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The CRISPR-Cas9 crADSL HeLa transcriptome: A first step in establishing a model for ADSL deficiency and SAICAR accumulation.

Mazzarino RC, Baresova V, Zikánová M, Duval N, Wilkinson TG 2nd, Patterson D, Vacano GN.

Mol Genet Metab Rep. 2019 Sep 4;21:100512. doi: 10.1016/j.ymgmr.2019.100512. eCollection 2019 Dec.


BMP4 patterns Smad activity and generates stereotyped cell fate organization in spinal organoids.

Duval N, Vaslin C, Barata TC, Frarma Y, Contremoulins V, Baudin X, Nedelec S, Ribes VC.

Development. 2019 Jul 25;146(14). pii: dev175430. doi: 10.1242/dev.175430.


Neuroprotection Comparison of Rosmarinic Acid and Carnosic Acid in Primary Cultures of Cerebellar Granule Neurons.

Taram F, Ignowski E, Duval N, Linseman DA.

Molecules. 2018 Nov 13;23(11). pii: E2956. doi: 10.3390/molecules23112956.


Rapamycin Treatment Ameliorates Age-Related Accumulation of Toxic Metabolic Intermediates in Brains of the Ts65Dn Mouse Model of Down Syndrome and Aging.

Duval N, Vacano GN, Patterson D.

Front Aging Neurosci. 2018 Sep 6;10:263. doi: 10.3389/fnagi.2018.00263. eCollection 2018.


The cysteine-rich whey protein supplement, Immunocal®, preserves brain glutathione and improves cognitive, motor, and histopathological indices of traumatic brain injury in a mouse model of controlled cortical impact.

Ignowski E, Winter AN, Duval N, Fleming H, Wallace T, Manning E, Koza L, Huber K, Serkova NJ, Linseman DA.

Free Radic Biol Med. 2018 Aug 20;124:328-341. doi: 10.1016/j.freeradbiomed.2018.06.026. Epub 2018 Jun 27.


The Bcl-2 Homology-3 Domain (BH3)-Only Proteins, Bid, DP5/Hrk, and BNip3L, Are Upregulated in Reactive Astrocytes of End-Stage Mutant SOD1 Mouse Spinal Cord.

Duval N, Sumner WA, Andrianakos AG, Gray JJ, Bouchard RJ, Wilkins HM, Linseman DA.

Front Cell Neurosci. 2018 Jan 30;12:15. doi: 10.3389/fncel.2018.00015. eCollection 2018.


Success factors for implementing and sustaining a mature electronic medical record in a low-resource setting: a case study of iSanté in Haiti.

deRiel E, Puttkammer N, Hyppolite N, Diallo J, Wagner S, Honoré JG, Balan JG, Celestin N, Vallès JS, Duval N, Thimothé G, Boncy J, Coq NRL, Barnhart S.

Health Policy Plan. 2018 Mar 1;33(2):237-246. doi: 10.1093/heapol/czx171.


Orthostatic hypotension associated with executive dysfunction in mild cognitive impairment.

Bocti C, Pépin F, Tétreault M, Cossette P, Langlois F, Imbeault H, Duval N, Lacombe G, Fulop T.

J Neurol Sci. 2017 Nov 15;382:79-83. doi: 10.1016/j.jns.2017.09.028. Epub 2017 Sep 27.


Retention Throughout the HIV Care and Treatment Cascade: From Diagnosis to Antiretroviral Treatment of Adults and Children Living with HIV-Haiti, 1985-2015.

Auld AF, Valerie Pelletier, Robin EG, Shiraishi RW, Dee J, Antoine M, Desir Y, Desforges G, Delcher C, Duval N, Joseph N, Francois K, Griswold M, Domercant JW, Patrice Joseph YA, Van Onacker JD, Deyde V, Lowrance DW, And The Groupe d'Analyses Salvh.

Am J Trop Med Hyg. 2017 Oct;97(4_Suppl):57-70. doi: 10.4269/ajtmh.17-0116.


Pax3- and Pax7-mediated Dbx1 regulation orchestrates the patterning of intermediate spinal interneurons.

Gard C, Gonzalez Curto G, Frarma YE, Chollet E, Duval N, Auzié V, Auradé F, Vigier L, Relaix F, Pierani A, Causeret F, Ribes V.

Dev Biol. 2017 Dec 1;432(1):24-33. doi: 10.1016/j.ydbio.2017.06.014. Epub 2017 Jun 16.


Trends in Prevalence of Advanced HIV Disease at Antiretroviral Therapy Enrollment - 10 Countries, 2004-2015.

Auld AF, Shiraishi RW, Oboho I, Ross C, Bateganya M, Pelletier V, Dee J, Francois K, Duval N, Antoine M, Delcher C, Desforges G, Griswold M, Domercant JW, Joseph N, Deyde V, Desir Y, Van Onacker JD, Robin E, Chun H, Zulu I, Pathmanathan I, Dokubo EK, Lloyd S, Pati R, Kaplan J, Raizes E, Spira T, Mitruka K, Couto A, Gudo ES, Mbofana F, Briggs M, Alfredo C, Xavier C, Vergara A, Hamunime N, Agolory S, Mutandi G, Shoopala NN, Sawadogo S, Baughman AL, Bashorun A, Dalhatu I, Swaminathan M, Onotu D, Odafe S, Abiri OO, Debem HH, Tomlinson H, Okello V, Preko P, Ao T, Ryan C, Bicego G, Ehrenkranz P, Kamiru H, Nuwagaba-Biribonwoha H, Kwesigabo G, Ramadhani AA, Ng'wangu K, Swai P, Mfaume M, Gongo R, Carpenter D, Mastro TD, Hamilton C, Denison J, Wabwire-Mangen F, Koole O, Torpey K, Williams SG, Colebunders R, Kalamya JN, Namale A, Adler MR, Mugisa B, Gupta S, Tsui S, van Praag E, Nguyen DB, Lyss S, Le Y, Abdul-Quader AS, Do NT, Mulenga M, Hachizovu S, Mugurungi O, Barr BAT, Gonese E, Mutasa-Apollo T, Balachandra S, Behel S, Bingham T, Mackellar D, Lowrance D, Ellerbrock TV.

MMWR Morb Mortal Wkly Rep. 2017 Jun 2;66(21):558-563. doi: 10.15585/mmwr.mm6621a3.


Fine-tuning the onset of myogenesis by homeobox proteins that interact with the Myf5 limb enhancer.

Daubas P, Duval N, Bajard L, Langa Vives F, Robert B, Mankoo BS, Buckingham M.

Biol Open. 2015 Nov 4;4(12):1614-24. doi: 10.1242/bio.014068.


Cognitive Impairment, Neuroimaging, and Alzheimer Neuropathology in Mouse Models of Down Syndrome.

Hamlett ED, Boger HA, Ledreux A, Kelley CM, Mufson EJ, Falangola MF, Guilfoyle DN, Nixon RA, Patterson D, Duval N, Granholm AC.

Curr Alzheimer Res. 2016;13(1):35-52. Review.


Msx1 and Msx2 act as essential activators of Atoh1 expression in the murine spinal cord.

Duval N, Daubas P, Bourcier de Carbon C, St Cloment C, Tinevez JY, Lopes M, Ribes V, Robert B.

Development. 2014 Apr;141(8):1726-36. doi: 10.1242/dev.099002.


A Cystine-Rich Whey Supplement (Immunocal(®)) Delays Disease Onset and Prevents Spinal Cord Glutathione Depletion in the hSOD1(G93A) Mouse Model of Amyotrophic Lateral Sclerosis.

Ross EK, Winter AN, Wilkins HM, Sumner WA, Duval N, Patterson D, Linseman DA.

Antioxidants (Basel). 2014 Dec 12;3(4):843-65. doi: 10.3390/antiox3040843.


Low sirtuin 1 levels in human osteoarthritis subchondral osteoblasts lead to abnormal sclerostin expression which decreases Wnt/β-catenin activity.

Abed É, Couchourel D, Delalandre A, Duval N, Pelletier JP, Martel-Pelletier J, Lajeunesse D.

Bone. 2014 Feb;59:28-36. doi: 10.1016/j.bone.2013.10.020. Epub 2013 Oct 31.


Alumina on alumina versus metal on conventional polyethylene: a randomized clinical trial with 9 to 15 years follow-up.

Vendittoli PA, Rivière C, Lavigne M, Lavoie P, Alghamdi A, Duval N.

Acta Orthop Belg. 2013 Apr;79(2):181-90.


Inherent properties of adenylosuccinate lyase could explain S-Ado/SAICAr ratio due to homozygous R426H and R303C mutations.

Ray SP, Duval N, Wilkinson TG 2nd, Shaheen SE, Ghosh K, Patterson D.

Biochim Biophys Acta. 2013 Aug;1834(8):1545-53. doi: 10.1016/j.bbapap.2013.05.013. Epub 2013 May 25.


Genetic and metabolomic analysis of AdeD and AdeI mutants of de novo purine biosynthesis: cellular models of de novo purine biosynthesis deficiency disorders.

Duval N, Luhrs K, Wilkinson TG 2nd, Baresova V, Skopova V, Kmoch S, Vacano GN, Zikanova M, Patterson D.

Mol Genet Metab. 2013 Mar;108(3):178-189. doi: 10.1016/j.ymgme.2013.01.002. Epub 2013 Jan 12.


N-terminal cleavage of the mitochondrial fusion GTPase OPA1 occurs via a caspase-independent mechanism in cerebellar granule neurons exposed to oxidative or nitrosative stress.

Gray JJ, Zommer AE, Bouchard RJ, Duval N, Blackstone C, Linseman DA.

Brain Res. 2013 Feb 4;1494:28-43. doi: 10.1016/j.brainres.2012.12.001. Epub 2012 Dec 7.


Lost to follow-up but perhaps not lost in the health system.

Delcher C, Meredith G, Griswold M, Roussel B, Duval N, Louissaint E, Joseph P.

J Acquir Immune Defic Syndr. 2012 Dec 15;61(5):e75-7. doi: 10.1097/QAI.0b013e3182771084. No abstract available.


The use of mouse models for understanding the biology of down syndrome and aging.

Vacano GN, Duval N, Patterson D.

Curr Gerontol Geriatr Res. 2012;2012:717315. doi: 10.1155/2012/717315. Epub 2012 Feb 23.


Egr-1 contributes to IL-1-mediated down-regulation of peroxisome proliferator-activated receptor γ expression in human osteoarthritic chondrocytes.

Nebbaki SS, El Mansouri FE, Afif H, Kapoor M, Benderdour M, Duval N, Pelletier JP, Martel-Pelletier J, Fahmi H.

Arthritis Res Ther. 2012 Mar 28;14(2):R69. doi: 10.1186/ar3788.


Msx1 and Msx2 promote meiosis initiation.

Le Bouffant R, Souquet B, Duval N, Duquenne C, Hervé R, Frydman N, Robert B, Habert R, Livera G.

Development. 2011 Dec;138(24):5393-402. doi: 10.1242/dev.068452. Epub 2011 Nov 9.


Persistence of Bacillus thuringiensis subsp. kurstaki in Urban Environments following Spraying.

Van Cuyk S, Deshpande A, Hollander A, Duval N, Ticknor L, Layshock J, Gallegos-Graves L, Omberg KM.

Appl Environ Microbiol. 2011 Nov;77(22):7954-61. doi: 10.1128/AEM.05207-11. Epub 2011 Sep 16.


Estrogen receptor-related receptor α regulation by interleukin-1β in prostaglandin E(2)- and cAMP-dependent pathways in osteoarthritic chondrocytes.

Bonnelye E, Reboul P, Duval N, Cardelli M, Aubin JE.

Arthritis Rheum. 2011 Aug;63(8):2374-84. doi: 10.1002/art.30398.


Elevated Dickkopf-2 levels contribute to the abnormal phenotype of human osteoarthritic osteoblasts.

Chan TF, Couchourel D, Abed E, Delalandre A, Duval N, Lajeunesse D.

J Bone Miner Res. 2011 Jul;26(7):1399-410. doi: 10.1002/jbmr.358.


Valproic acid suppresses interleukin-1ß-induced microsomal prostaglandin E2 synthase-1 expression in chondrocytes through upregulation of NAB1.

Zayed N, El Mansouri FE, Chabane N, Kapoor M, Martel-Pelletier J, Benderdour M, Pelletier JP, Duval N, Fahmi H.

J Rheumatol. 2011 Mar;38(3):492-502. doi: 10.3899/jrheum.100907. Epub 2011 Jan 15.


Molecular characterization of the AdeI mutant of Chinese hamster ovary cells: a cellular model of adenylosuccinate lyase deficiency.

Vliet LK, Wilkinson TG 2nd, Duval N, Vacano G, Graham C, Zikánová M, Skopova V, Baresova V, Hnízda A, Kmoch S, Patterson D.

Mol Genet Metab. 2011 Jan;102(1):61-8. doi: 10.1016/j.ymgme.2010.08.022. Epub 2010 Sep 6.


Contribution of H3K4 methylation by SET-1A to interleukin-1-induced cyclooxygenase 2 and inducible nitric oxide synthase expression in human osteoarthritis chondrocytes.

El Mansouri FE, Chabane N, Zayed N, Kapoor M, Benderdour M, Martel-Pelletier J, Pelletier JP, Duval N, Fahmi H.

Arthritis Rheum. 2011 Jan;63(1):168-79. doi: 10.1002/art.27762.


Variable effects of 3 different chondroitin sulfate compounds on human osteoarthritic cartilage/chondrocytes: relevance of purity and production process.

Tat SK, Pelletier JP, Mineau F, Duval N, Martel-Pelletier J.

J Rheumatol. 2010 Mar;37(3):656-64. doi: 10.3899/jrheum.090696. Epub 2010 Jan 28.


Regulation of the IGFBP-5 and MMP-13 genes by the microRNAs miR-140 and miR-27a in human osteoarthritic chondrocytes.

Tardif G, Hum D, Pelletier JP, Duval N, Martel-Pelletier J.

BMC Musculoskelet Disord. 2009 Nov 30;10:148. doi: 10.1186/1471-2474-10-148.


Modulation of OPG, RANK and RANKL by human chondrocytes and their implication during osteoarthritis.

Kwan Tat S, Amiable N, Pelletier JP, Boileau C, Lajeunesse D, Duval N, Martel-Pelletier J.

Rheumatology (Oxford). 2009 Dec;48(12):1482-90. doi: 10.1093/rheumatology/kep300. Epub 2009 Sep 17.


Human articular chondrocytes express 15-lipoxygenase-1 and -2: potential role in osteoarthritis.

Chabane N, Zayed N, Benderdour M, Martel-Pelletier J, Pelletier JP, Duval N, Fahmi H.

Arthritis Res Ther. 2009;11(2):R44. doi: 10.1186/ar2652. Epub 2009 Mar 18.


Proteinase-activated receptor (PAR)-2 activation impacts bone resorptive properties of human osteoarthritic subchondral bone osteoblasts.

Amiable N, Tat SK, Lajeunesse D, Duval N, Pelletier JP, Martel-Pelletier J, Boileau C.

Bone. 2009 Jun;44(6):1143-50. doi: 10.1016/j.bone.2009.02.015. Epub 2009 Mar 2.


[Interest of peri-operative immunonutrition in head and neck cancers].

Mayaleh HA, Vayer C, Amsellem C, Bouvet A, Duval N, Poiree B, Tran M, Lepeltier V, Hitier M, Rame JP, Louis Y, De Raucourt D.

Rev Laryngol Otol Rhinol (Bord). 2009;130(4-5):235-40. French.


Increased expression of lipocalin-type prostaglandin D2 synthase in osteoarthritic cartilage.

Zayed N, Li X, Chabane N, Benderdour M, Martel-Pelletier J, Pelletier JP, Duval N, Fahmi H.

Arthritis Res Ther. 2008;10(6):R146. doi: 10.1186/ar2581. Epub 2008 Dec 18.


Activation of the receptor EphB4 by its specific ligand ephrin B2 in human osteoarthritic subchondral bone osteoblasts.

Kwan Tat S, Pelletier JP, Amiable N, Boileau C, Lajeunesse D, Duval N, Martel-Pelletier J.

Arthritis Rheum. 2008 Dec;58(12):3820-30. doi: 10.1002/art.24029.


Inhibition of interleukin-1beta-induced matrix metalloproteinases 1 and 13 production in human osteoarthritic chondrocytes by prostaglandin D2.

Zayed N, Afif H, Chabane N, Mfuna-Endam L, Benderdour M, Martel-Pelletier J, Pelletier JP, Motiani RK, Trebak M, Duval N, Fahmi H.

Arthritis Rheum. 2008 Nov;58(11):3530-40. doi: 10.1002/art.23958.


Hsp90{beta} and p130(cas): novel regulatory factors of MMP-13 expression in human osteoarthritic chondrocytes.

Fan Z, Tardif G, Hum D, Duval N, Pelletier JP, Martel-Pelletier J.

Ann Rheum Dis. 2009 Jun;68(6):976-82. doi: 10.1136/ard.2008.092288. Epub 2008 Jul 1.


Differential modulation of RANKL isoforms by human osteoarthritic subchondral bone osteoblasts: influence of osteotropic factors.

Tat SK, Pelletier JP, Lajeunesse D, Fahmi H, Duval N, Martel-Pelletier J.

Bone. 2008 Aug;43(2):284-91. doi: 10.1016/j.bone.2008.04.006. Epub 2008 Apr 26.


Histone deacetylase inhibitors suppress interleukin-1beta-induced nitric oxide and prostaglandin E2 production in human chondrocytes.

Chabane N, Zayed N, Afif H, Mfuna-Endam L, Benderdour M, Boileau C, Martel-Pelletier J, Pelletier JP, Duval N, Fahmi H.

Osteoarthritis Cartilage. 2008 Oct;16(10):1267-74. doi: 10.1016/j.joca.2008.03.009. Epub 2008 Apr 15.


[Schizophrenia, special approach and continuity of care : The first episode program of Hôtel-Dieu Hospital in Lévis, Québec.].

Nicole L, Pires A, Routhier G, Bélanger R, Bussière G, L'heureux S, Gingras N, Rivard P, Chabot P, Descombes J, Sylvain C, Abdel-Baki A, Duval N, Vignola A, Rhéaume J.

Sante Ment Que. 1999;24(1):121-35. French.


Comparison of alumina-alumina to metal-polyethylene bearing surfaces in THA: a randomized study with 4- to 9-years follow-up.

Vendittoli P, Girard J, Lavigne M, Lavoie P, Duval N.

Acta Orthop Belg. 2007 Aug;73(4):468-77.


Gesture as an important factor in 3D kinematic assessment of the knee.

Lavoie F, Laplante M, Duval N, Doré S, de Guise JA.

Knee Surg Sports Traumatol Arthrosc. 2008 Jan;16(1):64-70. Epub 2007 Oct 13.


Randomised controlled trial comparing two methods of acetabular cup positioning during total hip arthroplasty.

Vendittoli PA, Ganapathi M, Duval N, Lavoie P, Roy A, Lavigne M.

Hip Int. 2007 Jul-Sep;17(3):137-42.


Intracellular localisation of galectin-3 has a protective role in chondrocyte survival.

Boileau C, Poirier F, Pelletier JP, Guévremont M, Duval N, Martel-Pelletier J, Reboul P.

Ann Rheum Dis. 2008 Feb;67(2):175-81. Epub 2007 Jun 1.


Extracellular localization of galectin-3 has a deleterious role in joint tissues.

Janelle-Montcalm A, Boileau C, Poirier F, Pelletier JP, Guévremont M, Duval N, Martel-Pelletier J, Reboul P.

Arthritis Res Ther. 2007;9(1):R20.

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