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Items: 1 to 50 of 216

1.

Targeting the pregnane X receptor using microbial metabolite mimicry.

Dvořák Z, Kopp F, Costello CM, Kemp JS, Li H, Vrzalová A, Štěpánková M, Bartoňková I, Jiskrová E, Poulíková K, Vyhlídalová B, Nordstroem LU, Karunaratne CV, Ranhotra HS, Mun KS, Naren AP, Murray IA, Perdew GH, Brtko J, Toporova L, Schön A, Wallace BD, Walton WG, Redinbo MR, Sun K, Beck A, Kortagere S, Neary MC, Chandran A, Vishveshwara S, Cavalluzzi MM, Lentini G, Cui JY, Gu H, March JC, Chatterjee S, Matson A, Wright D, Flannigan KL, Hirota SA, Sartor RB, Mani S.

EMBO Mol Med. 2020 Mar 10:e11621. doi: 10.15252/emmm.201911621. [Epub ahead of print]

2.

Differential activation of human pregnane X receptor PXR by isomeric mono-methylated indoles in intestinal and hepatic in vitro models.

Vyhlídalová B, Bartoňková I, Jiskrová E, Li H, Mani S, Dvořák Z.

Toxicol Lett. 2020 May 15;324:104-110. doi: 10.1016/j.toxlet.2020.02.010. Epub 2020 Feb 21.

PMID:
32092453
3.

Prognostic and predictive markers for perineural and bone invasion of oral squamous cell carcinoma.

Michalek J, Brychtova S, Pink R, Dvorak Z.

Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub. 2019 Dec;163(4):302-308. doi: 10.5507/bp.2019.032. Epub 2019 Aug 21.

4.

Mono-methylindoles induce CYP1A genes and inhibit CYP1A1 enzyme activity in human hepatocytes and HepaRG cells.

Vyhlídalová B, Poulíková K, Bartoňková I, Krasulová K, Vančo J, Trávníček Z, Mani S, Dvořák Z.

Toxicol Lett. 2019 Oct 1;313:66-76. doi: 10.1016/j.toxlet.2019.06.004. Epub 2019 Jun 12.

5.

Modulation of endocrine nuclear receptor activities by polyaromatic compounds present in fractionated extracts of diesel exhaust particles.

Pěnčíková K, Ciganek M, Neča J, Illés P, Dvořák Z, Vondráček J, Machala M.

Sci Total Environ. 2019 Aug 10;677:626-636. doi: 10.1016/j.scitotenv.2019.04.390. Epub 2019 Apr 27.

PMID:
31071665
6.

Pedicled pectoralis major flap in head and neck reconstruction - our experience.

Dvořák Z, Pink R, Michl P, Heinz P, Tvrdý P.

Acta Chir Plast. 2019 Winter;60(1):26-29.

PMID:
30939882
7.

Pedicled pectoralis major flap in head and neck reconstruction - technique and overview.

Dvořák Z, Pink R, Michl P, Heinz P, Tvrdý P.

Acta Chir Plast. 2019 Winter;60(1):14-21.

PMID:
30939879
8.

A half-sandwich TaV dichlorido complex containing an O,N,O'-tridentate Schiff base ligand: synthesis, crystal structure and in vitro cytotoxicity.

Trávníček Z, Štarha P, Čajan M, Dvořák Z.

Acta Crystallogr C Struct Chem. 2019 Mar 1;75(Pt 3):248-254. doi: 10.1107/S2053229619001323. Epub 2019 Feb 8.

PMID:
30833518
9.

In vitro anticancer active cis-Pt(II)-diiodido complexes containing 4-azaindoles.

Štarha P, Trávníček Z, Vančo J, Dvořák Z.

J Biol Inorg Chem. 2019 Mar;24(2):257-269. doi: 10.1007/s00775-019-01643-8. Epub 2019 Feb 14.

PMID:
30767079
10.

Belinostat, at Its Clinically Relevant Concentrations, Inhibits Rifampicin-Induced CYP3A4 and MDR1 Gene Expression.

Abbott KL, Chaudhury CS, Chandran A, Vishveshwara S, Dvorak Z, Jiskrova E, Poulikova K, Vyhlidalova B, Mani S, Pondugula SR.

Mol Pharmacol. 2019 Mar;95(3):324-334. doi: 10.1124/mol.118.114587. Epub 2019 Jan 8.

11.

Effects of Flavored Nonalcoholic Beverages on Transcriptional Activities of Nuclear and Steroid Hormone Receptors: Proof of Concept for Novel Reporter Cell Line PAZ-PPARg.

Illés P, Grycová A, Krasulová K, Dvořák Z.

J Agric Food Chem. 2018 Nov 14;66(45):12066-12078. doi: 10.1021/acs.jafc.8b05158. Epub 2018 Nov 5.

PMID:
30394742
12.

Trans-resveratrol, but not other natural stilbenes occurring in food, carries the risk of drug-food interaction via inhibition of cytochrome P450 enzymes or interaction with xenosensor receptors.

Hyrsova L, Vanduchova A, Dusek J, Smutny T, Carazo A, Maresova V, Trejtnar F, Barta P, Anzenbacher P, Dvorak Z, Pavek P.

Toxicol Lett. 2019 Jan;300:81-91. doi: 10.1016/j.toxlet.2018.10.028. Epub 2018 Oct 27.

PMID:
30394306
13.

Effects of selected triorganotin compounds on transcriptional activity of vitamin D3 receptor and peroxisome proliferator-activated receptor gamma.

Toporova L, Illes P, Dvorak Z, Bobal P, Otevrel J, Brtko J.

Gen Physiol Biophys. 2018 Sep;37(5):589-596. doi: 10.4149/gpb_2018021.

PMID:
30307405
14.

A cytotoxic tantalum(v) half-sandwich complex: a new challenge for metal-based anticancer agents.

Štarha P, Trávníček Z, Dvořák Z.

Chem Commun (Camb). 2018 Aug 21;54(68):9533-9536. doi: 10.1039/c8cc05223a.

PMID:
30094436
15.

Essential oils of culinary herbs and spices activate PXR and induce CYP3A4 in human intestinal and hepatic in vitro models.

Bartonkova I, Dvorak Z.

Toxicol Lett. 2018 Oct 15;296:1-9. doi: 10.1016/j.toxlet.2018.07.023. Epub 2018 Jul 30.

PMID:
30071242
16.

Mycophenolate Mofetil induces c-Jun-N-terminal kinase expression in 22Rv1 cells: an impact on androgen receptor signaling.

Zenata O, Dvorak Z, Vrzal R.

J Cancer. 2018 Apr 27;9(11):1915-1924. doi: 10.7150/jca.23648. eCollection 2018.

17.

A potential method to improve the in vitro cytotoxicity of half-sandwich Os(ii) complexes against A2780 cells.

Štarha P, Trávníček Z, Herchel R, Jewula P, Dvořák Z.

Dalton Trans. 2018 Apr 24;47(16):5714-5724. doi: 10.1039/c8dt00193f.

PMID:
29632937
18.
19.

Methylindoles and Methoxyindoles are Agonists and Antagonists of Human Aryl Hydrocarbon Receptor.

Stepankova M, Bartonkova I, Jiskrova E, Vrzal R, Mani S, Kortagere S, Dvorak Z.

Mol Pharmacol. 2018 Jun;93(6):631-644. doi: 10.1124/mol.118.112151. Epub 2018 Apr 6.

20.

In vitro profiling of toxic effects of prominent environmental lower-chlorinated PCB congeners linked with endocrine disruption and tumor promotion.

Pěnčíková K, Svržková L, Strapáčová S, Neča J, Bartoňková I, Dvořák Z, Hýžďalová M, Pivnička J, Pálková L, Lehmler HJ, Li X, Vondráček J, Machala M.

Environ Pollut. 2018 Jun;237:473-486. doi: 10.1016/j.envpol.2018.02.067. Epub 2018 Mar 15.

21.

Effects of human interleukins in the transgenic gene reporter cell lines IZ-VDRE and IZ-CYP24 designed to assess the transcriptional activity of vitamin D receptor.

Bartonkova I, Kallay E, Dvorak Z.

PLoS One. 2018 Feb 28;13(2):e0193655. doi: 10.1371/journal.pone.0193655. eCollection 2018.

22.

[Pedicled Flaps for Reconstruction of Head and Neck Region].

Pink R, Dvořák Z, Heinz P, Michl P, Tvrdý P, Azar B.

Klin Onkol. Winter 2017;31(1):59-65. doi: 10.14735/amko201859. Czech.

PMID:
29488780
23.

Half-Sandwich Ru(II) and Os(II) Bathophenanthroline Complexes Containing a Releasable Dichloroacetato Ligand.

Štarha P, Trávníček Z, Vančo J, Dvořák Z.

Molecules. 2018 Feb 14;23(2). pii: E420. doi: 10.3390/molecules23020420.

24.

In vitro analysis of itraconazole cis-diastereoisomers inhibition of nine cytochrome P450 enzymes: stereoselective inhibition of CYP3A.

Krasulova K, Dvorak Z, Anzenbacher P.

Xenobiotica. 2019 Jan;49(1):36-42. doi: 10.1080/00498254.2018.1425510. Epub 2018 Jan 22.

PMID:
29320899
25.

Copper(II) complexes based on tripodal pyrazolyl amines: Synthesis, structure, magnetic properties and anticancer activity.

Massoud SS, Louka FR, Ducharme GT, Fischer RC, Mautner FA, Vančo J, Herchel R, Dvořák Z, Trávníček Z.

J Inorg Biochem. 2018 Mar;180:39-46. doi: 10.1016/j.jinorgbio.2017.11.023. Epub 2017 Dec 5.

PMID:
29232637
26.

Essential oils of culinary herbs and spices display agonist and antagonist activities at human aryl hydrocarbon receptor AhR.

Bartoňková I, Dvořák Z.

Food Chem Toxicol. 2018 Jan;111:374-384. doi: 10.1016/j.fct.2017.11.049. Epub 2017 Nov 27.

PMID:
29191726
27.

Profiling of anthocyanidins against transcriptional activities of steroid and nuclear receptors.

Pastorková B, Illés P, Dvořák Z.

Drug Chem Toxicol. 2018 Oct;41(4):434-440. doi: 10.1080/01480545.2017.1380659. Epub 2017 Oct 26.

PMID:
29072505
28.

Profiling of bisphenol S towards nuclear receptors activities in human reporter cell lines.

Zenata O, Dvorak Z, Vrzal R.

Toxicol Lett. 2017 Nov 5;281:10-19. doi: 10.1016/j.toxlet.2017.09.006. Epub 2017 Sep 12.

PMID:
28916285
29.

Involvement of aryl hydrocarbon receptor (AhR) in polyphenol inhibition of benzo[a]pyrene-induced oxidative stress and neoplastic transformation.

Dvorak Z.

Food Chem Toxicol. 2017 Sep;107(Pt A):523-525. doi: 10.1016/j.fct.2017.07.001. Epub 2017 Jul 1. No abstract available.

PMID:
28676325
30.

Molecular, cellular and pharmacological effects of platinum(II) diiodido complexes containing 9-deazahypoxanthine derivatives: A group of broad-spectrum anticancer active agents.

Vančo J, Trávníček Z, Křikavová R, Gáliková J, Dvořák Z, Chalupová M.

J Photochem Photobiol B. 2017 Aug;173:423-433. doi: 10.1016/j.jphotobiol.2017.06.017. Epub 2017 Jun 19.

PMID:
28662469
31.

Activated thyroid hormone receptor modulates dioxin-inducible aryl hydrocarbon receptor-mediated CYP1A1 induction in human hepatocytes but not in human hepatocarcinoma HepG2 cells.

Vrzal R, Vrzalova A, Grycova A, Dvorak Z.

Toxicol Lett. 2017 Jun 5;275:77-82. doi: 10.1016/j.toxlet.2017.05.001. Epub 2017 May 3.

PMID:
28478156
32.

Itraconazole cis-diastereoisomers activate aryl hydrocarbon receptor AhR and pregnane X receptor PXR and induce CYP1A1 in human cell lines and human hepatocytes.

Stepankova M, Pastorkova B, Bachleda P, Dvorak Z.

Toxicology. 2017 May 15;383:40-49. doi: 10.1016/j.tox.2017.04.002. Epub 2017 Apr 5.

PMID:
28390928
33.

Janus-faced Acrolein prevents allergy but accelerates tumor growth by promoting immunoregulatory Foxp3+ cells: Mouse model for passive respiratory exposure.

Roth-Walter F, Bergmayr C, Meitz S, Buchleitner S, Stremnitzer C, Fazekas J, Moskovskich A, Müller MA, Roth GA, Manzano-Szalai K, Dvorak Z, Neunkirchner A, Jensen-Jarolim E.

Sci Rep. 2017 Mar 23;7:45067. doi: 10.1038/srep45067.

34.

Hydroxystilbenes and methoxystilbenes activate human aryl hydrocarbon receptor and induce CYP1A genes in human hepatoma cells and human hepatocytes.

Pastorková B, Vrzalová A, Bachleda P, Dvořák Z.

Food Chem Toxicol. 2017 May;103:122-132. doi: 10.1016/j.fct.2017.03.008. Epub 2017 Mar 6.

PMID:
28279696
35.

In vitro modulatory effects of functionalized pyrimidines and piperidine derivatives on Aryl hydrocarbon receptor (AhR) and glucocorticoid receptor (GR) activities.

Yar M, Shahzadi L, Farooq A, Jalil Imran S, Cerón-Carrasco JP, den-Haan H, Kumar S, Peña-García J, Pérez-Sánchez H, Grycova A, Dvorak Z, Vrzal R.

Bioorg Chem. 2017 Apr;71:285-293. doi: 10.1016/j.bioorg.2017.02.013. Epub 2017 Feb 21.

PMID:
28267985
36.

Lipomodelling - advanced technique for the correction of Congenital hypoplastic breast malformations and deformities.

Streit L, Dražan L, Novák P, Schneiderová M, Dvořák Z, Teplá K, Veselý J.

Acta Chir Plast. Winter 2016;58(2):70-76.

PMID:
28079392
38.

In Vitro Antitumor Active Gold(I) Triphenylphosphane Complexes Containing 7-Azaindoles.

Štarha P, Trávníček Z, Drahoš B, Dvořák Z.

Int J Mol Sci. 2016 Dec 11;17(12). pii: E2084.

39.

Platinum(II) Iodido Complexes of 7-Azaindoles with Significant Antiproliferative Effects: An Old Story Revisited with Unexpected Outcomes.

Štarha P, Vančo J, Trávníček Z, Hošek J, Klusáková J, Dvořák Z.

PLoS One. 2016 Dec 1;11(12):e0165062. doi: 10.1371/journal.pone.0165062. eCollection 2016.

40.

Design and characterization of highly in vitro antitumor active ternary copper(II) complexes containing 2'-hydroxychalcone ligands.

Křikavová R, Vančo J, Trávníček Z, Hutyra J, Dvořák Z.

J Inorg Biochem. 2016 Oct;163:8-17. doi: 10.1016/j.jinorgbio.2016.07.005. Epub 2016 Jul 9.

PMID:
27423037
41.

Optical isomers of dihydropyridine calcium channel blockers display enantiospecific effects on the expression and enzyme activities of human xenobiotics-metabolizing cytochromes P450.

Štěpánková M, Krasulová K, Dořičáková A, Kurka O, Anzenbacher P, Dvořák Z.

Toxicol Lett. 2016 Nov 16;262:173-186. doi: 10.1016/j.toxlet.2016.10.005. Epub 2016 Oct 11.

PMID:
27732883
42.

Assessment of the aryl hydrocarbon receptor-mediated activities of polycyclic aromatic hydrocarbons in a human cell-based reporter gene assay.

Vondráček J, Pěnčíková K, Neča J, Ciganek M, Grycová A, Dvořák Z, Machala M.

Environ Pollut. 2017 Jan;220(Pt A):307-316. doi: 10.1016/j.envpol.2016.09.064. Epub 2016 Sep 29.

PMID:
27692884
43.

Transplant drugs affect the expression of phase II and antioxidant enzymes in human carcinoma cells HepG2 but not in primary cultures of human hepatocytes: In vitro comparative study.

Vrzal R, Illes P, Dvorak Z.

Pharmacol Rep. 2016 Oct;68(5):1008-14. doi: 10.1016/j.pharep.2016.06.001. Epub 2016 Jul 17.

PMID:
27428762
45.

Platinum(II) carboxylato complexes containing 7-azaindoles as N-donor carrier ligands showed cytotoxicity against cancer cell lines.

Štarha P, Trávníček Z, Pazderová L, Dvořák Z.

J Inorg Biochem. 2016 Sep;162:109-116. doi: 10.1016/j.jinorgbio.2016.06.018. Epub 2016 Jun 16.

PMID:
27350081
46.

Profiling of Vitamin D Metabolic Intermediates toward VDR Using Novel Stable Gene Reporter Cell Lines IZ-VDRE and IZ-CYP24.

Bartonkova I, Grycova A, Dvorak Z.

Chem Res Toxicol. 2016 Jul 18;29(7):1211-22. doi: 10.1021/acs.chemrestox.6b00170. Epub 2016 Jul 1.

PMID:
27327272
47.
48.

Mixed-ligand copper(II) complexes activate aryl hydrocarbon receptor AhR and induce CYP1A genes expression in human hepatocytes and human cell lines.

Kubešová K, Dořičáková A, Trávníček Z, Dvořák Z.

Toxicol Lett. 2016 Jul 25;255:24-35. doi: 10.1016/j.toxlet.2016.05.014. Epub 2016 May 12.

PMID:
27180721
49.

Structural changes in amber due to uranium mineralization.

Havelcová M, Machovič V, Mizera J, Sýkorová I, René M, Borecká L, Lapčák L, Bičáková O, Janeček O, Dvořák Z.

J Environ Radioact. 2016 Jul;158-159:89-101. doi: 10.1016/j.jenvrad.2016.04.004. Epub 2016 Apr 13.

PMID:
27085038
50.

Pivotal role of the aryl hydrocarbon receptor in modulations caused by benzo[a]pyrene and ketoconazole in the estrogenic responses induced by 17β-estradiol in male goldfish.

Dvorak Z.

Environ Sci Pollut Res Int. 2016 May;23(9):9247-8. doi: 10.1007/s11356-016-6387-9. Epub 2016 Mar 8. No abstract available.

PMID:
26951223

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