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Items: 26


Influence of Plasmodium falciparum Calcium-Dependent Protein Kinase 5 (PfCDPK5) on the Late Schizont Stage Phosphoproteome.

Blomqvist K, Helmel M, Wang C, Absalon S, Labunska T, Rudlaff RM, Adapa S, Jiang R, Steen H, Dvorin JD.

mSphere. 2020 Jan 8;5(1). pii: e00921-19. doi: 10.1128/mSphere.00921-19.


A novel antiparasitic compound kills ring-stage Plasmodium falciparum and retains activity against artemisinin-resistant parasites.

Clements RL, Streva V, Dumoulin P, Huang W, Owens E, Raj DK, Burleigh B, LlinĂ¡s M, Winzeler EA, Zhang Q, Dvorin JD.

J Infect Dis. 2019 Oct 16. pii: jiz534. doi: 10.1093/infdis/jiz534. [Epub ahead of print]


An essential contractile ring protein controls cell division in Plasmodium falciparum.

Rudlaff RM, Kraemer S, Streva VA, Dvorin JD.

Nat Commun. 2019 May 16;10(1):2181. doi: 10.1038/s41467-019-10214-z.


Calcium-Dependent Protein Kinase 5 Is Required for Release of Egress-Specific Organelles in Plasmodium falciparum.

Absalon S, Blomqvist K, Rudlaff RM, DeLano TJ, Pollastri MP, Dvorin JD.

mBio. 2018 Feb 27;9(1). pii: e00130-18. doi: 10.1128/mBio.00130-18.


Getting Your Head around Cerebral Malaria.

Dvorin JD.

Cell Host Microbe. 2017 Nov 8;22(5):586-588. doi: 10.1016/j.chom.2017.10.017.


PfCDPK1 mediated signaling in erythrocytic stages of Plasmodium falciparum.

Kumar S, Kumar M, Ekka R, Dvorin JD, Paul AS, Madugundu AK, Gilberger T, Gowda H, Duraisingh MT, Keshava Prasad TS, Sharma P.

Nat Commun. 2017 Jul 5;8(1):63. doi: 10.1038/s41467-017-00053-1.


The Malaria Parasite Cyclin H Homolog PfCyc1 Is Required for Efficient Cytokinesis in Blood-Stage Plasmodium falciparum.

Robbins JA, Absalon S, Streva VA, Dvorin JD.

mBio. 2017 Jun 13;8(3). pii: e00605-17. doi: 10.1128/mBio.00605-17.


Functional Analysis Reveals Geographical Variation in Inhibitory Immune Responses Against a Polymorphic Malaria Antigen.

Bei AK, Ahouidi AD, Dvorin JD, Miura K, Diouf A, Ndiaye D, Premji Z, Diakite M, Mboup S, Long CA, Duraisingh MT.

J Infect Dis. 2017 Jul 15;216(2):267-275. doi: 10.1093/infdis/jix280.


Erratum: Plasmodium falciparum CRK4 directs continuous rounds of DNA replication during schizogony.

Ganter M, Goldberg JM, Dvorin JD, Paulo JA, King JG, Tripathi AK, Paul AS, Yang J, Coppens I, Jiang RH, Elsworth B, Baker DA, Dinglasan RR, Gygi SP, Duraisingh MT.

Nat Microbiol. 2017 Mar 6;2:17038. doi: 10.1038/nmicrobiol.2017.38. No abstract available.


Plasmodium falciparum CRK4 directs continuous rounds of DNA replication during schizogony.

Ganter M, Goldberg JM, Dvorin JD, Paulo JA, King JG, Tripathi AK, Paul AS, Yang J, Coppens I, Jiang RH, Elsworth B, Baker DA, Dinglasan RR, Gygi SP, Duraisingh MT.

Nat Microbiol. 2017 Feb 17;2:17017. doi: 10.1038/nmicrobiol.2017.17. Erratum in: Nat Microbiol. 2017 Mar 06;2:17038.


Receptor for Activated C-Kinase 1 (PfRACK1) is required for Plasmodium falciparum intra-erythrocytic proliferation.

Blomqvist K, DiPetrillo C, Streva VA, Pine S, Dvorin JD.

Mol Biochem Parasitol. 2017 Jan;211:62-66. doi: 10.1016/j.molbiopara.2016.10.002. Epub 2016 Oct 11.


An essential malaria protein defines the architecture of blood-stage and transmission-stage parasites.

Absalon S, Robbins JA, Dvorin JD.

Nat Commun. 2016 Apr 28;7:11449. doi: 10.1038/ncomms11449.


Dynamical features of the Plasmodium falciparum ribosome during translation.

Sun M, Li W, Blomqvist K, Das S, Hashem Y, Dvorin JD, Frank J.

Nucleic Acids Res. 2015 Dec 2;43(21):10515-24. doi: 10.1093/nar/gkv991. Epub 2015 Oct 1.


Antibodies to PfSEA-1 block parasite egress from RBCs and protect against malaria infection.

Raj DK, Nixon CP, Nixon CE, Dvorin JD, DiPetrillo CG, Pond-Tor S, Wu HW, Jolly G, Pischel L, Lu A, Michelow IC, Cheng L, Conteh S, McDonald EA, Absalon S, Holte SE, Friedman JF, Fried M, Duffy PE, Kurtis JD.

Science. 2014 May 23;344(6186):871-7. doi: 10.1126/science.1254417.


Inside scoop on outside proteins.

Dvorin JD.

Infect Immun. 2014 Mar;82(3):921-3. doi: 10.1128/IAI.01542-13. Epub 2013 Dec 16.


A DOC2 protein identified by mutational profiling is essential for apicomplexan parasite exocytosis.

Farrell A, Thirugnanam S, Lorestani A, Dvorin JD, Eidell KP, Ferguson DJ, Anderson-White BR, Duraisingh MT, Marth GT, Gubbels MJ.

Science. 2012 Jan 13;335(6065):218-21. doi: 10.1126/science.1210829. Erratum in: Science. 2012 Apr 13;336(6078):155.


Identification and validation of tetracyclic benzothiazepines as Plasmodium falciparum cytochrome bc1 inhibitors.

Dong CK, Urgaonkar S, Cortese JF, Gamo FJ, Garcia-Bustos JF, Lafuente MJ, Patel V, Ross L, Coleman BI, Derbyshire ER, Clish CB, Serrano AE, Cromwell M, Barker RH Jr, Dvorin JD, Duraisingh MT, Wirth DF, Clardy J, Mazitschek R.

Chem Biol. 2011 Dec 23;18(12):1602-10. doi: 10.1016/j.chembiol.2011.09.016.


Functional diversification between two related Plasmodium falciparum merozoite invasion ligands is determined by changes in the cytoplasmic domain.

Dvorin JD, Bei AK, Coleman BI, Duraisingh MT.

Mol Microbiol. 2010 Feb;75(4):990-1006. doi: 10.1111/j.1365-2958.2009.07040.x.


A plant-like kinase in Plasmodium falciparum regulates parasite egress from erythrocytes.

Dvorin JD, Martyn DC, Patel SD, Grimley JS, Collins CR, Hopp CS, Bright AT, Westenberger S, Winzeler E, Blackman MJ, Baker DA, Wandless TJ, Duraisingh MT.

Science. 2010 May 14;328(5980):910-2. doi: 10.1126/science.1188191.


Suggestive evidence for Darwinian Selection against asparagine-linked glycans of Plasmodium falciparum and Toxoplasma gondii.

Bushkin GG, Ratner DM, Cui J, Banerjee S, Duraisingh MT, Jennings CV, Dvorin JD, Gubbels MJ, Robertson SD, Steffen M, O'Keefe BR, Robbins PW, Samuelson J.

Eukaryot Cell. 2010 Feb;9(2):228-41. doi: 10.1128/EC.00197-09. Epub 2009 Sep 25.


Type II NADH dehydrogenase of the respiratory chain of Plasmodium falciparum and its inhibitors.

Dong CK, Patel V, Yang JC, Dvorin JD, Duraisingh MT, Clardy J, Wirth DF.

Bioorg Med Chem Lett. 2009 Feb 1;19(3):972-5. doi: 10.1016/j.bmcl.2008.11.071. Epub 2008 Nov 24.


Identification and characterization of small molecule inhibitors of Plasmodium falciparum dihydroorotate dehydrogenase.

Patel V, Booker M, Kramer M, Ross L, Celatka CA, Kennedy LM, Dvorin JD, Duraisingh MT, Sliz P, Wirth DF, Clardy J.

J Biol Chem. 2008 Dec 12;283(50):35078-85. doi: 10.1074/jbc.M804990200. Epub 2008 Oct 8.


Intracellular trafficking of HIV-1 cores: journey to the center of the cell.

Dvorin JD, Malim MH.

Curr Top Microbiol Immunol. 2003;281:179-208. Review.


Reassessment of the roles of integrase and the central DNA flap in human immunodeficiency virus type 1 nuclear import.

Dvorin JD, Bell P, Maul GG, Yamashita M, Emerman M, Malim MH.

J Virol. 2002 Dec;76(23):12087-96.


HIV-1 infection requires a functional integrase NLS.

Bouyac-Bertoia M, Dvorin JD, Fouchier RA, Jenkins Y, Meyer BE, Wu LI, Emerman M, Malim MH.

Mol Cell. 2001 May;7(5):1025-35.


In vivo attenuation of simian immunodeficiency virus by disruption of a tyrosine-dependent sorting signal in the envelope glycoprotein cytoplasmic tail.

Fultz PN, Vance PJ, Endres MJ, Tao B, Dvorin JD, Davis IC, Lifson JD, Montefiori DC, Marsh M, Malim MH, Hoxie JA.

J Virol. 2001 Jan;75(1):278-91.

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