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Determinants of Generic Drug Substitution in the United States.

Segal JB, Onasanya O, Daubresse M, Lee CY, Moechtar M, Pu X, Dutcher SK, Romanelli RJ.

Ther Innov Regul Sci. 2019 Jan 13:2168479018820050. doi: 10.1177/2168479018820050. [Epub ahead of print]


A Survey of Patients' Perceptions of Pill Appearance and Responses to Changes in Appearance for Four Chronic Disease Medications.

Sarpatwari A, Gagne JJ, Lu Z, Campbell EG, Carman WJ, Enger CL, Dutcher SK, Jiang W, Kesselheim AS.

J Gen Intern Med. 2019 Jan 10. doi: 10.1007/s11606-018-4791-1. [Epub ahead of print]


RPGRIP1L helps to establish the ciliary gate for entry of proteins.

Lin H, Guo S, Dutcher SK.

J Cell Sci. 2018 Oct 26;131(20). pii: jcs220905. doi: 10.1242/jcs.220905.


MAPINS, a Highly Efficient Detection Method That Identifies Insertional Mutations and Complex DNA Rearrangements.

Lin H, Cliften PF, Dutcher SK.

Plant Physiol. 2018 Dec;178(4):1436-1447. doi: 10.1104/pp.18.00474. Epub 2018 Sep 11.


Evaluation of Switching Patterns in FDA's Sentinel System: A New Tool to Assess Generic Drugs.

Gagne JJ, Popovic JR, Nguyen M, Sandhu SK, Greene P, Izem R, Jiang W, Wang Z, Zhao Y, Petrone AB, Wagner AK, Dutcher SK.

Drug Saf. 2018 Dec;41(12):1313-1323. doi: 10.1007/s40264-018-0709-4.


Functional characterization of biallelic RTTN variants identified in an infant with microcephaly, simplified gyral pattern, pontocerebellar hypoplasia, and seizures.

Wambach JA, Wegner DJ, Yang P, Shinawi M, Baldridge D, Betleja E, Shimony JS, Spencer D, Hackett BP, Andrews MV, Ferkol T, Dutcher SK, Mahjoub MR, Cole FS.

Pediatr Res. 2018 Sep;84(3):435-441. doi: 10.1038/s41390-018-0083-z. Epub 2018 Jun 4.


High-resolution comparative analysis of great ape genomes.

Kronenberg ZN, Fiddes IT, Gordon D, Murali S, Cantsilieris S, Meyerson OS, Underwood JG, Nelson BJ, Chaisson MJP, Dougherty ML, Munson KM, Hastie AR, Diekhans M, Hormozdiari F, Lorusso N, Hoekzema K, Qiu R, Clark K, Raja A, Welch AE, Sorensen M, Baker C, Fulton RS, Armstrong J, Graves-Lindsay TA, Denli AM, Hoppe ER, Hsieh P, Hill CM, Pang AWC, Lee J, Lam ET, Dutcher SK, Gage FH, Warren WC, Shendure J, Haussler D, Schneider VA, Cao H, Ventura M, Wilson RK, Paten B, Pollen A, Eichler EE.

Science. 2018 Jun 8;360(6393). pii: eaar6343. doi: 10.1126/science.aar6343.


Differences in rates of switchbacks after switching from branded to authorized generic and branded to generic drug products: cohort study.

Desai RJ, Sarpatwari A, Dejene S, Khan NF, Lii J, Rogers JR, Dutcher SK, Raofi S, Bohn J, Connolly J, Fischer MA, Kesselheim AS, Gagne JJ.

BMJ. 2018 Apr 3;361:k1180. doi: 10.1136/bmj.k1180.


Correction to: Outcomes Associated with Generic Drugs Approved Using Product-Specific Determinations of Therapeutic Equivalence.

Gagne JJ, Polinski JM, Jiang W, Dutcher SK, Xie J, Lii J, Fulchino LA, Kesselheim AS.

Drugs. 2018 Mar;78(4):523-524. doi: 10.1007/s40265-018-0890-x.


Identifying RNA splicing factors using IFT genes in Chlamydomonas reinhardtii.

Lin H, Zhang Z, Iomini C, Dutcher SK.

Open Biol. 2018 Mar;8(3). pii: 170211. doi: 10.1098/rsob.170211.


The IDA3 adapter, required for intraflagellar transport of I1 dynein, is regulated by ciliary length.

Hunter EL, Lechtreck K, Fu G, Hwang J, Lin H, Gokhale A, Alford LM, Lewis B, Yamamoto R, Kamiya R, Yang F, Nicastro D, Dutcher SK, Wirschell M, Sale WS.

Mol Biol Cell. 2018 Apr 15;29(8):886-896. doi: 10.1091/mbc.E17-12-0729. Epub 2018 Mar 29.


Generic Versions of Narrow Therapeutic Index Drugs: A National Survey of Pharmacists' Substitution Beliefs and Practices.

Sarpatwari A, Lee MP, Gagne JJ, Lu Z, Dutcher SK, Jiang W, Campbell EG, Kesselheim AS.

Clin Pharmacol Ther. 2018 Jun;103(6):1093-1099. doi: 10.1002/cpt.884. Epub 2017 Nov 22.


Chlamydomonas DYX1C1/PF23 is essential for axonemal assembly and proper morphology of inner dynein arms.

Yamamoto R, Obbineni JM, Alford LM, Ide T, Owa M, Hwang J, Kon T, Inaba K, James N, King SM, Ishikawa T, Sale WS, Dutcher SK.

PLoS Genet. 2017 Sep 11;13(9):e1006996. doi: 10.1371/journal.pgen.1006996. eCollection 2017 Sep. Erratum in: PLoS Genet. 2017 Oct 23;13(10 ):e1007063.


Provider and Patient Determinants of Generic Levothyroxine Prescribing: An Electronic Health Records-Based Study.

Romanelli RJ, Nimbal V, Dutcher SK, Pu X, Segal JB.

Ann Pharmacother. 2017 Aug;51(8):640-648. doi: 10.1177/1060028017705393. Epub 2017 Apr 20.


Outcomes Associated with Generic Drugs Approved Using Product-Specific Determinations of Therapeutic Equivalence.

Gagne JJ, Polinski JM, Jiang W, Dutcher SK, Xie J, Lii J, Fulchino LA, Kesselheim AS.

Drugs. 2017 Mar;77(4):427-433. doi: 10.1007/s40265-017-0696-2. Erratum in: Drugs. 2018 Mar 8;:.


Comparison of Generic-to-Brand Switchback Rates Between Generic and Authorized Generic Drugs.

Hansen RA, Qian J, Berg R, Linneman J, Seoane-Vazquez E, Dutcher SK, Raofi S, Page CD, Peissig P.

Pharmacotherapy. 2017 Apr;37(4):429-437. doi: 10.1002/phar.1908. Epub 2017 Mar 20.


Flexural Rigidity and Shear Stiffness of Flagella Estimated from Induced Bends and Counterbends.

Xu G, Wilson KS, Okamoto RJ, Shao JY, Dutcher SK, Bayly PV.

Biophys J. 2016 Jun 21;110(12):2759-2768. doi: 10.1016/j.bpj.2016.05.017.


The basal bodies of Chlamydomonas reinhardtii.

Dutcher SK, O'Toole ET.

Cilia. 2016 Jun 1;5:18. doi: 10.1186/s13630-016-0039-z. eCollection 2016. Review.


Switch-backs associated with generic drugs approved using product-specific determinations of therapeutic equivalence.

Gagne JJ, Polinski JM, Jiang W, Dutcher SK, Xie J, Lii J, Fulchino LA, Kesselheim AS.

Pharmacoepidemiol Drug Saf. 2016 Aug;25(8):944-52. doi: 10.1002/pds.4009. Epub 2016 Apr 22.


Correction: Katanin Localization Requires Triplet Microtubules in Chlamydomonas reinhardtii.

Esparza JM, O'Toole E, Li L, Giddings TH Jr, Kozak B, Albee AJ, Dutcher SK.

PLoS One. 2016 Jan 15;11(1):e0145569. doi: 10.1371/journal.pone.0145569. eCollection 2016. No abstract available.


Genetics and biology of primary ciliary dyskinesia.

Horani A, Ferkol TW, Dutcher SK, Brody SL.

Paediatr Respir Rev. 2016 Mar;18:18-24. doi: 10.1016/j.prrv.2015.09.001. Epub 2015 Sep 11. Review.


A NIMA-Related Kinase Suppresses the Flagellar Instability Associated with the Loss of Multiple Axonemal Structures.

Lin H, Zhang Z, Guo S, Chen F, Kessler JM, Wang YM, Dutcher SK.

PLoS Genet. 2015 Sep 8;11(9):e1005508. doi: 10.1371/journal.pgen.1005508. eCollection 2015 Sep.


Dynein-deficient flagella respond to increased viscosity with contrasting changes in power and recovery strokes.

Wilson KS, Gonzalez O, Dutcher SK, Bayly PV.

Cytoskeleton (Hoboken). 2015 Sep;72(9):477-90. doi: 10.1002/cm.21252. Epub 2015 Sep 16.


Genetic and genomic approaches to identify genes involved in flagellar assembly in Chlamydomonas reinhardtii.

Lin H, Dutcher SK.

Methods Cell Biol. 2015;127:349-86. doi: 10.1016/bs.mcb.2014.12.001. Epub 2015 Feb 14.


Uni-directional ciliary membrane protein trafficking by a cytoplasmic retrograde IFT motor and ciliary ectosome shedding.

Cao M, Ning J, Hernandez-Lara CI, Belzile O, Wang Q, Dutcher SK, Liu Y, Snell WJ.

Elife. 2015 Feb 17;4. doi: 10.7554/eLife.05242.


The ciliary inner dynein arm, I1 dynein, is assembled in the cytoplasm and transported by IFT before axonemal docking.

Viswanadha R, Hunter EL, Yamamoto R, Wirschell M, Alford LM, Dutcher SK, Sale WS.

Cytoskeleton (Hoboken). 2014 Oct;71(10):573-86. doi: 10.1002/cm.21192. Epub 2014 Oct 30.


A Systematic Review of the Benefits and Risks of Anticoagulation Following Traumatic Brain Injury.

Shen X, Dutcher SK, Palmer J, Liu X, Kiptanui Z, Khokhar B, Al-Jawadi MH, Zhu Y, Zuckerman IH.

J Head Trauma Rehabil. 2015 Jul-Aug;30(4):E29-37. doi: 10.1097/HTR.0000000000000077. Review.


Effect of medications on physical function and cognition in nursing home residents with dementia.

Dutcher SK, Rattinger GB, Langenberg P, Chhabra PT, Liu X, Rosenberg PB, Leoutsakos JM, Simoni-Wastila L, Walker LD, Franey CS, Zuckerman IH.

J Am Geriatr Soc. 2014 Jun;62(6):1046-55. doi: 10.1111/jgs.12838. Epub 2014 May 13.


The awesome power of dikaryons for studying flagella and basal bodies in Chlamydomonas reinhardtii.

Dutcher SK.

Cytoskeleton (Hoboken). 2014 Feb;71(2):79-94. doi: 10.1002/cm.21157. Epub 2013 Dec 12. Review.


New mutations in flagellar motors identified by whole genome sequencing in Chlamydomonas.

Lin H, Nauman NP, Albee AJ, Hsu S, Dutcher SK.

Cilia. 2013 Oct 30;2(1):14. doi: 10.1186/2046-2530-2-14.


Site-specific basal body duplication in Chlamydomonas.

O'Toole ET, Dutcher SK.

Cytoskeleton (Hoboken). 2014 Feb;71(2):108-18. doi: 10.1002/cm.21155. Epub 2013 Nov 15.


The Chlamydomonas mutant pf27 reveals novel features of ciliary radial spoke assembly.

Alford LM, Mattheyses AL, Hunter EL, Lin H, Dutcher SK, Sale WS.

Cytoskeleton (Hoboken). 2013 Dec;70(12):804-18. doi: 10.1002/cm.21144.


Whole genome sequencing identifies a deletion in protein phosphatase 2A that affects its stability and localization in Chlamydomonas reinhardtii.

Lin H, Miller ML, Granas DM, Dutcher SK.

PLoS Genet. 2013;9(9):e1003841. doi: 10.1371/journal.pgen.1003841. Epub 2013 Sep 26.


CCDC65 mutation causes primary ciliary dyskinesia with normal ultrastructure and hyperkinetic cilia.

Horani A, Brody SL, Ferkol TW, Shoseyov D, Wasserman MG, Ta-shma A, Wilson KS, Bayly PV, Amirav I, Cohen-Cymberknoh M, Dutcher SK, Elpeleg O, Kerem E.

PLoS One. 2013 Aug 26;8(8):e72299. doi: 10.1371/journal.pone.0072299. eCollection 2013.


Identification of cilia genes that affect cell-cycle progression using whole-genome transcriptome analysis in Chlamydomonas reinhardtti.

Albee AJ, Kwan AL, Lin H, Granas D, Stormo GD, Dutcher SK.

G3 (Bethesda). 2013 Jun 21;3(6):979-91. doi: 10.1534/g3.113.006338.


Pharmacotherapeutic management of dementia across settings of care.

Rattinger GB, Burcu M, Dutcher SK, Chhabra PT, Rosenberg PB, Simoni-Wastila L, Franey CS, Walker LD, Zuckerman IH.

J Am Geriatr Soc. 2013 May;61(5):723-33. doi: 10.1111/jgs.12210. Epub 2013 Apr 16.


LRRC6 mutation causes primary ciliary dyskinesia with dynein arm defects.

Horani A, Ferkol TW, Shoseyov D, Wasserman MG, Oren YS, Kerem B, Amirav I, Cohen-Cymberknoh M, Dutcher SK, Brody SL, Elpeleg O, Kerem E.

PLoS One. 2013;8(3):e59436. doi: 10.1371/journal.pone.0059436. Epub 2013 Mar 19.


Katanin localization requires triplet microtubules in Chlamydomonas reinhardtii.

Esparza JM, O'Toole E, Li L, Giddings TH Jr, Kozak B, Albee AJ, Dutcher SK.

PLoS One. 2013;8(1):e53940. doi: 10.1371/journal.pone.0053940. Epub 2013 Jan 8. Erratum in: PLoS One. 2016;11(1):e0145569.


Whole-exome capture and sequencing identifies HEATR2 mutation as a cause of primary ciliary dyskinesia.

Horani A, Druley TE, Zariwala MA, Patel AC, Levinson BT, Van Arendonk LG, Thornton KC, Giacalone JC, Albee AJ, Wilson KS, Turner EH, Nickerson DA, Shendure J, Bayly PV, Leigh MW, Knowles MR, Brody SL, Dutcher SK, Ferkol TW.

Am J Hum Genet. 2012 Oct 5;91(4):685-93. doi: 10.1016/j.ajhg.2012.08.022.


Whole-Genome Sequencing to Identify Mutants and Polymorphisms in Chlamydomonas reinhardtii.

Dutcher SK, Li L, Lin H, Meyer L, Giddings TH Jr, Kwan AL, Lewis BL.

G3 (Bethesda). 2012 Jan;2(1):15-22. doi: 10.1534/g3.111.000919. Epub 2012 Jan 1.


The effect of dementia on medication use and adherence among Medicare beneficiaries with chronic heart failure.

Rattinger GB, Dutcher SK, Chhabra PT, Franey CS, Simoni-Wastila L, Gottlieb SS, Stuart B, Zuckerman IH.

Am J Geriatr Pharmacother. 2012 Feb;10(1):69-80. doi: 10.1016/j.amjopharm.2011.11.003. Epub 2012 Jan 20.


A unified taxonomy for ciliary dyneins.

Hom EF, Witman GB, Harris EH, Dutcher SK, Kamiya R, Mitchell DR, Pazour GJ, Porter ME, Sale WS, Wirschell M, Yagi T, King SM.

Cytoskeleton (Hoboken). 2011 Oct;68(10):555-65. doi: 10.1002/cm.20533.


Cilia and models for studying structure and function.

Ostrowski LE, Dutcher SK, Lo CW.

Proc Am Thorac Soc. 2011 Sep;8(5):423-9. doi: 10.1513/pats.201103-027SD. Review.


bop5 Mutations reveal new roles for the IC138 phosphoprotein in the regulation of flagellar motility and asymmetric waveforms.

VanderWaal KE, Yamamoto R, Wakabayashi K, Fox L, Kamiya R, Dutcher SK, Bayly PV, Sale WS, Porter ME.

Mol Biol Cell. 2011 Aug 15;22(16):2862-74. doi: 10.1091/mbc.E11-03-0270. Epub 2011 Jun 22.


An axonemal PP2A B-subunit is required for PP2A localization and flagellar motility.

Elam CA, Wirschell M, Yamamoto R, Fox LA, York K, Kamiya R, Dutcher SK, Sale WS.

Cytoskeleton (Hoboken). 2011 Jul;68(7):363-72. doi: 10.1002/cm.20519. Epub 2011 Jul 1.


Propulsive forces on the flagellum during locomotion of Chlamydomonas reinhardtii.

Bayly PV, Lewis BL, Ranz EC, Okamoto RJ, Pless RB, Dutcher SK.

Biophys J. 2011 Jun 8;100(11):2716-25. doi: 10.1016/j.bpj.2011.05.001.


Medication reconciliation during the transition to and from long-term care settings: a systematic review.

Chhabra PT, Rattinger GB, Dutcher SK, Hare ME, Parsons KL, Zuckerman IH.

Res Social Adm Pharm. 2012 Jan-Feb;8(1):60-75. doi: 10.1016/j.sapharm.2010.12.002. Epub 2011 Apr 21. Review.


Tying TAZ and Nek1 into polycystic kidney disease through polycystin 2 levels.

Dutcher SK, Lin H.

J Am Soc Nephrol. 2011 May;22(5):791-3. doi: 10.1681/ASN.2011030256. Epub 2011 Apr 7. No abstract available.


Synthesizing and salvaging NAD: lessons learned from Chlamydomonas reinhardtii.

Lin H, Kwan AL, Dutcher SK.

PLoS Genet. 2010 Sep 9;6(9):e1001105. doi: 10.1371/journal.pgen.1001105.

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