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Items: 1 to 50 of 58

1.

Disrupting Mitochondrial Pyruvate Uptake Directs Glutamine into the TCA Cycle away from Glutathione Synthesis and Impairs Hepatocellular Tumorigenesis.

Tompkins SC, Sheldon RD, Rauckhorst AJ, Noterman MF, Solst SR, Buchanan JL, Mapuskar KA, Pewa AD, Gray LR, Oonthonpan L, Sharma A, Scerbo DA, Dupuy AJ, Spitz DR, Taylor EB.

Cell Rep. 2019 Sep 3;28(10):2608-2619.e6. doi: 10.1016/j.celrep.2019.07.098.

2.

Src-Dependent DBL Family Members Drive Resistance to Vemurafenib in Human Melanoma.

Feddersen CR, Schillo JL, Varzavand A, Vaughn HR, Wadsworth LS, Voigt AP, Zhu EY, Jennings BM, Mullen SA, Bobera J, Riordan JD, Stipp CS, Dupuy AJ.

Cancer Res. 2019 Oct 1;79(19):5074-5087. doi: 10.1158/0008-5472.CAN-19-0244. Epub 2019 Aug 15.

PMID:
31416844
3.

Sleeping Beauty Mouse Models of Cancer: Microenvironmental Influences on Cancer Genetics.

Guimaraes-Young A, Feddersen CR, Dupuy AJ.

Front Oncol. 2019 Jul 9;9:611. doi: 10.3389/fonc.2019.00611. eCollection 2019. Review.

4.

A simplified transposon mutagenesis method to perform phenotypic forward genetic screens in cultured cells.

Feddersen CR, Wadsworth LS, Zhu EY, Vaughn HR, Voigt AP, Riordan JD, Dupuy AJ.

BMC Genomics. 2019 Jun 17;20(1):497. doi: 10.1186/s12864-019-5888-6.

5.

Insertional mutagenesis using the Sleeping Beauty transposon system identifies drivers of erythroleukemia in mice.

Loeb KR, Hughes BT, Fissel BM, Osteen NJ, Knoblaugh SE, Grim JE, Drury LJ, Sarver A, Dupuy AJ, Clurman BE.

Sci Rep. 2019 Apr 2;9(1):5488. doi: 10.1038/s41598-019-41805-x.

6.

A comprehensive evaluation of Hippo pathway silencing in sarcomas.

Merritt NM, Fullenkamp CA, Hall SL, Qian Q, Desai C, Thomason J, Lambertz AM, Dupuy AJ, Darbro B, Tanas MR.

Oncotarget. 2018 Aug 3;9(60):31620-31636. doi: 10.18632/oncotarget.25824. eCollection 2018 Aug 3.

7.

A Forward Genetic Screen Targeting the Endothelium Reveals a Regulatory Role for the Lipid Kinase Pi4ka in Myelo- and Erythropoiesis.

Ziyad S, Riordan JD, Cavanaugh AM, Su T, Hernandez GE, Hilfenhaus G, Morselli M, Huynh K, Wang K, Chen JN, Dupuy AJ, Iruela-Arispe ML.

Cell Rep. 2018 Jan 30;22(5):1211-1224. doi: 10.1016/j.celrep.2018.01.017.

8.

The mitochondrial pyruvate carrier mediates high fat diet-induced increases in hepatic TCA cycle capacity.

Rauckhorst AJ, Gray LR, Sheldon RD, Fu X, Pewa AD, Feddersen CR, Dupuy AJ, Gibson-Corley KN, Cox JE, Burgess SC, Taylor EB.

Mol Metab. 2017 Nov;6(11):1468-1479. doi: 10.1016/j.molmet.2017.09.002. Epub 2017 Sep 18.

9.

Sleeping Beauty Insertional Mutagenesis in Mice Identifies Drivers of Steatosis-Associated Hepatic Tumors.

Tschida BR, Temiz NA, Kuka TP, Lee LA, Riordan JD, Tierrablanca CA, Hullsiek R, Wagner S, Hudson WA, Linden MA, Amin K, Beckmann PJ, Heuer RA, Sarver AL, Yang JD, Roberts LR, Nadeau JH, Dupuy AJ, Keng VW, Largaespada DA.

Cancer Res. 2017 Dec 1;77(23):6576-6588. doi: 10.1158/0008-5472.CAN-17-2281. Epub 2017 Oct 9.

10.

Chronic liver injury alters driver mutation profiles in hepatocellular carcinoma in mice.

Riordan JD, Feddersen CR, Tschida BR, Beckmann PJ, Keng VW, Linden MA, Amin K, Stipp CS, Largaespada DA, Dupuy AJ.

Hepatology. 2018 Mar;67(3):924-939. doi: 10.1002/hep.29565. Epub 2018 Jan 26.

11.

A Trp53fl/flPtenfl/fl mouse model of undifferentiated pleomorphic sarcoma mediated by adeno-Cre injection and in vivo bioluminescence imaging.

Buchakjian MR, Merritt NM, Moose DL, Dupuy AJ, Tanas MR, Henry MD.

PLoS One. 2017 Aug 25;12(8):e0183469. doi: 10.1371/journal.pone.0183469. eCollection 2017.

12.

Transposon mutagenesis identifies chromatin modifiers cooperating with Ras in thyroid tumorigenesis and detects ATXN7 as a cancer gene.

Montero-Conde C, Leandro-Garcia LJ, Chen X, Oler G, Ruiz-Llorente S, Ryder M, Landa I, Sanchez-Vega F, La K, Ghossein RA, Bajorin DF, Knauf JA, Riordan JD, Dupuy AJ, Fagin JA.

Proc Natl Acad Sci U S A. 2017 Jun 20;114(25):E4951-E4960. doi: 10.1073/pnas.1702723114. Epub 2017 Jun 5.

13.

A Transposon-based Analysis Reveals RASA1 Is Involved in Triple-Negative Breast Cancer.

Suárez-Cabrera C, Quintana RM, Bravo A, Casanova ML, Page A, Alameda JP, Paramio JM, Maroto A, Salamanca J, Dupuy AJ, Ramírez A, Navarro M.

Cancer Res. 2017 Mar 15;77(6):1357-1368. doi: 10.1158/0008-5472.CAN-16-1586. Epub 2017 Jan 20.

14.

Transposon mutagenesis identifies candidate genes that cooperate with loss of transforming growth factor-beta signaling in mouse intestinal neoplasms.

Morris SM, Davison J, Carter KT, O'Leary RM, Trobridge P, Knoblaugh SE, Myeroff LL, Markowitz SD, Brett BT, Scheetz TE, Dupuy AJ, Starr TK, Grady WM.

Int J Cancer. 2017 Feb 15;140(4):853-863. doi: 10.1002/ijc.30491. Epub 2016 Nov 7.

15.

Conditional deletion of Sox17 reveals complex effects on uterine adenogenesis and function.

Guimarães-Young A, Neff T, Dupuy AJ, Goodheart MJ.

Dev Biol. 2016 Jun 15;414(2):219-27. doi: 10.1016/j.ydbio.2016.04.010. Epub 2016 Apr 19.

16.

Divergent clonal selection dominates medulloblastoma at recurrence.

Morrissy AS, Garzia L, Shih DJ, Zuyderduyn S, Huang X, Skowron P, Remke M, Cavalli FM, Ramaswamy V, Lindsay PE, Jelveh S, Donovan LK, Wang X, Luu B, Zayne K, Li Y, Mayoh C, Thiessen N, Mercier E, Mungall KL, Ma Y, Tse K, Zeng T, Shumansky K, Roth AJ, Shah S, Farooq H, Kijima N, Holgado BL, Lee JJ, Matan-Lithwick S, Liu J, Mack SC, Manno A, Michealraj KA, Nor C, Peacock J, Qin L, Reimand J, Rolider A, Thompson YY, Wu X, Pugh T, Ally A, Bilenky M, Butterfield YS, Carlsen R, Cheng Y, Chuah E, Corbett RD, Dhalla N, He A, Lee D, Li HI, Long W, Mayo M, Plettner P, Qian JQ, Schein JE, Tam A, Wong T, Birol I, Zhao Y, Faria CC, Pimentel J, Nunes S, Shalaby T, Grotzer M, Pollack IF, Hamilton RL, Li XN, Bendel AE, Fults DW, Walter AW, Kumabe T, Tominaga T, Collins VP, Cho YJ, Hoffman C, Lyden D, Wisoff JH, Garvin JH Jr, Stearns DS, Massimi L, Schüller U, Sterba J, Zitterbart K, Puget S, Ayrault O, Dunn SE, Tirapelli DP, Carlotti CG, Wheeler H, Hallahan AR, Ingram W, MacDonald TJ, Olson JJ, Van Meir EG, Lee JY, Wang KC, Kim SK, Cho BK, Pietsch T, Fleischhack G, Tippelt S, Ra YS, Bailey S, Lindsey JC, Clifford SC, Eberhart CG, Cooper MK, Packer RJ, Massimino M, Garre ML, Bartels U, Tabori U, Hawkins CE, Dirks P, Bouffet E, Rutka JT, Wechsler-Reya RJ, Weiss WA, Collier LS, Dupuy AJ, Korshunov A, Jones DT, Kool M, Northcott PA, Pfister SM, Largaespada DA, Mungall AJ, Moore RA, Jabado N, Bader GD, Jones SJ, Malkin D, Marra MA, Taylor MD.

Nature. 2016 Jan 21;529(7586):351-7. doi: 10.1038/nature16478. Epub 2016 Jan 13.

17.

RNA sequencing of Sleeping Beauty transposon-induced tumors detects transposon-RNA fusions in forward genetic cancer screens.

Temiz NA, Moriarity BS, Wolf NK, Riordan JD, Dupuy AJ, Largaespada DA, Sarver AL.

Genome Res. 2016 Jan;26(1):119-29. doi: 10.1101/gr.188649.114. Epub 2015 Nov 9.

18.

Transposon mutagenesis identifies genetic drivers of Braf(V600E) melanoma.

Mann MB, Black MA, Jones DJ, Ward JM, Yew CC, Newberg JY, Dupuy AJ, Rust AG, Bosenberg MW, McMahon M, Print CG, Copeland NG, Jenkins NA.

Nat Genet. 2015 May;47(5):486-95. doi: 10.1038/ng.3275. Epub 2015 Apr 13.

19.

A Hybrid Adenoviral Vector System Achieves Efficient Long-Term Gene Expression in the Liver via piggyBac Transposition.

Smith RP, Riordan JD, Feddersen CR, Dupuy AJ.

Hum Gene Ther. 2015 Jun;26(6):377-85. doi: 10.1089/hum.2014.123.

20.

Sequencing methods and datasets to improve functional interpretation of sleeping beauty mutagenesis screens.

Riordan JD, Drury LJ, Smith RP, Brett BT, Rogers LM, Scheetz TE, Dupuy AJ.

BMC Genomics. 2014 Dec 19;15:1150. doi: 10.1186/1471-2164-15-1150.

21.

Cell-internalization SELEX: method for identifying cell-internalizing RNA aptamers for delivering siRNAs to target cells.

Thiel WH, Thiel KW, Flenker KS, Bair T, Dupuy AJ, McNamara JO 2nd, Miller FJ, Giangrande PH.

Methods Mol Biol. 2015;1218:187-99. doi: 10.1007/978-1-4939-1538-5_11.

22.

Keratoacanthoma Pathobiology in Mouse Models.

Gibson-Corley KN, Rogers LM, Goeken A, Dupuy AJ, Meyerholz DK.

Diseases. 2014 May 23;2(2):106-119.

23.

MicroRNA-26b represses colon cancer cell proliferation by inhibiting lymphoid enhancer factor 1 expression.

Zhang Z, Kim K, Li X, Moreno M, Sharp T, Goodheart MJ, Safe S, Dupuy AJ, Amendt BA.

Mol Cancer Ther. 2014 Jul;13(7):1942-51. doi: 10.1158/1535-7163.MCT-13-1000. Epub 2014 Apr 30.

24.

The stress-regulated transcription factor CHOP promotes hepatic inflammatory gene expression, fibrosis, and oncogenesis.

DeZwaan-McCabe D, Riordan JD, Arensdorf AM, Icardi MS, Dupuy AJ, Rutkowski DT.

PLoS Genet. 2013;9(12):e1003937. doi: 10.1371/journal.pgen.1003937. Epub 2013 Dec 19.

25.

Transposon mutagenesis identifies genes driving hepatocellular carcinoma in a chronic hepatitis B mouse model.

Bard-Chapeau EA, Nguyen AT, Rust AG, Sayadi A, Lee P, Chua BQ, New LS, de Jong J, Ward JM, Chin CK, Chew V, Toh HC, Abastado JP, Benoukraf T, Soong R, Bard FA, Dupuy AJ, Johnson RL, Radda GK, Chan EC, Wessels LF, Adams DJ, Jenkins NA, Copeland NG.

Nat Genet. 2014 Jan;46(1):24-32. doi: 10.1038/ng.2847. Epub 2013 Dec 8.

26.

Domesticated transposable element gene products in human cancer.

Riordan JD, Dupuy AJ.

Mob Genet Elements. 2013 Sep 1;3(5):e26693. Epub 2013 Oct 14.

27.

Identification of rtl1, a retrotransposon-derived imprinted gene, as a novel driver of hepatocarcinogenesis.

Riordan JD, Keng VW, Tschida BR, Scheetz TE, Bell JB, Podetz-Pedersen KM, Moser CD, Copeland NG, Jenkins NA, Roberts LR, Largaespada DA, Dupuy AJ.

PLoS Genet. 2013 Apr;9(4):e1003441. doi: 10.1371/journal.pgen.1003441. Epub 2013 Apr 4.

28.

A Sleeping Beauty screen reveals NF-kB activation in CLL mouse model.

Zanesi N, Balatti V, Riordan J, Burch A, Rizzotto L, Palamarchuk A, Cascione L, Lagana A, Dupuy AJ, Croce CM, Pekarsky Y.

Blood. 2013 May 23;121(21):4355-8. doi: 10.1182/blood-2013-02-486035. Epub 2013 Apr 16.

29.

Adaptive immunity does not strongly suppress spontaneous tumors in a Sleeping Beauty model of cancer.

Rogers LM, Olivier AK, Meyerholz DK, Dupuy AJ.

J Immunol. 2013 Apr 15;190(8):4393-9. doi: 10.4049/jimmunol.1203227. Epub 2013 Mar 8.

30.

Ectopic expression of Zmiz1 induces cutaneous squamous cell malignancies in a mouse model of cancer.

Rogers LM, Riordan JD, Swick BL, Meyerholz DK, Dupuy AJ.

J Invest Dermatol. 2013 Jul;133(7):1863-9. doi: 10.1038/jid.2013.77. Epub 2013 Feb 20.

31.

Sex bias occurrence of hepatocellular carcinoma in Poly7 molecular subclass is associated with EGFR.

Keng VW, Sia D, Sarver AL, Tschida BR, Fan D, Alsinet C, Solé M, Lee WL, Kuka TP, Moriarity BS, Villanueva A, Dupuy AJ, Riordan JD, Bell JB, Silverstein KA, Llovet JM, Largaespada DA.

Hepatology. 2013 Jan;57(1):120-30. doi: 10.1002/hep.26004. Epub 2012 Oct 19.

32.

A transposon-based analysis of gene mutations related to skin cancer development.

Quintana RM, Dupuy AJ, Bravo A, Casanova ML, Alameda JP, Page A, Sánchez-Viera M, Ramírez A, Navarro M.

J Invest Dermatol. 2013 Jan;133(1):239-48. doi: 10.1038/jid.2012.245. Epub 2012 Jul 26.

33.

Sleeping Beauty mutagenesis reveals cooperating mutations and pathways in pancreatic adenocarcinoma.

Mann KM, Ward JM, Yew CC, Kovochich A, Dawson DW, Black MA, Brett BT, Sheetz TE, Dupuy AJ; Australian Pancreatic Cancer Genome Initiative, Chang DK, Biankin AV, Waddell N, Kassahn KS, Grimmond SM, Rust AG, Adams DJ, Jenkins NA, Copeland NG.

Proc Natl Acad Sci U S A. 2012 Apr 17;109(16):5934-41. doi: 10.1073/pnas.1202490109. Epub 2012 Mar 15.

34.

Clonal selection drives genetic divergence of metastatic medulloblastoma.

Wu X, Northcott PA, Dubuc A, Dupuy AJ, Shih DJ, Witt H, Croul S, Bouffet E, Fults DW, Eberhart CG, Garzia L, Van Meter T, Zagzag D, Jabado N, Schwartzentruber J, Majewski J, Scheetz TE, Pfister SM, Korshunov A, Li XN, Scherer SW, Cho YJ, Akagi K, MacDonald TJ, Koster J, McCabe MG, Sarver AL, Collins VP, Weiss WA, Largaespada DA, Collier LS, Taylor MD.

Nature. 2012 Feb 15;482(7386):529-33. doi: 10.1038/nature10825.

35.

Novel molecular and computational methods improve the accuracy of insertion site analysis in Sleeping Beauty-induced tumors.

Brett BT, Berquam-Vrieze KE, Nannapaneni K, Huang J, Scheetz TE, Dupuy AJ.

PLoS One. 2011;6(9):e24668. doi: 10.1371/journal.pone.0024668. Epub 2011 Sep 13.

36.

Characterization of transgenic mice expressing cancer-associated variants of human NOTCH1.

Berquam-Vrieze KE, Swing DA, Tessarollo L, Dupuy AJ.

Genesis. 2012 Feb;50(2):112-8. doi: 10.1002/dvg.20798. Epub 2012 Jan 6.

37.

Cell of origin strongly influences genetic selection in a mouse model of T-ALL.

Berquam-Vrieze KE, Nannapaneni K, Brett BT, Holmfeldt L, Ma J, Zagorodna O, Jenkins NA, Copeland NG, Meyerholz DK, Knudson CM, Mullighan CG, Scheetz TE, Dupuy AJ.

Blood. 2011 Oct 27;118(17):4646-56. doi: 10.1182/blood-2011-03-343947. Epub 2011 Aug 9.

38.

Nucleotide bias observed with a short SELEX RNA aptamer library.

Thiel WH, Bair T, Wyatt Thiel K, Dassie JP, Rockey WM, Howell CA, Liu XY, Dupuy AJ, Huang L, Owczarzy R, Behlke MA, McNamara JO, Giangrande PH.

Nucleic Acid Ther. 2011 Aug;21(4):253-63. doi: 10.1089/nat.2011.0288. Epub 2011 Jun 28.

39.

Somatic mutagenesis with a Sleeping Beauty transposon system leads to solid tumor formation in zebrafish.

McGrail M, Hatler JM, Kuang X, Liao HK, Nannapaneni K, Watt KE, Uhl JD, Largaespada DA, Vollbrecht E, Scheetz TE, Dupuy AJ, Hostetter JM, Essner JJ.

PLoS One. 2011 Apr 21;6(4):e18826. doi: 10.1371/journal.pone.0018826.

40.

A Sleeping Beauty transposon-mediated screen identifies murine susceptibility genes for adenomatous polyposis coli (Apc)-dependent intestinal tumorigenesis.

Starr TK, Scott PM, Marsh BM, Zhao L, Than BL, O'Sullivan MG, Sarver AL, Dupuy AJ, Largaespada DA, Cormier RT.

Proc Natl Acad Sci U S A. 2011 Apr 5;108(14):5765-70. doi: 10.1073/pnas.1018012108. Epub 2011 Mar 21.

41.

Current applications of transposons in mouse genetics.

Dupuy AJ.

Methods Enzymol. 2010;477:53-70. doi: 10.1016/S0076-6879(10)77004-X.

PMID:
20699136
42.

Transposon-based screens for cancer gene discovery in mouse models.

Dupuy AJ.

Semin Cancer Biol. 2010 Aug;20(4):261-8. doi: 10.1016/j.semcancer.2010.05.003. Epub 2010 May 15. Review.

43.

Aberrant epithelial-mesenchymal Hedgehog signaling characterizes Barrett's metaplasia.

Wang DH, Clemons NJ, Miyashita T, Dupuy AJ, Zhang W, Szczepny A, Corcoran-Schwartz IM, Wilburn DL, Montgomery EA, Wang JS, Jenkins NA, Copeland NA, Harmon JW, Phillips WA, Watkins DN.

Gastroenterology. 2010 May;138(5):1810-22. doi: 10.1053/j.gastro.2010.01.048. Epub 2010 Feb 4.

44.

Whole-body sleeping beauty mutagenesis can cause penetrant leukemia/lymphoma and rare high-grade glioma without associated embryonic lethality.

Collier LS, Adams DJ, Hackett CS, Bendzick LE, Akagi K, Davies MN, Diers MD, Rodriguez FJ, Bender AM, Tieu C, Matise I, Dupuy AJ, Copeland NG, Jenkins NA, Hodgson JG, Weiss WA, Jenkins RB, Largaespada DA.

Cancer Res. 2009 Nov 1;69(21):8429-37. doi: 10.1158/0008-5472.CAN-09-1760. Epub 2009 Oct 20.

45.

A modified sleeping beauty transposon system that can be used to model a wide variety of human cancers in mice.

Dupuy AJ, Rogers LM, Kim J, Nannapaneni K, Starr TK, Liu P, Largaespada DA, Scheetz TE, Jenkins NA, Copeland NG.

Cancer Res. 2009 Oct 15;69(20):8150-6. doi: 10.1158/0008-5472.CAN-09-1135. Epub 2009 Oct 6.

46.

A transposon-based genetic screen in mice identifies genes altered in colorectal cancer.

Starr TK, Allaei R, Silverstein KA, Staggs RA, Sarver AL, Bergemann TL, Gupta M, O'Sullivan MG, Matise I, Dupuy AJ, Collier LS, Powers S, Oberg AL, Asmann YW, Thibodeau SN, Tessarollo L, Copeland NG, Jenkins NA, Cormier RT, Largaespada DA.

Science. 2009 Mar 27;323(5922):1747-50. doi: 10.1126/science.1163040. Epub 2009 Feb 26.

47.

A conditional transposon-based insertional mutagenesis screen for genes associated with mouse hepatocellular carcinoma.

Keng VW, Villanueva A, Chiang DY, Dupuy AJ, Ryan BJ, Matise I, Silverstein KA, Sarver A, Starr TK, Akagi K, Tessarollo L, Collier LS, Powers S, Lowe SW, Jenkins NA, Copeland NG, Llovet JM, Largaespada DA.

Nat Biotechnol. 2009 Mar;27(3):264-74. doi: 10.1038/nbt.1526. Epub 2009 Feb 22.

48.

A DNA transposon-based approach to validate oncogenic mutations in the mouse.

Su Q, Prosser HM, Campos LS, Ortiz M, Nakamura T, Warren M, Dupuy AJ, Jenkins NA, Copeland NG, Bradley A, Liu P.

Proc Natl Acad Sci U S A. 2008 Dec 16;105(50):19904-9. doi: 10.1073/pnas.0807785105. Epub 2008 Dec 8.

49.

Sleeping beauty: a novel cancer gene discovery tool.

Dupuy AJ, Jenkins NA, Copeland NG.

Hum Mol Genet. 2006 Apr 15;15 Spec No 1:R75-9. Review.

PMID:
16651372
50.

Cancer gene discovery in solid tumours using transposon-based somatic mutagenesis in the mouse.

Collier LS, Carlson CM, Ravimohan S, Dupuy AJ, Largaespada DA.

Nature. 2005 Jul 14;436(7048):272-6.

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