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Items: 44

1.

Cryo-EM structures and functional characterization of murine Slc26a9 reveal mechanism of uncoupled chloride transport.

Walter JD, Sawicka M, Dutzler R.

Elife. 2019 Jul 24;8. pii: e46986. doi: 10.7554/eLife.46986.

2.

Cryo-EM structures and functional characterization of the murine lipid scramblase TMEM16F.

Alvadia C, Lim NK, Clerico Mosina V, Oostergetel GT, Dutzler R, Paulino C.

Elife. 2019 Feb 20;8. pii: e44365. doi: 10.7554/eLife.44365.

3.

Stepwise activation mechanism of the scramblase nhTMEM16 revealed by cryo-EM.

Kalienkova V, Clerico Mosina V, Bryner L, Oostergetel GT, Dutzler R, Paulino C.

Elife. 2019 Feb 21;8. pii: e44364. doi: 10.7554/eLife.44364.

4.
5.

Structure of a volume-regulated anion channel of the LRRC8 family.

Deneka D, Sawicka M, Lam AKM, Paulino C, Dutzler R.

Nature. 2018 Jun;558(7709):254-259. doi: 10.1038/s41586-018-0134-y. Epub 2018 May 16.

PMID:
29769723
6.

Activation mechanism of the calcium-activated chloride channel TMEM16A revealed by cryo-EM.

Paulino C, Kalienkova V, Lam AKM, Neldner Y, Dutzler R.

Nature. 2017 Dec 21;552(7685):421-425. doi: 10.1038/nature24652. Epub 2017 Dec 13.

PMID:
29236691
7.

Generation and Characterization of Anti-VGLUT Nanobodies Acting as Inhibitors of Transport.

Schenck S, Kunz L, Sahlender D, Pardon E, Geertsma ER, Savtchouk I, Suzuki T, Neldner Y, Štefanić S, Steyaert J, Volterra A, Dutzler R.

Biochemistry. 2017 Aug 1;56(30):3962-3971. doi: 10.1021/acs.biochem.7b00436. Epub 2017 Jul 21.

PMID:
28731329
8.

Structural basis for anion conduction in the calcium-activated chloride channel TMEM16A.

Paulino C, Neldner Y, Lam AK, Kalienkova V, Brunner JD, Schenck S, Dutzler R.

Elife. 2017 May 31;6. pii: e26232. doi: 10.7554/eLife.26232.

9.

Structural and mechanistic basis of proton-coupled metal ion transport in the SLC11/NRAMP family.

Ehrnstorfer IA, Manatschal C, Arnold FM, Laederach J, Dutzler R.

Nat Commun. 2017 Jan 6;8:14033. doi: 10.1038/ncomms14033.

10.

Independent activation of ion conduction pores in the double-barreled calcium-activated chloride channel TMEM16A.

Lim NK, Lam AK, Dutzler R.

J Gen Physiol. 2016 Nov;148(5):375-392. Epub 2016 Oct 17.

11.

Structural basis for phospholipid scrambling in the TMEM16 family.

Brunner JD, Schenck S, Dutzler R.

Curr Opin Struct Biol. 2016 Aug;39:61-70. doi: 10.1016/j.sbi.2016.05.020. Epub 2016 Jun 10. Review.

PMID:
27295354
12.

Corrigendum: Structure of a prokaryotic fumarate transporter reveals the architecture of the SLC26 family.

Geertsma ER, Chang YN, Shaik FR, Neldner Y, Pardon E, Steyaert J, Dutzler R.

Nat Struct Mol Biol. 2016 May 4;23(5):462. doi: 10.1038/nsmb0516-462. No abstract available.

PMID:
27142325
13.

Signal Transduction at the Domain Interface of Prokaryotic Pentameric Ligand-Gated Ion Channels.

Bertozzi C, Zimmermann I, Engeler S, Hilf RJ, Dutzler R.

PLoS Biol. 2016 Mar 4;14(3):e1002393. doi: 10.1371/journal.pbio.1002393. eCollection 2016 Mar. Erratum in: PLoS Biol. 2016 Jun;14(6):e1002490.

14.

Structure of a prokaryotic fumarate transporter reveals the architecture of the SLC26 family.

Geertsma ER, Chang YN, Shaik FR, Neldner Y, Pardon E, Steyaert J, Dutzler R.

Nat Struct Mol Biol. 2015 Oct;22(10):803-8. doi: 10.1038/nsmb.3091. Epub 2015 Sep 14. Erratum in: Nat Struct Mol Biol. 2016 May 4;23 (5):462.

PMID:
26367249
15.

X-ray structure of a calcium-activated TMEM16 lipid scramblase.

Brunner JD, Lim NK, Schenck S, Duerst A, Dutzler R.

Nature. 2014 Dec 11;516(7530):207-12. doi: 10.1038/nature13984. Epub 2014 Nov 12.

PMID:
25383531
16.

Crystal structure of a SLC11 (NRAMP) transporter reveals the basis for transition-metal ion transport.

Ehrnstorfer IA, Geertsma ER, Pardon E, Steyaert J, Dutzler R.

Nat Struct Mol Biol. 2014 Nov;21(11):990-6. doi: 10.1038/nsmb.2904. Epub 2014 Oct 19.

PMID:
25326704
17.

Functional characterization of a ClC transporter by solid-supported membrane electrophysiology.

Garcia-Celma J, Szydelko A, Dutzler R.

J Gen Physiol. 2013 Apr;141(4):479-91. doi: 10.1085/jgp.201210927. Epub 2013 Mar 11.

18.

Inhibition of the prokaryotic pentameric ligand-gated ion channel ELIC by divalent cations.

Zimmermann I, Marabelli A, Bertozzi C, Sivilotti LG, Dutzler R.

PLoS Biol. 2012;10(11):e1001429. doi: 10.1371/journal.pbio.1001429. Epub 2012 Nov 20.

19.

Ligand activation of the prokaryotic pentameric ligand-gated ion channel ELIC.

Zimmermann I, Dutzler R.

PLoS Biol. 2011 Jun;9(6):e1001101. doi: 10.1371/journal.pbio.1001101. Epub 2011 Jun 21.

20.

A versatile and efficient high-throughput cloning tool for structural biology.

Geertsma ER, Dutzler R.

Biochemistry. 2011 Apr 19;50(15):3272-8. doi: 10.1021/bi200178z. Epub 2011 Mar 25.

PMID:
21410291
21.
22.

Structural basis of open channel block in a prokaryotic pentameric ligand-gated ion channel.

Hilf RJ, Bertozzi C, Zimmermann I, Reiter A, Trauner D, Dutzler R.

Nat Struct Mol Biol. 2010 Nov;17(11):1330-6. doi: 10.1038/nsmb.1933. Epub 2010 Oct 31.

PMID:
21037567
23.

A prokaryotic perspective on pentameric ligand-gated ion channel structure.

Hilf RJ, Dutzler R.

Curr Opin Struct Biol. 2009 Aug;19(4):418-24. doi: 10.1016/j.sbi.2009.07.006. Epub 2009 Jul 29. Review.

PMID:
19646860
24.

X-ray structure of the C-terminal domain of a prokaryotic cation-chloride cotransporter.

Warmuth S, Zimmermann I, Dutzler R.

Structure. 2009 Apr 15;17(4):538-46. doi: 10.1016/j.str.2009.02.009.

25.

Structure of a potentially open state of a proton-activated pentameric ligand-gated ion channel.

Hilf RJ, Dutzler R.

Nature. 2009 Jan 1;457(7225):115-8. doi: 10.1038/nature07461. Epub 2008 Nov 5.

PMID:
18987630
26.

X-ray structure of a prokaryotic pentameric ligand-gated ion channel.

Hilf RJ, Dutzler R.

Nature. 2008 Mar 20;452(7185):375-9. doi: 10.1038/nature06717. Epub 2008 Mar 5.

PMID:
18322461
27.
28.

The cytoplasmic domain of the chloride channel ClC-0: structural and dynamic characterization of flexible regions.

Alioth S, Meyer S, Dutzler R, Pervushin K.

J Mol Biol. 2007 Jun 22;369(5):1163-9. Epub 2007 Apr 14.

PMID:
17482645
29.

A structural perspective on ClC channel and transporter function.

Dutzler R.

FEBS Lett. 2007 Jun 19;581(15):2839-44. Epub 2007 Apr 18. Review.

30.

Nucleotide recognition by the cytoplasmic domain of the human chloride transporter ClC-5.

Meyer S, Savaresi S, Forster IC, Dutzler R.

Nat Struct Mol Biol. 2007 Jan;14(1):60-7. Epub 2006 Dec 31. Erratum in: Nat Struct Mol Biol. 2007 Feb;14(2):172.

PMID:
17195847
31.

Synergism between halide binding and proton transport in a CLC-type exchanger.

Accardi A, Lobet S, Williams C, Miller C, Dutzler R.

J Mol Biol. 2006 Sep 29;362(4):691-9. Epub 2006 Aug 2.

PMID:
16949616
32.

The ClC family of chloride channels and transporters.

Dutzler R.

Curr Opin Struct Biol. 2006 Aug;16(4):439-46. Epub 2006 Jun 30. Review.

PMID:
16814540
33.

Crystal structure of the cytoplasmic domain of the chloride channel ClC-0.

Meyer S, Dutzler R.

Structure. 2006 Feb;14(2):299-307.

34.

Ion-binding properties of the ClC chloride selectivity filter.

Lobet S, Dutzler R.

EMBO J. 2006 Jan 11;25(1):24-33. Epub 2005 Dec 8.

35.

The structural basis of ClC chloride channel function.

Dutzler R.

Trends Neurosci. 2004 Jun;27(6):315-20. Review.

PMID:
15165735
36.

Structural basis for ion conduction and gating in ClC chloride channels.

Dutzler R.

FEBS Lett. 2004 Apr 30;564(3):229-33. Review.

37.

Gating the selectivity filter in ClC chloride channels.

Dutzler R, Campbell EB, MacKinnon R.

Science. 2003 Apr 4;300(5616):108-12. Epub 2003 Mar 20.

38.

Translocation mechanism of long sugar chains across the maltoporin membrane channel.

Dutzler R, Schirmer T, Karplus M, Fischer S.

Structure. 2002 Sep;10(9):1273-84.

39.

X-ray structure of a ClC chloride channel at 3.0 A reveals the molecular basis of anion selectivity.

Dutzler R, Campbell EB, Cadene M, Chait BT, MacKinnon R.

Nature. 2002 Jan 17;415(6869):287-94.

PMID:
11796999
40.

Sucrose transport through maltoporin mutants of Escherichia coli.

Van Gelder P, Dutzler R, Dumas F, Koebnik R, Schirmer T.

Protein Eng. 2001 Nov;14(11):943-8.

PMID:
11742115
41.

Crystal structure and functional characterization of OmpK36, the osmoporin of Klebsiella pneumoniae.

Dutzler R, Rummel G, Albertí S, Hernández-Allés S, Phale P, Rosenbusch J, Benedí V, Schirmer T.

Structure. 1999 Apr 15;7(4):425-34.

42.

X-ray structure and conformational dynamics of the HIV-1 protease in complex with the inhibitor SDZ283-910: agreement of time-resolved spectroscopy and molecular dynamics simulations.

Ringhofer S, Kallen J, Dutzler R, Billich A, Visser AJ, Scholz D, Steinhauser O, Schreiber H, Auer M, Kungl AJ.

J Mol Biol. 1999 Mar 5;286(4):1147-59.

PMID:
10047488
43.

Channel specificity: structural basis for sugar discrimination and differential flux rates in maltoporin.

Wang YF, Dutzler R, Rizkallah PJ, Rosenbusch JP, Schirmer T.

J Mol Biol. 1997 Sep 12;272(1):56-63.

PMID:
9299337
44.

Crystal structures of various maltooligosaccharides bound to maltoporin reveal a specific sugar translocation pathway.

Dutzler R, Wang YF, Rizkallah P, Rosenbusch JP, Schirmer T.

Structure. 1996 Feb 15;4(2):127-34.

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