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Items: 1 to 50 of 100

1.

Mapping DNA damage-dependent genetic interactions in yeast via party mating and barcode fusion genetics.

Díaz-Mejía JJ, Celaj A, Mellor JC, Coté A, Balint A, Ho B, Bansal P, Shaeri F, Gebbia M, Weile J, Verby M, Karkhanina A, Zhang Y, Wong C, Rich J, Prendergast D, Gupta G, Öztürk S, Durocher D, Brown GW, Roth FP.

Mol Syst Biol. 2018 May 28;14(5):e7985. doi: 10.15252/msb.20177985.

2.

A physician-led initiative to improve clinical documentation results in improved health care documentation, case mix index, and increased contribution margin.

Aiello FA, Judelson DR, Durgin JM, Doucet DR, Simons JP, Durocher DM, Flahive JM, Schanzer A.

J Vasc Surg. 2018 May 4. pii: S0741-5214(18)30437-3. doi: 10.1016/j.jvs.2018.02.038. [Epub ahead of print]

PMID:
29735302
3.

ATM and CDK2 control chromatin remodeler CSB to inhibit RIF1 in DSB repair pathway choice.

Batenburg NL, Walker JR, Noordermeer SM, Moatti N, Durocher D, Zhu XD.

Nat Commun. 2017 Dec 4;8(1):1921. doi: 10.1038/s41467-017-02114-x.

4.

Inhibition of 53BP1 favors homology-dependent DNA repair and increases CRISPR-Cas9 genome-editing efficiency.

Canny MD, Moatti N, Wan LCK, Fradet-Turcotte A, Krasner D, Mateos-Gomez PA, Zimmermann M, Orthwein A, Juang YC, Zhang W, Noordermeer SM, Seclen E, Wilson MD, Vorobyov A, Munro M, Ernst A, Ng TF, Cho T, Cannon PM, Sidhu SS, Sicheri F, Durocher D.

Nat Biotechnol. 2018 Jan;36(1):95-102. doi: 10.1038/nbt.4021. Epub 2017 Nov 27.

5.

Reading chromatin signatures after DNA double-strand breaks.

Wilson MD, Durocher D.

Philos Trans R Soc Lond B Biol Sci. 2017 Oct 5;372(1731). pii: 20160280. doi: 10.1098/rstb.2016.0280. Review.

PMID:
28847817
6.

A sharp Pif1-dependent threshold separates DNA double-strand breaks from critically short telomeres.

Strecker J, Stinus S, Caballero MP, Szilard RK, Chang M, Durocher D.

Elife. 2017 Aug 3;6. pii: e23783. doi: 10.7554/eLife.23783.

7.

Relation of Telemetry Use and Mortality Risk, Hospital Length of Stay, and Readmission Rates in Patients With Respiratory Illness.

Dawson N, Burton MC, Hull B, Beliles G, Pritchard I, Trautman C, Ferry L, Doyon A, Colby R, Chuu A, Kung ST, Khang T, Durocher D, Buras M, Kosiorek H, Agrwal N, Sen A, Goss D, Geyer H.

Am J Cardiol. 2017 Oct 15;120(8):1416-1420. doi: 10.1016/j.amjcard.2017.07.029. Epub 2017 Jul 25.

PMID:
28823483
8.

Evaluation and Design of Genome-Wide CRISPR/SpCas9 Knockout Screens.

Hart T, Tong AHY, Chan K, Van Leeuwen J, Seetharaman A, Aregger M, Chandrashekhar M, Hustedt N, Seth S, Noonan A, Habsid A, Sizova O, Nedyalkova L, Climie R, Tworzyanski L, Lawson K, Sartori MA, Alibeh S, Tieu D, Masud S, Mero P, Weiss A, Brown KR, Usaj M, Billmann M, Rahman M, Constanzo M, Myers CL, Andrews BJ, Boone C, Durocher D, Moffat J.

G3 (Bethesda). 2017 Aug 7;7(8):2719-2727. doi: 10.1534/g3.117.041277.

9.

The RNF168 paralog RNF169 defines a new class of ubiquitylated histone reader involved in the response to DNA damage.

Kitevski-LeBlanc J, Fradet-Turcotte A, Kukic P, Wilson MD, Portella G, Yuwen T, Panier S, Duan S, Canny MD, van Ingen H, Arrowsmith CH, Rubinstein JL, Vendruscolo M, Durocher D, Kay LE.

Elife. 2017 Apr 13;6. pii: e23872. doi: 10.7554/eLife.23872.

10.

ZMYM3 regulates BRCA1 localization at damaged chromatin to promote DNA repair.

Leung JW, Makharashvili N, Agarwal P, Chiu LY, Pourpre R, Cammarata MB, Cannon JR, Sherker A, Durocher D, Brodbelt JS, Paull TT, Miller KM.

Genes Dev. 2017 Feb 1;31(3):260-274. doi: 10.1101/gad.292516.116. Epub 2017 Feb 27.

11.

The control of DNA repair by the cell cycle.

Hustedt N, Durocher D.

Nat Cell Biol. 2016 Dec 23;19(1):1-9. doi: 10.1038/ncb3452. Review.

PMID:
28008184
12.

Proteomic analysis of the human KEOPS complex identifies C14ORF142 as a core subunit homologous to yeast Gon7.

Wan LC, Maisonneuve P, Szilard RK, Lambert JP, Ng TF, Manczyk N, Huang H, Laister R, Caudy AA, Gingras AC, Durocher D, Sicheri F.

Nucleic Acids Res. 2017 Jan 25;45(2):805-817. doi: 10.1093/nar/gkw1181. Epub 2016 Nov 29.

13.

Association of Distinct Mutational Signatures With Correlates of Increased Immune Activity in Pancreatic Ductal Adenocarcinoma.

Connor AA, Denroche RE, Jang GH, Timms L, Kalimuthu SN, Selander I, McPherson T, Wilson GW, Chan-Seng-Yue MA, Borozan I, Ferretti V, Grant RC, Lungu IM, Costello E, Greenhalf W, Palmer D, Ghaneh P, Neoptolemos JP, Buchler M, Petersen G, Thayer S, Hollingsworth MA, Sherker A, Durocher D, Dhani N, Hedley D, Serra S, Pollett A, Roehrl MHA, Bavi P, Bartlett JMS, Cleary S, Wilson JM, Alexandrov LB, Moore M, Wouters BG, McPherson JD, Notta F, Stein LD, Gallinger S.

JAMA Oncol. 2017 Jun 1;3(6):774-783. doi: 10.1001/jamaoncol.2016.3916.

14.

53BP1 Goes Back to Its p53 Roots.

Durocher D, Pelletier L.

Mol Cell. 2016 Oct 6;64(1):3-4. doi: 10.1016/j.molcel.2016.09.024.

15.

Excess Polθ functions in response to replicative stress in homologous recombination-proficient cancer cells.

Goullet de Rugy T, Bashkurov M, Datti A, Betous R, Guitton-Sert L, Cazaux C, Durocher D, Hoffmann JS.

Biol Open. 2016 Oct 15;5(10):1485-1492. doi: 10.1242/bio.018028.

16.

The structural basis of modified nucleosome recognition by 53BP1.

Wilson MD, Benlekbir S, Fradet-Turcotte A, Sherker A, Julien JP, McEwan A, Noordermeer SM, Sicheri F, Rubinstein JL, Durocher D.

Nature. 2016 Aug 4;536(7614):100-3. Epub 2016 Jul 27.

PMID:
27462807
17.

Structural and functional characterization of KEOPS dimerization by Pcc1 and its role in t6A biosynthesis.

Wan LC, Pillon MC, Thevakumaran N, Sun Y, Chakrabartty A, Guarné A, Kurinov I, Durocher D, Sicheri F.

Nucleic Acids Res. 2016 Aug 19;44(14):6971-80. doi: 10.1093/nar/gkw542. Epub 2016 Jun 14.

18.

The TIP60 Complex Regulates Bivalent Chromatin Recognition by 53BP1 through Direct H4K20me Binding and H2AK15 Acetylation.

Jacquet K, Fradet-Turcotte A, Avvakumov N, Lambert JP, Roques C, Pandita RK, Paquet E, Herst P, Gingras AC, Pandita TK, Legube G, Doyon Y, Durocher D, Côté J.

Mol Cell. 2016 May 5;62(3):409-421. doi: 10.1016/j.molcel.2016.03.031.

19.

DNA damage signalling targets the kinetochore to promote chromatin mobility.

Strecker J, Gupta GD, Zhang W, Bashkurov M, Landry MC, Pelletier L, Durocher D.

Nat Cell Biol. 2016 Mar;18(3):281-90. doi: 10.1038/ncb3308. Epub 2016 Feb 1.

PMID:
26829389
20.

HELB Is a Feedback Inhibitor of DNA End Resection.

Tkáč J, Xu G, Adhikary H, Young JTF, Gallo D, Escribano-Díaz C, Krietsch J, Orthwein A, Munro M, Sol W, Al-Hakim A, Lin ZY, Jonkers J, Borst P, Brown GW, Gingras AC, Rottenberg S, Masson JY, Durocher D.

Mol Cell. 2016 Feb 4;61(3):405-418. doi: 10.1016/j.molcel.2015.12.013. Epub 2016 Jan 7.

21.

A mechanism for the suppression of homologous recombination in G1 cells.

Orthwein A, Noordermeer SM, Wilson MD, Landry S, Enchev RI, Sherker A, Munro M, Pinder J, Salsman J, Dellaire G, Xia B, Peter M, Durocher D.

Nature. 2015 Dec 17;528(7582):422-6. doi: 10.1038/nature16142. Epub 2015 Dec 9.

22.

High-Resolution CRISPR Screens Reveal Fitness Genes and Genotype-Specific Cancer Liabilities.

Hart T, Chandrashekhar M, Aregger M, Steinhart Z, Brown KR, MacLeod G, Mis M, Zimmermann M, Fradet-Turcotte A, Sun S, Mero P, Dirks P, Sidhu S, Roth FP, Rissland OS, Durocher D, Angers S, Moffat J.

Cell. 2015 Dec 3;163(6):1515-26. doi: 10.1016/j.cell.2015.11.015. Epub 2015 Nov 25.

23.

Analysis of the Histone H3.1 Interactome: A Suitable Chaperone for the Right Event.

Campos EI, Smits AH, Kang YH, Landry S, Escobar TM, Nayak S, Ueberheide BM, Durocher D, Vermeulen M, Hurwitz J, Reinberg D.

Mol Cell. 2015 Nov 19;60(4):697-709. doi: 10.1016/j.molcel.2015.08.005. Epub 2015 Oct 29.

24.

Perinuclear tethers license telomeric DSBs for a broad kinesin- and NPC-dependent DNA repair process.

Chung DK, Chan JN, Strecker J, Zhang W, Ebrahimi-Ardebili S, Lu T, Abraham KJ, Durocher D, Mekhail K.

Nat Commun. 2015 Jul 24;6:7742. doi: 10.1038/ncomms8742.

PMID:
26205667
25.

MAD2L2 controls DNA repair at telomeres and DNA breaks by inhibiting 5' end resection.

Boersma V, Moatti N, Segura-Bayona S, Peuscher MH, van der Torre J, Wevers BA, Orthwein A, Durocher D, Jacobs JJL.

Nature. 2015 May 28;521(7553):537-540. doi: 10.1038/nature14216. Epub 2015 Mar 23.

26.

Structure and mechanism of action of the hydroxy-aryl-aldehyde class of IRE1 endoribonuclease inhibitors.

Sanches M, Duffy NM, Talukdar M, Thevakumaran N, Chiovitti D, Canny MD, Lee K, Kurinov I, Uehling D, Al-awar R, Poda G, Prakesch M, Wilson B, Tam V, Schweitzer C, Toro A, Lucas JL, Vuga D, Lehmann L, Durocher D, Zeng Q, Patterson JB, Sicheri F.

Nat Commun. 2014 Aug 28;5:4202. doi: 10.1038/ncomms5202.

27.

Structural basis of Rad53 kinase activation by dimerization and activation segment exchange.

Wybenga-Groot LE, Ho CS, Sweeney FD, Ceccarelli DF, McGlade CJ, Durocher D, Sicheri F.

Cell Signal. 2014 Sep;26(9):1825-36. doi: 10.1016/j.cellsig.2014.05.004. Epub 2014 May 9.

PMID:
24815189
28.

Mitosis inhibits DNA double-strand break repair to guard against telomere fusions.

Orthwein A, Fradet-Turcotte A, Noordermeer SM, Canny MD, Brun CM, Strecker J, Escribano-Diaz C, Durocher D.

Science. 2014 Apr 11;344(6180):189-93. doi: 10.1126/science.1248024. Epub 2014 Mar 20.

29.

Nucleosome acidic patch promotes RNF168- and RING1B/BMI1-dependent H2AX and H2A ubiquitination and DNA damage signaling.

Leung JW, Agarwal P, Canny MD, Gong F, Robison AD, Finkelstein IJ, Durocher D, Miller KM.

PLoS Genet. 2014 Mar 6;10(3):e1004178. doi: 10.1371/journal.pgen.1004178. eCollection 2014 Mar.

30.

RNF8-independent Lys63 poly-ubiquitylation prevents genomic instability in response to replication-associated DNA damage.

Ramaekers CH, van den Beucken T, Bristow RG, Chiu RK, Durocher D, Wouters BG.

PLoS One. 2014 Feb 28;9(2):e89997. doi: 10.1371/journal.pone.0089997. eCollection 2014.

31.

Push back to respond better: regulatory inhibition of the DNA double-strand break response.

Panier S, Durocher D.

Nat Rev Mol Cell Biol. 2013 Oct;14(10):661-72. doi: 10.1038/nrm3659. Epub 2013 Sep 4. Review.

PMID:
24002223
32.

The CRAPome: a contaminant repository for affinity purification-mass spectrometry data.

Mellacheruvu D, Wright Z, Couzens AL, Lambert JP, St-Denis NA, Li T, Miteva YV, Hauri S, Sardiu ME, Low TY, Halim VA, Bagshaw RD, Hubner NC, Al-Hakim A, Bouchard A, Faubert D, Fermin D, Dunham WH, Goudreault M, Lin ZY, Badillo BG, Pawson T, Durocher D, Coulombe B, Aebersold R, Superti-Furga G, Colinge J, Heck AJ, Choi H, Gstaiger M, Mohammed S, Cristea IM, Bennett KL, Washburn MP, Raught B, Ewing RM, Gingras AC, Nesvizhskii AI.

Nat Methods. 2013 Aug;10(8):730-6. doi: 10.1038/nmeth.2557. Epub 2013 Jul 7.

33.

DNA repair pathway choice--a PTIP of the hat to 53BP1.

Escribano-Diaz C, Durocher D.

EMBO Rep. 2013 Aug;14(8):665-6. doi: 10.1038/embor.2013.99. Epub 2013 Jul 12. No abstract available.

34.

53BP1 is a reader of the DNA-damage-induced H2A Lys 15 ubiquitin mark.

Fradet-Turcotte A, Canny MD, Escribano-Díaz C, Orthwein A, Leung CC, Huang H, Landry MC, Kitevski-LeBlanc J, Noordermeer SM, Sicheri F, Durocher D.

Nature. 2013 Jul 4;499(7456):50-4. doi: 10.1038/nature12318. Epub 2013 Jun 12.

35.

Reconstitution and characterization of eukaryotic N6-threonylcarbamoylation of tRNA using a minimal enzyme system.

Wan LC, Mao DY, Neculai D, Strecker J, Chiovitti D, Kurinov I, Poda G, Thevakumaran N, Yuan F, Szilard RK, Lissina E, Nislow C, Caudy AA, Durocher D, Sicheri F.

Nucleic Acids Res. 2013 Jul;41(12):6332-46. doi: 10.1093/nar/gkt322. Epub 2013 Apr 25.

36.

Regulation of DNA damage responses by ubiquitin and SUMO.

Jackson SP, Durocher D.

Mol Cell. 2013 Mar 7;49(5):795-807. doi: 10.1016/j.molcel.2013.01.017. Epub 2013 Feb 14. Review.

37.

A cell cycle-dependent regulatory circuit composed of 53BP1-RIF1 and BRCA1-CtIP controls DNA repair pathway choice.

Escribano-Díaz C, Orthwein A, Fradet-Turcotte A, Xing M, Young JT, Tkáč J, Cook MA, Rosebrock AP, Munro M, Canny MD, Xu D, Durocher D.

Mol Cell. 2013 Mar 7;49(5):872-83. doi: 10.1016/j.molcel.2013.01.001. Epub 2013 Jan 17.

38.

A strategy for modulation of enzymes in the ubiquitin system.

Ernst A, Avvakumov G, Tong J, Fan Y, Zhao Y, Alberts P, Persaud A, Walker JR, Neculai AM, Neculai D, Vorobyov A, Garg P, Beatty L, Chan PK, Juang YC, Landry MC, Yeh C, Zeqiraj E, Karamboulas K, Allali-Hassani A, Vedadi M, Tyers M, Moffat J, Sicheri F, Pelletier L, Durocher D, Raught B, Rotin D, Yang J, Moran MF, Dhe-Paganon S, Sidhu SS.

Science. 2013 Feb 1;339(6119):590-5. doi: 10.1126/science.1230161. Epub 2013 Jan 3.

39.

Tandem protein interaction modules organize the ubiquitin-dependent response to DNA double-strand breaks.

Panier S, Ichijima Y, Fradet-Turcotte A, Leung CC, Kaustov L, Arrowsmith CH, Durocher D.

Mol Cell. 2012 Aug 10;47(3):383-95. doi: 10.1016/j.molcel.2012.05.045. Epub 2012 Jun 27.

40.

RMI1 promotes DNA replication fork progression and recovery from replication fork stress.

Yang J, O'Donnell L, Durocher D, Brown GW.

Mol Cell Biol. 2012 Aug;32(15):3054-64. doi: 10.1128/MCB.00255-12. Epub 2012 May 29.

41.

OTUB1 co-opts Lys48-linked ubiquitin recognition to suppress E2 enzyme function.

Juang YC, Landry MC, Sanches M, Vittal V, Leung CC, Ceccarelli DF, Mateo AR, Pruneda JN, Mao DY, Szilard RK, Orlicky S, Munro M, Brzovic PS, Klevit RE, Sicheri F, Durocher D.

Mol Cell. 2012 Feb 10;45(3):384-97. doi: 10.1016/j.molcel.2012.01.011. Erratum in: Mol Cell. 2012 May 25;46(4):549.

42.

Interaction proteomics identify NEURL4 and the HECT E3 ligase HERC2 as novel modulators of centrosome architecture.

Al-Hakim AK, Bashkurov M, Gingras AC, Durocher D, Pelletier L.

Mol Cell Proteomics. 2012 Jun;11(6):M111.014233. doi: 10.1074/mcp.M111.014233. Epub 2012 Jan 19.

43.

Srs2 enables checkpoint recovery by promoting disassembly of DNA damage foci from chromatin.

Yeung M, Durocher D.

DNA Repair (Amst). 2011 Dec 10;10(12):1213-22. doi: 10.1016/j.dnarep.2011.09.005. Epub 2011 Oct 5.

PMID:
21982442
44.

A siRNA-based screen for genes involved in chromosome end protection.

Lackner DH, Durocher D, Karlseder J.

PLoS One. 2011;6(6):e21407. doi: 10.1371/journal.pone.0021407. Epub 2011 Jun 23.

45.

An allosteric inhibitor of the human Cdc34 ubiquitin-conjugating enzyme.

Ceccarelli DF, Tang X, Pelletier B, Orlicky S, Xie W, Plantevin V, Neculai D, Chou YC, Ogunjimi A, Al-Hakim A, Varelas X, Koszela J, Wasney GA, Vedadi M, Dhe-Paganon S, Cox S, Xu S, Lopez-Girona A, Mercurio F, Wrana J, Durocher D, Meloche S, Webb DR, Tyers M, Sicheri F.

Cell. 2011 Jun 24;145(7):1075-87. doi: 10.1016/j.cell.2011.05.039. Epub 2011 Jun 16.

46.

MRE11 promotes AKT phosphorylation in direct response to DNA double-strand breaks.

Fraser M, Harding SM, Zhao H, Coackley C, Durocher D, Bristow RG.

Cell Cycle. 2011 Jul 1;10(13):2218-32. Epub 2011 Jul 1.

PMID:
21623170
47.

Genomic instability, defective spermatogenesis, immunodeficiency, and cancer in a mouse model of the RIDDLE syndrome.

Bohgaki T, Bohgaki M, Cardoso R, Panier S, Zeegers D, Li L, Stewart GS, Sanchez O, Hande MP, Durocher D, Hakem A, Hakem R.

PLoS Genet. 2011 Apr;7(4):e1001381. doi: 10.1371/journal.pgen.1001381. Epub 2011 Apr 28.

48.

Potent and selective inhibitors of the inositol-requiring enzyme 1 endoribonuclease.

Volkmann K, Lucas JL, Vuga D, Wang X, Brumm D, Stiles C, Kriebel D, Der-Sarkissian A, Krishnan K, Schweitzer C, Liu Z, Malyankar UM, Chiovitti D, Canny M, Durocher D, Sicheri F, Patterson JB.

J Biol Chem. 2011 Apr 8;286(14):12743-55. doi: 10.1074/jbc.M110.199737. Epub 2011 Feb 8.

49.

Uroporphyrinogen decarboxylase is a radiosensitizing target for head and neck cancer.

Ito E, Yue S, Moriyama EH, Hui AB, Kim I, Shi W, Alajez NM, Bhogal N, Li G, Datti A, Schimmer AD, Wilson BC, Liu PP, Durocher D, Neel BG, O'Sullivan B, Cummings B, Bristow R, Wrana J, Liu FF.

Sci Transl Med. 2011 Jan 26;3(67):67ra7. doi: 10.1126/scitranslmed.3001922.

50.

The ubiquitous role of ubiquitin in the DNA damage response.

Al-Hakim A, Escribano-Diaz C, Landry MC, O'Donnell L, Panier S, Szilard RK, Durocher D.

DNA Repair (Amst). 2010 Dec 10;9(12):1229-40. doi: 10.1016/j.dnarep.2010.09.011. Epub 2010 Nov 4. Review.

PMID:
21056014

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