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Items: 37

1.

NF-κB mediates radio-sensitization by the PARP-1 inhibitor, AG-014699.

Hunter JE, Willmore E, Irving JA, Hostomsky Z, Veuger SJ, Durkacz BW.

Oncogene. 2012 Jan 12;31(2):251-64. doi: 10.1038/onc.2011.229. Epub 2011 Jun 27.

2.

Persistence of unrepaired DNA double strand breaks caused by inhibition of ATM does not lead to radio-sensitisation in the absence of NF-κB activation.

Veuger SJ, Durkacz BW.

DNA Repair (Amst). 2011 Feb 7;10(2):235-44. doi: 10.1016/j.dnarep.2010.11.005. Epub 2010 Dec 8.

PMID:
21144805
3.

Mitoxantrone in combination with an inhibitor of DNA-dependent protein kinase: a potential therapy for high risk B-cell chronic lymphocytic leukaemia.

Elliott SL, Crawford C, Mulligan E, Summerfield G, Newton P, Wallis J, Mainou-Fowler T, Evans P, Bedwell C, Durkacz BW, Willmore E.

Br J Haematol. 2011 Jan;152(1):61-71. doi: 10.1111/j.1365-2141.2010.08425.x. Epub 2010 Nov 18.

PMID:
21083655
4.

Ionizing radiation-induced NF-kappaB activation requires PARP-1 function to confer radioresistance.

Veuger SJ, Hunter JE, Durkacz BW.

Oncogene. 2009 Feb 12;28(6):832-42. doi: 10.1038/onc.2008.439. Epub 2008 Dec 8.

5.

DNA-dependent protein kinase is a therapeutic target and an indicator of poor prognosis in B-cell chronic lymphocytic leukemia.

Willmore E, Elliott SL, Mainou-Fowler T, Summerfield GP, Jackson GH, O'Neill F, Lowe C, Carter A, Harris R, Pettitt AR, Cano-Soumillac C, Griffin RJ, Cowell IG, Austin CA, Durkacz BW.

Clin Cancer Res. 2008 Jun 15;14(12):3984-92. doi: 10.1158/1078-0432.CCR-07-5158.

6.

gammaH2AX foci form preferentially in euchromatin after ionising-radiation.

Cowell IG, Sunter NJ, Singh PB, Austin CA, Durkacz BW, Tilby MJ.

PLoS One. 2007 Oct 24;2(10):e1057.

7.
8.
9.

A novel DNA-dependent protein kinase inhibitor, NU7026, potentiates the cytotoxicity of topoisomerase II poisons used in the treatment of leukemia.

Willmore E, de Caux S, Sunter NJ, Tilby MJ, Jackson GH, Austin CA, Durkacz BW.

Blood. 2004 Jun 15;103(12):4659-65. Epub 2004 Mar 9.

10.

Novel poly(ADP-ribose) polymerase-1 inhibitor, AG14361, restores sensitivity to temozolomide in mismatch repair-deficient cells.

Curtin NJ, Wang LZ, Yiakouvaki A, Kyle S, Arris CA, Canan-Koch S, Webber SE, Durkacz BW, Calvert HA, Hostomsky Z, Newell DR.

Clin Cancer Res. 2004 Feb 1;10(3):881-9.

11.

Anticancer chemosensitization and radiosensitization by the novel poly(ADP-ribose) polymerase-1 inhibitor AG14361.

Calabrese CR, Almassy R, Barton S, Batey MA, Calvert AH, Canan-Koch S, Durkacz BW, Hostomsky Z, Kumpf RA, Kyle S, Li J, Maegley K, Newell DR, Notarianni E, Stratford IJ, Skalitzky D, Thomas HD, Wang LZ, Webber SE, Williams KJ, Curtin NJ.

J Natl Cancer Inst. 2004 Jan 7;96(1):56-67.

PMID:
14709739
12.
13.

Identification of potent nontoxic poly(ADP-Ribose) polymerase-1 inhibitors: chemopotentiation and pharmacological studies.

Calabrese CR, Batey MA, Thomas HD, Durkacz BW, Wang LZ, Kyle S, Skalitzky D, Li J, Zhang C, Boritzki T, Maegley K, Calvert AH, Hostomsky Z, Newell DR, Curtin NJ.

Clin Cancer Res. 2003 Jul;9(7):2711-8.

14.

Potentiation of temozolomide and topotecan growth inhibition and cytotoxicity by novel poly(adenosine diphosphoribose) polymerase inhibitors in a panel of human tumor cell lines.

Delaney CA, Wang LZ, Kyle S, White AW, Calvert AH, Curtin NJ, Durkacz BW, Hostomsky Z, Newell DR.

Clin Cancer Res. 2000 Jul;6(7):2860-7.

15.
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18.

Wortmannin is a potent inhibitor of DNA double strand break but not single strand break repair in Chinese hamster ovary cells.

Boulton S, Kyle S, Yalçintepe L, Durkacz BW.

Carcinogenesis. 1996 Nov;17(11):2285-90.

PMID:
8968039
19.

Potentiation of temozolomide-induced cytotoxicity: a comparative study of the biological effects of poly(ADP-ribose) polymerase inhibitors.

Boulton S, Pemberton LC, Porteous JK, Curtin NJ, Griffin RJ, Golding BT, Durkacz BW.

Br J Cancer. 1995 Oct;72(4):849-56.

20.

Novel potent inhibitors of the DNA repair enzyme poly(ADP-ribose)polymerase (PARP).

Griffin RJ, Pemberton LC, Rhodes D, Bleasdale C, Bowman K, Calvert AH, Curtin NJ, Durkacz BW, Newell DR, Porteous JK, et al.

Anticancer Drug Des. 1995 Sep;10(6):507-14. No abstract available.

PMID:
7575991
21.

The role of inhibitors of poly(ADP-ribose) polymerase as resistance-modifying agents in cancer therapy.

Griffin RJ, Curtin NJ, Newell DR, Golding BT, Durkacz BW, Calvert AH.

Biochimie. 1995;77(6):408-22. Review.

PMID:
7578423
22.
24.

Murine melanoma cell differentiation and melanogenesis induced by poly(ADP-ribose) polymerase inhibitors.

Durkacz BW, Lunec J, Grindley H, Griffin S, Horner O, Simm A.

Exp Cell Res. 1992 Oct;202(2):287-91.

PMID:
1327852
26.

Synergistic enhancement of 6-thioguanine cytotoxicity by ADP-ribosyltransferase inhibitors.

Moses K, Harris AL, Durkacz BW.

Cancer Res. 1988 Oct 15;48(20):5650-4.

27.
28.

A mammalian cell variant in which 3-aminobenzamide does not potentiate the cytotoxicity of dimethyl sulphate.

Murray B, Irwin J, Creissen D, Tavassoli M, Durkacz BW, Shall S.

Mutat Res. 1986 May;165(3):191-8.

PMID:
3010097
29.
30.

Evidence that poly(ADP-ribose) polymerase is involved in the loss of NAD from cultured rat liver cells.

Paine AJ, Allen CM, Durkacz BW, Shall S.

Biochem J. 1982 Feb 15;202(2):551-3.

31.
32.

Inhibition of (ADP-ribose)n biosynthesis retards DNA repair but does not inhibit DNA repair synthesis.

Durkacz BW, Irwin J, Shall S.

Biochem Biophys Res Commun. 1981 Aug 31;101(4):1433-41. No abstract available.

PMID:
6272786
34.

(ADP-ribose)n participates in DNA excision repair.

Durkacz BW, Omidiji O, Gray DA, Shall S.

Nature. 1980 Feb 7;283(5747):593-6.

PMID:
6243744
35.

Homologous regions of colicins E1 and K and colicins E2 and E3 [proceedings].

Watson DH, Durkacz BW, Sherratt DJ.

Biochem Soc Trans. 1978;6(6):1257-9. No abstract available.

PMID:
744405
36.

Plasmid replication and the induced synthesis of colicins E1 and E2 in Escherichia coli.

Durkacz BW, Kennedy CK, Sherratt DJ.

J Bacteriol. 1974 Mar;117(3):940-6.

37.

Segregation kinetics of colicinogenic factor col E1 from a bacterial population temperature sensitive for DNA polymerase I.

Durkacz BW, Sherratt DJ.

Mol Gen Genet. 1973;121(1):71-5. No abstract available.

PMID:
4351553

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