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Gaboxadol Normalizes Behavioral Abnormalities in a Mouse Model of Fragile X Syndrome.

Cogram P, Deacon RMJ, Warner-Schmidt JL, von Schimmelmann MJ, Abrahams BS, During MJ.

Front Behav Neurosci. 2019 Jun 25;13:141. doi: 10.3389/fnbeh.2019.00141. eCollection 2019.


Olanzapine: A potent agonist at the hM4D(Gi) DREADD amenable to clinical translation of chemogenetics.

Weston M, Kaserer T, Wu A, Mouravlev A, Carpenter JC, Snowball A, Knauss S, von Schimmelmann M, During MJ, Lignani G, Schorge S, Young D, Kullmann DM, Lieb A.

Sci Adv. 2019 Apr 17;5(4):eaaw1567. doi: 10.1126/sciadv.aaw1567. eCollection 2019 Apr.


Gene therapy reduces Parkinson's disease symptoms by reorganizing functional brain connectivity.

Niethammer M, Tang CC, Vo A, Nguyen N, Spetsieris P, Dhawan V, Ma Y, Small M, Feigin A, During MJ, Kaplitt MG, Eidelberg D.

Sci Transl Med. 2018 Nov 28;10(469). pii: eaau0713. doi: 10.1126/scitranslmed.aau0713.


N-methyl-d-aspartate receptor mediated calcium influx supports in vitro differentiation of normal mouse megakaryocytes but proliferation of leukemic cell lines.

Kamal T, Green TN, Hearn JI, Josefsson EC, Morel-Kopp MC, Ward CM, During MJ, Kalev-Zylinska ML.

Res Pract Thromb Haemost. 2017 Dec 14;2(1):125-138. doi: 10.1002/rth2.12068. eCollection 2018 Jan.


A clinical-grade gene therapy vector for pharmacoresistant epilepsy successfully overexpresses NPY in a human neuronal cell line.

Patrício MI, Barnard AR, Green AL, During MJ, Sen A, MacLaren RE.

Seizure. 2018 Feb;55:25-29. doi: 10.1016/j.seizure.2017.12.005. Epub 2017 Dec 18.


Long-term restoration of visual function in end-stage retinal degeneration using subretinal human melanopsin gene therapy.

De Silva SR, Barnard AR, Hughes S, Tam SKE, Martin C, Singh MS, Barnea-Cramer AO, McClements ME, During MJ, Peirson SN, Hankins MW, MacLaren RE.

Proc Natl Acad Sci U S A. 2017 Oct 17;114(42):11211-11216. doi: 10.1073/pnas.1701589114. Epub 2017 Oct 2.


Cdc25A Is a Critical Mediator of Ischemic Neuronal Death In Vitro and In Vivo.

Iyirhiaro GO, Im DS, Boonying W, Callaghan SM, During MJ, Slack RS, Park DS.

J Neurosci. 2017 Jul 12;37(28):6729-6740. doi: 10.1523/JNEUROSCI.3017-16.2017. Epub 2017 Jun 12.


Long-term follow-up of a randomized AAV2-GAD gene therapy trial for Parkinson's disease.

Niethammer M, Tang CC, LeWitt PA, Rezai AR, Leehey MA, Ojemann SG, Flaherty AW, Eskandar EN, Kostyk SK, Sarkar A, Siddiqui MS, Tatter SB, Schwalb JM, Poston KL, Henderson JM, Kurlan RM, Richard IH, Sapan CV, Eidelberg D, During MJ, Kaplitt MG, Feigin A.

JCI Insight. 2017 Apr 6;2(7):e90133. doi: 10.1172/jci.insight.90133.


Inhibition of NMDA receptor function with an anti-GluN1-S2 antibody impairs human platelet function and thrombosis.

Green TN, Hamilton JR, Morel-Kopp MC, Zheng Z, Chen TT, Hearn JI, Sun PP, Flanagan JU, Young D, Barber PA, During MJ, Ward CM, Kalev-Zylinska ML.

Platelets. 2017 Dec;28(8):799-811. doi: 10.1080/09537104.2017.1280149. Epub 2017 Feb 21.


Selected GRIN2A mutations in melanoma cause oncogenic effects that can be modulated by extracellular glutamate.

D'mello SA, Joseph WR, Green TN, Leung EY, During MJ, Finlay GJ, Baguley BC, Kalev-Zylinska ML.

Cell Calcium. 2016 Dec;60(6):384-395. doi: 10.1016/j.ceca.2016.09.003. Epub 2016 Sep 14.


A Therapeutic Role for Survivin in Mitigating the Harmful Effects of Ionizing Radiation.

Carruthers KH, Metzger G, Choi E, During MJ, Kocak E.

Sarcoma. 2016;2016:1830849. doi: 10.1155/2016/1830849. Epub 2016 Apr 17.


Inhibition of glutamate regulated calcium entry into leukemic megakaryoblasts reduces cell proliferation and supports differentiation.

Kamal T, Green TN, Morel-Kopp MC, Ward CM, McGregor AL, McGlashan SR, Bohlander SK, Browett PJ, Teague L, During MJ, Skerry TM, Josefsson EC, Kalev-Zylinska ML.

Cell Signal. 2015 Sep;27(9):1860-72. doi: 10.1016/j.cellsig.2015.05.004. Epub 2015 May 14.


Adipose VEGF Links the White-to-Brown Fat Switch With Environmental, Genetic, and Pharmacological Stimuli in Male Mice.

During MJ, Liu X, Huang W, Magee D, Slater A, McMurphy T, Wang C, Cao L.

Endocrinology. 2015 Jun;156(6):2059-73. doi: 10.1210/en.2014-1905. Epub 2015 Mar 12.


Social overcrowding as a chronic stress model that increases adiposity in mice.

Lin EJ, Sun M, Choi EY, Magee D, Stets CW, During MJ.

Psychoneuroendocrinology. 2015 Jan;51:318-30. doi: 10.1016/j.psyneuen.2014.10.007. Epub 2014 Oct 16.


Gene-directed enzyme prodrug therapy for localized chemotherapeutics in allograft and xenograft tumor models.

Carruthers KH, Metzger G, During MJ, Muravlev A, Wang C, Kocak E.

Cancer Gene Ther. 2014 Oct;21(10):434-40. doi: 10.1038/cgt.2014.47. Epub 2014 Sep 19.


Adenosine kinase, glutamine synthetase and EAAT2 as gene therapy targets for temporal lobe epilepsy.

Young D, Fong DM, Lawlor PA, Wu A, Mouravlev A, McRae M, Glass M, Dragunow M, During MJ.

Gene Ther. 2014 Dec;21(12):1029-40. doi: 10.1038/gt.2014.82. Epub 2014 Sep 18.


Network modulation following sham surgery in Parkinson's disease.

Ko JH, Feigin A, Mattis PJ, Tang CC, Ma Y, Dhawan V, During MJ, Kaplitt MG, Eidelberg D.

J Clin Invest. 2014 Aug;124(8):3656-66. doi: 10.1172/JCI75073. Epub 2014 Jul 18.


An Immunological Approach to Increase the Brain's Resilience to Insults.

Lin EJ, Symes CW, Townsend-Nicholson A, Klugmann M, Klugmann CB, Lehnert K, Fong D, Young D, During MJ.

ISRN Neurosci. 2014 Apr 24;2014:103213. doi: 10.1155/2014/103213. eCollection 2014.


Regulation of ischemic neuronal death by E2F4-p130 protein complexes.

Iyirhiaro GO, Zhang Y, Estey C, O'Hare MJ, Safarpour F, Parsanejad M, Wang S, Abdel-Messih E, Callaghan SM, During MJ, Slack RS, Park DS.

J Biol Chem. 2014 Jun 27;289(26):18202-13. doi: 10.1074/jbc.M114.574145. Epub 2014 May 14.


AAV-mediated overexpression of neuroserpin in the hippocampus decreases PSD-95 expression but does not affect hippocampal-dependent learning and memory.

Tsang VW, Young D, During MJ, Birch NP.

PLoS One. 2014 Mar 7;9(3):e91050. doi: 10.1371/journal.pone.0091050. eCollection 2014.


N-methyl-D-aspartate receptors amplify activation and aggregation of human platelets.

Kalev-Zylinska ML, Green TN, Morel-Kopp MC, Sun PP, Park YE, Lasham A, During MJ, Ward CM.

Thromb Res. 2014 May;133(5):837-47. doi: 10.1016/j.thromres.2014.02.011. Epub 2014 Feb 21.


Neuropeptide y attenuates stress-induced bone loss through suppression of noradrenaline circuits.

Baldock PA, Lin S, Zhang L, Karl T, Shi Y, Driessler F, Zengin A, Hörmer B, Lee NJ, Wong IP, Lin EJ, Enriquez RF, Stehrer B, During MJ, Yulyaningsih E, Zolotukhin S, Ruohonen ST, Savontaus E, Sainsbury A, Herzog H.

J Bone Miner Res. 2014 Oct;29(10):2238-49. doi: 10.1002/jbmr.2205.


Evidence That GRIN2A Mutations in Melanoma Correlate with Decreased Survival.

D'mello SA, Flanagan JU, Green TN, Leung EY, Askarian-Amiri ME, Joseph WR, McCrystal MR, Isaacs RJ, Shaw JH, Furneaux CE, During MJ, Finlay GJ, Baguley BC, Kalev-Zylinska ML.

Front Oncol. 2014 Jan 13;3:333. doi: 10.3389/fonc.2013.00333. eCollection 2014 Jan 13.


Retinal gene therapy in patients with choroideremia: initial findings from a phase 1/2 clinical trial.

MacLaren RE, Groppe M, Barnard AR, Cottriall CL, Tolmachova T, Seymour L, Clark KR, During MJ, Cremers FP, Black GC, Lotery AJ, Downes SM, Webster AR, Seabra MC.

Lancet. 2014 Mar 29;383(9923):1129-37. doi: 10.1016/S0140-6736(13)62117-0. Epub 2014 Jan 16.


Behavior of knock-in mice with a cocaine-insensitive dopamine transporter after virogenetic restoration of cocaine sensitivity in the striatum.

O'Neill B, Tilley MR, Han DD, Thirtamara-Rajamani K, Hill ER, Bishop GA, Zhou FM, During MJ, Gu HH.

Neuropharmacology. 2014 Apr;79:626-33. doi: 10.1016/j.neuropharm.2013.12.023. Epub 2014 Jan 9.


Metabolic Effects of Social Isolation in Adult C57BL/6 Mice.

Sun M, Choi EY, Magee DJ, Stets CW, During MJ, Lin EJ.

Int Sch Res Notices. 2014 Nov 26;2014:690950. doi: 10.1155/2014/690950. eCollection 2014.


Neuronal activity-regulated pentraxin expressed in medial prefrontal cortex neurons is not necessary for extinction of heroin self-administration.

Blouin AM, Stern AL, Han S, Theberge FR, Wang C, During MJ, Baraban JM, Reti IM.

Behav Pharmacol. 2013 Aug;24(4):332-6. doi: 10.1097/FBP.0b013e328363367b.


Stroke patients develop antibodies that react with components of N-methyl-D-aspartate receptor subunit 1 in proportion to lesion size.

Kalev-Zylinska ML, Symes W, Little KC, Sun P, Wen D, Qiao L, Young D, During MJ, Barber PA.

Stroke. 2013 Aug;44(8):2212-9. doi: 10.1161/STROKEAHA.113.001235. Epub 2013 May 30.


Assessment of tropism and effectiveness of new primate-derived hybrid recombinant AAV serotypes in the mouse and primate retina.

Charbel Issa P, De Silva SR, Lipinski DM, Singh MS, Mouravlev A, You Q, Barnard AR, Hankins MW, During MJ, Maclaren RE.

PLoS One. 2013 Apr 9;8(4):e60361. doi: 10.1371/journal.pone.0060361. Print 2013.


Fat grafting as a vehicle for the delivery of recombinant adenoassociated viral vectors to achieve gene modification of muscle flaps.

Carruthers KH, During MJ, Muravlev A, Wang C, Kocak E.

Ann Plast Surg. 2013 Jun;70(6):726-31. doi: 10.1097/SAP.0b013e3182414add.


Role of medial prefrontal cortex Narp in the extinction of morphine conditioned place preference.

Blouin AM, Han S, Pearce AM, Cheng K, Lee JJ, Johnson AW, Wang C, During MJ, Holland PC, Shaham Y, Baraban JM, Reti IM.

Learn Mem. 2013 Jan 15;20(2):75-9. doi: 10.1101/lm.028621.112.


Long-term follow-up after gene therapy for canavan disease.

Leone P, Shera D, McPhee SW, Francis JS, Kolodny EH, Bilaniuk LT, Wang DJ, Assadi M, Goldfarb O, Goldman HW, Freese A, Young D, During MJ, Samulski RJ, Janson CG.

Sci Transl Med. 2012 Dec 19;4(165):165ra163. doi: 10.1126/scitranslmed.3003454.


SOCS1 gene transfer accelerates the transition to heart failure through the inhibition of the gp130/JAK/STAT pathway.

Cittadini A, Monti MG, Iaccarino G, Castiello MC, Baldi A, Bossone E, Longobardi S, Marra AM, Petrillo V, Saldamarco L, During MJ, Saccà L, Condorelli G.

Cardiovasc Res. 2012 Dec 1;96(3):381-90. doi: 10.1093/cvr/cvs261. Epub 2012 Aug 8.


What is the brain-cancer connection?

Cao L, During MJ.

Annu Rev Neurosci. 2012;35:331-45. doi: 10.1146/annurev-neuro-062111-150546. Epub 2012 Mar 29. Review.


Specific knockdown of the D2 long dopamine receptor variant.

Naughton BJ, Thirtamara-Rajamani K, Wang C, During MJ, Gu HH.

Neuroreport. 2012 Jan 4;23(1):1-5. doi: 10.1097/WNR.0b013e32834d2216.


Distinct modes of AMPA receptor suppression at developing synapses by GluN2A and GluN2B: single-cell NMDA receptor subunit deletion in vivo.

Gray JA, Shi Y, Usui H, During MJ, Sakimura K, Nicoll RA.

Neuron. 2011 Sep 22;71(6):1085-101. doi: 10.1016/j.neuron.2011.08.007. Epub 2011 Sep 21.


White to brown fat phenotypic switch induced by genetic and environmental activation of a hypothalamic-adipocyte axis.

Cao L, Choi EY, Liu X, Martin A, Wang C, Xu X, During MJ.

Cell Metab. 2011 Sep 7;14(3):324-38. doi: 10.1016/j.cmet.2011.06.020.


AAV2-GAD gene therapy for advanced Parkinson's disease: a double-blind, sham-surgery controlled, randomised trial.

LeWitt PA, Rezai AR, Leehey MA, Ojemann SG, Flaherty AW, Eskandar EN, Kostyk SK, Thomas K, Sarkar A, Siddiqui MS, Tatter SB, Schwalb JM, Poston KL, Henderson JM, Kurlan RM, Richard IH, Van Meter L, Sapan CV, During MJ, Kaplitt MG, Feigin A.

Lancet Neurol. 2011 Apr;10(4):309-19. doi: 10.1016/S1474-4422(11)70039-4.


Localized disruption of Narp in medial prefrontal cortex blocks reinforcer devaluation performance.

Johnson AW, Han S, Blouin AM, Saini J, Worley PF, During MJ, Holland PC, Baraban JM, Reti IM.

Learn Mem. 2010 Nov 22;17(12):620-6. doi: 10.1101/lm.1937210. Print 2010 Dec.


Potentiation of synaptic AMPA receptors induced by the deletion of NMDA receptors requires the GluA2 subunit.

Lu W, Gray JA, Granger AJ, During MJ, Nicoll RA.

J Neurophysiol. 2011 Feb;105(2):923-8. doi: 10.1152/jn.00725.2010. Epub 2010 Oct 27.


Environmental enrichment exerts sex-specific effects on emotionality in C57BL/6J mice.

Lin EJ, Choi E, Liu X, Martin A, During MJ.

Behav Brain Res. 2011 Jan 1;216(1):349-57. doi: 10.1016/j.bbr.2010.08.019. Epub 2010 Aug 21.


Environmental and genetic activation of a brain-adipocyte BDNF/leptin axis causes cancer remission and inhibition.

Cao L, Liu X, Lin EJ, Wang C, Choi EY, Riban V, Lin B, During MJ.

Cell. 2010 Jul 9;142(1):52-64. doi: 10.1016/j.cell.2010.05.029.


Biodistribution and safety assessment of AAV2-GAD following intrasubthalamic injection in the rat.

Fitzsimons HL, Riban V, Bland RJ, Wendelken JL, Sapan CV, During MJ.

J Gene Med. 2010 Apr;12(4):385-98. doi: 10.1002/jgm.1449.


Anticonvulsant effects and behavioural outcomes of rAAV serotype 1 vector-mediated neuropeptide Y overexpression in rat hippocampus.

Noe F, Vaghi V, Balducci C, Fitzsimons H, Bland R, Zardoni D, Sperk G, Carli M, During MJ, Vezzani A.

Gene Ther. 2010 May;17(5):643-52. doi: 10.1038/gt.2010.23. Epub 2010 Mar 11.


Critical role of arcuate Y4 receptors and the melanocortin system in pancreatic polypeptide-induced reduction in food intake in mice.

Lin S, Shi YC, Yulyaningsih E, Aljanova A, Zhang L, Macia L, Nguyen AD, Lin EJ, During MJ, Herzog H, Sainsbury A.

PLoS One. 2009 Dec 30;4(12):e8488. doi: 10.1371/journal.pone.0008488.


Essential role of cytoplasmic cdk5 and Prx2 in multiple ischemic injury models, in vivo.

Rashidian J, Rousseaux MW, Venderova K, Qu D, Callaghan SM, Phillips M, Bland RJ, During MJ, Mao Z, Slack RS, Park DS.

J Neurosci. 2009 Oct 7;29(40):12497-505. doi: 10.1523/JNEUROSCI.3892-09.2009.


Adult-onset hippocampal-specific neuropeptide Y overexpression confers mild anxiolytic effect in mice.

Lin EJ, Lin S, Aljanova A, During MJ, Herzog H.

Eur Neuropsychopharmacol. 2010 Mar;20(3):164-75. doi: 10.1016/j.euroneuro.2009.08.004. Epub 2009 Sep 24.


Efficient gene delivery and selective transduction of glial cells in the mammalian brain by AAV serotypes isolated from nonhuman primates.

Lawlor PA, Bland RJ, Mouravlev A, Young D, During MJ.

Mol Ther. 2009 Oct;17(10):1692-702. doi: 10.1038/mt.2009.170. Epub 2009 Jul 28.


Regulation of the postnatal development of dopamine neurons of the substantia nigra in vivo by Akt/protein kinase B.

Ries V, Cheng HC, Baohan A, Kareva T, Oo TF, Rzhetskaya M, Bland RJ, During MJ, Kholodilov N, Burke RE.

J Neurochem. 2009 Jul;110(1):23-33. doi: 10.1111/j.1471-4159.2009.06101.x. Epub 2009 Apr 16.


Subunit composition of synaptic AMPA receptors revealed by a single-cell genetic approach.

Lu W, Shi Y, Jackson AC, Bjorgan K, During MJ, Sprengel R, Seeburg PH, Nicoll RA.

Neuron. 2009 Apr 30;62(2):254-68. doi: 10.1016/j.neuron.2009.02.027.

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