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Items: 17


Mechanisms underlying synergy between DNA topoisomerase I-targeted drugs and mTOR kinase inhibitors in NF1-associated malignant peripheral nerve sheath tumors.

Ki DH, Oppel F, Durbin AD, Look AT.

Oncogene. 2019 Aug 23. doi: 10.1038/s41388-019-0965-5. [Epub ahead of print]


Selective gene dependencies in MYCN-amplified neuroblastoma include the core transcriptional regulatory circuitry.

Durbin AD, Zimmerman MW, Dharia NV, Abraham BJ, Iniguez AB, Weichert-Leahey N, He S, Krill-Burger JM, Root DE, Vazquez F, Tsherniak A, Hahn WC, Golub TR, Young RA, Look AT, Stegmaier K.

Nat Genet. 2018 Sep;50(9):1240-1246. doi: 10.1038/s41588-018-0191-z. Epub 2018 Aug 20.


Diffusion-Weighted Imaging Changes in a Child With Posterior Ischemic Optic Neuropathy.

Harrar DB, Solomon J, Shah AS, Vaughn J, Durbin AD, Rivkin MJ.

Pediatr Neurol. 2018 Jul;84:49-52. doi: 10.1016/j.pediatrneurol.2018.03.014. Epub 2018 Apr 4.


MYC Drives a Subset of High-Risk Pediatric Neuroblastomas and Is Activated through Mechanisms Including Enhancer Hijacking and Focal Enhancer Amplification.

Zimmerman MW, Liu Y, He S, Durbin AD, Abraham BJ, Easton J, Shao Y, Xu B, Zhu S, Zhang X, Li Z, Weichert-Leahey N, Young RA, Zhang J, Look AT.

Cancer Discov. 2018 Mar;8(3):320-335. doi: 10.1158/2159-8290.CD-17-0993. Epub 2017 Dec 28.


The NOTCH1/SNAIL1/MEF2C Pathway Regulates Growth and Self-Renewal in Embryonal Rhabdomyosarcoma.

Ignatius MS, Hayes MN, Lobbardi R, Chen EY, McCarthy KM, Sreenivas P, Motala Z, Durbin AD, Molodtsov A, Reeder S, Jin A, Sindiri S, Beleyea BC, Bhere D, Alexander MS, Shah K, Keller C, Linardic CM, Nielsen PG, Malkin D, Khan J, Langenau DM.

Cell Rep. 2017 Jun 13;19(11):2304-2318. doi: 10.1016/j.celrep.2017.05.061.


Vitamin B12 Deficiency Presenting with Neurological Dysfunction in an Adolescent.

Stredny CM, Frosch O, Singhi S, Furutani E, Durbin AD, Grace RF, Ullrich NJ.

Pediatr Neurol. 2016 Sep;62:66-70. doi: 10.1016/j.pediatrneurol.2016.03.022. Epub 2016 Apr 23.


Malignant Peripheral Nerve Sheath Tumors.

Durbin AD, Ki DH, He S, Look AT.

Adv Exp Med Biol. 2016;916:495-530. doi: 10.1007/978-3-319-30654-4_22. Review.


Genetic predisposition to neuroblastoma mediated by a LMO1 super-enhancer polymorphism.

Oldridge DA, Wood AC, Weichert-Leahey N, Crimmins I, Sussman R, Winter C, McDaniel LD, Diamond M, Hart LS, Zhu S, Durbin AD, Abraham BJ, Anders L, Tian L, Zhang S, Wei JS, Khan J, Bramlett K, Rahman N, Capasso M, Iolascon A, Gerhard DS, Guidry Auvil JM, Young RA, Hakonarson H, Diskin SJ, Look AT, Maris JM.

Nature. 2015 Dec 17;528(7582):418-21. doi: 10.1038/nature15540. Epub 2015 Nov 11.


Oncogene regulation. An oncogenic super-enhancer formed through somatic mutation of a noncoding intergenic element.

Mansour MR, Abraham BJ, Anders L, Berezovskaya A, Gutierrez A, Durbin AD, Etchin J, Lawton L, Sallan SE, Silverman LB, Loh ML, Hunger SP, Sanda T, Young RA, Look AT.

Science. 2014 Dec 12;346(6215):1373-7. doi: 10.1126/science.1259037. Epub 2014 Nov 13.


The oncogenic and growth-suppressive functions of the integrin-linked kinase are distinguished by JNK1 expression in human cancer cells.

Durbin AD, Pasic I, Wong DK, Hannigan GE, Malkin D.

Cell Cycle. 2010 May 15;9(10):1951-9. Epub 2010 May 15.


Recurrent focal copy-number changes and loss of heterozygosity implicate two noncoding RNAs and one tumor suppressor gene at chromosome 3q13.31 in osteosarcoma.

Pasic I, Shlien A, Durbin AD, Stavropoulos DJ, Baskin B, Ray PN, Novokmet A, Malkin D.

Cancer Res. 2010 Jan 1;70(1):160-71. doi: 10.1158/0008-5472.CAN-09-1902.


Oncogenic ILK, tumor suppression and all that JNK.

Durbin AD, Hannigan GE, Malkin D.

Cell Cycle. 2009 Dec 15;8(24):4060-6. Epub 2009 Dec 15. Review.


JNK1 determines the oncogenic or tumor-suppressive activity of the integrin-linked kinase in human rhabdomyosarcoma.

Durbin AD, Somers GR, Forrester M, Pienkowska M, Hannigan GE, Malkin D.

J Clin Invest. 2009 Jun;119(6):1558-70. doi: 10.1172/JCI37958. Epub 2009 May 26.


Expression of insulin-like growth factor pathway proteins in rhabdomyosarcoma: IGF-2 expression is associated with translocation-negative tumors.

Makawita S, Ho M, Durbin AD, Thorner PS, Malkin D, Somers GR.

Pediatr Dev Pathol. 2009 Mar-Apr;12(2):127-35. doi: 10.2350/08-05-0477.1. Epub 2008 Sep 12.


The estrogen receptor pathway in rhabdomyosarcoma: a role for estrogen receptor-beta in proliferation and response to the antiestrogen 4'OH-tamoxifen.

Greenberg JA, Somme S, Russnes HE, Durbin AD, Malkin D.

Cancer Res. 2008 May 1;68(9):3476-85. doi: 10.1158/0008-5472.CAN-07-3046.


The CXCR4-SDF1alpha axis is a critical mediator of rhabdomyosarcoma metastatic signaling induced by bone marrow stroma.

Strahm B, Durbin AD, Sexsmith E, Malkin D.

Clin Exp Metastasis. 2008;25(1):1-10. Epub 2007 Sep 1.


Advances towards understanding heart valve response to injury.

Durbin AD, Gotlieb AI.

Cardiovasc Pathol. 2002 Mar-Apr;11(2):69-77. Review.


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