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Reciprocity in the Co-Production of Public Services: The Role of Volunteering through Community Time Exchange?

Burgess G, Durrant D.

Soc Policy Soc. 2019 Apr;18(2):171-186. doi: 10.1017/S1474746418000076. Epub 2018 Mar 26.


Targeting the Raf kinases in human cancer: the Raf dimer dilemma.

Durrant DE, Morrison DK.

Br J Cancer. 2018 Jan;118(1):3-8. doi: 10.1038/bjc.2017.399. Epub 2017 Dec 14. Review.


Chronic treatment with novel nanoformulated micelles of rapamycin, Rapatar, protects diabetic heart against ischaemia/reperfusion injury.

Samidurai A, Salloum FN, Durrant D, Chernova OB, Kukreja RC, Das A.

Br J Pharmacol. 2017 Dec;174(24):4771-4784. doi: 10.1111/bph.14059. Epub 2017 Nov 24.


Long-acting PDE5 inhibitor tadalafil prevents early doxorubicin-induced left ventricle diastolic dysfunction in juvenile mice: potential role of cytoskeletal proteins.

Nagiub M, Filippone S, Durrant D, Das A, Kukreja RC.

Can J Physiol Pharmacol. 2017 Mar;95(3):295-304. doi: 10.1139/cjpp-2016-0551. Epub 2017 Feb 26.


Regional astrocyte IFN signaling restricts pathogenesis during neurotropic viral infection.

Daniels BP, Jujjavarapu H, Durrant DM, Williams JL, Green RR, White JP, Lazear HM, Gale M Jr, Diamond MS, Klein RS.

J Clin Invest. 2017 Mar 1;127(3):843-856. doi: 10.1172/JCI88720. Epub 2017 Jan 30.


Inhibition of Ras/Raf/MEK/ERK Pathway Signaling by a Stress-Induced Phospho-Regulatory Circuit.

Ritt DA, Abreu-Blanco MT, Bindu L, Durrant DE, Zhou M, Specht SI, Stephen AG, Holderfield M, Morrison DK.

Mol Cell. 2016 Dec 1;64(5):875-887. doi: 10.1016/j.molcel.2016.10.029. Epub 2016 Nov 23.


A complement-microglial axis drives synapse loss during virus-induced memory impairment.

Vasek MJ, Garber C, Dorsey D, Durrant DM, Bollman B, Soung A, Yu J, Perez-Torres C, Frouin A, Wilton DK, Funk K, DeMasters BK, Jiang X, Bowen JR, Mennerick S, Robinson JK, Garbow JR, Tyler KL, Suthar MS, Schmidt RE, Stevens B, Klein RS.

Nature. 2016 Jun 23;534(7608):538-43. doi: 10.1038/nature18283.


The Olfactory Bulb: An Immunosensory Effector Organ during Neurotropic Viral Infections.

Durrant DM, Ghosh S, Klein RS.

ACS Chem Neurosci. 2016 Apr 20;7(4):464-9. doi: 10.1021/acschemneuro.6b00043. Epub 2016 Apr 8. Review.


Sildenafil (Viagra) sensitizes prostate cancer cells to doxorubicin-mediated apoptosis through CD95.

Das A, Durrant D, Mitchell C, Dent P, Batra SK, Kukreja RC.

Oncotarget. 2016 Jan 26;7(4):4399-413. doi: 10.18632/oncotarget.6749.


CCR5 limits cortical viral loads during West Nile virus infection of the central nervous system.

Durrant DM, Daniels BP, Pasieka T, Dorsey D, Klein RS.

J Neuroinflammation. 2015 Dec 15;12:233. doi: 10.1186/s12974-015-0447-9.


Patient experience of non-malignant ascites and its treatment: a qualitative study.

Day R, Hollywood C, Durrant D, Perkins P.

Int J Palliat Nurs. 2015 Aug;21(8):372-9. doi: 10.12968/ijpn.2015.21.8.372.


Targeted Inhibition of Phosphoinositide 3-Kinase/Mammalian Target of Rapamycin Sensitizes Pancreatic Cancer Cells to Doxorubicin without Exacerbating Cardiac Toxicity.

Durrant DE, Das A, Dyer S, Tavallai S, Dent P, Kukreja RC.

Mol Pharmacol. 2015 Sep;88(3):512-23. doi: 10.1124/mol.115.099143. Epub 2015 Jun 22.


Border Patrol Gone Awry: Lung NKT Cell Activation by Francisella tularensis Exacerbates Tularemia-Like Disease.

Hill TM, Gilchuk P, Cicek BB, Osina MA, Boyd KL, Durrant DM, Metzger DW, Khanna KM, Joyce S.

PLoS Pathog. 2015 Jun 11;11(6):e1004975. doi: 10.1371/journal.ppat.1004975. eCollection 2015 Jun.


Inhibition of mammalian target of rapamycin protects against reperfusion injury in diabetic heart through STAT3 signaling.

Das A, Salloum FN, Filippone SM, Durrant DE, Rokosh G, Bolli R, Kukreja RC.

Basic Res Cardiol. 2015 May;110(3):31. doi: 10.1007/s00395-015-0486-5. Epub 2015 Apr 25.


PDE5 inhibitors as therapeutics for heart disease, diabetes and cancer.

Das A, Durrant D, Salloum FN, Xi L, Kukreja RC.

Pharmacol Ther. 2015 Mar;147:12-21. doi: 10.1016/j.pharmthera.2014.10.003. Epub 2014 Oct 31. Review.


IL-1R1 signaling regulates CXCL12-mediated T cell localization and fate within the central nervous system during West Nile Virus encephalitis.

Durrant DM, Daniels BP, Klein RS.

J Immunol. 2014 Oct 15;193(8):4095-106. doi: 10.4049/jimmunol.1401192. Epub 2014 Sep 8.


Viral pathogen-associated molecular patterns regulate blood-brain barrier integrity via competing innate cytokine signals.

Daniels BP, Holman DW, Cruz-Orengo L, Jujjavarapu H, Durrant DM, Klein RS.

MBio. 2014 Aug 26;5(5):e01476-14. doi: 10.1128/mBio.01476-14.


Induction of microRNA-21 with exogenous hydrogen sulfide attenuates myocardial ischemic and inflammatory injury in mice.

Toldo S, Das A, Mezzaroma E, Chau VQ, Marchetti C, Durrant D, Samidurai A, Van Tassell BW, Yin C, Ockaili RA, Vigneshwar N, Mukhopadhyay ND, Kukreja RC, Abbate A, Salloum FN.

Circ Cardiovasc Genet. 2014 Jun;7(3):311-20. doi: 10.1161/CIRCGENETICS.113.000381. Epub 2014 May 13.


Degradation of Keap1 activates BH3-only proteins Bim and PUMA during hepatocyte lipoapoptosis.

Cazanave SC, Wang X, Zhou H, Rahmani M, Grant S, Durrant DE, Klaassen CD, Yamamoto M, Sanyal AJ.

Cell Death Differ. 2014 Aug;21(8):1303-12. doi: 10.1038/cdd.2014.49. Epub 2014 Apr 25.


Chemokines Referee Inflammation within the Central Nervous System during Infection and Disease.

Durrant DM, Williams JL, Daniels BP, Klein RS.

Adv Med. 2014;2014:806741. doi: 10.1155/2014/806741. Epub 2014 Sep 30. Review.


Mammalian target of rapamycin (mTOR) inhibition with rapamycin improves cardiac function in type 2 diabetic mice: potential role of attenuated oxidative stress and altered contractile protein expression.

Das A, Durrant D, Koka S, Salloum FN, Xi L, Kukreja RC.

J Biol Chem. 2014 Feb 14;289(7):4145-60. doi: 10.1074/jbc.M113.521062. Epub 2013 Dec 26.


Phosphodiesterase 5 inhibitors enhance chemotherapy killing in gastrointestinal/genitourinary cancer cells.

Booth L, Roberts JL, Cruickshanks N, Conley A, Durrant DE, Das A, Fisher PB, Kukreja RC, Grant S, Poklepovic A, Dent P.

Mol Pharmacol. 2014 Mar;85(3):408-19. doi: 10.1124/mol.113.090043. Epub 2013 Dec 18.


Stilbene 5c, a microtubule poison with vascular disrupting properties that induces multiple modes of growth arrest and cell death.

Alotaibi MR, Asnake B, Di X, Beckman MJ, Durrant D, Simoni D, Baruchello R, Lee RM, Schwartz EL, Gewirtz DA.

Biochem Pharmacol. 2013 Dec 15;86(12):1688-98. doi: 10.1016/j.bcp.2013.10.007. Epub 2013 Oct 19.


IL-1R1 is required for dendritic cell-mediated T cell reactivation within the CNS during West Nile virus encephalitis.

Durrant DM, Robinette ML, Klein RS.

J Exp Med. 2013 Mar 11;210(3):503-16. doi: 10.1084/jem.20121897. Epub 2013 Mar 4.


Anti-inflammatory and cardioprotective effects of tadalafil in diabetic mice.

Varma A, Das A, Hoke NN, Durrant DE, Salloum FN, Kukreja RC.

PLoS One. 2012;7(9):e45243. doi: 10.1371/journal.pone.0045243. Epub 2012 Sep 21.


Rapamycin protects against myocardial ischemia-reperfusion injury through JAK2-STAT3 signaling pathway.

Das A, Salloum FN, Durrant D, Ockaili R, Kukreja RC.

J Mol Cell Cardiol. 2012 Dec;53(6):858-69. doi: 10.1016/j.yjmcc.2012.09.007. Epub 2012 Sep 19.


Dietary inorganic nitrate alleviates doxorubicin cardiotoxicity: mechanisms and implications.

Xi L, Zhu SG, Das A, Chen Q, Durrant D, Hobbs DC, Lesnefsky EJ, Kukreja RC.

Nitric Oxide. 2012 May 15;26(4):274-84. doi: 10.1016/j.niox.2012.03.006. Epub 2012 Apr 5. Review.


Development of hemiasterlin derivatives as potential anticancer agents that inhibit tubulin polymerization and synergize with a stilbene tubulin inhibitor.

Hsu LC, Durrant DE, Huang CC, Chi NW, Baruchello R, Rondanin R, Rullo C, Marchetti P, Grisolia G, Simoni D, Lee RM.

Invest New Drugs. 2012 Aug;30(4):1379-88. doi: 10.1007/s10637-011-9702-9. Epub 2011 Jun 8.


Sildenafil increases chemotherapeutic efficacy of doxorubicin in prostate cancer and ameliorates cardiac dysfunction.

Das A, Durrant D, Mitchell C, Mayton E, Hoke NN, Salloum FN, Park MA, Qureshi I, Lee R, Dent P, Kukreja RC.

Proc Natl Acad Sci U S A. 2010 Oct 19;107(42):18202-7. doi: 10.1073/pnas.1006965107. Epub 2010 Sep 30.


Long-acting phosphodiesterase-5 inhibitor tadalafil attenuates doxorubicin-induced cardiomyopathy without interfering with chemotherapeutic effect.

Koka S, Das A, Zhu SG, Durrant D, Xi L, Kukreja RC.

J Pharmacol Exp Ther. 2010 Sep 1;334(3):1023-30. doi: 10.1124/jpet.110.170191. Epub 2010 Jun 11.


Emerging roles of T helper subsets in the pathogenesis of asthma.

Durrant DM, Metzger DW.

Immunol Invest. 2010;39(4-5):526-49. doi: 10.3109/08820131003615498. Review.


Versatile synthesis of new cytotoxic agents structurally related to hemiasterlins.

Simoni D, Lee RM, Durrant DE, Chi NW, Baruchello R, Rondanin R, Rullo C, Marchetti P.

Bioorg Med Chem Lett. 2010 Jun 1;20(11):3431-5. doi: 10.1016/j.bmcl.2010.03.098. Epub 2010 Apr 1.


IL-12 can alleviate Th17-mediated allergic lung inflammation through induction of pulmonary IL-10 expression.

Durrant DM, Metzger DW.

Mucosal Immunol. 2010 May;3(3):301-11. doi: 10.1038/mi.2010.9. Epub 2010 Mar 17.


Chemical fluxes in time through forest ecosystems in the UK - soil response to pollution recovery.

Vanguelova EI, Benham S, Pitman R, Moffat AJ, Broadmeadow M, Nisbet T, Durrant D, Barsoum N, Wilkinson M, Bochereau F, Hutchings T, Broadmeadow S, Crow P, Taylor P, Durrant Houston T.

Environ Pollut. 2010 May;158(5):1857-69. doi: 10.1016/j.envpol.2009.10.044. Epub 2009 Dec 4.


Hydropathic analysis and biological evaluation of stilbene derivatives as colchicine site microtubule inhibitors with anti-leukemic activity.

Tripathi A, Durrant D, Lee RM, Baruchello R, Romagnoli R, Simoni D, Kellogg GE.

J Enzyme Inhib Med Chem. 2009 Dec;24(6):1237-44. doi: 10.3109/14756360902787055.


Development of allergen-induced airway inflammation in the absence of T-bet regulation is dependent on IL-17.

Durrant DM, Gaffen SL, Riesenfeld EP, Irvin CG, Metzger DW.

J Immunol. 2009 Oct 15;183(8):5293-300. doi: 10.4049/jimmunol.0803109. Epub 2009 Sep 25.


Design, synthesis and biological evaluation of novel stilbene-based antitumor agents.

Simoni D, Invidiata FP, Eleopra M, Marchetti P, Rondanin R, Baruchello R, Grisolia G, Tripathi A, Kellogg GE, Durrant D, Lee RM.

Bioorg Med Chem. 2009 Jan 15;17(2):512-22. doi: 10.1016/j.bmc.2008.12.002. Epub 2008 Dec 9.


Development of water soluble derivatives of cis-3, 4', 5-trimethoxy-3'-aminostilbene for optimization and use in cancer therapy.

Durrant DE, Richards J, Tripathi A, Kellogg GE, Marchetti P, Eleopra M, Grisolia G, Simoni D, Lee RM.

Invest New Drugs. 2009 Feb;27(1):41-52. doi: 10.1007/s10637-008-9139-y. Epub 2008 May 31.


Mechanism of cell death induced by cis-3, 4', 5-trimethoxy-3'-aminostilbene in ovarian cancer.

Durrant D, Richards JE, Walker WT, Baker KA, Simoni D, Lee RM.

Gynecol Oncol. 2008 Jul;110(1):110-7. doi: 10.1016/j.ygyno.2008.02.031. Epub 2008 Apr 22.


cis-3, 4', 5-Trimethoxy-3'-aminostilbene disrupts tumor vascular perfusion without damaging normal organ perfusion.

Durrant D, Corwin F, Simoni D, Zhao M, Rudek MA, Salloum FN, Kukreja RC, Fatouros PP, Lee RM.

Cancer Chemother Pharmacol. 2009 Jan;63(2):191-200. doi: 10.1007/s00280-008-0726-6. Epub 2008 Mar 26.


Role of phospholipid scramblase 3 in the regulation of tumor necrosis factor-alpha-induced apoptosis.

Liu J, Epand RF, Durrant D, Grossman D, Chi NW, Epand RM, Lee RM.

Biochemistry. 2008 Apr 15;47(15):4518-29. doi: 10.1021/bi701962c. Epub 2008 Mar 22.


Stilbene derivatives that are colchicine-site microtubule inhibitors have antileukemic activity and minimal systemic toxicity.

Cao TM, Durrant D, Tripathi A, Liu J, Tsai S, Kellogg GE, Simoni D, Lee RM.

Am J Hematol. 2008 May;83(5):390-7. doi: 10.1002/ajh.21104.


Phosphorylation of mitochondrial phospholipid scramblase 3 by protein kinase C-delta induces its activation and facilitates mitochondrial targeting of tBid.

He Y, Liu J, Grossman D, Durrant D, Sweatman T, Lothstein L, Epand RF, Epand RM, Lee RM.

J Cell Biochem. 2007 Aug 1;101(5):1210-21.


N-benzyladriamycin-14-valerate (AD198) induces apoptosis through protein kinase C-delta-induced phosphorylation of phospholipid scramblase 3.

He Y, Liu J, Durrant D, Yang HS, Sweatman T, Lothstein L, Lee RM.

Cancer Res. 2005 Nov 1;65(21):10016-23.


The interaction between tBid and cardiolipin or monolysocardiolipin.

Liu J, Durrant D, Yang HS, He Y, Whitby FG, Myszka DG, Lee RM.

Biochem Biophys Res Commun. 2005 May 13;330(3):865-70.


The bortezomib-induced mitochondrial damage is mediated by accumulation of active protein kinase C-delta.

Durrant D, Liu J, Yang HS, Lee RM.

Biochem Biophys Res Commun. 2004 Sep 3;321(4):905-8.


The cardiolipin-binding domain of Bid affects mitochondrial respiration and enhances cytochrome c release.

Liu J, Weiss A, Durrant D, Chi NW, Lee RM.

Apoptosis. 2004 Sep;9(5):533-41.


Mitochondrial ceramide increases in UV-irradiated HeLa cells and is mainly derived from hydrolysis of sphingomyelin.

Dai Q, Liu J, Chen J, Durrant D, McIntyre TM, Lee RM.

Oncogene. 2004 Apr 29;23(20):3650-8.


Phospholipid scramblase 3 controls mitochondrial structure, function, and apoptotic response.

Liu J, Dai Q, Chen J, Durrant D, Freeman A, Liu T, Grossman D, Lee RM.

Mol Cancer Res. 2003 Oct;1(12):892-902.

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