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Items: 24


LSD1 inhibition attenuates androgen receptor V7 splice variant activation in castration resistant prostate cancer models.

Regufe da Mota S, Bailey S, Strivens RA, Hayden AL, Douglas LR, Duriez PJ, Borrello MT, Benelkebir H, Ganesan A, Packham G, Crabb SJ.

Cancer Cell Int. 2018 May 9;18:71. doi: 10.1186/s12935-018-0568-1. eCollection 2018.


Linear doggybone DNA vaccine induces similar immunological responses to conventional plasmid DNA independently of immune recognition by TLR9 in a pre-clinical model.

Allen A, Wang C, Caproni LJ, Sugiyarto G, Harden E, Douglas LR, Duriez PJ, Karbowniczek K, Extance J, Rothwell PJ, Orefo I, Tite JP, Stevenson FK, Ottensmeier CH, Savelyeva N.

Cancer Immunol Immunother. 2018 Apr;67(4):627-638. doi: 10.1007/s00262-017-2111-y. Epub 2018 Jan 12.


STING Activation Reverses Lymphoma-Mediated Resistance to Antibody Immunotherapy.

Dahal LN, Dou L, Hussain K, Liu R, Earley A, Cox KL, Murinello S, Tracy I, Forconi F, Steele AJ, Duriez PJ, Gomez-Nicola D, Teeling JL, Glennie MJ, Cragg MS, Beers SA.

Cancer Res. 2017 Jul 1;77(13):3619-3631. doi: 10.1158/0008-5472.CAN-16-2784. Epub 2017 May 16.


Fluorinated tranylcypromine analogues as inhibitors of lysine-specific demethylase 1 (LSD1, KDM1A).

Borrello MT, Schinor B, Bartels K, Benelkebir H, Pereira S, Al-Jamal WT, Douglas L, Duriez PJ, Packham G, Haufe G, Ganesan A.

Bioorg Med Chem Lett. 2017 May 15;27(10):2099-2101. doi: 10.1016/j.bmcl.2017.03.081. Epub 2017 Mar 29.


TAPBPR alters MHC class I peptide presentation by functioning as a peptide exchange catalyst.

Hermann C, van Hateren A, Trautwein N, Neerincx A, Duriez PJ, Stevanović S, Trowsdale J, Deane JE, Elliott T, Boyle LH.

Elife. 2015 Oct 6;4. pii: e09617. doi: 10.7554/eLife.09617.


A novel zinc finger gene, ZNF465, is inappropriately expressed in acute myeloid leukaemia cells.

Collin JF, Wells JW, Czepulkowski B, Lyne L, Duriez PJ, Banham AH, Mufti GJ, Guinn BA.

Genes Chromosomes Cancer. 2015 May;54(5):288-302. doi: 10.1002/gcc.22242. Epub 2015 Feb 23.


Antigenic modulation limits the effector cell mechanisms employed by type I anti-CD20 monoclonal antibodies.

Tipton TR, Roghanian A, Oldham RJ, Carter MJ, Cox KL, Mockridge CI, French RR, Dahal LN, Duriez PJ, Hargreaves PG, Cragg MS, Beers SA.

Blood. 2015 Mar 19;125(12):1901-9. doi: 10.1182/blood-2014-07-588376. Epub 2015 Jan 28.


Enantioselective synthesis of tranylcypromine analogues as lysine demethylase (LSD1) inhibitors.

Benelkebir H, Hodgkinson C, Duriez PJ, Hayden AL, Bulleid RA, Crabb SJ, Packham G, Ganesan A.

Bioorg Med Chem. 2011 Jun 15;19(12):3709-16. doi: 10.1016/j.bmc.2011.02.017. Epub 2011 Feb 13.


Suppression of interleukin-33 bioactivity through proteolysis by apoptotic caspases.

Lüthi AU, Cullen SP, McNeela EA, Duriez PJ, Afonina IS, Sheridan C, Brumatti G, Taylor RC, Kersse K, Vandenabeele P, Lavelle EC, Martin SJ.

Immunity. 2009 Jul 17;31(1):84-98. doi: 10.1016/j.immuni.2009.05.007. Epub 2009 Jun 25.


Bicaudal is a conserved substrate for Drosophila and mammalian caspases and is essential for cell survival.

Creagh EM, Brumatti G, Sheridan C, Duriez PJ, Taylor RC, Cullen SP, Adrain C, Martin SJ.

PLoS One. 2009;4(3):e5055. doi: 10.1371/journal.pone.0005055. Epub 2009 Mar 30. Erratum in: PLoS ONE. 2009;4(3). doi: 10.1371/annotation/dbafbfb3-0c37-4e20-931a-8f041ff5d721.


Human and murine granzyme B exhibit divergent substrate preferences.

Cullen SP, Adrain C, Lüthi AU, Duriez PJ, Martin SJ.

J Cell Biol. 2007 Feb 12;176(4):435-44. Epub 2007 Feb 5.


Role for CED-9 and Egl-1 as regulators of mitochondrial fission and fusion dynamics.

Delivani P, Adrain C, Taylor RC, Duriez PJ, Martin SJ.

Mol Cell. 2006 Mar 17;21(6):761-73.


The cytotoxic lymphocyte protease, granzyme B, targets the cytoskeleton and perturbs microtubule polymerization dynamics.

Adrain C, Duriez PJ, Brumatti G, Delivani P, Martin SJ.

J Biol Chem. 2006 Mar 24;281(12):8118-25. Epub 2006 Jan 16.


Analysis of the composition, assembly kinetics and activity of native Apaf-1 apoptosomes.

Hill MM, Adrain C, Duriez PJ, Creagh EM, Martin SJ.

EMBO J. 2004 May 19;23(10):2134-45. Epub 2004 Apr 22.


Smac/Diablo antagonizes ubiquitin ligase activity of inhibitor of apoptosis proteins.

Creagh EM, Murphy BM, Duriez PJ, Duckett CS, Martin SJ.

J Biol Chem. 2004 Jun 25;279(26):26906-14. Epub 2004 Apr 12.


Effects of transient global ischemia and kainate on poly(ADP-ribose) polymerase (PARP) gene expression and proteolytic cleavage in gerbil and rat brains.

Liu J, Ying W, Massa S, Duriez PJ, Swanson RA, Poirier GG, Sharp FR.

Brain Res Mol Brain Res. 2000 Aug 14;80(1):7-16.


A1 functions at the mitochondria to delay endothelial apoptosis in response to tumor necrosis factor.

Duriez PJ, Wong F, Dorovini-Zis K, Shahidi R, Karsan A.

J Biol Chem. 2000 Jun 16;275(24):18099-107.


Immunological determination and size characterization of poly(ADP-ribose) synthesized in vitro and in vivo.

Affar EB, Duriez PJ, Shah RG, Winstall E, Germain M, Boucher C, Bourassa S, Kirkland JB, Poirier GG.

Biochim Biophys Acta. 1999 Aug 5;1428(2-3):137-46.


Immunodot blot method for the detection of poly(ADP-ribose) synthesized in vitro and in vivo.

Affar EB, Duriez PJ, Shah RG, Sallmann FR, Bourassa S, Küpper JH, Bürkle A, Poirier GG.

Anal Biochem. 1998 Jun 1;259(2):280-3. No abstract available.


Purification of the death substrate poly(ADP-ribose) polymerase.

D'Amours D, Duriez PJ, Orth K, Shah RG, Dixit VM, Earnshaw WC, Alnemri ES, Poirier GG.

Anal Biochem. 1997 Jun 15;249(1):106-8. No abstract available.


Characterization of anti-peptide antibodies directed towards the automodification domain and apoptotic fragment of poly (ADP-ribose) polymerase.

Duriez PJ, Desnoyers S, Hoflack JC, Shah GM, Morelle B, Bourassa S, Poirier GG, Talbot B.

Biochim Biophys Acta. 1997 Feb 11;1334(1):65-72.


Cleavage of poly(ADP-ribose) polymerase: a sensitive parameter to study cell death.

Duriez PJ, Shah GM.

Biochem Cell Biol. 1997;75(4):337-49. Review.


Granzyme B/perforin-mediated apoptosis of Jurkat cells results in cleavage of poly(ADP-ribose) polymerase to the 89-kDa apoptotic fragment and less abundant 64-kDa fragment.

Froelich CJ, Hanna WL, Poirier GG, Duriez PJ, D'Amours D, Salvesen GS, Alnemri ES, Earnshaw WC, Shah GM.

Biochem Biophys Res Commun. 1996 Oct 23;227(3):658-65.


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