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Items: 1 to 50 of 161

1.

NRARP displays either pro- or anti-tumoral roles in T-cell acute lymphoblastic leukemia depending on Notch and Wnt signaling.

Pinto I, Duque M, Gonçalves J, Akkapeddi P, Oliveira ML, Cabrita R, Yunes JA, Durum SK, Barata JT, Fragoso R.

Oncogene. 2019 Oct 4. doi: 10.1038/s41388-019-1042-9. [Epub ahead of print]

PMID:
31586130
2.

Interleukin 22 disrupts pancreatic function in newborn mice expressing IL-23.

Chen L, Strohmeier V, He Z, Deshpande M, Catalan-Dibene J, Durum SK, Moran TM, Kraus T, Xiong H, Faith JJ, Sodhi CP, Hackam DJ, Lira SA, Furtado GC.

Nat Commun. 2019 Oct 4;10(1):4517. doi: 10.1038/s41467-019-12540-8.

3.

New anti-IL-7Rα monoclonal antibodies show efficacy against T cell acute lymphoblastic leukemia in pre-clinical models.

Hixon JA, Andrews C, Kashi L, Kohnhorst CL, Senkevitch E, Czarra K, Barata JT, Li W, Schneider JP, Walsh STR, Durum SK.

Leukemia. 2019 Aug 22. doi: 10.1038/s41375-019-0531-8. [Epub ahead of print]

PMID:
31439943
4.

IL-22 and its receptors are increased in human and experimental COPD and contribute to pathogenesis.

Starkey MR, Plank MW, Casolari P, Papi A, Pavlidis S, Guo Y, Cameron GJM, Haw TJ, Tam A, Obiedat M, Donovan C, Hansbro NG, Nguyen DH, Nair PM, Kim RY, Horvat JC, Kaiko GE, Durum SK, Wark PA, Sin DD, Caramori G, Adcock IM, Foster PS, Hansbro PM.

Eur Respir J. 2019 Jul 18;54(1). pii: 1800174. doi: 10.1183/13993003.00174-2018. Print 2019 Jul.

PMID:
31196943
5.

Clonal Vγ6+Vδ4+ T cells promote IL-17-mediated immunity against Staphylococcus aureus skin infection.

Marchitto MC, Dillen CA, Liu H, Miller RJ, Archer NK, Ortines RV, Alphonse MP, Marusina AI, Merleev AA, Wang Y, Pinsker BL, Byrd AS, Brown ID, Ravipati A, Zhang E, Cai SS, Limjunyawong N, Dong X, Yeaman MR, Simon SI, Shen W, Durum SK, O'Brien RL, Maverakis E, Miller LS.

Proc Natl Acad Sci U S A. 2019 May 28;116(22):10917-10926. doi: 10.1073/pnas.1818256116. Epub 2019 May 14.

PMID:
31088972
6.

A fully human anti-IL-7Rα antibody promotes antitumor activity against T-cell acute lymphoblastic leukemia.

Akkapeddi P, Fragoso R, Hixon JA, Ramalho AS, Oliveira ML, Carvalho T, Gloger A, Matasci M, Corzana F, Durum SK, Neri D, Bernardes GJL, Barata JT.

Leukemia. 2019 Sep;33(9):2155-2168. doi: 10.1038/s41375-019-0434-8. Epub 2019 Mar 8.

7.

Tumour-elicited neutrophils engage mitochondrial metabolism to circumvent nutrient limitations and maintain immune suppression.

Rice CM, Davies LC, Subleski JJ, Maio N, Gonzalez-Cotto M, Andrews C, Patel NL, Palmieri EM, Weiss JM, Lee JM, Annunziata CM, Rouault TA, Durum SK, McVicar DW.

Nat Commun. 2018 Nov 30;9(1):5099. doi: 10.1038/s41467-018-07505-2.

8.

Can We Target Endogenous Anti-inflammatory Responses as a Therapeutic Strategy for Inflammatory Bowel Disease?

Porter RJ, Andrews C, Brice DP, Durum SK, McLean MH.

Inflamm Bowel Dis. 2018 Sep 15;24(10):2123-2134. doi: 10.1093/ibd/izy230. Review.

9.

Cytokine Tuning of Intestinal Epithelial Function.

Andrews C, McLean MH, Durum SK.

Front Immunol. 2018 Jun 5;9:1270. doi: 10.3389/fimmu.2018.01270. eCollection 2018. Review.

10.

Inhibiting Janus Kinase 1 and BCL-2 to treat T cell acute lymphoblastic leukemia with IL7-Rα mutations.

Senkevitch E, Li W, Hixon JA, Andrews C, Cramer SD, Pauly GT, Back T, Czarra K, Durum SK.

Oncotarget. 2018 Apr 27;9(32):22605-22617. doi: 10.18632/oncotarget.25194. eCollection 2018 Apr 27.

11.

IL-7-induced phosphorylation of the adaptor Crk-like and other targets.

Aiello FB, Guszczynski T, Li W, Hixon JA, Jiang Q, Hodge DL, Massignan T, Di Lisio C, Merchant A, Procopio AD, Bonetto V, Durum SK.

Cell Signal. 2018 Jul;47:131-141. doi: 10.1016/j.cellsig.2018.03.008. Epub 2018 Mar 24.

PMID:
29581031
12.

The Artificial Sweetener Splenda Promotes Gut Proteobacteria, Dysbiosis, and Myeloperoxidase Reactivity in Crohn's Disease-Like Ileitis.

Rodriguez-Palacios A, Harding A, Menghini P, Himmelman C, Retuerto M, Nickerson KP, Lam M, Croniger CM, McLean MH, Durum SK, Pizarro TT, Ghannoum MA, Ilic S, McDonald C, Cominelli F.

Inflamm Bowel Dis. 2018 Apr 23;24(5):1005-1020. doi: 10.1093/ibd/izy060.

13.

Mutant IL-7Rα and mutant NRas are sufficient to induce murine T cell acute lymphoblastic leukemia.

Cramer SD, Hixon JA, Andrews C, Porter RJ, Rodrigues GOL, Wu X, Back T, Czarra K, Michael H, Cam M, Chen J, Esposito D, Senkevitch E, Negi V, Aplan PD, Li W, Durum SK.

Leukemia. 2018 Aug;32(8):1795-1882. doi: 10.1038/s41375-017-0001-0. Epub 2018 Feb 15. No abstract available.

PMID:
29535426
14.

Interleukin-7 restores lymphocytes in septic shock: the IRIS-7 randomized clinical trial.

Francois B, Jeannet R, Daix T, Walton AH, Shotwell MS, Unsinger J, Monneret G, Rimmelé T, Blood T, Morre M, Gregoire A, Mayo GA, Blood J, Durum SK, Sherwood ER, Hotchkiss RS.

JCI Insight. 2018 Mar 8;3(5). pii: 98960. doi: 10.1172/jci.insight.98960.

15.

The Antimicrobial Peptide CRAMP Is Essential for Colon Homeostasis by Maintaining Microbiota Balance.

Yoshimura T, McLean MH, Dzutsev AK, Yao X, Chen K, Huang J, Gong W, Zhou J, Xiang Y, H Badger J, O'hUigin C, Thovarai V, Tessarollo L, Durum SK, Trinchieri G, Bian XW, Wang JM.

J Immunol. 2018 Mar 15;200(6):2174-2185. doi: 10.4049/jimmunol.1602073. Epub 2018 Feb 12.

16.

Interleukin-27 Is a Potential Rescue Therapy for Acute Severe Colitis Through Interleukin-10-Dependent, T-Cell-Independent Attenuation of Colonic Mucosal Innate Immune Responses.

McLean MH, Andrews C, Hanson ML, Baseler WA, Anver MR, Senkevitch E, Staniszewska AK, Smith C, Davies LC, Hixon J, Li W, Shen W, Steidler L, Durum SK.

Inflamm Bowel Dis. 2017 Nov;23(11):1983-1995. doi: 10.1097/MIB.0000000000001274.

17.

The promise of Janus kinase inhibitors in the treatment of hematological malignancies.

Senkevitch E, Durum S.

Cytokine. 2017 Oct;98:33-41. doi: 10.1016/j.cyto.2016.10.012. Epub 2016 Oct 27. Review.

18.

Visualization of IL-22-expressing Lymphocytes Using Reporter Mice.

Shen W, Li W, Hixon JA, Andrews C, Durum SK.

J Vis Exp. 2017 Jan 25;(119). doi: 10.3791/54710.

19.

Th22 Cells Form a Distinct Th Lineage from Th17 Cells In Vitro with Unique Transcriptional Properties and Tbet-Dependent Th1 Plasticity.

Plank MW, Kaiko GE, Maltby S, Weaver J, Tay HL, Shen W, Wilson MS, Durum SK, Foster PS.

J Immunol. 2017 Mar 1;198(5):2182-2190. doi: 10.4049/jimmunol.1601480. Epub 2017 Jan 18.

20.

Therapeutic targeting of IL-7Rα signaling pathways in ALL treatment.

Cramer SD, Aplan PD, Durum SK.

Blood. 2016 Jul 28;128(4):473-8. doi: 10.1182/blood-2016-03-679209. Epub 2016 Jun 6. Review.

21.

Interleukin-27 as a Novel Therapy for Inflammatory Bowel Disease: A Critical Review of the Literature.

Andrews C, McLean MH, Durum SK.

Inflamm Bowel Dis. 2016 Sep;22(9):2255-64. doi: 10.1097/MIB.0000000000000818. Review.

22.

Development and Preclinical Application of an Immunocompetent Transplant Model of Basal Breast Cancer with Lung, Liver and Brain Metastases.

Aprelikova O, Tomlinson CC, Hoenerhoff M, Hixon JA, Durum SK, Qiu TH, He S, Burkett S, Liu ZY, Swanson SM, Green JE.

PLoS One. 2016 May 12;11(5):e0155262. doi: 10.1371/journal.pone.0155262. eCollection 2016.

23.

IL-22-Expressing Murine Lymphocytes Display Plasticity and Pathogenicity in Reporter Mice.

Shen W, Hixon JA, McLean MH, Li WQ, Durum SK.

Front Immunol. 2016 Jan 19;6:662. doi: 10.3389/fimmu.2015.00662. eCollection 2015.

24.

Transcriptional programs define molecular characteristics of innate lymphoid cell classes and subsets.

Robinette ML, Fuchs A, Cortez VS, Lee JS, Wang Y, Durum SK, Gilfillan S, Colonna M; Immunological Genome Consortium.

Nat Immunol. 2015 Mar;16(3):306-17. doi: 10.1038/ni.3094. Epub 2015 Jan 26.

25.

Adaptive immunity to murine skin commensals.

Shen W, Li W, Hixon JA, Bouladoux N, Belkaid Y, Dzutzev A, Durum SK.

Proc Natl Acad Sci U S A. 2014 Jul 22;111(29):E2977-86. doi: 10.1073/pnas.1401820111. Epub 2014 Jul 7.

26.

IL-7 and TSLP receptors: twisted sisters.

Durum SK.

Blood. 2014 Jul 3;124(1):4-5. doi: 10.1182/blood-2014-05-574327.

PMID:
24993875
27.

Chronic exposure to type-I IFN under lymphopenic conditions alters CD4 T cell homeostasis.

Le Saout C, Hasley RB, Imamichi H, Tcheung L, Hu Z, Luckey MA, Park JH, Durum SK, Smith M, Rupert AW, Sneller MC, Lane HC, Catalfamo M.

PLoS Pathog. 2014 Mar 6;10(3):e1003976. doi: 10.1371/journal.ppat.1003976. eCollection 2014 Mar.

28.

Targeting interleukins for the treatment of inflammatory bowel disease-what lies beyond anti-TNF therapy?

McLean MH, Neurath MF, Durum SK.

Inflamm Bowel Dis. 2014 Feb;20(2):389-97. doi: 10.1097/01.MIB.0000437616.37000.41. Review.

PMID:
24356385
29.

Stemness of T cells and the hematopoietic stem cells: fate, memory, niche, cytokines.

Aiello FB, Graciotti L, Procopio AD, Keller JR, Durum SK.

Cytokine Growth Factor Rev. 2013 Dec;24(6):485-501. doi: 10.1016/j.cytogfr.2013.10.002. Epub 2013 Oct 27. Review.

30.

Oral delivery of IL-27 recombinant bacteria attenuates immune colitis in mice.

Hanson ML, Hixon JA, Li W, Felber BK, Anver MR, Stewart CA, Janelsins BM, Datta SK, Shen W, McLean MH, Durum SK.

Gastroenterology. 2014 Jan;146(1):210-221.e13. doi: 10.1053/j.gastro.2013.09.060. Epub 2013 Oct 9.

31.

HIV immune activation drives increased Eomes expression in memory CD8 T cells in association with transcriptional downregulation of CD127.

Hasley RB, Hong C, Li W, Friesen T, Nakamura Y, Kim GY, Park JH, Hixon JA, Durum S, Hu Z, Sneller MC, Oguariri R, Imamichi T, Lane HC, Catalfamo M.

AIDS. 2013 Jul 31;27(12):1867-77. doi: 10.1097/QAD.0b013e3283618487.

PMID:
23965471
32.

Formylpeptide receptor-2 contributes to colonic epithelial homeostasis, inflammation, and tumorigenesis.

Chen K, Liu M, Liu Y, Yoshimura T, Shen W, Le Y, Durum S, Gong W, Wang C, Gao JL, Murphy PM, Wang JM.

J Clin Invest. 2013 Apr;123(4):1694-704.

33.

Regulation of in vitro human T cell development through interleukin-7 deprivation and anti-CD3 stimulation.

Patel ES, Okada S, Hachey K, Yang LJ, Durum SK, Moreb JS, Chang LJ.

BMC Immunol. 2012 Aug 16;13:46. doi: 10.1186/1471-2172-13-46.

34.

The major isoforms of Bim contribute to distinct biological activities that govern the processes of autophagy and apoptosis in interleukin-7 dependent lymphocytes.

Ruppert SM, Li W, Zhang G, Carlson AL, Limaye A, Durum SK, Khaled AR.

Biochim Biophys Acta. 2012 Oct;1823(10):1877-93. doi: 10.1016/j.bbamcr.2012.06.017. Epub 2012 Jun 21.

35.

The human IL-7 receptor gene: deletions, polymorphisms and mutations.

Mazzucchelli RI, Riva A, Durum SK.

Semin Immunol. 2012 Jun;24(3):225-30. doi: 10.1016/j.smim.2012.02.007. Epub 2012 Mar 17. Review.

36.

IL-7Rα deficiency in p53null mice exacerbates thymocyte telomere erosion and lymphomagenesis.

Kibe R, Zhang S, Guo D, Marrero L, Tsien F, Rodriguez P, Khan S, Zieske A, Huang J, Li W, Durum SK, Iwakuma T, Cui Y.

Cell Death Differ. 2012 Jul;19(7):1139-51. doi: 10.1038/cdd.2011.203. Epub 2012 Jan 27.

37.

Th17 cells are long lived and retain a stem cell-like molecular signature.

Muranski P, Borman ZA, Kerkar SP, Klebanoff CA, Ji Y, Sanchez-Perez L, Sukumar M, Reger RN, Yu Z, Kern SJ, Roychoudhuri R, Ferreyra GA, Shen W, Durum SK, Feigenbaum L, Palmer DC, Antony PA, Chan CC, Laurence A, Danner RL, Gattinoni L, Restifo NP.

Immunity. 2011 Dec 23;35(6):972-85. doi: 10.1016/j.immuni.2011.09.019. Epub 2011 Dec 15.

38.

Detection of nuclear and membrane antigens by liquid-based cytology following long-term storage of d1 cells, karpas cells, and peripheral blood mononuclear cells.

Zappacosta R, Aiello FB, D'Antuono T, Procopio AD, Durum SK, Conti P, Rosini S.

Ann Clin Lab Sci. 2011 Fall;41(4):353-9.

PMID:
22166505
39.

Oncogenic IL7R gain-of-function mutations in childhood T-cell acute lymphoblastic leukemia.

Zenatti PP, Ribeiro D, Li W, Zuurbier L, Silva MC, Paganin M, Tritapoe J, Hixon JA, Silveira AB, Cardoso BA, Sarmento LM, Correia N, Toribio ML, Kobarg J, Horstmann M, Pieters R, Brandalise SR, Ferrando AA, Meijerink JP, Durum SK, Yunes JA, Barata JT.

Nat Genet. 2011 Sep 4;43(10):932-9. doi: 10.1038/ng.924.

PMID:
21892159
40.

Cdc25A-driven proliferation regulates CD62L levels and lymphocyte movement in response to interleukin-7.

Kittipatarin C, Li W, Durum SK, Khaled AR.

Exp Hematol. 2010 Dec;38(12):1143-56. doi: 10.1016/j.exphem.2010.08.010. Epub 2010 Sep 8.

41.

Interleukin-7 regulates Bim proapoptotic activity in peripheral T-cell survival.

Li WQ, Guszczynski T, Hixon JA, Durum SK.

Mol Cell Biol. 2010 Feb;30(3):590-600. doi: 10.1128/MCB.01006-09. Epub 2009 Nov 23.

42.

Synergy of IL-23 and Th17 cytokines: new light on inflammatory bowel disease.

Shen W, Durum SK.

Neurochem Res. 2010 Jun;35(6):940-6. doi: 10.1007/s11064-009-0091-9. Epub 2009 Nov 14. Review.

PMID:
19915978
43.

Visualization and identification of IL-7 producing cells in reporter mice.

Mazzucchelli RI, Warming S, Lawrence SM, Ishii M, Abshari M, Washington AV, Feigenbaum L, Warner AC, Sims DJ, Li WQ, Hixon JA, Gray DH, Rich BE, Morrow M, Anver MR, Cherry J, Naf D, Sternberg LR, McVicar DW, Farr AG, Germain RN, Rogers K, Jenkins NA, Copeland NG, Durum SK.

PLoS One. 2009 Nov 10;4(11):e7637. doi: 10.1371/journal.pone.0007637.

44.

Live from the liver: hepatocyte IL-7.

Durum SK, Mazzucchelli RI.

Immunity. 2009 Mar 20;30(3):320-1. doi: 10.1016/j.immuni.2009.03.001.

45.

Development of regulatory T cells requires IL-7Ralpha stimulation by IL-7 or TSLP.

Mazzucchelli R, Hixon JA, Spolski R, Chen X, Li WQ, Hall VL, Willette-Brown J, Hurwitz AA, Leonard WJ, Durum SK.

Blood. 2008 Oct 15;112(8):3283-92. doi: 10.1182/blood-2008-02-137414. Epub 2008 Jul 29.

46.

The influence of IL-2 family cytokines on activation and function of naturally occurring regulatory T cells.

Wuest TY, Willette-Brown J, Durum SK, Hurwitz AA.

J Leukoc Biol. 2008 Oct;84(4):973-80. doi: 10.1189/jlb.1107778. Epub 2008 Jul 23.

47.

Measurement of soluble and membrane-bound interleukin 1 using a fibroblast bioassay.

Dinarello CA, Muegge K, Durum SK.

Curr Protoc Immunol. 2001 May;Chapter 6:Unit 6.2. doi: 10.1002/0471142735.im0602s37.

PMID:
18432810
48.

Interleukin-7 receptor expression: intelligent design.

Mazzucchelli R, Durum SK.

Nat Rev Immunol. 2007 Feb;7(2):144-54. Review.

PMID:
17259970
49.

IL-7 induces myelopoiesis and erythropoiesis.

Aiello FB, Keller JR, Klarmann KD, Dranoff G, Mazzucchelli R, Durum SK.

J Immunol. 2007 Feb 1;178(3):1553-63.

50.

Role of the intracellular domain of IL-7 receptor in T cell development.

Jiang Q, Huang J, Li WQ, Cavinato T, Keller JR, Durum SK.

J Immunol. 2007 Jan 1;178(1):228-34.

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