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Items: 14

1.

Mutant MRPS5 affects mitoribosomal accuracy and confers stress-related behavioral alterations.

Akbergenov R, Duscha S, Fritz AK, Juskeviciene R, Oishi N, Schmitt K, Shcherbakov D, Teo Y, Boukari H, Freihofer P, Isnard-Petit P, Oettinghaus B, Frank S, Thiam K, Rehrauer H, Westhof E, Schacht J, Eckert A, Wolfer D, Böttger EC.

EMBO Rep. 2018 Nov;19(11). pii: e46193. doi: 10.15252/embr.201846193. Epub 2018 Sep 20.

2.

Systematic Identification of Pharmacological Targets from Small-Molecule Phenotypic Screens.

Liu X, Baarsma HA, Thiam CH, Montrone C, Brauner B, Fobo G, Heier JS, Duscha S, Königshoff M, Angeli V, Ruepp A, Campillos M.

Cell Chem Biol. 2016 Oct 20;23(10):1302-1313. doi: 10.1016/j.chembiol.2016.08.011. Epub 2016 Sep 22.

3.

Corrigendum: A large light-mass component of cosmic rays at 1017-1017.5 electronvolts from radio observations.

Buitink S, Corstanje A, Falcke H, Hörandel JR, Huege T, Nelles A, Rachen JP, Rossetto L, Schellart P, Scholten O, Ter Veen S, Thoudam S, Trinh TN, Anderson J, Asgekar A, Avruch IM, Bell ME, Bentum MJ, Bernardi G, Best P, Bonafede A, Breitling F, Broderick JW, Brouw WN, Brüggen M, Butcher HR, Carbone D, Ciardi B, Conway JE, de Gasperin F, de Geus E, Deller A, Dettmar RJ, van Diepen G, Duscha S, Eislöffel J, Engels D, Enriquez JE, Fallows RA, Fender R, Ferrari C, Frieswijk W, Garrett MA, Grießmeier JM, Gunst AW, van Haarlem MP, Hassall TE, Heald G, Hessels JW, Hoeft M, Horneffer A, Iacobelli M, Intema H, Juette E, Karastergiou A, Kondratiev VI, Kramer M, Kuniyoshi M, Kuper G, van Leeuwen J, Loose GM, Maat P, Mann G, Markoff S, McFadden R, McKay-Bukowski D, McKean JP, Mevius M, Mulcahy DD, Munk H, Norden MJ, Orru E, Paas H, Pandey-Pommier M, Pandey VN, Pietka M, Pizzo R, Polatidis AG, Reich W, Röttgering HJ, Scaife AM, Schwarz DJ, Serylak M, Sluman J, Smirnov O, Stappers BW, Steinmetz M, Stewart A, Swinbank J, Tagger M, Tang Y, Tasse C, Toribio MC, Vermeulen R, Vocks C, Vogt C, van Weeren RJ, Wijers RA, Wijnholds SJ, Wise MW, Wucknitz O, Yatawatta S, Zarka P, Zensus JA.

Nature. 2016 Sep 22;537(7621):572. doi: 10.1038/nature18936. Epub 2016 Jul 20. No abstract available.

PMID:
27437581
4.

A large light-mass component of cosmic rays at 10(17)-10(17.5) electronvolts from radio observations.

Buitink S, Corstanje A, Falcke H, Hörandel JR, Huege T, Nelles A, Rachen JP, Rossetto L, Schellart P, Scholten O, ter Veen S, Thoudam S, Trinh TN, Anderson J, Asgekar A, Avruch IM, Bell ME, Bentum MJ, Bernardi G, Best P, Bonafede A, Breitling F, Broderick JW, Brouw WN, Brüggen M, Butcher HR, Carbone D, Ciardi B, Conway JE, de Gasperin F, de Geus E, Deller A, Dettmar RJ, van Diepen G, Duscha S, Eislöffel J, Engels D, Enriquez JE, Fallows RA, Fender R, Ferrari C, Frieswijk W, Garrett MA, Grießmeier JM, Gunst AW, van Haarlem MP, Hassall TE, Heald G, Hessels JW, Hoeft M, Horneffer A, Iacobelli M, Intema H, Juette E, Karastergiou A, Kondratiev VI, Kramer M, Kuniyoshi M, Kuper G, van Leeuwen J, Loose GM, Maat P, Mann G, Markoff S, McFadden R, McKay-Bukowski D, McKean JP, Mevius M, Mulcahy DD, Munk H, Norden MJ, Orru E, Paas H, Pandey-Pommier M, Pandey VN, Pietka M, Pizzo R, Polatidis AG, Reich W, Röttgering HJ, Scaife AM, Schwarz DJ, Serylak M, Sluman J, Smirnov O, Stappers BW, Steinmetz M, Stewart A, Swinbank J, Tagger M, Tang Y, Tasse C, Toribio MC, Vermeulen R, Vocks C, Vogt C, van Weeren RJ, Wijers RA, Wijnholds SJ, Wise MW, Wucknitz O, Yatawatta S, Zarka P, Zensus JA.

Nature. 2016 Mar 3;531(7592):70-3. doi: 10.1038/nature16976.

PMID:
26935696
5.

Aminomethyl spectinomycins as therapeutics for drug-resistant respiratory tract and sexually transmitted bacterial infections.

Bruhn DF, Waidyarachchi SL, Madhura DB, Shcherbakov D, Zheng Z, Liu J, Abdelrahman YM, Singh AP, Duscha S, Rathi C, Lee RB, Belland RJ, Meibohm B, Rosch JW, Böttger EC, Lee RE.

Sci Transl Med. 2015 May 20;7(288):288ra75. doi: 10.1126/scitranslmed.3010572.

6.

XBP1 mitigates aminoglycoside-induced endoplasmic reticulum stress and neuronal cell death.

Oishi N, Duscha S, Boukari H, Meyer M, Xie J, Wei G, Schrepfer T, Roschitzki B, Boettger EC, Schacht J.

Cell Death Dis. 2015 May 14;6:e1763. doi: 10.1038/cddis.2015.108.

7.

Probing Atmospheric Electric Fields in Thunderstorms through Radio Emission from Cosmic-Ray-Induced Air Showers.

Schellart P, Trinh TN, Buitink S, Corstanje A, Enriquez JE, Falcke H, Hörandel JR, Nelles A, Rachen JP, Rossetto L, Scholten O, Ter Veen S, Thoudam S, Ebert U, Koehn C, Rutjes C, Alexov A, Anderson JM, Avruch IM, Bentum MJ, Bernardi G, Best P, Bonafede A, Breitling F, Broderick JW, Brüggen M, Butcher HR, Ciardi B, de Geus E, de Vos M, Duscha S, Eislöffel J, Fallows RA, Frieswijk W, Garrett MA, Grießmeier J, Gunst AW, Heald G, Hessels JW, Hoeft M, Holties HA, Juette E, Kondratiev VI, Kuniyoshi M, Kuper G, Mann G, McFadden R, McKay-Bukowski D, McKean JP, Mevius M, Moldon J, Norden MJ, Orru E, Paas H, Pandey-Pommier M, Pizzo R, Polatidis AG, Reich W, Röttgering H, Scaife AM, Schwarz DJ, Serylak M, Smirnov O, Steinmetz M, Swinbank J, Tagger M, Tasse C, Toribio MC, van Weeren RJ, Vermeulen R, Vocks C, Wise MW, Wucknitz O, Zarka P.

Phys Rev Lett. 2015 Apr 24;114(16):165001. Epub 2015 Apr 24.

PMID:
25955053
8.

Identification and evaluation of improved 4'-O-(alkyl) 4,5-disubstituted 2-deoxystreptamines as next-generation aminoglycoside antibiotics.

Duscha S, Boukari H, Shcherbakov D, Salian S, Silva S, Kendall A, Kato T, Akbergenov R, Perez-Fernandez D, Bernet B, Vaddi S, Thommes P, Schacht J, Crich D, Vasella A, Böttger EC.

MBio. 2014 Sep 30;5(5):e01827-14. doi: 10.1128/mBio.01827-14.

9.

Importance of the 6'-hydroxy group and its configuration for apramycin activity.

Mandhapati AR, Shcherbakov D, Duscha S, Vasella A, Böttger EC, Crich D.

ChemMedChem. 2014 Sep;9(9):2074-83. doi: 10.1002/cmdc.201402146. Epub 2014 Jul 17.

PMID:
25045149
10.

4'-O-substitutions determine selectivity of aminoglycoside antibiotics.

Perez-Fernandez D, Shcherbakov D, Matt T, Leong NC, Kudyba I, Duscha S, Boukari H, Patak R, Dubbaka SR, Lang K, Meyer M, Akbergenov R, Freihofer P, Vaddi S, Thommes P, Ramakrishnan V, Vasella A, Böttger EC.

Nat Commun. 2014;5:3112. doi: 10.1038/ncomms4112.

11.

Synchronous x-ray and radio mode switches: a rapid global transformation of the pulsar magnetosphere.

Hermsen W, Hessels JW, Kuiper L, van Leeuwen J, Mitra D, de Plaa J, Rankin JM, Stappers BW, Wright GA, Basu R, Alexov A, Coenen T, Grießmeier JM, Hassall TE, Karastergiou A, Keane E, Kondratiev VI, Kramer M, Kuniyoshi M, Noutsos A, Serylak M, Pilia M, Sobey C, Weltevrede P, Zagkouris K, Asgekar A, Avruch IM, Batejat F, Bell ME, Bell MR, Bentum MJ, Bernardi G, Best P, Bîrzan L, Bonafede A, Breitling F, Broderick J, Brüggen M, Butcher HR, Ciardi B, Duscha S, Eislöffel J, Falcke H, Fender R, Ferrari C, Frieswijk W, Garrett MA, de Gasperin F, de Geus E, Gunst AW, Heald G, Hoeft M, Horneffer A, Iacobelli M, Kuper G, Maat P, Macario G, Markoff S, McKean JP, Mevius M, Miller-Jones JC, Morganti R, Munk H, Orrú E, Paas H, Pandey-Pommier M, Pandey VN, Pizzo R, Polatidis AG, Rawlings S, Reich W, Röttgering H, Scaife AM, Schoenmakers A, Shulevski A, Sluman J, Steinmetz M, Tagger M, Tang Y, Tasse C, ter Veen S, Vermeulen R, van de Brink RH, van Weeren RJ, Wijers RA, Wise MW, Wucknitz O, Yatawatta S, Zarka P.

Science. 2013 Jan 25;339(6118):436-9. doi: 10.1126/science.1230960.

12.

Structure-activity relationships among the kanamycin aminoglycosides: role of ring I hydroxyl and amino groups.

Salian S, Matt T, Akbergenov R, Harish S, Meyer M, Duscha S, Shcherbakov D, Bernet BB, Vasella A, Westhof E, Böttger EC.

Antimicrob Agents Chemother. 2012 Dec;56(12):6104-8. doi: 10.1128/AAC.01326-12. Epub 2012 Sep 4.

13.

Dissociation of antibacterial activity and aminoglycoside ototoxicity in the 4-monosubstituted 2-deoxystreptamine apramycin.

Matt T, Ng CL, Lang K, Sha SH, Akbergenov R, Shcherbakov D, Meyer M, Duscha S, Xie J, Dubbaka SR, Perez-Fernandez D, Vasella A, Ramakrishnan V, Schacht J, Böttger EC.

Proc Natl Acad Sci U S A. 2012 Jul 3;109(27):10984-9. doi: 10.1073/pnas.1204073109. Epub 2012 Jun 14.

14.

Molecular basis for the selectivity of antituberculosis compounds capreomycin and viomycin.

Akbergenov R, Shcherbakov D, Matt T, Duscha S, Meyer M, Wilson DN, Böttger EC.

Antimicrob Agents Chemother. 2011 Oct;55(10):4712-7. doi: 10.1128/AAC.00628-11. Epub 2011 Jul 18.

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