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Conotoxins: Chemistry and Biology.

Jin AH, Muttenthaler M, Dutertre S, Himaya SWA, Kaas Q, Craik DJ, Lewis RJ, Alewood PF.

Chem Rev. 2019 Nov 13;119(21):11510-11549. doi: 10.1021/acs.chemrev.9b00207. Epub 2019 Oct 21.


Poly(ADP-ribose)-dependent chromatin unfolding facilitates the association of DNA-binding proteins with DNA at sites of damage.

Smith R, Lebeaupin T, Juhász S, Chapuis C, D'Augustin O, Dutertre S, Burkovics P, Biertümpfel C, Timinszky G, Huet S.

Nucleic Acids Res. 2019 Dec 2;47(21):11250-11267. doi: 10.1093/nar/gkz820.


Periplasmic Expression of 4/7 α-Conotoxin TxIA Analogs in E. coli Favors Ribbon Isomer Formation - Suggestion of a Binding Mode at the α7 nAChR.

El Hamdaoui Y, Wu X, Clark RJ, Giribaldi J, Anangi R, Craik DJ, King GF, Dutertre S, Kaas Q, Herzig V, Nicke A.

Front Pharmacol. 2019 May 31;10:577. doi: 10.3389/fphar.2019.00577. eCollection 2019.


Staphylococcus aureus induces DNA damage in host cell.

Deplanche M, Mouhali N, Nguyen MT, Cauty C, Ezan F, Diot A, Raulin L, Dutertre S, Langouet S, Legembre P, Taieb F, Otto M, Laurent F, Götz F, Le Loir Y, Berkova N.

Sci Rep. 2019 May 22;9(1):7694. doi: 10.1038/s41598-019-44213-3.


Transcriptomic-Proteomic Correlation in the Predation-Evoked Venom of the Cone Snail, Conus imperialis.

Jin AH, Dutertre S, Dutt M, Lavergne V, Jones A, Lewis RJ, Alewood PF.

Mar Drugs. 2019 Mar 19;17(3). pii: E177. doi: 10.3390/md17030177.


A Recurrent Motif: Diversity and Evolution of ShKT Domain Containing Proteins in the Vampire Snail Cumia reticulata.

Gerdol M, Cervelli M, Mariottini P, Oliverio M, Dutertre S, Modica MV.

Toxins (Basel). 2019 Feb 12;11(2). pii: E106. doi: 10.3390/toxins11020106.


Venomics Reveals Venom Complexity of the Piscivorous Cone Snail, Conus tulipa.

Dutt M, Dutertre S, Jin AH, Lavergne V, Alewood PF, Lewis RJ.

Mar Drugs. 2019 Jan 21;17(1). pii: E71. doi: 10.3390/md17010071.


N-Terminal Liver-Expressed Antimicrobial Peptide 2 (LEAP2) Region Exhibits Inverse Agonist Activity toward the Ghrelin Receptor.

M'Kadmi C, Cabral A, Barrile F, Giribaldi J, Cantel S, Damian M, Mary S, Denoyelle S, Dutertre S, Péraldi-Roux S, Neasta J, Oiry C, Banères JL, Marie J, Perello M, Fehrentz JA.

J Med Chem. 2019 Jan 24;62(2):965-973. doi: 10.1021/acs.jmedchem.8b01644. Epub 2018 Dec 24.


Novel analgesic ω-conotoxins from the vermivorous cone snail Conus moncuri provide new insights into the evolution of conopeptides.

Sousa SR, McArthur JR, Brust A, Bhola RF, Rosengren KJ, Ragnarsson L, Dutertre S, Alewood PF, Christie MJ, Adams DJ, Vetter I, Lewis RJ.

Sci Rep. 2018 Sep 7;8(1):13397. doi: 10.1038/s41598-018-31245-4.


Endotoxin regulates matrix genes increasing reactive oxygen species generation by intercellular communication between palmitate-treated hepatocyte and stellate cell.

Dornas W, Glaise D, Bodin A, Sharanek A, Burban A, Le Guillou D, Robert S, Dutertre S, Aninat C, Corlu A, Lagente V.

J Cell Physiol. 2018 Jan;234(1):122-133. doi: 10.1002/jcp.27175. Epub 2018 Sep 7.


Synthesis, Structure and Biological Activity of CIA and CIB, Two α-Conotoxins from the Predation-Evoked Venom of Conus catus.

Giribaldi J, Wilson D, Nicke A, El Hamdaoui Y, Laconde G, Faucherre A, Moha Ou Maati H, Daly NL, Enjalbal C, Dutertre S.

Toxins (Basel). 2018 Jun 1;10(6). pii: E222. doi: 10.3390/toxins10060222.


A targeted 3D EM and correlative microscopy method using SEM array tomography.

Burel A, Lavault MT, Chevalier C, Gnaegi H, Prigent S, Mucciolo A, Dutertre S, Humbel BM, Guillaudeux T, Kolotuev I.

Development. 2018 Jun 21;145(12). pii: dev160879. doi: 10.1242/dev.160879.


A Dipteran's Novel Sucker Punch: Evolution of Arthropod Atypical Venom with a Neurotoxic Component in Robber Flies (Asilidae, Diptera).

Drukewitz SH, Fuhrmann N, Undheim EAB, Blanke A, Giribaldi J, Mary R, Laconde G, Dutertre S, von Reumont BM.

Toxins (Basel). 2018 Jan 5;10(1). pii: E29. doi: 10.3390/toxins10010029.


α-Conotoxins to explore the molecular, physiological and pathophysiological functions of neuronal nicotinic acetylcholine receptors.

Giribaldi J, Dutertre S.

Neurosci Lett. 2018 Jul 13;679:24-34. doi: 10.1016/j.neulet.2017.11.063. Epub 2017 Dec 2. Review.


Bioconjugated fluorescent organic nanoparticles targeting EGFR-overexpressing cancer cells.

Faucon A, Benhelli-Mokrani H, Fleury F, Dutertre S, Tramier M, Boucard J, Lartigue L, Nedellec S, Hulin P, Ishow E.

Nanoscale. 2017 Nov 23;9(45):18094-18106. doi: 10.1039/c7nr06533g.


Pharmacology of predatory and defensive venom peptides in cone snails.

Prashanth JR, Dutertre S, Lewis RJ.

Mol Biosyst. 2017 Nov 21;13(12):2453-2465. doi: 10.1039/c7mb00511c. Review.


Conotoxin Φ-MiXXVIIA from the Superfamily G2 Employs a Novel Cysteine Framework that Mimics Granulin and Displays Anti-Apoptotic Activity.

Jin AH, Dekan Z, Smout MJ, Wilson D, Dutertre S, Vetter I, Lewis RJ, Loukas A, Daly NL, Alewood PF.

Angew Chem Int Ed Engl. 2017 Nov 20;56(47):14973-14976. doi: 10.1002/anie.201708927. Epub 2017 Oct 24.


Discovery and mode of action of a novel analgesic β-toxin from the African spider Ceratogyrus darlingi.

Sousa SR, Wingerd JS, Brust A, Bladen C, Ragnarsson L, Herzig V, Deuis JR, Dutertre S, Vetter I, Zamponi GW, King GF, Alewood PF, Lewis RJ.

PLoS One. 2017 Sep 7;12(9):e0182848. doi: 10.1371/journal.pone.0182848. eCollection 2017.


Propionibacterium freudenreichii Surface Protein SlpB Is Involved in Adhesion to Intestinal HT-29 Cells.

do Carmo FLR, Rabah H, Huang S, Gaucher F, Deplanche M, Dutertre S, Jardin J, Le Loir Y, Azevedo V, Jan G.

Front Microbiol. 2017 Jun 8;8:1033. doi: 10.3389/fmicb.2017.01033. eCollection 2017.


Nicotinic acetylcholine receptor inhibitors derived from snake and snail venoms.

Dutertre S, Nicke A, Tsetlin VI.

Neuropharmacology. 2017 Dec;127:196-223. doi: 10.1016/j.neuropharm.2017.06.011. Epub 2017 Jun 13. Review.


Neurite analyzer: An original Fiji plugin for quantification of neuritogenesis in two-dimensional images.

Haas AJ, Prigent S, Dutertre S, Le Dréan Y, Le Page Y.

J Neurosci Methods. 2016 Sep 15;271:86-91. doi: 10.1016/j.jneumeth.2016.07.011. Epub 2016 Jul 20.


The role of defensive ecological interactions in the evolution of conotoxins.

Prashanth JR, Dutertre S, Jin AH, Lavergne V, Hamilton B, Cardoso FC, Griffin J, Venter DJ, Alewood PF, Lewis RJ.

Mol Ecol. 2016 Jan;25(2):598-615. doi: 10.1111/mec.13504. Epub 2016 Jan 20.


Transcriptome and proteome of Conus planorbis identify the nicotinic receptors as primary target for the defensive venom.

Jin AH, Vetter I, Himaya SW, Alewood PF, Lewis RJ, Dutertre S.

Proteomics. 2015 Dec;15(23-24):4030-40. doi: 10.1002/pmic.201500220. Epub 2015 Nov 17.


Comparative Venomics Reveals the Complex Prey Capture Strategy of the Piscivorous Cone Snail Conus catus.

Himaya SW, Jin AH, Dutertre S, Giacomotto J, Mohialdeen H, Vetter I, Alewood PF, Lewis RJ.

J Proteome Res. 2015 Oct 2;14(10):4372-81. doi: 10.1021/acs.jproteome.5b00630. Epub 2015 Sep 10.


A rare P2X7 variant Arg307Gln with absent pore formation function protects against neuroinflammation in multiple sclerosis.

Gu BJ, Field J, Dutertre S, Ou A, Kilpatrick TJ, Lechner-Scott J, Scott R, Lea R, Taylor BV, Stankovich J, Butzkueven H, Gresle M, Laws SM, Petrou S, Hoffjan S, Akkad DA, Graham CA, Hawkins S, Glaser A, Bedri SK, Hillert J, Matute C, Antiguedad A; ANZgene Consortium, Wiley JS.

Hum Mol Genet. 2015 Oct 1;24(19):5644-54. doi: 10.1093/hmg/ddv278. Epub 2015 Jul 17.


δ-Conotoxin SuVIA suggests an evolutionary link between ancestral predator defence and the origin of fish-hunting behaviour in carnivorous cone snails.

Jin AH, Israel MR, Inserra MC, Smith JJ, Lewis RJ, Alewood PF, Vetter I, Dutertre S.

Proc Biol Sci. 2015 Jul 22;282(1811). pii: 20150817. doi: 10.1098/rspb.2015.0817.


Intraspecific variations in Conus purpurascens injected venom using LC/MALDI-TOF-MS and LC-ESI-TripleTOF-MS.

Rodriguez AM, Dutertre S, Lewis RJ, Marí F.

Anal Bioanal Chem. 2015 Aug;407(20):6105-16. doi: 10.1007/s00216-015-8787-y. Epub 2015 Jun 6.


Impact of recommendations on crushing medications in geriatrics: from prescription to administration.

Bourdenet G, Giraud S, Artur M, Dutertre S, Dufour M, Lefèbvre-Caussin M, Proux A, Philippe S, Capet C, Fontaine-Adam M, Kadri K, Landrin I, Gréboval E, Touflet M, Nanfack J, Tharasse C, Varin R, Rémy E, Daouphars M, Doucet J.

Fundam Clin Pharmacol. 2015 Jun;29(3):316-20. doi: 10.1111/fcp.12116. Epub 2015 Apr 15.


α-Conotoxin MrIC is a biased agonist at α7 nicotinic acetylcholine receptors.

Mueller A, Starobova H, Inserra MC, Jin AH, Deuis JR, Dutertre S, Lewis RJ, Alewood PF, Daly NL, Vetter I.

Biochem Pharmacol. 2015 Mar 15;94(2):155-63. doi: 10.1016/j.bcp.2015.01.011. Epub 2015 Jan 31.


Quantifying Ca2+ current and permeability in ATP-gated P2X7 receptors.

Liang X, Samways DS, Wolf K, Bowles EA, Richards JP, Bruno J, Dutertre S, DiPaolo RJ, Egan TM.

J Biol Chem. 2015 Mar 20;290(12):7930-42. doi: 10.1074/jbc.M114.627810. Epub 2015 Feb 2.


Cone snail venomics: from novel biology to novel therapeutics.

Prashanth JR, Brust A, Jin AH, Alewood PF, Dutertre S, Lewis RJ.

Future Med Chem. 2014 Oct;6(15):1659-75. doi: 10.4155/fmc.14.99. Review. Erratum in: Future Med Chem. 2014;6(18):2134.


Venomics in medicinal chemistry.

Dutertre S.

Future Med Chem. 2014 Oct;6(15):1609-10. doi: 10.4155/fmc.14.117. No abstract available.


Intraspecific variations in Conus geographus defence-evoked venom and estimation of the human lethal dose.

Dutertre S, Jin AH, Alewood PF, Lewis RJ.

Toxicon. 2014 Dec;91:135-44. doi: 10.1016/j.toxicon.2014.09.011. Epub 2014 Oct 7.


Miniaturized bioaffinity assessment coupled to mass spectrometry for guided purification of bioactives from toad and cone snail.

Heus F, Otvos RA, Aspers RL, van Elk R, Halff JI, Ehlers AW, Dutertre S, Lewis RJ, Wijmenga S, Smit AB, Niessen WM, Kool J.

Biology (Basel). 2014 Feb 13;3(1):139-56. doi: 10.3390/biology3010139.


Discovery, synthesis, and structure-activity relationships of conotoxins.

Akondi KB, Muttenthaler M, Dutertre S, Kaas Q, Craik DJ, Lewis RJ, Alewood PF.

Chem Rev. 2014 Jun 11;114(11):5815-47. doi: 10.1021/cr400401e. Epub 2014 Apr 10. Review. No abstract available.


Evolution of separate predation- and defence-evoked venoms in carnivorous cone snails.

Dutertre S, Jin AH, Vetter I, Hamilton B, Sunagar K, Lavergne V, Dutertre V, Fry BG, Antunes A, Venter DJ, Alewood PF, Lewis RJ.

Nat Commun. 2014 Mar 24;5:3521. doi: 10.1038/ncomms4521.


MrIC, a novel α-conotoxin agonist in the presence of PNU at endogenous α7 nicotinic acetylcholine receptors.

Jin AH, Vetter I, Dutertre S, Abraham N, Emidio NB, Inserra M, Murali SS, Christie MJ, Alewood PF, Lewis RJ.

Biochemistry. 2014 Jan 14;53(1):1-3. doi: 10.1021/bi400882s. Epub 2013 Dec 30.


Systematic interrogation of the Conus marmoreus venom duct transcriptome with ConoSorter reveals 158 novel conotoxins and 13 new gene superfamilies.

Lavergne V, Dutertre S, Jin AH, Lewis RJ, Taft RJ, Alewood PF.

BMC Genomics. 2013 Oct 16;14:708. doi: 10.1186/1471-2164-14-708.


Transcriptomic messiness in the venom duct of Conus miles contributes to conotoxin diversity.

Jin AH, Dutertre S, Kaas Q, Lavergne V, Kubala P, Lewis RJ, Alewood PF.

Mol Cell Proteomics. 2013 Dec;12(12):3824-33. doi: 10.1074/mcp.M113.030353. Epub 2013 Sep 16.


Unravelling the complex venom landscapes of lethal Australian funnel-web spiders (Hexathelidae: Atracinae) using LC-MALDI-TOF mass spectrometry.

Palagi A, Koh JM, Leblanc M, Wilson D, Dutertre S, King GF, Nicholson GM, Escoubas P.

J Proteomics. 2013 Mar 27;80:292-310. doi: 10.1016/j.jprot.2013.01.002. Epub 2013 Jan 23.


Structure of the O-glycosylated conopeptide CcTx from Conus consors venom.

Hocking HG, Gerwig GJ, Dutertre S, Violette A, Favreau P, Stöcklin R, Kamerling JP, Boelens R.

Chemistry. 2013 Jan 14;19(3):870-9. doi: 10.1002/chem.201202713. Epub 2012 Dec 27.


Deep venomics reveals the mechanism for expanded peptide diversity in cone snail venom.

Dutertre S, Jin AH, Kaas Q, Jones A, Alewood PF, Lewis RJ.

Mol Cell Proteomics. 2013 Feb;12(2):312-29. doi: 10.1074/mcp.M112.021469. Epub 2012 Nov 14.


Inhibitory glycine receptors: an update.

Dutertre S, Becker CM, Betz H.

J Biol Chem. 2012 Nov 23;287(48):40216-23. doi: 10.1074/jbc.R112.408229. Epub 2012 Oct 4. Review.


Efficient binding of 4/7 α-conotoxins to nicotinic α4β2 receptors is prevented by Arg185 and Pro195 in the α4 subunit.

Beissner M, Dutertre S, Schemm R, Danker T, Sporning A, Grubmüller H, Nicke A.

Mol Pharmacol. 2012 Oct;82(4):711-8. Epub 2012 Jul 16.


Involvement of the cysteine-rich head domain in activation and desensitization of the P2X1 receptor.

Lörinczi É, Bhargava Y, Marino SF, Taly A, Kaczmarek-Hájek K, Barrantes-Freer A, Dutertre S, Grutter T, Rettinger J, Nicke A.

Proc Natl Acad Sci U S A. 2012 Jul 10;109(28):11396-401. doi: 10.1073/pnas.1118759109. Epub 2012 Jun 27.


Large-scale discovery of conopeptides and conoproteins in the injectable venom of a fish-hunting cone snail using a combined proteomic and transcriptomic approach.

Violette A, Biass D, Dutertre S, Koua D, Piquemal D, Pierrat F, Stöcklin R, Favreau P.

J Proteomics. 2012 Sep 18;75(17):5215-25. doi: 10.1016/j.jprot.2012.06.001. Epub 2012 Jun 13.


Towards an integrated venomics approach for accelerated conopeptide discovery.

Prashanth JR, Lewis RJ, Dutertre S.

Toxicon. 2012 Sep 15;60(4):470-7. doi: 10.1016/j.toxicon.2012.04.340. Epub 2012 Apr 28. Review.


Probing the pharmacological properties of distinct subunit interfaces within heteromeric glycine receptors reveals a functional ββ agonist-binding site.

Dutertre S, Drwal M, Laube B, Betz H.

J Neurochem. 2012 Jul;122(1):38-47. doi: 10.1111/j.1471-4159.2012.07755.x. Epub 2012 Apr 27.


MNK1 kinase activity is required for abscission.

Rannou Y, Salaun P, Benaud C, Khan J, Dutertre S, Giet R, Prigent C.

J Cell Sci. 2012 Jun 15;125(Pt 12):2844-52. doi: 10.1242/jcs.058081. Epub 2012 Mar 27.


Recruitment of glycosyl hydrolase proteins in a cone snail venomous arsenal: further insights into biomolecular features of Conus venoms.

Violette A, Leonardi A, Piquemal D, Terrat Y, Biass D, Dutertre S, Noguier F, Ducancel F, Stöcklin R, Križaj I, Favreau P.

Mar Drugs. 2012 Feb;10(2):258-80. doi: 10.3390/md10020258. Epub 2012 Jan 31.

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