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Items: 26


Liraglutide improves hepatic steatosis and metabolic dysfunctions in a 3-week dietary mouse model of nonalcoholic steatohepatitis.

Duparc T, Briand F, Trenteseaux C, Merian J, Combes G, Najib S, Sulpice T, Martinez LO.

Am J Physiol Gastrointest Liver Physiol. 2019 Oct 1;317(4):G508-G517. doi: 10.1152/ajpgi.00139.2019. Epub 2019 Aug 28.


Pharmacological inhibition of the F1 -ATPase/P2Y1 pathway suppresses the effect of apolipoprotein A1 on endothelial nitric oxide synthesis and vasorelaxation.

Cabou C, Honorato P, Briceño L, Ghezali L, Duparc T, León M, Combes G, Frayssinhes L, Fournel A, Abot A, Masri B, Parada N, Aguilera V, Aguayo C, Knauf C, González M, Radojkovic C, Martinez LO.

Acta Physiol (Oxf). 2019 Jul;226(3):e13268. doi: 10.1111/apha.13268. Epub 2019 Apr 4.


Genetic deletion of soluble 5'-nucleotidase II reduces body weight gain and insulin resistance induced by a high-fat diet.

Johanns M, Kviklyte S, Chuang SJ, Corbeels K, Jacobs R, Herinckx G, Vertommen D, Schakman O, Duparc T, Cani PD, Bouzin C, Andersén H, Bohlooly-Y M, Van der Schueren B, Oscarsson J, Rider MH.

Mol Genet Metab. 2019 Apr;126(4):377-387. doi: 10.1016/j.ymgme.2019.01.017. Epub 2019 Feb 14.


Fecal Enterobacteriales enrichment is associated with increased in vivo intestinal permeability in humans.

Pedersen C, Ijaz UZ, Gallagher E, Horton F, Ellis RJ, Jaiyeola E, Duparc T, Russell-Jones D, Hinton P, Cani PD, La Ragione RM, Robertson MD.

Physiol Rep. 2018 Apr;6(7):e13649. doi: 10.14814/phy2.13649.


Serum inhibitory factor 1, high-density lipoprotein and cardiovascular diseases.

Martinez LO, Genoux A, Ferrières J, Duparc T, Perret B.

Curr Opin Lipidol. 2017 Aug;28(4):337-346. doi: 10.1097/MOL.0000000000000434. Review.


Ectopic adenine nucleotide translocase activity controls extracellular ADP levels and regulates the F1-ATPase-mediated HDL endocytosis pathway on hepatocytes.

Cardouat G, Duparc T, Fried S, Perret B, Najib S, Martinez LO.

Biochim Biophys Acta Mol Cell Biol Lipids. 2017 Sep;1862(9):832-841. doi: 10.1016/j.bbalip.2017.05.005. Epub 2017 May 11.


Host-microbiome interactions in human type 2 diabetes following prebiotic fibre (galacto-oligosaccharide) intake.

Pedersen C, Gallagher E, Horton F, Ellis RJ, Ijaz UZ, Wu H, Jaiyeola E, Diribe O, Duparc T, Cani PD, Gibson GR, Hinton P, Wright J, La Ragione R, Robertson MD.

Br J Nutr. 2016 Dec;116(11):1869-1877. doi: 10.1017/S0007114516004086. Epub 2016 Dec 15.


A purified membrane protein from Akkermansia muciniphila or the pasteurized bacterium improves metabolism in obese and diabetic mice.

Plovier H, Everard A, Druart C, Depommier C, Van Hul M, Geurts L, Chilloux J, Ottman N, Duparc T, Lichtenstein L, Myridakis A, Delzenne NM, Klievink J, Bhattacharjee A, van der Ark KC, Aalvink S, Martinez LO, Dumas ME, Maiter D, Loumaye A, Hermans MP, Thissen JP, Belzer C, de Vos WM, Cani PD.

Nat Med. 2017 Jan;23(1):107-113. doi: 10.1038/nm.4236. Epub 2016 Nov 28.


Serum levels of mitochondrial inhibitory factor 1 are independently associated with long-term prognosis in coronary artery disease: the GENES Study.

Genoux A, Lichtenstein L, Ferrières J, Duparc T, Bongard V, Vervueren PL, Combes G, Taraszkiewicz D, Elbaz M, Galinier M, Nassar B, Ruidavets JB, Perret B, Martinez LO.

BMC Med. 2016 Aug 23;14(1):125. doi: 10.1186/s12916-016-0672-9.


Central chronic apelin infusion decreases energy expenditure and thermogenesis in mice.

Drougard A, Fournel A, Marlin A, Meunier E, Abot A, Bautzova T, Duparc T, Louche K, Batut A, Lucas A, Le-Gonidec S, Lesage J, Fioramonti X, Moro C, Valet P, Cani PD, Knauf C.

Sci Rep. 2016 Aug 23;6:31849. doi: 10.1038/srep31849.


Hepatocyte MyD88 affects bile acids, gut microbiota and metabolome contributing to regulate glucose and lipid metabolism.

Duparc T, Plovier H, Marrachelli VG, Van Hul M, Essaghir A, Ståhlman M, Matamoros S, Geurts L, Pardo-Tendero MM, Druart C, Delzenne NM, Demoulin JB, van der Merwe SW, van Pelt J, Bäckhed F, Monleon D, Everard A, Cani PD.

Gut. 2017 Apr;66(4):620-632. doi: 10.1136/gutjnl-2015-310904. Epub 2016 May 5.


Apelin targets gut contraction to control glucose metabolism via the brain.

Fournel A, Drougard A, Duparc T, Marlin A, Brierley SM, Castro J, Le-Gonidec S, Masri B, Colom A, Lucas A, Rousset P, Cenac N, Vergnolle N, Valet P, Cani PD, Knauf C.

Gut. 2017 Feb;66(2):258-269. doi: 10.1136/gutjnl-2015-310230. Epub 2015 Nov 12.


Adipose tissue NAPE-PLD controls fat mass development by altering the browning process and gut microbiota.

Geurts L, Everard A, Van Hul M, Essaghir A, Duparc T, Matamoros S, Plovier H, Castel J, Denis RG, Bergiers M, Druart C, Alhouayek M, Delzenne NM, Muccioli GG, Demoulin JB, Luquet S, Cani PD.

Nat Commun. 2015 Mar 11;6:6495. doi: 10.1038/ncomms7495.


Intestinal epithelial MyD88 is a sensor switching host metabolism towards obesity according to nutritional status.

Everard A, Geurts L, Caesar R, Van Hul M, Matamoros S, Duparc T, Denis RG, Cochez P, Pierard F, Castel J, Bindels LB, Plovier H, Robine S, Muccioli GG, Renauld JC, Dumoutier L, Delzenne NM, Luquet S, Bäckhed F, Cani PD.

Nat Commun. 2014 Dec 5;5:5648. doi: 10.1038/ncomms6648.


Glucose metabolism: focus on gut microbiota, the endocannabinoid system and beyond.

Cani PD, Geurts L, Matamoros S, Plovier H, Duparc T.

Diabetes Metab. 2014 Sep;40(4):246-57. doi: 10.1016/j.diabet.2014.02.004. Epub 2014 Mar 14. Review.


Gut microbiota, enteroendocrine functions and metabolism.

Cani PD, Everard A, Duparc T.

Curr Opin Pharmacol. 2013 Dec;13(6):935-40. doi: 10.1016/j.coph.2013.09.008. Epub 2013 Sep 24. Review.


Hypothalamic actions of apelin on energy metabolism: new insight on glucose homeostasis and metabolic disorders.

Knauf C, Drougard A, Fournel A, Duparc T, Valet P.

Horm Metab Res. 2013 Dec;45(13):928-34. doi: 10.1055/s-0033-1351321. Epub 2013 Aug 15.


Hypothalamic apelin/reactive oxygen species signaling controls hepatic glucose metabolism in the onset of diabetes.

Drougard A, Duparc T, Brenachot X, Carneiro L, Gouazé A, Fournel A, Geurts L, Cadoudal T, Prats AC, Pénicaud L, Vieau D, Lesage J, Leloup C, Benani A, Cani PD, Valet P, Knauf C.

Antioxid Redox Signal. 2014 Feb 1;20(4):557-73. doi: 10.1089/ars.2013.5182. Epub 2013 Sep 18.


Food intake adaptation to dietary fat involves PSA-dependent rewiring of the arcuate melanocortin system in mice.

Benani A, Hryhorczuk C, Gouazé A, Fioramonti X, Brenachot X, Guissard C, Krezymon A, Duparc T, Colom A, Nédélec E, Rigault C, Lemoine A, Gascuel J, Gerardy-Schahn R, Valet P, Knauf C, Lorsignol A, Pénicaud L.

J Neurosci. 2012 Aug 29;32(35):11970-9. doi: 10.1523/JNEUROSCI.0624-12.2012.


p53-PGC-1α pathway mediates oxidative mitochondrial damage and cardiomyocyte necrosis induced by monoamine oxidase-A upregulation: role in chronic left ventricular dysfunction in mice.

Villeneuve C, Guilbeau-Frugier C, Sicard P, Lairez O, Ordener C, Duparc T, De Paulis D, Couderc B, Spreux-Varoquaux O, Tortosa F, Garnier A, Knauf C, Valet P, Borchi E, Nediani C, Gharib A, Ovize M, Delisle MB, Parini A, Mialet-Perez J.

Antioxid Redox Signal. 2013 Jan 1;18(1):5-18. doi: 10.1089/ars.2011.4373. Epub 2012 Aug 10.


Prenatal fasudil exposure alleviates fetal growth but programs hyperphagia and overweight in the adult male rat.

Butruille L, Mayeur S, Duparc T, Knauf C, Moitrot E, Fajardy I, Valet P, Storme L, Deruelle P, Lesage J.

Eur J Pharmacol. 2012 Aug 15;689(1-3):278-84. doi: 10.1016/j.ejphar.2012.05.040. Epub 2012 Jun 7.


Apelin, diabetes, and obesity.

Castan-Laurell I, Dray C, Attané C, Duparc T, Knauf C, Valet P.

Endocrine. 2011 Aug;40(1):1-9. doi: 10.1007/s12020-011-9507-9. Review.


Central apelin controls glucose homeostasis via a nitric oxide-dependent pathway in mice.

Duparc T, Colom A, Cani PD, Massaly N, Rastrelli S, Drougard A, Le Gonidec S, Moulédous L, Frances B, Leclercq I, Llorens-Cortes C, Pospisilik JA, Delzenne NM, Valet P, Castan-Laurell I, Knauf C.

Antioxid Redox Signal. 2011 Sep 15;15(6):1477-96. doi: 10.1089/ars.2010.3454. Epub 2011 May 25.


Jejunum inflammation in obese and diabetic mice impairs enteric glucose detection and modifies nitric oxide release in the hypothalamus.

Duparc T, Naslain D, Colom A, Muccioli GG, Massaly N, Delzenne NM, Valet P, Cani PD, Knauf C.

Antioxid Redox Signal. 2011 Feb 1;14(3):415-23. doi: 10.1089/ars.2010.3330. Epub 2010 Sep 29.


Ventromedial hypothalamic nitric oxide production is necessary for hypoglycemia detection and counterregulation.

Fioramonti X, Marsollier N, Song Z, Fakira KA, Patel RM, Brown S, Duparc T, Pica-Mendez A, Sanders NM, Knauf C, Valet P, McCrimmon RJ, Beuve A, Magnan C, Routh VH.

Diabetes. 2010 Feb;59(2):519-28. doi: 10.2337/db09-0421. Epub 2009 Nov 23.


Enhanced hypothalamic glucose sensing in obesity: alteration of redox signaling.

Colombani AL, Carneiro L, Benani A, Galinier A, Jaillard T, Duparc T, Offer G, Lorsignol A, Magnan C, Casteilla L, Pénicaud L, Leloup C.

Diabetes. 2009 Oct;58(10):2189-97. doi: 10.2337/db09-0110. Epub 2009 Jul 6.

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