Sort by
Items per page

Send to

Choose Destination

Search results

Items: 1 to 50 of 122


Utility and limitations of serodiagnostic tests in monitoring the response to treatment of leprosy patients.

Duthie MS, Roferos FO, Abellana JF, Taborada T, Sanchez R, Maghanoy A, Balagon MF.

Diagn Microbiol Infect Dis. 2020 Jan 3:114984. doi: 10.1016/j.diagmicrobio.2019.114984. [Epub ahead of print]


A phase 1 antigen dose escalation trial to evaluate safety, tolerability and immunogenicity of the leprosy vaccine candidate LepVax (LEP-F1 + GLA-SE) in healthy adults.

Duthie MS, Frevol A, Day T, Coler RN, Vergara J, Rolf T, Sagawa ZK, Marie Beckmann A, Casper C, Reed SG.

Vaccine. 2020 Feb 11;38(7):1700-1707. doi: 10.1016/j.vaccine.2019.12.050. Epub 2019 Dec 30.


Allopurinol therapy provides long term clinical improvement, but additional immunotherapy is required for sustained parasite clearance, in L. infantum-infected dogs.

Nascimento LFM, Miranda DFH, Moura LD, Pinho FA, Werneck GL, Khouri R, Reed SG, Duthie MS, Barral A, Barral-Netto M, Cruz MSP.

Vaccine X. 2019 Nov 20;4:100048. doi: 10.1016/j.jvacx.2019.100048. eCollection 2020 Apr 9.


Serological and molecular detection of infection with Mycobacterium leprae in Brazilian six banded armadillos (Euphractus sexcinctus).

da Silva Ferreira J, de Carvalho FM, Vidal Pessolani MC, de Paula Antunes JMA, de Medeiros Oliveira IVP, Ferreira Moura GH, Truman RW, Peña MT, Sharma R, Duthie MS, de Paula Souza E Guimarães RJ, Nogueira Brum Fontes A, NoelSuffys P, McIntosh D.

Comp Immunol Microbiol Infect Dis. 2019 Nov 18;68:101397. doi: 10.1016/j.cimid.2019.101397. [Epub ahead of print]


Evaluation of antibody detection against the NDO-BSA, LID-1 and NDO-LID antigens as confirmatory tests to support the diagnosis of leprosy in Yunnan province, southwest China.

Jian L, Xiujian S, Yuangang Y, Yan X, Lianchao Y, Duthie MS, Yan W.

Trans R Soc Trop Med Hyg. 2019 Oct 31. pii: trz089. doi: 10.1093/trstmh/trz089. [Epub ahead of print]


Relationship of Serum Antileishmanial Antibody With Development of Visceral Leishmaniasis, Post-kala-azar Dermal Leishmaniasis and Visceral Leishmaniasis Relapse.

Mondal D, Ghosh P, Chowdhury R, Halleux C, Ruiz-Postigo JA, Alim A, Hossain F, Khan MAA, Nath R, Duthie MS, Kroeger A, Matlashewski G, Argaw D, Olliaro P.

Front Microbiol. 2019 Oct 9;10:2268. doi: 10.3389/fmicb.2019.02268. eCollection 2019.


Vaccines for leishmaniasis and the implications of their development for American tegumentary leishmaniasis.

Coutinho De Oliveira B, Duthie MS, Alves Pereira VR.

Hum Vaccin Immunother. 2019 Nov 11:1-12. doi: 10.1080/21645515.2019.1678998. [Epub ahead of print]


Impact of sequelae of visceral leishmaniasis and their contribution to ongoing transmission of Leishmania donovani.

Duthie MS, Goto Y, Ghosh P, Mondal D.

Pathog Dis. 2019 Aug 1;77(6). pii: ftz057. doi: 10.1093/femspd/ftz057.


Clinical and epidemiological indicators and spatial analysis of leprosy cases in patients under 15 years old in an endemic area of Northeast Brazil: an ecological and time series study.

Santos MB, Santos ADD, Barreto AS, Souza MDR, Goes MAO, Barreto Alves JA, Barreto IDC, Silva JS, Oliveira DT, Araújo KCGM, Duthie MS, Jesus AR.

BMJ Open. 2019 Jul 27;9(7):e023420. doi: 10.1136/bmjopen-2018-023420.


Social and environmental conditions related to Mycobacterium leprae infection in children and adolescents from three leprosy endemic regions of Colombia.

Serrano-Coll H, Mora HR, Beltrán JC, Duthie MS, Cardona-Castro N.

BMC Infect Dis. 2019 Jun 13;19(1):520. doi: 10.1186/s12879-019-4120-2.


Could canine visceral leishmaniosis take hold in the UK?

Duthie MS, Petersen C.

Vet Rec. 2019 Apr 6;184(14):438-440. doi: 10.1136/vr.l985. No abstract available.


Differential immunoglobulin and complement levels in leprosy prior to development of reversal reaction and erythema nodosum leprosum.

Amorim FM, Nobre ML, Nascimento LS, Miranda AM, Monteiro GRG, Freire-Neto FP, Queiroz MDCP, Queiroz JW, Duthie MS, Costa MR, Reed SG, Johnson WD Jr, Dupnik KM, Jeronimo SMB.

PLoS Negl Trop Dis. 2019 Jan 28;13(1):e0007089. doi: 10.1371/journal.pntd.0007089. eCollection 2019 Jan.


Mycobacterium leprae Recombinant Antigen Induces High Expression of Multifunction T Lymphocytes and Is Promising as a Specific Vaccine for Leprosy.

Bezerra-Santos M, do Vale-Simon M, Barreto AS, Cazzaniga RA, de Oliveira DT, Barrios MR, Ferreira AR, Santos-Bio NC, Reed SG, de Almeida RP, Corrêa CB, Duthie MS, de Jesus AR.

Front Immunol. 2018 Dec 12;9:2920. doi: 10.3389/fimmu.2018.02920. eCollection 2018.


Heterologous Immunization With Defined RNA and Subunit Vaccines Enhances T Cell Responses That Protect Against Leishmania donovani.

Duthie MS, Van Hoeven N, MacMillen Z, Picone A, Mohamath R, Erasmus J, Hsu FC, Stinchcomb DT, Reed SG.

Front Immunol. 2018 Oct 17;9:2420. doi: 10.3389/fimmu.2018.02420. eCollection 2018.


Correlates of GLA family adjuvants' activities.

Reed SG, Carter D, Casper C, Duthie MS, Fox CB.

Semin Immunol. 2018 Oct;39:22-29. doi: 10.1016/j.smim.2018.10.004. Epub 2018 Oct 23. Review.


Computationally Designed Bispecific MD2/CD14 Binding Peptides Show TLR4 Agonist Activity.

Michaeli A, Mezan S, Kühbacher A, Finkelmeier D, Elias M, Zatsepin M, Reed SG, Duthie MS, Rupp S, Lerner I, Burger-Kentischer A.

J Immunol. 2018 Dec 1;201(11):3383-3391. doi: 10.4049/jimmunol.1800380. Epub 2018 Oct 22.


Evaluation of Real-time PCR for Diagnosis of Post-Kala-azar Dermal Leishmaniasis in Endemic Foci of Bangladesh.

Ghosh P, Hasnain MG, Hossain F, Khan MAA, Chowdhury R, Faisal K, Mural MA, Baker J, Nath R, Ghosh D, Maruf S, Shomik MS, Haque R, Matlashewski G, Hamano S, Duthie MS, Mondal D.

Open Forum Infect Dis. 2018 Sep 15;5(10):ofy234. doi: 10.1093/ofid/ofy234. eCollection 2018 Oct.


Second coming: the re-emergence and modernization of immunotherapy by vaccines as a component of leprosy control.

Duthie MS, Casper C, Reed SG.

Future Microbiol. 2018 Oct;13:1449-1451. doi: 10.2217/fmb-2018-0186. Epub 2018 Oct 12. No abstract available.


Advances toward Diagnostic Tools for Managing Zoonotic Visceral Leishmaniasis.

Duthie MS, Lison A, Courtenay O.

Trends Parasitol. 2018 Oct;34(10):881-890. doi: 10.1016/ Epub 2018 Aug 18. Review.



Carter D, Duthie MS, Reed SG.

Curr Top Microbiol Immunol. 2018 Jul 25. doi: 10.1007/82_2018_112. [Epub ahead of print]


Assessing epidemiology of leprosy and socio-economic distribution of cases.

Matos AMF, Coelho ACO, Araújo LPT, Alves MJM, Baquero OS, Duthie MS, Teixeira HC.

Epidemiol Infect. 2018 Oct;146(14):1750-1755. doi: 10.1017/S0950268818001814. Epub 2018 Jul 6.


Erratum: Author Correction: LepVax, a defined subunit vaccine that provides effective pre-exposure and post-exposure prophylaxis of M. leprae infection.

Duthie MS, Pena MT, Ebenezer GJ, Gillis TP, Sharma R, Cunningham K, Polydefkis M, Maeda Y, Makino M, Truman RW, Reed SG.

NPJ Vaccines. 2018 May 15;3:18. doi: 10.1038/s41541-018-0055-7. eCollection 2018.


LepVax, a defined subunit vaccine that provides effective pre-exposure and post-exposure prophylaxis of M. leprae infection.

Duthie MS, Pena MT, Ebenezer GJ, Gillis TP, Sharma R, Cunningham K, Polydefkis M, Maeda Y, Makino M, Truman RW, Reed SG.

NPJ Vaccines. 2018 Mar 28;3:12. doi: 10.1038/s41541-018-0050-z. eCollection 2018. Erratum in: NPJ Vaccines. 2018 May 15;3:18.


Utility of immunoglobulin isotypes against LID-1 and NDO-LID for, particularly IgG1, confirming the diagnosis of multibacillary leprosy.

Marçal PHF, Fraga LAO, Mattos AMM, Menegati L, Coelho ADCO, Pinheiro RO, Sarno EN, Duthie MS, Teixeira HC.

Mem Inst Oswaldo Cruz. 2018;113(5):e170467. doi: 10.1590/0074-02760170467. Epub 2018 Feb 26.


A defined subunit vaccine that protects against vector-borne visceral leishmaniasis.

Duthie MS, Pereira L, Favila M, Hofmeyer KA, Reed SJ, Metangmo S, Townsend S, Laurance JD, Picone A, Misquith A, Hossain F, Ghosh P, Khan MAA, Guderian J, Bailor HR, Liang H, Vergara J, Oliveira F, Howard RF, Kamhawi S, Mondal D, Coler RN, Valenzuela JG, Reed SG.

NPJ Vaccines. 2017 Aug 21;2:23. doi: 10.1038/s41541-017-0025-5. eCollection 2017.


Comparison of Enzyme-Linked Immunosorbent Assay Using Either Natural Octyl Disaccharide-Leprosy IDRI Diagnostic or Phenolic Glycolipid-I Antigens for the Detection of Leprosy Patients in Colombia.

Muñoz M, Beltrán-Alzate JC, Duthie MS, Serrano-Coll H, Cardona-Castro N.

Am J Trop Med Hyg. 2018 Jan;98(1):274-277. doi: 10.4269/ajtmh.17-0500. Epub 2018 Jan 1.


Real-time PCR in detection and quantitation of Leishmania donovani for the diagnosis of Visceral Leishmaniasis patients and the monitoring of their response to treatment.

Hossain F, Ghosh P, Khan MAA, Duthie MS, Vallur AC, Picone A, Howard RF, Reed SG, Mondal D.

PLoS One. 2017 Sep 28;12(9):e0185606. doi: 10.1371/journal.pone.0185606. eCollection 2017.


Nitazoxanide is active against Mycobacterium leprae.

Bailey MA, Na H, Duthie MS, Gillis TP, Lahiri R, Parish T.

PLoS One. 2017 Aug 29;12(8):e0184107. doi: 10.1371/journal.pone.0184107. eCollection 2017.


Anti-natural octyl disaccharide-leprosy IDRI diagnostic (NDO-LID) antibodies as indicators of leprosy reactions and neuritis.

Serrano-Coll H, Muñoz M, Camilo Beltrán J, Duthie MS, Cardona-Castro N.

Trans R Soc Trop Med Hyg. 2017 Mar 1;111(3):125-131. doi: 10.1093/trstmh/trx026.


Not All Antigens Are Created Equally: Progress, Challenges, and Lessons Associated with Developing a Vaccine for Leishmaniasis.

Duthie MS, Reed SG.

Clin Vaccine Immunol. 2017 Jul 5;24(7). pii: e00108-17. doi: 10.1128/CVI.00108-17. Print 2017 Jul. Review.


Distinct Roles of Th17 and Th1 Cells in Inflammatory Responses Associated with the Presentation of Paucibacillary Leprosy and Leprosy Reactions.

Santos MB, de Oliveira DT, Cazzaniga RA, Varjão CS, Dos Santos PL, Santos MLB, Correia CB, Faria DR, Simon MDV, Silva JS, Dutra WO, Reed SG, Duthie MS, de Almeida RP, de Jesus AR.

Scand J Immunol. 2017 Jul;86(1):40-49. doi: 10.1111/sji.12558.


sCD163 levels as a biomarker of disease severity in leprosy and visceral leishmaniasis.

Silva RL, Santos MB, Almeida PL, Barros TS, Magalhães L, Cazzaniga RA, Souza PR, Luz NF, França-Costa J, Borges VM, Lima-Junior DS, Lipscomb MW, Duthie MS, Reed SG, Almeida RP, Jesus AR.

PLoS Negl Trop Dis. 2017 Mar 29;11(3):e0005486. doi: 10.1371/journal.pntd.0005486. eCollection 2017 Mar.


Unexpectedly high leprosy seroprevalence detected using a random surveillance strategy in midwestern Brazil: A comparison of ELISA and a rapid diagnostic test.

Frade MA, de Paula NA, Gomes CM, Vernal S, Bernardes Filho F, Lugão HB, de Abreu MM, Botini P, Duthie MS, Spencer JS, Soares RC, Foss NT.

PLoS Negl Trop Dis. 2017 Feb 23;11(2):e0005375. doi: 10.1371/journal.pntd.0005375. eCollection 2017 Feb.


The influence of innate and adaptative immune responses on the differential clinical outcomes of leprosy.

Fonseca AB, Simon MD, Cazzaniga RA, de Moura TR, de Almeida RP, Duthie MS, Reed SG, de Jesus AR.

Infect Dis Poverty. 2017 Feb 6;6(1):5. doi: 10.1186/s40249-016-0229-3. Review.


Antigen-specific secretion of IFNγ and CXCL10 in whole blood assay detects Mycobacterium leprae infection but does not discriminate asymptomatic infection from symptomatic leprosy.

Hungria EM, Freitas AA, Pontes MA, Gonçalves HS, Sousa AL, Costa MB, Castilho ML, Duthie MS, Stefani MM.

Diagn Microbiol Infect Dis. 2017 Apr;87(4):328-334. doi: 10.1016/j.diagmicrobio.2017.01.002. Epub 2017 Jan 5.


A structure-function approach to optimizing TLR4 ligands for human vaccines.

Carter D, Fox CB, Day TA, Guderian JA, Liang H, Rolf T, Vergara J, Sagawa ZK, Ireton G, Orr MT, Desbien A, Duthie MS, Coler RN, Reed SG.

Clin Transl Immunology. 2016 Nov 2;5(11):e108. eCollection 2016 Nov.


Use of Recombinant Antigens for Sensitive Serodiagnosis of American Tegumentary Leishmaniasis Caused by Different Leishmania Species.

Sato CM, Sanchez MC, Celeste BJ, Duthie MS, Guderian J, Reed SG, de Brito ME, Campos MB, de Souza Encarnação HV, Guerra J, de Mesquita TG, Pinheiro SK, Ramasawmy R, Silveira FT, de Assis Souza M, Goto H.

J Clin Microbiol. 2017 Feb;55(2):495-503. doi: 10.1128/JCM.01904-16. Epub 2016 Dec 7.


Semi-quantitative measurement of asymptomatic L. infantum infection and symptomatic visceral leishmaniasis in dogs using Dual-Path Platform® CVL.

Larson M, Toepp A, Scott B; EPID:158:001, Kurtz M, Fowler H, Esfandiari J, Howard RF, Vallur AC, Duthie MS, Petersen C.

Appl Microbiol Biotechnol. 2017 Jan;101(1):381-390. doi: 10.1007/s00253-016-7925-6. Epub 2016 Oct 31.


IL-18 and Subcapsular Lymph Node Macrophages are Essential for Enhanced B Cell Responses with TLR4 Agonist Adjuvants.

Desbien AL, Dubois Cauwelaert N, Reed SJ, Bailor HR, Liang H, Carter D, Duthie MS, Fox CB, Reed SG, Orr MT.

J Immunol. 2016 Dec 1;197(11):4351-4359. Epub 2016 Oct 28.


Recovery of antigen-specific T cell responses from dogs infected with Leishmania (L.) infantum by use of vaccine associated TLR-agonist adjuvant.

Schaut RG, Grinnage-Pulley TL, Esch KJ, Toepp AJ, Duthie MS, Howard RF, Reed SG, Petersen CA.

Vaccine. 2016 Oct 17;34(44):5225-5234. doi: 10.1016/j.vaccine.2016.09.016. Epub 2016 Sep 21.


Identifying Leprosy and Those at Risk of Developing Leprosy by Detection of Antibodies against LID-1 and LID-NDO.

Amorim FM, Nobre ML, Ferreira LC, Nascimento LS, Miranda AM, Monteiro GR, Dupnik KM, Duthie MS, Reed SG, Jeronimo SM.

PLoS Negl Trop Dis. 2016 Sep 22;10(9):e0004934. doi: 10.1371/journal.pntd.0004934. eCollection 2016 Sep.


Application of Mycobacterium Leprae-specific cellular and serological tests for the differential diagnosis of leprosy from confounding dermatoses.

Freitas AA, Hungria EM, Costa MB, Sousa AL, Castilho ML, Gonçalves HS, Pontes MA, Duthie MS, Stefani MM.

Diagn Microbiol Infect Dis. 2016 Oct;86(2):163-8. doi: 10.1016/j.diagmicrobio.2016.07.024. Epub 2016 Jul 27.


Optimizing Immunization Strategies for the Induction of Antigen-Specific CD4 and CD8 T Cell Responses for Protection against Intracellular Parasites.

Hofmeyer KA, Duthie MS, Laurance JD, Favila MA, Van Hoeven N, Coler RN, Reed SG.

Clin Vaccine Immunol. 2016 Sep 6;23(9):785-94. doi: 10.1128/CVI.00251-16. Print 2016 Sep.


Evaluation of diagnostic performance of rK28 ELISA using urine for diagnosis of visceral leishmaniasis.

Ghosh P, Bhaskar KR, Hossain F, Khan MA, Vallur AC, Duthie MS, Hamano S, Salam MA, Huda MM, Khan MG, Coler RN, Reed SG, Mondal D.

Parasit Vectors. 2016 Jul 4;9(1):383. doi: 10.1186/s13071-016-1667-2.


Tuberculosis and leprosy infections in the Marshallese population of Arkansas, USA.

Cardenas VM, Orloff MS, Kaminaga J, Cardenas IC, Brown J, Hainline-Williams S, Duthie MS, Gonzalez-Puche AC, Mukasa L, Patil N, Mcelfish PA, Bates JH.

Lepr Rev. 2016 Mar;87(1):109-12.


Need for, and acceptability of, rapid diagnostic tests that can facilitate the diagnosis of leprosy.

Duthie MS, Orcullo FM, Maghanoy A, Balagon MF.

Lepr Rev. 2016 Jun;87(2):158-70.


Integrative literature review of the reported uses of serological tests in leprosy management.

Fabri Ada C, Carvalho AP, Vieira NF, Bueno Ide C, Rodrigues RN, Monteiro TB, Correa-Oliveira R, Duthie MS, Lana FC.

Rev Soc Bras Med Trop. 2016 Apr;49(2):158-64. doi: 10.1590/0037-8682-0226-2015. Review.


Combination chemoprophylaxis and immunoprophylaxis in reducing the incidence of leprosy.

Duthie MS, Balagon MF.

Risk Manag Healthc Policy. 2016 Apr 27;9:43-53. doi: 10.2147/RMHP.S76058. eCollection 2016. Review.


Strategic evaluation of vaccine candidate antigens for the prevention of Visceral Leishmaniasis.

Duthie MS, Favila M, Hofmeyer KA, Tutterrow YL, Reed SJ, Laurance JD, Picone A, Guderian J, Bailor HR, Vallur AC, Liang H, Mohamath R, Vergara J, Howard RF, Coler RN, Reed SG.

Vaccine. 2016 May 27;34(25):2779-86. doi: 10.1016/j.vaccine.2016.04.067. Epub 2016 May 1.


Vaccination with the Surface Proteins MUL_2232 and MUL_3720 of Mycobacterium ulcerans Induces Antibodies but Fails to Provide Protection against Buruli Ulcer.

Bolz M, Bénard A, Dreyer AM, Kerber S, Vettiger A, Oehlmann W, Singh M, Duthie MS, Pluschke G.

PLoS Negl Trop Dis. 2016 Feb 5;10(2):e0004431. doi: 10.1371/journal.pntd.0004431. eCollection 2016 Feb.

Supplemental Content

Loading ...
Support Center