Format
Sort by
Items per page

Send to

Choose Destination

Search results

Items: 43

1.

Molecular flexibility of DNA as a key determinant of RAD51 recruitment.

Paoletti F, El-Sagheer AH, Allard J, Brown T, Dushek O, Esashi F.

EMBO J. 2020 Jan 14:e103002. doi: 10.15252/embj.2019103002. [Epub ahead of print]

2.

A tissue-like platform for studying engineered quiescent human T-cells' interactions with dendritic cells.

Abu-Shah E, Demetriou P, Bálint Š, Mayya V, Kutuzov MA, Dushek O, Dustin ML.

Elife. 2019 Sep 25;8. pii: e48221. doi: 10.7554/eLife.48221.

3.

The Influence of Molecular Reach and Diffusivity on the Efficacy of Membrane-Confined Reactions.

Zhang Y, Clemens L, Goyette J, Allard J, Dushek O, Isaacson SA.

Biophys J. 2019 Oct 1;117(7):1189-1201. doi: 10.1016/j.bpj.2019.08.023. Epub 2019 Aug 28.

4.

MHC binding affects the dynamics of different T-cell receptors in different ways.

Knapp B, van der Merwe PA, Dushek O, Deane CM.

PLoS Comput Biol. 2019 Sep 9;15(9):e1007338. doi: 10.1371/journal.pcbi.1007338. eCollection 2019 Sep.

5.

TCR-pMHC kinetics under force in a cell-free system show no intrinsic catch bond, but a minimal encounter duration before binding.

Limozin L, Bridge M, Bongrand P, Dushek O, van der Merwe PA, Robert P.

Proc Natl Acad Sci U S A. 2019 Aug 20;116(34):16943-16948. doi: 10.1073/pnas.1902141116. Epub 2019 Jul 17.

6.

A cell topography-based mechanism for ligand discrimination by the T cell receptor.

Fernandes RA, Ganzinger KA, Tzou JC, Jönsson P, Lee SF, Palayret M, Santos AM, Carr AR, Ponjavic A, Chang VT, Macleod C, Lagerholm BC, Lindsay AE, Dushek O, Tilevik A, Davis SJ, Klenerman D.

Proc Natl Acad Sci U S A. 2019 Jul 9;116(28):14002-14010. doi: 10.1073/pnas.1817255116. Epub 2019 Jun 20.

7.

CD8 helps TCR catch slippery self pMHC.

Dushek O, Dustin ML.

Nat Immunol. 2018 Dec;19(12):1280-1281. doi: 10.1038/s41590-018-0261-5. No abstract available.

PMID:
30420625
8.

Membrane Ultrastructure and T Cell Activation.

Pettmann J, Santos AM, Dushek O, Davis SJ.

Front Immunol. 2018 Sep 25;9:2152. doi: 10.3389/fimmu.2018.02152. eCollection 2018. Review.

9.

Molecular mechanisms of T cell sensitivity to antigen.

Siller-Farfán JA, Dushek O.

Immunol Rev. 2018 Sep;285(1):194-205. doi: 10.1111/imr.12690. Review.

PMID:
30129204
10.

Comparison of T Cell Activities Mediated by Human TCRs and CARs That Use the Same Recognition Domains.

Harris DT, Hager MV, Smith SN, Cai Q, Stone JD, Kruger P, Lever M, Dushek O, Schmitt TM, Greenberg PD, Kranz DM.

J Immunol. 2018 Feb 1;200(3):1088-1100. doi: 10.4049/jimmunol.1700236. Epub 2017 Dec 29.

11.

Dynamic regulation of CD28 conformation and signaling by charged lipids and ions.

Yang W, Pan W, Chen S, Trendel N, Jiang S, Xiao F, Xue M, Wu W, Peng Z, Li X, Ji H, Liu X, Jiang H, Wang H, Shen H, Dushek O, Li H, Xu C.

Nat Struct Mol Biol. 2017 Dec;24(12):1081-1092. doi: 10.1038/nsmb.3489. Epub 2017 Oct 23.

PMID:
29058713
12.

Biophysical assay for tethered signaling reactions reveals tether-controlled activity for the phosphatase SHP-1.

Goyette J, Salas CS, Coker-Gordon N, Bridge M, Isaacson SA, Allard J, Dushek O.

Sci Adv. 2017 Mar 24;3(3):e1601692. doi: 10.1126/sciadv.1601692. eCollection 2017 Mar.

13.

PD-L1 blockade enhances response of pancreatic ductal adenocarcinoma to radiotherapy.

Azad A, Yin Lim S, D'Costa Z, Jones K, Diana A, Sansom OJ, Kruger P, Liu S, McKenna WG, Dushek O, Muschel RJ, Fokas E.

EMBO Mol Med. 2017 Feb;9(2):167-180. doi: 10.15252/emmm.201606674.

14.

Architecture of a minimal signaling pathway explains the T-cell response to a 1 million-fold variation in antigen affinity and dose.

Lever M, Lim HS, Kruger P, Nguyen J, Trendel N, Abu-Shah E, Maini PK, van der Merwe PA, Dushek O.

Proc Natl Acad Sci U S A. 2016 Oct 25;113(43):E6630-E6638. Epub 2016 Oct 4. Erratum in: Proc Natl Acad Sci U S A. 2017 Jan 3;:.

15.

The contribution of major histocompatibility complex contacts to the affinity and kinetics of T cell receptor binding.

Zhang H, Lim HS, Knapp B, Deane CM, Aleksic M, Dushek O, van der Merwe PA.

Sci Rep. 2016 Oct 13;6:35326. doi: 10.1038/srep35326.

16.

Homodimerization of the Lymph Vessel Endothelial Receptor LYVE-1 through a Redox-labile Disulfide Is Critical for Hyaluronan Binding in Lymphatic Endothelium.

Banerji S, Lawrance W, Metcalfe C, Briggs DC, Yamauchi A, Dushek O, van der Merwe PA, Day AJ, Jackson DG.

J Biol Chem. 2016 Nov 25;291(48):25004-25018. Epub 2016 Oct 12.

17.

Multisite Phosphorylation Modulates the T Cell Receptor ζ-Chain Potency but not the Switchlike Response.

Mukhopadhyay H, de Wet B, Clemens L, Maini PK, Allard J, van der Merwe PA, Dushek O.

Biophys J. 2016 Apr 26;110(8):1896-1906. doi: 10.1016/j.bpj.2016.03.024.

18.

Remarkably low affinity of CD4/peptide-major histocompatibility complex class II protein interactions.

Jönsson P, Southcombe JH, Santos AM, Huo J, Fernandes RA, McColl J, Lever M, Evans EJ, Hudson A, Chang VT, Hanke T, Godkin A, Dunne PD, Horrocks MH, Palayret M, Screaton GR, Petersen J, Rossjohn J, Fugger L, Dushek O, Xu XN, Davis SJ, Klenerman D.

Proc Natl Acad Sci U S A. 2016 May 17;113(20):5682-7. doi: 10.1073/pnas.1513918113. Epub 2016 Apr 25.

19.

Costimulation of IL-2 Production through CD28 Is Dependent on the Size of Its Ligand.

Lim HS, Cordoba SP, Dushek O, Goyette J, Taylor A, Rudd CE, van der Merwe PA.

J Immunol. 2015 Dec 1;195(11):5432-9. doi: 10.4049/jimmunol.1500707. Epub 2015 Oct 23.

20.

A THEMIS:SHP1 complex promotes T-cell survival.

Paster W, Bruger AM, Katsch K, Grégoire C, Roncagalli R, Fu G, Gascoigne NR, Nika K, Cohnen A, Feller SM, Simister PC, Molder KC, Cordoba SP, Dushek O, Malissen B, Acuto O.

EMBO J. 2015 Feb 3;34(3):393-409. doi: 10.15252/embj.201387725. Epub 2014 Dec 22.

21.

Phenotypic models of T cell activation.

Lever M, Maini PK, van der Merwe PA, Dushek O.

Nat Rev Immunol. 2014 Sep;14(9):619-29. doi: 10.1038/nri3728. Review.

PMID:
25145757
22.

SpyAvidin hubs enable precise and ultrastable orthogonal nanoassembly.

Fairhead M, Veggiani G, Lever M, Yan J, Mesner D, Robinson CV, Dushek O, van der Merwe PA, Howarth M.

J Am Chem Soc. 2014 Sep 3;136(35):12355-63. doi: 10.1021/ja505584f. Epub 2014 Aug 21.

23.

Biosensor architectures for high-fidelity reporting of cellular signaling.

Dushek O, Lellouch AC, Vaux DJ, Shahrezaei V.

Biophys J. 2014 Aug 5;107(3):773-782. doi: 10.1016/j.bpj.2014.06.021.

24.

An induced rebinding model of antigen discrimination.

Dushek O, van der Merwe PA.

Trends Immunol. 2014 Apr;35(4):153-8. doi: 10.1016/j.it.2014.02.002. Epub 2014 Mar 15. Review.

25.

Saposins modulate human invariant Natural Killer T cells self-reactivity and facilitate lipid exchange with CD1d molecules during antigen presentation.

Salio M, Ghadbane H, Dushek O, Shepherd D, Cypen J, Gileadi U, Aichinger MC, Napolitani G, Qi X, van der Merwe PA, Wojno J, Veerapen N, Cox LR, Besra GS, Yuan W, Cresswell P, Cerundolo V.

Proc Natl Acad Sci U S A. 2013 Dec 3;110(49):E4753-61. doi: 10.1073/pnas.1310050110. Epub 2013 Nov 18.

26.

Quantitative phosphoproteome analysis unveils LAT as a modulator of CD3ζ and ZAP-70 tyrosine phosphorylation.

Salek M, McGowan S, Trudgian DC, Dushek O, de Wet B, Efstathiou G, Acuto O.

PLoS One. 2013 Oct 30;8(10):e77423. doi: 10.1371/journal.pone.0077423. eCollection 2013.

27.

Systems model of T cell receptor proximal signaling reveals emergent ultrasensitivity.

Mukhopadhyay H, Cordoba SP, Maini PK, van der Merwe PA, Dushek O.

PLoS Comput Biol. 2013;9(3):e1003004. doi: 10.1371/journal.pcbi.1003004. Epub 2013 Mar 28.

28.

Non-catalytic tyrosine-phosphorylated receptors.

Dushek O, Goyette J, van der Merwe PA.

Immunol Rev. 2012 Nov;250(1):258-76. doi: 10.1111/imr.12008. Review.

PMID:
23046135
29.

Mechanical modulation of receptor-ligand interactions at cell-cell interfaces.

Allard JF, Dushek O, Coombs D, van der Merwe PA.

Biophys J. 2012 Mar 21;102(6):1265-73. doi: 10.1016/j.bpj.2012.02.006. Epub 2012 Mar 20.

30.

Kinetics and mechanics of two-dimensional interactions between T cell receptors and different activating ligands.

Robert P, Aleksic M, Dushek O, Cerundolo V, Bongrand P, van der Merwe PA.

Biophys J. 2012 Jan 18;102(2):248-57. doi: 10.1016/j.bpj.2011.11.4018. Erratum in: Biophys J. 2014 Oct 7;107(7):1773.

31.

Basic residues in the T-cell receptor ζ cytoplasmic domain mediate membrane association and modulate signaling.

Zhang H, Cordoba SP, Dushek O, van der Merwe PA.

Proc Natl Acad Sci U S A. 2011 Nov 29;108(48):19323-8. doi: 10.1073/pnas.1108052108. Epub 2011 Nov 14.

32.

Antigen potency and maximal efficacy reveal a mechanism of efficient T cell activation.

Dushek O, Aleksic M, Wheeler RJ, Zhang H, Cordoba SP, Peng YC, Chen JL, Cerundolo V, Dong T, Coombs D, van der Merwe PA.

Sci Signal. 2011 Jun 7;4(176):ra39. doi: 10.1126/scisignal.2001430.

33.

Ultrasensitivity in multisite phosphorylation of membrane-anchored proteins.

Dushek O, van der Merwe PA, Shahrezaei V.

Biophys J. 2011 Mar 2;100(5):1189-97. doi: 10.1016/j.bpj.2011.01.060.

34.

Elementary steps in T cell receptor triggering.

Dushek O.

Front Immunol. 2012 Jan 10;2:91. doi: 10.3389/fimmu.2011.00091. eCollection 2011.

35.

Mechanisms for T cell receptor triggering.

van der Merwe PA, Dushek O.

Nat Rev Immunol. 2011 Jan;11(1):47-55. doi: 10.1038/nri2887. Epub 2010 Dec 3. Review.

PMID:
21127503
36.

Constitutively active Lck kinase in T cells drives antigen receptor signal transduction.

Nika K, Soldani C, Salek M, Paster W, Gray A, Etzensperger R, Fugger L, Polzella P, Cerundolo V, Dushek O, Höfer T, Viola A, Acuto O.

Immunity. 2010 Jun 25;32(6):766-77. doi: 10.1016/j.immuni.2010.05.011. Epub 2010 Jun 11.

37.

The membrane skeleton controls diffusion dynamics and signaling through the B cell receptor.

Treanor B, Depoil D, Gonzalez-Granja A, Barral P, Weber M, Dushek O, Bruckbauer A, Batista FD.

Immunity. 2010 Feb 26;32(2):187-99. doi: 10.1016/j.immuni.2009.12.005. Epub 2010 Feb 18.

38.

Dependence of T cell antigen recognition on T cell receptor-peptide MHC confinement time.

Aleksic M, Dushek O, Zhang H, Shenderov E, Chen JL, Cerundolo V, Coombs D, van der Merwe PA.

Immunity. 2010 Feb 26;32(2):163-74. doi: 10.1016/j.immuni.2009.11.013. Epub 2010 Feb 4.

39.

A role for rebinding in rapid and reliable T cell responses to antigen.

Dushek O, Das R, Coombs D.

PLoS Comput Biol. 2009 Nov;5(11):e1000578. doi: 10.1371/journal.pcbi.1000578. Epub 2009 Nov 26.

40.

Effects of intracellular calcium and actin cytoskeleton on TCR mobility measured by fluorescence recovery.

Dushek O, Mueller S, Soubies S, Depoil D, Caramalho I, Coombs D, Valitutti S.

PLoS One. 2008;3(12):e3913. doi: 10.1371/journal.pone.0003913. Epub 2008 Dec 11.

41.

Analysis of membrane-localized binding kinetics with FRAP.

Dushek O, Das R, Coombs D.

Eur Biophys J. 2008 Jun;37(5):627-38. doi: 10.1007/s00249-008-0286-z. Epub 2008 Feb 26.

PMID:
18299825
42.

Analysis of serial engagement and peptide-MHC transport in T cell receptor microclusters.

Dushek O, Coombs D.

Biophys J. 2008 May 1;94(9):3447-60. doi: 10.1529/biophysj.107.116897. Epub 2008 Jan 28.

43.

Improving parameter estimation for cell surface FRAP data.

Dushek O, Coombs D.

J Biochem Biophys Methods. 2008 Apr 24;70(6):1224-31. Epub 2007 Jul 19.

PMID:
17707082

Supplemental Content

Loading ...
Support Center