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Items: 14


Gamma secretase modulators and BACE inhibitors reduce Aβ production without altering gene expression in Alzheimer's disease iPSC-derived neurons and mice.

Cusulin C, Wells I, Badillo S, Duran-Pacheco GC, Baumann K, Patsch C.

Mol Cell Neurosci. 2019 Aug 2;100:103392. doi: 10.1016/j.mcn.2019.103392. [Epub ahead of print]


Path mediation analysis reveals GBA impacts Lewy body disease status by increasing α-synuclein levels.

Gündner AL, Duran-Pacheco G, Zimmermann S, Ruf I, Moors T, Baumann K, Jagasia R, van de Berg WDJ, Kremer T.

Neurobiol Dis. 2019 Jan;121:205-213. doi: 10.1016/j.nbd.2018.09.015. Epub 2018 Sep 17.


Characterization of Brain Lysosomal Activities in GBA-Related and Sporadic Parkinson's Disease and Dementia with Lewy Bodies.

Moors TE, Paciotti S, Ingrassia A, Quadri M, Breedveld G, Tasegian A, Chiasserini D, Eusebi P, Duran-Pacheco G, Kremer T, Calabresi P, Bonifati V, Parnetti L, Beccari T, van de Berg WDJ.

Mol Neurobiol. 2019 Feb;56(2):1344-1355. doi: 10.1007/s12035-018-1090-0. Epub 2018 Jun 8.


Binding to SMN2 pre-mRNA-protein complex elicits specificity for small molecule splicing modifiers.

Sivaramakrishnan M, McCarthy KD, Campagne S, Huber S, Meier S, Augustin A, Heckel T, Meistermann H, Hug MN, Birrer P, Moursy A, Khawaja S, Schmucki R, Berntenis N, Giroud N, Golling S, Tzouros M, Banfai B, Duran-Pacheco G, Lamerz J, Hsiu Liu Y, Luebbers T, Ratni H, Ebeling M, Cléry A, Paushkin S, Krainer AR, Allain FH, Metzger F.

Nat Commun. 2017 Nov 14;8(1):1476. doi: 10.1038/s41467-017-01559-4.


Correction to: An appraisal of critical effect sizes for the benchmark dose approach to assess dose-response relationships in genetic toxicology.

Zeller A, Duran-Pacheco G, Guérard M.

Arch Toxicol. 2017 Dec;91(12):3809. doi: 10.1007/s00204-017-2110-y.


An appraisal of critical effect sizes for the benchmark dose approach to assess dose-response relationships in genetic toxicology.

Zeller A, Duran-Pacheco G, Guérard M.

Arch Toxicol. 2017 Dec;91(12):3799-3807. doi: 10.1007/s00204-017-2037-3. Epub 2017 Aug 10. Erratum in: Arch Toxicol. 2017 Nov 11;:.


Glypican-2 levels in cerebrospinal fluid predict the status of adult hippocampal neurogenesis.

Lugert S, Kremer T, Jagasia R, Herrmann A, Aigner S, Giachino C, Mendez-David I, Gardier AM, Carralot JP, Meistermann H, Augustin A, Saxe MD, Lamerz J, Duran-Pacheco G, Ducret A, Taylor V, David DJ, Czech C.

Sci Rep. 2017 Apr 25;7:46543. doi: 10.1038/srep46543.


Dose-response relationship of temozolomide, determined by the Pig-a, comet, and micronucleus assay.

Guérard M, Johnson G, Dertinger S, Duran-Pacheco G, Funk J, Zeller A.

Arch Toxicol. 2017 Jun;91(6):2443-2453. doi: 10.1007/s00204-016-1923-4. Epub 2017 Feb 15.


Rapid stress-induced transcriptomic changes in the brain depend on beta-adrenergic signaling.

Roszkowski M, Manuella F, von Ziegler L, Durán-Pacheco G, Moreau JL, Mansuy IM, Bohacek J.

Neuropharmacology. 2016 Aug;107:329-338. doi: 10.1016/j.neuropharm.2016.03.046. Epub 2016 Mar 26.


Tissue transcriptome-driven identification of epidermal growth factor as a chronic kidney disease biomarker.

Ju W, Nair V, Smith S, Zhu L, Shedden K, Song PXK, Mariani LH, Eichinger FH, Berthier CC, Randolph A, Lai JY, Zhou Y, Hawkins JJ, Bitzer M, Sampson MG, Thier M, Solier C, Duran-Pacheco GC, Duchateau-Nguyen G, Essioux L, Schott B, Formentini I, Magnone MC, Bobadilla M, Cohen CD, Bagnasco SM, Barisoni L, Lv J, Zhang H, Wang HY, Brosius FC, Gadegbeku CA, Kretzler M; ERCB, C-PROBE, NEPTUNE, and PKU-IgAN Consortium.

Sci Transl Med. 2015 Dec 2;7(316):316ra193. doi: 10.1126/scitranslmed.aac7071.


A proposal for a novel rationale for critical effect size in dose-response analysis based on a multi-endpoint in vivo study with methyl methanesulfonate.

Zeller A, Tang L, Dertinger SD, Funk J, Duran-Pacheco G, Guérard M.

Mutagenesis. 2016 May;31(3):239-53. doi: 10.1093/mutage/gev077. Epub 2015 Nov 20.


Pathological brain plasticity and cognition in the offspring of males subjected to postnatal traumatic stress.

Bohacek J, Farinelli M, Mirante O, Steiner G, Gapp K, Coiret G, Ebeling M, Durán-Pacheco G, Iniguez AL, Manuella F, Moreau JL, Mansuy IM.

Mol Psychiatry. 2015 May;20(5):621-31. doi: 10.1038/mp.2014.80. Epub 2014 Aug 5.


Factors associated with compliance among users of solar water disinfection in rural Bolivia.

Christen A, Duran Pacheco G, Hattendorf J, Arnold BF, Cevallos M, Indergand S, Colford JM, Mäusezahl D.

BMC Public Health. 2011 Apr 4;11:210. doi: 10.1186/1471-2458-11-210.


Performance of analytical methods for overdispersed counts in cluster randomized trials: sample size, degree of clustering and imbalance.

Durán Pacheco G, Hattendorf J, Colford JM Jr, Mäusezahl D, Smith T.

Stat Med. 2009 Oct 30;28(24):2989-3011. doi: 10.1002/sim.3681.


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