Sort by
Items per page

Send to

Choose Destination

Search results

Items: 26


STORI Plots Enable Accurate Tracking of Individual Ion Signals.

Kafader JO, Beu SC, Early BP, Melani RD, Durbin KR, Zabrouskov V, Makarov AA, Maze JT, Shinholt DL, Yip PF, Kelleher NL, Compton PD, Senko MW.

J Am Soc Mass Spectrom. 2019 Sep 11. doi: 10.1007/s13361-019-02309-0. [Epub ahead of print]


Determination of IL-23 Pharmacokinetics by Highly Sensitive Accelerator Mass Spectrometry and Subsequent Modeling to Project IL-23 Suppression in Psoriasis Patients Treated with Anti-IL-23 Antibodies.

Zhang TT, Ma J, Durbin KR, Montavon T, Lacy SE, Jenkins GJ, Doktor S, Kalvass JC.

AAPS J. 2019 Jun 27;21(5):82. doi: 10.1208/s12248-019-0352-8.


Potential mechanisms of target-independent uptake and toxicity of antibody-drug conjugates.

Mahalingaiah PK, Ciurlionis R, Durbin KR, Yeager RL, Philip BK, Bawa B, Mantena SR, Enright BP, Liguori MJ, Van Vleet TR.

Pharmacol Ther. 2019 Aug;200:110-125. doi: 10.1016/j.pharmthera.2019.04.008. Epub 2019 Apr 24. Review.


High-Throughput, Multispecies, Parallelized Plasma Stability Assay for the Determination and Characterization of Antibody-Drug Conjugate Aggregation and Drug Release.

Durbin KR, Nottoli MS, Catron ND, Richwine N, Jenkins GJ.

ACS Omega. 2017 Aug 31;2(8):4207-4215. doi: 10.1021/acsomega.7b00452. Epub 2017 Aug 3.


Accurate Sequence Analysis of a Monoclonal Antibody by Top-Down and Middle-Down Orbitrap Mass Spectrometry Applying Multiple Ion Activation Techniques.

Fornelli L, Srzentić K, Huguet R, Mullen C, Sharma S, Zabrouskov V, Fellers RT, Durbin KR, Compton PD, Kelleher NL.

Anal Chem. 2018 Jul 17;90(14):8421-8429. doi: 10.1021/acs.analchem.8b00984. Epub 2018 Jun 28.


Mechanistic Modeling of Antibody-Drug Conjugate Internalization at the Cellular Level Reveals Inefficient Processing Steps.

Durbin KR, Phipps C, Liao X.

Mol Cancer Ther. 2018 Jun;17(6):1341-1351. doi: 10.1158/1535-7163.MCT-17-0672. Epub 2018 Mar 28.


Characterization of ABBV-221, a Tumor-Selective EGFR-Targeting Antibody Drug Conjugate.

Phillips AC, Boghaert ER, Vaidya KS, Falls HD, Mitten MJ, DeVries PJ, Benatuil L, Hsieh CM, Meulbroek JA, Panchal SC, Buchanan FG, Durbin KR, Voorbach MJ, Reuter DR, Mudd SR, Loberg LI, Ralston SL, Cao D, Gan HK, Scott AM, Reilly EB.

Mol Cancer Ther. 2018 Apr;17(4):795-805. doi: 10.1158/1535-7163.MCT-17-0710. Epub 2018 Feb 26.


Advancing Top-down Analysis of the Human Proteome Using a Benchtop Quadrupole-Orbitrap Mass Spectrometer.

Fornelli L, Durbin KR, Fellers RT, Early BP, Greer JB, LeDuc RD, Compton PD, Kelleher NL.

J Proteome Res. 2017 Feb 3;16(2):609-618. doi: 10.1021/acs.jproteome.6b00698. Epub 2016 Dec 2.


Quantitation and Identification of Thousands of Human Proteoforms below 30 kDa.

Durbin KR, Fornelli L, Fellers RT, Doubleday PF, Narita M, Kelleher NL.

J Proteome Res. 2016 Mar 4;15(3):976-82. doi: 10.1021/acs.jproteome.5b00997. Epub 2016 Feb 11.


An informatic framework for decoding protein complexes by top-down mass spectrometry.

Skinner OS, Havugimana PC, Haverland NA, Fornelli L, Early BP, Greer JB, Fellers RT, Durbin KR, Do Vale LH, Melani RD, Seckler HS, Nelp MT, Belov ME, Horning SR, Makarov AA, LeDuc RD, Bandarian V, Compton PD, Kelleher NL.

Nat Methods. 2016 Mar;13(3):237-40. doi: 10.1038/nmeth.3731. Epub 2016 Jan 18.


Analyzing internal fragmentation of electrosprayed ubiquitin ions during beam-type collisional dissociation.

Durbin KR, Skinner OS, Fellers RT, Kelleher NL.

J Am Soc Mass Spectrom. 2015 May;26(5):782-7. doi: 10.1007/s13361-015-1078-1. Epub 2015 Feb 26.


The first pilot project of the consortium for top-down proteomics: a status report.

Dang X, Scotcher J, Wu S, Chu RK, Tolić N, Ntai I, Thomas PM, Fellers RT, Early BP, Zheng Y, Durbin KR, Leduc RD, Wolff JJ, Thompson CJ, Pan J, Han J, Shaw JB, Salisbury JP, Easterling M, Borchers CH, Brodbelt JS, Agar JN, Paša-Tolić L, Kelleher NL, Young NL.

Proteomics. 2014 May;14(10):1130-40. doi: 10.1002/pmic.201300438. Epub 2014 Apr 14.


Autopilot: an online data acquisition control system for the enhanced high-throughput characterization of intact proteins.

Durbin KR, Fellers RT, Ntai I, Kelleher NL, Compton PD.

Anal Chem. 2014 Feb 4;86(3):1485-92. doi: 10.1021/ac402904h. Epub 2014 Jan 23.


Large-scale top-down proteomics of the human proteome: membrane proteins, mitochondria, and senescence.

Catherman AD, Durbin KR, Ahlf DR, Early BP, Fellers RT, Tran JC, Thomas PM, Kelleher NL.

Mol Cell Proteomics. 2013 Dec;12(12):3465-73. doi: 10.1074/mcp.M113.030114. Epub 2013 Sep 10.


Oncogene-induced cellular senescence elicits an anti-Warburg effect.

Li M, Durbin KR, Sweet SM, Tipton JD, Zheng Y, Kelleher NL.

Proteomics. 2013 Sep;13(17):2585-96. doi: 10.1002/pmic.201200298. Epub 2013 Jul 30.


Top down proteomics of human membrane proteins from enriched mitochondrial fractions.

Catherman AD, Li M, Tran JC, Durbin KR, Compton PD, Early BP, Thomas PM, Kelleher NL.

Anal Chem. 2013 Feb 5;85(3):1880-8. doi: 10.1021/ac3031527. Epub 2013 Jan 23.


A protease for 'middle-down' proteomics.

Wu C, Tran JC, Zamdborg L, Durbin KR, Li M, Ahlf DR, Early BP, Thomas PM, Sweedler JV, Kelleher NL.

Nat Methods. 2012 Jun 17;9(8):822-4. doi: 10.1038/nmeth.2074.


Nano-LC FTICR tandem mass spectrometry for top-down proteomics: routine baseline unit mass resolution of whole cell lysate proteins up to 72 kDa.

Tipton JD, Tran JC, Catherman AD, Ahlf DR, Durbin KR, Lee JE, Kellie JF, Kelleher NL, Hendrickson CL, Marshall AG.

Anal Chem. 2012 Mar 6;84(5):2111-7. doi: 10.1021/ac202651v. Epub 2012 Feb 22.


Robust analysis of the yeast proteome under 50 kDa by molecular-mass-based fractionation and top-down mass spectrometry.

Kellie JF, Catherman AD, Durbin KR, Tran JC, Tipton JD, Norris JL, Witkowski CE 2nd, Thomas PM, Kelleher NL.

Anal Chem. 2012 Jan 3;84(1):209-15. doi: 10.1021/ac202384v. Epub 2011 Dec 14.


Mapping intact protein isoforms in discovery mode using top-down proteomics.

Tran JC, Zamdborg L, Ahlf DR, Lee JE, Catherman AD, Durbin KR, Tipton JD, Vellaichamy A, Kellie JF, Li M, Wu C, Sweet SM, Early BP, Siuti N, LeDuc RD, Compton PD, Thomas PM, Kelleher NL.

Nature. 2011 Oct 30;480(7376):254-8. doi: 10.1038/nature10575.


Analysis of intact protein isoforms by mass spectrometry.

Tipton JD, Tran JC, Catherman AD, Ahlf DR, Durbin KR, Kelleher NL.

J Biol Chem. 2011 Jul 22;286(29):25451-8. doi: 10.1074/jbc.R111.239442. Epub 2011 Jun 1. Review.


Intact mass detection, interpretation, and visualization to automate Top-Down proteomics on a large scale.

Durbin KR, Tran JC, Zamdborg L, Sweet SM, Catherman AD, Lee JE, Li M, Kellie JF, Kelleher NL.

Proteomics. 2010 Oct;10(20):3589-97. doi: 10.1002/pmic.201000177.


The emerging process of Top Down mass spectrometry for protein analysis: biomarkers, protein-therapeutics, and achieving high throughput.

Kellie JF, Tran JC, Lee JE, Ahlf DR, Thomas HM, Ntai I, Catherman AD, Durbin KR, Zamdborg L, Vellaichamy A, Thomas PM, Kelleher NL.

Mol Biosyst. 2010 Sep;6(9):1532-9. doi: 10.1039/c000896f. Epub 2010 Mar 29.


Kinetics of re-establishing H3K79 methylation marks in global human chromatin.

Sweet SM, Li M, Thomas PM, Durbin KR, Kelleher NL.

J Biol Chem. 2010 Oct 22;285(43):32778-86. doi: 10.1074/jbc.M110.145094. Epub 2010 Aug 9.


Size-sorting combined with improved nanocapillary liquid chromatography-mass spectrometry for identification of intact proteins up to 80 kDa.

Vellaichamy A, Tran JC, Catherman AD, Lee JE, Kellie JF, Sweet SM, Zamdborg L, Thomas PM, Ahlf DR, Durbin KR, Valaskovic GA, Kelleher NL.

Anal Chem. 2010 Feb 15;82(4):1234-44. doi: 10.1021/ac9021083.


A robust two-dimensional separation for top-down tandem mass spectrometry of the low-mass proteome.

Lee JE, Kellie JF, Tran JC, Tipton JD, Catherman AD, Thomas HM, Ahlf DR, Durbin KR, Vellaichamy A, Ntai I, Marshall AG, Kelleher NL.

J Am Soc Mass Spectrom. 2009 Dec;20(12):2183-91. doi: 10.1016/j.jasms.2009.08.001. Epub 2009 Aug 12.

Supplemental Content

Loading ...
Support Center