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Items: 24

1.

Safety and immunogenicity of an anti-Middle East respiratory syndrome coronavirus DNA vaccine: a phase 1, open-label, single-arm, dose-escalation trial.

Modjarrad K, Roberts CC, Mills KT, Castellano AR, Paolino K, Muthumani K, Reuschel EL, Robb ML, Racine T, Oh MD, Lamarre C, Zaidi FI, Boyer J, Kudchodkar SB, Jeong M, Darden JM, Park YK, Scott PT, Remigio C, Parikh AP, Wise MC, Patel A, Duperret EK, Kim KY, Choi H, White S, Bagarazzi M, May JM, Kane D, Lee H, Kobinger G, Michael NL, Weiner DB, Thomas SJ, Maslow JN.

Lancet Infect Dis. 2019 Sep;19(9):1013-1022. doi: 10.1016/S1473-3099(19)30266-X. Epub 2019 Jul 24.

PMID:
31351922
2.

DNA-encoded bispecific T cell engagers and antibodies present long-term antitumor activity.

Perales-Puchalt A, Duperret EK, Yang X, Hernandez P, Wojtak K, Zhu X, Jung SH, Tello-Ruiz E, Wise MC, Montaner LJ, Muthumani K, Weiner DB.

JCI Insight. 2019 Apr 18;4(8). pii: 126086. doi: 10.1172/jci.insight.126086. eCollection 2019 Apr 18.

3.

Simplifying checkpoint inhibitor delivery through in vivo generation of synthetic DNA-encoded monoclonal antibodies (DMAbs).

Perales-Puchalt A, Duperret EK, Muthumani K, Weiner DB.

Oncotarget. 2019 Jan 1;10(1):13-16. doi: 10.18632/oncotarget.26535. eCollection 2019 Jan 1.

4.

A Synthetic DNA, Multi-Neoantigen Vaccine Drives Predominately MHC Class I CD8+ T-cell Responses, Impacting Tumor Challenge.

Duperret EK, Perales-Puchalt A, Stoltz R, G H H, Mandloi N, Barlow J, Chaudhuri A, Sardesai NY, Weiner DB.

Cancer Immunol Res. 2019 Feb;7(2):174-182. doi: 10.1158/2326-6066.CIR-18-0283. Epub 2019 Jan 24.

PMID:
30679156
5.

Engineered DNA Vaccination against Follicle-Stimulating Hormone Receptor Delays Ovarian Cancer Progression in Animal Models.

Perales-Puchalt A, Wojtak K, Duperret EK, Yang X, Slager AM, Yan J, Muthumani K, Montaner LJ, Weiner DB.

Mol Ther. 2019 Feb 6;27(2):314-325. doi: 10.1016/j.ymthe.2018.11.014. Epub 2018 Dec 13.

PMID:
30554854
6.

IL-33 delays metastatic peritoneal cancer progression inducing an allergic microenvironment.

Perales-Puchalt A, Svoronos N, Villarreal DO, Zankharia U, Reuschel E, Wojtak K, Payne KK, Duperret EK, Muthumani K, Conejo-Garcia JR, Weiner DB.

Oncoimmunology. 2018 Sep 6;8(1):e1515058. doi: 10.1080/2162402X.2018.1515058. eCollection 2019.

7.

Designing consensus immunogens to break tolerance to self-antigens for cancer therapy.

Duperret EK, Yan J, Weiner DB.

Oncotarget. 2018 Oct 30;9(85):35513-35514. doi: 10.18632/oncotarget.26275. eCollection 2018 Oct 30. No abstract available.

8.

Synthetic DNA-Encoded Monoclonal Antibody Delivery of Anti-CTLA-4 Antibodies Induces Tumor Shrinkage In Vivo.

Duperret EK, Trautz A, Stoltz R, Patel A, Wise MC, Perales-Puchalt A, Smith T, Broderick KE, Masteller E, Kim JJ, Humeau L, Muthumani K, Weiner DB.

Cancer Res. 2018 Nov 15;78(22):6363-6370. doi: 10.1158/0008-5472.CAN-18-1429. Epub 2018 Oct 4.

PMID:
30287678
9.

A Designer Cross-reactive DNA Immunotherapeutic Vaccine that Targets Multiple MAGE-A Family Members Simultaneously for Cancer Therapy.

Duperret EK, Liu S, Paik M, Trautz A, Stoltz R, Liu X, Ze K, Perales-Puchalt A, Reed C, Yan J, Xu X, Weiner DB.

Clin Cancer Res. 2018 Dec 1;24(23):6015-6027. doi: 10.1158/1078-0432.CCR-18-1013. Epub 2018 Sep 27.

PMID:
30262507
10.

Alteration of the Tumor Stroma Using a Consensus DNA Vaccine Targeting Fibroblast Activation Protein (FAP) Synergizes with Antitumor Vaccine Therapy in Mice.

Duperret EK, Trautz A, Ammons D, Perales-Puchalt A, Wise MC, Yan J, Reed C, Weiner DB.

Clin Cancer Res. 2018 Mar 1;24(5):1190-1201. doi: 10.1158/1078-0432.CCR-17-2033. Epub 2017 Dec 21.

11.

In vivo protection against ZIKV infection and pathogenesis through passive antibody transfer and active immunisation with a prMEnv DNA vaccine.

Muthumani K, Griffin BD, Agarwal S, Kudchodkar SB, Reuschel EL, Choi H, Kraynyak KA, Duperret EK, Keaton AA, Chung C, Kim YK, Booth SA, Racine T, Yan J, Morrow MP, Jiang J, Lee B, Ramos S, Broderick KE, Reed CC, Khan AS, Humeau L, Ugen KE, Park YK, Maslow JN, Sardesai NY, Joseph Kim J, Kobinger GP, Weiner DB.

NPJ Vaccines. 2016 Nov 10;1:16021. doi: 10.1038/npjvaccines.2016.21. eCollection 2016.

12.

Synergy of Immune Checkpoint Blockade with a Novel Synthetic Consensus DNA Vaccine Targeting TERT.

Duperret EK, Wise MC, Trautz A, Villarreal DO, Ferraro B, Walters J, Yan J, Khan A, Masteller E, Humeau L, Weiner DB.

Mol Ther. 2018 Feb 7;26(2):435-445. doi: 10.1016/j.ymthe.2017.11.010. Epub 2017 Nov 21.

13.

Lipid bodies containing oxidatively truncated lipids block antigen cross-presentation by dendritic cells in cancer.

Veglia F, Tyurin VA, Mohammadyani D, Blasi M, Duperret EK, Donthireddy L, Hashimoto A, Kapralov A, Amoscato A, Angelini R, Patel S, Alicea-Torres K, Weiner D, Murphy ME, Klein-Seetharaman J, Celis E, Kagan VE, Gabrilovich DI.

Nat Commun. 2017 Dec 14;8(1):2122. doi: 10.1038/s41467-017-02186-9.

14.

Novel prostate cancer immunotherapy with a DNA-encoded anti-prostate-specific membrane antigen monoclonal antibody.

Muthumani K, Marnin L, Kudchodkar SB, Perales-Puchalt A, Choi H, Agarwal S, Scott VL, Reuschel EL, Zaidi FI, Duperret EK, Wise MC, Kraynyak KA, Ugen KE, Sardesai NY, Joseph Kim J, Weiner DB.

Cancer Immunol Immunother. 2017 Dec;66(12):1577-1588. doi: 10.1007/s00262-017-2042-7. Epub 2017 Aug 17.

15.

A Novel DNA Vaccine Platform Enhances Neo-antigen-like T Cell Responses against WT1 to Break Tolerance and Induce Anti-tumor Immunity.

Walters JN, Ferraro B, Duperret EK, Kraynyak KA, Chu J, Saint-Fleur A, Yan J, Levitsky H, Khan AS, Sardesai NY, Weiner DB.

Mol Ther. 2017 Apr 5;25(4):976-988. doi: 10.1016/j.ymthe.2017.01.022. Epub 2017 Feb 22.

16.

The integrin αv-TGFβ signaling axis is necessary for epidermal proliferation during cutaneous wound healing.

Duperret EK, Natale CA, Monteleon C, Dahal A, Ridky TW.

Cell Cycle. 2016 Aug 2;15(15):2077-86. doi: 10.1080/15384101.2016.1199306. Epub 2016 Jun 13.

17.

Sex steroids regulate skin pigmentation through nonclassical membrane-bound receptors.

Natale CA, Duperret EK, Zhang J, Sadeghi R, Dahal A, O'Brien KT, Cookson R, Winkler JD, Ridky TW.

Elife. 2016 Apr 26;5. pii: e15104. doi: 10.7554/eLife.15104.

18.

Focal-adhesion-independent integrin-αv regulation of FAK and c-Myc is necessary for 3D skin formation and tumor invasion.

Duperret EK, Dahal A, Ridky TW.

J Cell Sci. 2015 Nov 1;128(21):3997-4013. doi: 10.1242/jcs.175539. Epub 2015 Sep 10.

19.

CDKN2B Loss Promotes Progression from Benign Melanocytic Nevus to Melanoma.

McNeal AS, Liu K, Nakhate V, Natale CA, Duperret EK, Capell BC, Dentchev T, Berger SL, Herlyn M, Seykora JT, Ridky TW.

Cancer Discov. 2015 Oct;5(10):1072-85. doi: 10.1158/2159-8290.CD-15-0196. Epub 2015 Jul 16.

20.

IQGAP1 and IQGAP3 Serve Individually Essential Roles in Normal Epidermal Homeostasis and Tumor Progression.

Monteleon CL, McNeal A, Duperret EK, Oh SJ, Schapira E, Ridky TW.

J Invest Dermatol. 2015 Sep;135(9):2258-2265. doi: 10.1038/jid.2015.140. Epub 2015 Apr 7.

21.

Kindler syndrome in mice and men.

Duperret EK, Ridky TW.

Cancer Biol Ther. 2014 Sep;15(9):1113-6. doi: 10.4161/cbt.29482. Epub 2014 Jun 11.

22.

Masking epistasis between MYC and TGF-β pathways in antiangiogenesis-mediated colon cancer suppression.

Dews M, Tan GS, Hultine S, Raman P, Choi J, Duperret EK, Lawler J, Bass A, Thomas-Tikhonenko A.

J Natl Cancer Inst. 2014 Apr;106(4):dju043. doi: 10.1093/jnci/dju043. Epub 2014 Mar 13.

23.

Activating FGFR3 mutations cause mild hyperplasia in human skin, but are insufficient to drive benign or malignant skin tumors.

Duperret EK, Oh SJ, McNeal A, Prouty SM, Ridky TW.

Cell Cycle. 2014;13(10):1551-9. doi: 10.4161/cc.28492. Epub 2014 Mar 12.

24.

Focal adhesion complex proteins in epidermis and squamous cell carcinoma.

Duperret EK, Ridky TW.

Cell Cycle. 2013 Oct 15;12(20):3272-85. doi: 10.4161/cc.26385. Epub 2013 Sep 12. Review.

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