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Items: 36

1.

Dose evaluation of intravenous metamizole (dipyrone) in infants and children: a prospective population pharmacokinetic study.

Ziesenitz VC, Rodieux F, Atkinson A, Borter C, Bielicki JA, Haschke M, Duthaler U, Bachmann F, Erb TO, Gürtler N, Holland-Cunz S, van den Anker JN, Gotta V, Pfister M.

Eur J Clin Pharmacol. 2019 Aug 7. doi: 10.1007/s00228-019-02720-2. [Epub ahead of print]

PMID:
31388703
2.

Toxicity of metamizole on differentiating HL60 cells and human neutrophil granulocytes.

Rudin D, Roos NJ, Duthaler U, Krähenbühl S.

Toxicology. 2019 Jul 26;426:152254. doi: 10.1016/j.tox.2019.152254. [Epub ahead of print]

PMID:
31356851
3.

OATP1B3-1B7 (LST-3TM12) Is a Drug Transporter That Affects Endoplasmic Reticulum Access and the Metabolism of Ezetimibe.

Malagnino V, Duthaler U, Seibert I, Krähenbühl S, Meyer Zu Schwabedissen HE.

Mol Pharmacol. 2019 Aug;96(2):128-137. doi: 10.1124/mol.118.114934. Epub 2019 May 24.

PMID:
31127008
4.

Development and validation of an LC-MS/MS method for the analysis of ivermectin in plasma, whole blood, and dried blood spots using a fully automatic extraction system.

Duthaler U, Suenderhauf C, Gaugler S, Vetter B, Krähenbühl S, Hammann F.

J Pharm Biomed Anal. 2019 Aug 5;172:18-25. doi: 10.1016/j.jpba.2019.04.007. Epub 2019 Apr 16.

PMID:
31015095
5.

Cytochrome P450 enzymes contribute to the metabolism of LSD to nor-LSD and 2-oxo-3-hydroxy-LSD: Implications for clinical LSD use.

Luethi D, Hoener MC, Krähenbühl S, Liechti ME, Duthaler U.

Biochem Pharmacol. 2019 Jun;164:129-138. doi: 10.1016/j.bcp.2019.04.013. Epub 2019 Apr 11.

PMID:
30981875
6.

Pharmacokinetics and subjective effects of a novel oral LSD formulation in healthy subjects.

Holze F, Duthaler U, Vizeli P, Müller F, Borgwardt S, Liechti ME.

Br J Clin Pharmacol. 2019 Jul;85(7):1474-1483. doi: 10.1111/bcp.13918. Epub 2019 Apr 29.

PMID:
30883864
7.

Population pharmacokinetics of oral ivermectin in venous plasma and dried blood spots in healthy volunteers.

Duthaler U, Suenderhauf C, Karlsson MO, Hussner J, Meyer Zu Schwabedissen H, Krähenbühl S, Hammann F.

Br J Clin Pharmacol. 2019 Mar;85(3):626-633. doi: 10.1111/bcp.13840. Epub 2019 Jan 24.

PMID:
30566757
8.

PGC-1β modulates statin-associated myotoxicity in mice.

Singh F, Zoll J, Duthaler U, Charles AL, Panajatovic MV, Laverny G, McWilliams TG, Metzger D, Geny B, Krähenbühl S, Bouitbir J.

Arch Toxicol. 2019 Feb;93(2):487-504. doi: 10.1007/s00204-018-2369-7. Epub 2018 Dec 3.

PMID:
30511338
9.

Pharmacokinetics of oxycodone/naloxone and its metabolites in patients with end-stage renal disease during and between haemodialysis sessions.

Leuppi-Taegtmeyer A, Duthaler U, Hammann F, Schmid Y, Dickenmann M, Amico P, Jehle AW, Kalbermatter S, Lenherr C, Meyer Zu Schwabedissen HE, Haschke M, Liechti ME, Krähenbühl S.

Nephrol Dial Transplant. 2019 Apr 1;34(4):692-702. doi: 10.1093/ndt/gfy285.

PMID:
30189012
10.

Cytochrome P450 Enzymes Involved in Metoprolol Metabolism and Use of Metoprolol as a CYP2D6 Phenotyping Probe Drug.

Berger B, Bachmann F, Duthaler U, Krähenbühl S, Haschke M.

Front Pharmacol. 2018 Jul 24;9:774. doi: 10.3389/fphar.2018.00774. eCollection 2018.

11.

Using dried blood spots to facilitate therapeutic drug monitoring of antiretroviral drugs in resource-poor regions.

Duthaler U, Berger B, Erb S, Battegay M, Letang E, Gaugler S, Natamatungiro A, Mnzava D, Donzelli M, Krähenbühl S, Haschke M.

J Antimicrob Chemother. 2018 Oct 1;73(10):2729-2737. doi: 10.1093/jac/dky254.

PMID:
30052975
12.

Sunitinib induces hepatocyte mitochondrial damage and apoptosis in mice.

Paech F, Abegg VF, Duthaler U, Terracciano L, Bouitbir J, Krähenbühl S.

Toxicology. 2018 Nov 1;409:13-23. doi: 10.1016/j.tox.2018.07.009. Epub 2018 Jul 18.

PMID:
30031043
13.

N-demethylation of N-methyl-4-aminoantipyrine, the main metabolite of metamizole.

Bachmann F, Duthaler U, Rudin D, Krähenbühl S, Haschke M.

Eur J Pharm Sci. 2018 Jul 30;120:172-180. doi: 10.1016/j.ejps.2018.05.003. Epub 2018 May 8.

PMID:
29746911
14.

Effect of Toxicants on Fatty Acid Metabolism in HepG2 Cells.

Grünig D, Duthaler U, Krähenbühl S.

Front Pharmacol. 2018 Apr 23;9:257. doi: 10.3389/fphar.2018.00257. eCollection 2018.

15.

Effect of the Catechol-O-Methyltransferase Inhibitors Tolcapone and Entacapone on Fatty Acid Metabolism in HepaRG Cells.

Grünig D, Felser A, Duthaler U, Bouitbir J, Krähenbühl S.

Toxicol Sci. 2018 Aug 1;164(2):477-488. doi: 10.1093/toxsci/kfy101.

PMID:
29688484
16.

Automated high throughput analysis of antiretroviral drugs in dried blood spots.

Duthaler U, Berger B, Erb S, Battegay M, Letang E, Gaugler S, Krähenbühl S, Haschke M.

J Mass Spectrom. 2017 Aug;52(8):534-542. doi: 10.1002/jms.3952.

PMID:
28557187
17.

Health care provider communication training in rural Tanzania empowers HIV-infected patients on antiretroviral therapy to discuss adherence problems.

Erb S, Letang E, Glass TR, Natamatungiro A, Mnzava D, Mapesi H, Haschke M, Duthaler U, Berger B, Muri L, Bader J, Marzolini C, Elzi L, Klimkait T, Langewitz W, Battegay M; Kilombero Ulanga Antiretroviral Cohort (KIULARCO) study group.

HIV Med. 2017 Oct;18(9):623-634. doi: 10.1111/hiv.12499. Epub 2017 Mar 13.

18.

Impaired Exercise Performance and Skeletal Muscle Mitochondrial Function in Rats with Secondary Carnitine Deficiency.

Bouitbir J, Haegler P, Singh F, Joerin L, Felser A, Duthaler U, Krähenbühl S.

Front Physiol. 2016 Aug 10;7:345. doi: 10.3389/fphys.2016.00345. eCollection 2016.

19.

Efficacy and safety of tribendimidine against Opisthorchis viverrini: two randomised, parallel-group, single-blind, dose-ranging, phase 2 trials.

Sayasone S, Odermatt P, Vonghachack Y, Xayavong S, Senggnam K, Duthaler U, Akkhavong K, Hattendorf J, Keiser J.

Lancet Infect Dis. 2016 Oct;16(10):1145-1153. doi: 10.1016/S1473-3099(16)30198-0. Epub 2016 Jul 26.

PMID:
27472949
20.

Single-Ascending-Dose Pharmacokinetic Study of Tribendimidine in Opisthorchis viverrini-Infected Patients.

Duthaler U, Sayasone S, Vanobbergen F, Penny MA, Odermatt P, Huwyler J, Keiser J.

Antimicrob Agents Chemother. 2016 Sep 23;60(10):5705-15. doi: 10.1128/AAC.00992-16. Print 2016 Oct.

21.

Population Pharmacokinetic Modeling of Tribendimidine Metabolites in Opisthorchis viverrini-Infected Adults.

Vanobberghen F, Penny MA, Duthaler U, Odermatt P, Sayasone S, Keiser J, Tarning J.

Antimicrob Agents Chemother. 2016 Sep 23;60(10):5695-704. doi: 10.1128/AAC.00655-16. Print 2016 Oct.

22.

Pharmacokinetic Study of Praziquantel Enantiomers and Its Main Metabolite R-trans-4-OH-PZQ in Plasma, Blood and Dried Blood Spots in Opisthorchis viverrini-Infected Patients.

Meister I, Kovac J, Duthaler U, Odermatt P, Huwyler J, Vanobberghen F, Sayasone S, Keiser J.

PLoS Negl Trop Dis. 2016 May 6;10(5):e0004700. doi: 10.1371/journal.pntd.0004700. eCollection 2016 May.

23.

Development and validation of an enantioselective LC-MS/MS method for the analysis of the anthelmintic drug praziquantel and its main metabolite in human plasma, blood and dried blood spots.

Meister I, Leonidova A, Kovač J, Duthaler U, Keiser J, Huwyler J.

J Pharm Biomed Anal. 2016 Jan 25;118:81-88. doi: 10.1016/j.jpba.2015.10.011. Epub 2015 Oct 22.

PMID:
26517852
24.

Interactions between bupropion and 3,4-methylenedioxymethamphetamine in healthy subjects.

Schmid Y, Rickli A, Schaffner A, Duthaler U, Grouzmann E, Hysek CM, Liechti ME.

J Pharmacol Exp Ther. 2015 Apr;353(1):102-11. doi: 10.1124/jpet.114.222356. Epub 2015 Feb 5.

PMID:
25655950
25.

LC-MS/MS method for the determination of two metabolites of tribendimidine, deacylated amidantel and its acetylated metabolite in plasma, blood and dried blood spots.

Duthaler U, Keiser J, Huwyler J.

J Pharm Biomed Anal. 2015 Feb;105:163-73. doi: 10.1016/j.jpba.2014.12.006. Epub 2014 Dec 12.

PMID:
25553533
26.

Repurposing drugs for the treatment and control of helminth infections.

Panic G, Duthaler U, Speich B, Keiser J.

Int J Parasitol Drugs Drug Resist. 2014 Jul 30;4(3):185-200. doi: 10.1016/j.ijpddr.2014.07.002. eCollection 2014 Dec. Review.

27.

Efficacy and pharmacokinetics of OZ78 and MT04 against a natural infection with Fasciola hepatica in sheep.

Meister I, Duthaler U, Huwyler J, Rinaldi L, Bosco A, Cringoli G, Keiser J.

Vet Parasitol. 2013 Nov 15;198(1-2):102-10. doi: 10.1016/j.vetpar.2013.08.007. Epub 2013 Aug 14.

PMID:
24011678
28.

Disposition of mefloquine and enpiroline is highly influenced by a chronic Schistosoma mansoni infection.

Ingram K, Duthaler U, Vargas M, Ellis W, Keiser J.

Antimicrob Agents Chemother. 2013 Sep;57(9):4506-11. doi: 10.1128/AAC.01129-13. Epub 2013 Jul 8.

29.

Systematic evaluation of extraction methods for multiplatform-based metabotyping: application to the Fasciola hepatica metabolome.

Saric J, Want EJ, Duthaler U, Lewis M, Keiser J, Shockcor JP, Ross GA, Nicholson JK, Holmes E, Tavares MF.

Anal Chem. 2012 Aug 21;84(16):6963-72. doi: 10.1021/ac300586m. Epub 2012 Aug 10.

30.

Trematode infections: liver and lung flukes.

Fürst T, Duthaler U, Sripa B, Utzinger J, Keiser J.

Infect Dis Clin North Am. 2012 Jun;26(2):399-419. doi: 10.1016/j.idc.2012.03.008.

PMID:
22632646
31.

Evaluation of the pharmacokinetic profile of artesunate, artemether and their metabolites in sheep naturally infected with Fasciola hepatica.

Duthaler U, Huwyler J, Rinaldi L, Cringoli G, Keiser J.

Vet Parasitol. 2012 May 25;186(3-4):270-80. doi: 10.1016/j.vetpar.2011.11.076. Epub 2011 Dec 6.

PMID:
22206644
33.

In vivo and in vitro sensitivity of Fasciola hepatica to triclabendazole combined with artesunate, artemether, or OZ78.

Duthaler U, Smith TA, Keiser J.

Antimicrob Agents Chemother. 2010 Nov;54(11):4596-604. doi: 10.1128/AAC.00828-10. Epub 2010 Aug 23.

34.

Update on the diagnosis and treatment of food-borne trematode infections.

Keiser J, Duthaler U, Utzinger J.

Curr Opin Infect Dis. 2010 Oct;23(5):513-20. doi: 10.1097/QCO.0b013e32833de06a. Review.

PMID:
20683264
35.

Fasciola hepatica: comparison of the sedimentation and FLOTAC techniques for the detection and quantification of faecal egg counts in rats.

Duthaler U, Rinaldi L, Maurelli MP, Vargas M, Utzinger J, Cringoli G, Keiser J.

Exp Parasitol. 2010 Oct;126(2):161-6. doi: 10.1016/j.exppara.2010.04.020. Epub 2010 Apr 29.

PMID:
20434442
36.

Anthelmintic activity of artesunate against Fasciola hepatica in naturally infected sheep.

Keiser J, Veneziano V, Rinaldi L, Mezzino L, Duthaler U, Cringoli G.

Res Vet Sci. 2010 Feb;88(1):107-10. doi: 10.1016/j.rvsc.2009.05.007. Epub 2009 Jun 5.

PMID:
19501379

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