stephenson KB, Tzelepis F, Bakhshinyan D, Nikota JK, Son HH, Jirovec A, Lefebvre C, Dvorkin-Gheva A, Ashkar AA, Wan Y, Stojdl DF, Belanger EC, Breau RH, Bell JC, Saad F, Singh SK, Diallo JS, Lichty BD.

Oncoimmunology. 2018 Mar 27;7(7):e1445459. doi: 10.1080/2162402X.2018.1445459. eCollection 2018.


Identification of Drug Candidates to Suppress Cigarette Smoke-induced Inflammation via Connectivity Map Analyses.

Vanderstocken G, Dvorkin-Gheva A, Shen P, Brandsma CA, Obeidat M, Bossé Y, Hassell JA, Stampfli MR.

Am J Respir Cell Mol Biol. 2018 Jun;58(6):727-735. doi: 10.1165/rcmb.2017-0202OC.


Changes in gut microbiota during development of compulsive checking and locomotor sensitization induced by chronic treatment with the dopamine agonist quinpirole.

Jung TD, Jung PS, Raveendran L, Farbod Y, Dvorkin-Gheva A, Sakic B, Surette MG, Szechtman H.

Behav Pharmacol. 2018 Apr;29(2 and 3-Spec Issue):211-224. doi: 10.1097/FBP.0000000000000363.


Customized Viral Immunotherapy for HPV-Associated Cancer.

Atherton MJ, Stephenson KB, Pol J, Wang F, Lefebvre C, Stojdl DF, Nikota JK, Dvorkin-Gheva A, Nguyen A, Chen L, Johnson-Obaseki S, Villeneuve PJ, Diallo JS, Dimitroulakos J, Wan Y, Lichty BD.

Cancer Immunol Res. 2017 Oct;5(10):847-859. doi: 10.1158/2326-6066.CIR-17-0102. Epub 2017 Sep 14.


The POZ-ZF transcription factor Znf131 is implicated as a regulator of Kaiso-mediated biological processes.

Robinson SC, Donaldson-Kabwe NS, Dvorkin-Gheva A, Longo J, He L, Daniel JM.

Biochem Biophys Res Commun. 2017 Nov 4;493(1):416-421. doi: 10.1016/j.bbrc.2017.09.007. Epub 2017 Sep 4.


A Single TCF Transcription Factor, Regardless of Its Activation Capacity, Is Sufficient for Effective Trilineage Differentiation of ESCs.

Moreira S, Polena E, Gordon V, Abdulla S, Mahendram S, Cao J, Blais A, Wood GA, Dvorkin-Gheva A, Doble BW.

Cell Rep. 2017 Sep 5;20(10):2424-2438. doi: 10.1016/j.celrep.2017.08.043.


CXCR3 Signaling Is Required for Restricted Homing of Parenteral Tuberculosis Vaccine-Induced T Cells to Both the Lung Parenchyma and Airway.

Jeyanathan M, Afkhami S, Khera A, Mandur T, Damjanovic D, Yao Y, Lai R, Haddadi S, Dvorkin-Gheva A, Jordana M, Kunkel SL, Xing Z.

J Immunol. 2017 Oct 1;199(7):2555-2569. doi: 10.4049/jimmunol.1700382. Epub 2017 Aug 21.


Serotonergic system antagonists target breast tumor initiating cells and synergize with chemotherapy to shrink human breast tumor xenografts.

Gwynne WD, Hallett RM, Girgis-Gabardo A, Bojovic B, Dvorkin-Gheva A, Aarts C, Dias K, Bane A, Hassell JA.

Oncotarget. 2017 May 9;8(19):32101-32116. doi: 10.18632/oncotarget.16646.


Kaiso depletion attenuates the growth and survival of triple negative breast cancer cells.

Bassey-Archibong BI, Rayner LG, Hercules SM, Aarts CW, Dvorkin-Gheva A, Bramson JL, Hassell JA, Daniel JM.

Cell Death Dis. 2017 Mar 23;8(3):e2689. doi: 10.1038/cddis.2017.92.


Claudin-Low Breast Cancer; Clinical & Pathological Characteristics.

Dias K, Dvorkin-Gheva A, Hallett RM, Wu Y, Hassell J, Pond GR, Levine M, Whelan T, Bane AL.

PLoS One. 2017 Jan 3;12(1):e0168669. doi: 10.1371/journal.pone.0168669. eCollection 2017.


Total particulate matter concentration skews cigarette smoke's gene expression profile.

Dvorkin-Gheva A, Vanderstocken G, Yildirim AÖ, Brandsma CA, Obeidat M, Bossé Y, Hassell JA, Stampfli MR.

ERJ Open Res. 2016 Nov 9;2(4). pii: 00029-2016. eCollection 2016 Oct.


Serotonin transporter antagonists target tumor-initiating cells in a transgenic mouse model of breast cancer.

Hallett RM, Girgis-Gabardo A, Gwynne WD, Giacomelli AO, Bisson JN, Jensen JE, Dvorkin-Gheva A, Hassell JA.

Oncotarget. 2016 Aug 16;7(33):53137-53152. doi: 10.18632/oncotarget.10614.


T Cells Engineered With Chimeric Antigen Receptors Targeting NKG2D Ligands Display Lethal Toxicity in Mice.

VanSeggelen H, Hammill JA, Dvorkin-Gheva A, Tantalo DG, Kwiecien JM, Denisova GF, Rabinovich B, Wan Y, Bramson JL.

Mol Ther. 2015 Oct;23(10):1600-10. doi: 10.1038/mt.2015.119. Epub 2015 Jun 30.


Identification and evaluation of network modules for the prognosis of basal-like breast cancer.

Hallett RM, Cockburn JG, Li B, Dvorkin-Gheva A, Hassell JA, Bane A.

Oncotarget. 2015 Jul 10;6(19):17713-24.


5-HT2A/C receptors do not mediate the attenuation of compulsive checking by mCPP in the quinpirole sensitization rat model of obsessive-compulsive disorder (OCD).

Tucci MC, Dvorkin-Gheva A, Johnson E, Wong M, Szechtman H.

Behav Brain Res. 2015 Feb 15;279:211-7. doi: 10.1016/j.bbr.2014.11.017. Epub 2014 Nov 15.


Nucleus accumbens core and pathogenesis of compulsive checking.

Ballester González J, Dvorkin-Gheva A, Silva C, Foster JA, Szechtman H.

Behav Pharmacol. 2015 Feb;26(1-2):200-16. doi: 10.1097/FBP.0000000000000112.


Identification of a novel luminal molecular subtype of breast cancer.

Dvorkin-Gheva A, Hassell JA.

PLoS One. 2014 Jul 30;9(7):e103514. doi: 10.1371/journal.pone.0103514. eCollection 2014.


Performance of compulsive behavior in rats is not a unitary phenomenon - validation of separate functional components in compulsive checking behavior.

Tucci MC, Dvorkin-Gheva A, Johnson E, Cheon P, Taji L, Agarwal A, Foster J, Szechtman H.

Eur J Neurosci. 2014 Sep;40(6):2971-9. doi: 10.1111/ejn.12652. Epub 2014 Jun 16.


Separate mechanisms for development and performance of compulsive checking in the quinpirole sensitization rat model of obsessive-compulsive disorder (OCD).

Tucci MC, Dvorkin-Gheva A, Sharma R, Taji L, Cheon P, Peel J, Kirk A, Szechtman H.

Psychopharmacology (Berl). 2014 Sep;231(18):3707-18. doi: 10.1007/s00213-014-3505-6. Epub 2014 Feb 28.


Effects of the serotonergic agonist mCPP on male rats in the quinpirole sensitization model of obsessive-compulsive disorder (OCD).

Tucci MC, Dvorkin-Gheva A, Graham D, Amodeo S, Cheon P, Kirk A, Peel J, Taji L, Szechtman H.

Psychopharmacology (Berl). 2013 May;227(2):277-85. doi: 10.1007/s00213-013-2976-1. Epub 2013 Jan 25.


Quinpirole and 8-OH-DPAT induce compulsive checking behavior in male rats by acting on different functional parts of an OCD neurocircuit.

Alkhatib AH, Dvorkin-Gheva A, Szechtman H.

Behav Pharmacol. 2013 Feb;24(1):65-73. doi: 10.1097/FBP.0b013e32835d5b7a.


A gene signature for predicting outcome in patients with basal-like breast cancer.

Hallett RM, Dvorkin-Gheva A, Bane A, Hassell JA.

Sci Rep. 2012;2:227. doi: 10.1038/srep00227. Epub 2012 Jan 17. No abstract available.


Hormone receptor and ERBB2 status in gene expression profiles of human breast tumor samples.

Dvorkin-Gheva A, Hassell JA.

PLoS One. 2011;6(10):e26023. doi: 10.1371/journal.pone.0026023. Epub 2011 Oct 13.

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