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RPA-coated single-stranded DNA promotes the ETAA1-dependent activation of ATR.

Lyu K, Kumagai A, Dunphy WG.

Cell Cycle. 2019 Apr;18(8):898-913. doi: 10.1080/15384101.2019.1598728. Epub 2019 Apr 12.


MTBP, the partner of Treslin, contains a novel DNA-binding domain that is essential for proper initiation of DNA replication.

Kumagai A, Dunphy WG.

Mol Biol Cell. 2017 Nov 1;28(22):2998-3012. doi: 10.1091/mbc.E17-07-0448. Epub 2017 Sep 6.


CKS Proteins Promote Checkpoint Recovery by Stimulating Phosphorylation of Treslin.

Mu R, Tat J, Zamudio R, Zhang Y, Yates JR 3rd, Kumagai A, Dunphy WG, Reed SI.

Mol Cell Biol. 2017 Sep 26;37(20). pii: e00344-17. doi: 10.1128/MCB.00344-17. Print 2017 Oct 15.


SUMOylation of the C-terminal domain of DNA topoisomerase IIα regulates the centromeric localization of Claspin.

Ryu H, Yoshida MM, Sridharan V, Kumagai A, Dunphy WG, Dasso M, Azuma Y.

Cell Cycle. 2015;14(17):2777-84. doi: 10.1080/15384101.2015.1066537. Epub 2015 Jul 1.


Interaction of Chk1 with Treslin negatively regulates the initiation of chromosomal DNA replication.

Guo C, Kumagai A, Schlacher K, Shevchenko A, Shevchenko A, Dunphy WG.

Mol Cell. 2015 Feb 5;57(3):492-505. doi: 10.1016/j.molcel.2014.12.003. Epub 2014 Dec 31.


The Mre11-Rad50-Nbs1 (MRN) complex has a specific role in the activation of Chk1 in response to stalled replication forks.

Lee J, Dunphy WG.

Mol Biol Cell. 2013 May;24(9):1343-53. doi: 10.1091/mbc.E13-01-0025. Epub 2013 Mar 6.


Role for Rif1 in the checkpoint response to damaged DNA in Xenopus egg extracts.

Kumar S, Yoo HY, Kumagai A, Shevchenko A, Shevchenko A, Dunphy WG.

Cell Cycle. 2012 Mar 15;11(6):1183-94. doi: 10.4161/cc.11.6.19636. Epub 2012 Mar 15.


Role for casein kinase 1 in the phosphorylation of Claspin on critical residues necessary for the activation of Chk1.

Meng Z, Capalbo L, Glover DM, Dunphy WG.

Mol Biol Cell. 2011 Aug 15;22(16):2834-47. doi: 10.1091/mbc.E11-01-0048. Epub 2011 Jun 16.


Direct regulation of Treslin by cyclin-dependent kinase is essential for the onset of DNA replication.

Kumagai A, Shevchenko A, Shevchenko A, Dunphy WG.

J Cell Biol. 2011 Jun 13;193(6):995-1007. doi: 10.1083/jcb.201102003. Epub 2011 Jun 6.


CtIP interacts with TopBP1 and Nbs1 in the response to double-stranded DNA breaks (DSBs) in Xenopus egg extracts.

Ramírez-Lugo JS, Yoo HY, Yoon SJ, Dunphy WG.

Cell Cycle. 2011 Feb 1;10(3):469-80. Epub 2011 Feb 1.


Xenopus DNA2 is a helicase/nuclease that is found in complexes with replication proteins And-1/Ctf4 and Mcm10 and DSB response proteins Nbs1 and ATM.

Wawrousek KE, Fortini BK, Polaczek P, Chen L, Liu Q, Dunphy WG, Campbell JL.

Cell Cycle. 2010 Mar 15;9(6):1156-66. Epub 2010 Mar 15.


Drf1-dependent kinase interacts with Claspin through a conserved protein motif.

Gold DA, Dunphy WG.

J Biol Chem. 2010 Apr 23;285(17):12638-46. doi: 10.1074/jbc.M109.077370. Epub 2010 Feb 27.


Treslin collaborates with TopBP1 in triggering the initiation of DNA replication.

Kumagai A, Shevchenko A, Shevchenko A, Dunphy WG.

Cell. 2010 Feb 5;140(3):349-59. doi: 10.1016/j.cell.2009.12.049. Epub 2010 Jan 28.


Rad17 plays a central role in establishment of the interaction between TopBP1 and the Rad9-Hus1-Rad1 complex at stalled replication forks.

Lee J, Dunphy WG.

Mol Biol Cell. 2010 Mar 15;21(6):926-35. doi: 10.1091/mbc.E09-11-0958. Epub 2010 Jan 28.


The Mre11-Rad50-Nbs1 complex mediates activation of TopBP1 by ATM.

Yoo HY, Kumagai A, Shevchenko A, Shevchenko A, Dunphy WG.

Mol Biol Cell. 2009 May;20(9):2351-60. doi: 10.1091/mbc.E08-12-1190. Epub 2009 Mar 11.


Aven-dependent activation of ATM following DNA damage.

Guo JY, Yamada A, Kajino T, Wu JQ, Tang W, Freel CD, Feng J, Chau BN, Wang MZ, Margolis SS, Yoo HY, Wang XF, Dunphy WG, Irusta PM, Hardwick JM, Kornbluth S.

Curr Biol. 2008 Jul 8;18(13):933-42. doi: 10.1016/j.cub.2008.05.045. Epub 2008 Jun 19.


The Rad9-Hus1-Rad1 checkpoint clamp regulates interaction of TopBP1 with ATR.

Lee J, Kumagai A, Dunphy WG.

J Biol Chem. 2007 Sep 21;282(38):28036-44. Epub 2007 Jul 18.


Ataxia-telangiectasia mutated (ATM)-dependent activation of ATR occurs through phosphorylation of TopBP1 by ATM.

Yoo HY, Kumagai A, Shevchenko A, Shevchenko A, Dunphy WG.

J Biol Chem. 2007 Jun 15;282(24):17501-6. Epub 2007 Apr 19.


Role for the PP2A/B56delta phosphatase in regulating 14-3-3 release from Cdc25 to control mitosis.

Margolis SS, Perry JA, Forester CM, Nutt LK, Guo Y, Jardim MJ, Thomenius MJ, Freel CD, Darbandi R, Ahn JH, Arroyo JD, Wang XF, Shenolikar S, Nairn AC, Dunphy WG, Hahn WC, Virshup DM, Kornbluth S.

Cell. 2006 Nov 17;127(4):759-73.


How cells activate ATR.

Kumagai A, Dunphy WG.

Cell Cycle. 2006 Jun;5(12):1265-8. Epub 2006 Jun 15.


TopBP1 activates the ATR-ATRIP complex.

Kumagai A, Lee J, Yoo HY, Dunphy WG.

Cell. 2006 Mar 10;124(5):943-55.


Metabolic regulation of oocyte cell death through the CaMKII-mediated phosphorylation of caspase-2.

Nutt LK, Margolis SS, Jensen M, Herman CE, Dunphy WG, Rathmell JC, Kornbluth S.

Cell. 2005 Oct 7;123(1):89-103.


Roles of replication fork-interacting and Chk1-activating domains from Claspin in a DNA replication checkpoint response.

Lee J, Gold DA, Shevchenko A, Shevchenko A, Dunphy WG.

Mol Biol Cell. 2005 Nov;16(11):5269-82. Epub 2005 Sep 7.


Initiation of DNA replication requires the RECQL4 protein mutated in Rothmund-Thomson syndrome.

Sangrithi MN, Bernal JA, Madine M, Philpott A, Lee J, Dunphy WG, Venkitaraman AR.

Cell. 2005 Jun 17;121(6):887-98.


Mcm2 is a direct substrate of ATM and ATR during DNA damage and DNA replication checkpoint responses.

Yoo HY, Shevchenko A, Shevchenko A, Dunphy WG.

J Biol Chem. 2004 Dec 17;279(51):53353-64. Epub 2004 Sep 22.


Claspin and the activated form of ATR-ATRIP collaborate in the activation of Chk1.

Kumagai A, Kim SM, Dunphy WG.

J Biol Chem. 2004 Nov 26;279(48):49599-608. Epub 2004 Sep 15.


Absence of BLM leads to accumulation of chromosomal DNA breaks during both unperturbed and disrupted S phases.

Li W, Kim SM, Lee J, Dunphy WG.

J Cell Biol. 2004 Jun 21;165(6):801-12. Epub 2004 Jun 14.


Adaptation of a DNA replication checkpoint response depends upon inactivation of Claspin by the Polo-like kinase.

Yoo HY, Kumagai A, Shevchenko A, Shevchenko A, Dunphy WG.

Cell. 2004 May 28;117(5):575-88.


Phosphorylated claspin interacts with a phosphate-binding site in the kinase domain of Chk1 during ATR-mediated activation.

Jeong SY, Kumagai A, Lee J, Dunphy WG.

J Biol Chem. 2003 Nov 21;278(47):46782-8. Epub 2003 Sep 8.


Xenopus Drf1, a regulator of Cdc7, displays checkpoint-dependent accumulation on chromatin during an S-phase arrest.

Yanow SK, Gold DA, Yoo HY, Dunphy WG.

J Biol Chem. 2003 Oct 17;278(42):41083-92. Epub 2003 Aug 1.


Repeated phosphopeptide motifs in Claspin mediate the regulated binding of Chk1.

Kumagai A, Dunphy WG.

Nat Cell Biol. 2003 Feb;5(2):161-5.


Dissection of c-MOS degron.

Sheng J, Kumagai A, Dunphy WG, Varshavsky A.

EMBO J. 2002 Nov 15;21(22):6061-71.


Regulation of Op18 during spindle assembly in Xenopus egg extracts.

Budde PP, Kumagai A, Dunphy WG, Heald R.

J Cell Biol. 2001 Apr 2;153(1):149-58.


Positive regulation of Wee1 by Chk1 and 14-3-3 proteins.

Lee J, Kumagai A, Dunphy WG.

Mol Biol Cell. 2001 Mar;12(3):551-63.


Activation of Xenopus Chk1 by mutagenesis of threonine-377.

Wang SX, Dunphy WG.

FEBS Lett. 2000 Dec 29;487(2):277-81.


Negative cell cycle regulation and DNA damage-inducible phosphorylation of the BRCT protein 53BP1.

Xia Z, Morales JC, Dunphy WG, Carpenter PB.

J Biol Chem. 2001 Jan 26;276(4):2708-18. Epub 2000 Oct 20.


The xenopus Suc1/Cks protein promotes the phosphorylation of G(2)/M regulators.

Patra D, Wang SX, Kumagai A, Dunphy WG.

J Biol Chem. 1999 Dec 24;274(52):36839-42.


The Xenopus Chk1 protein kinase mediates a caffeine-sensitive pathway of checkpoint control in cell-free extracts.

Kumagai A, Guo Z, Emami KH, Wang SX, Dunphy WG.

J Cell Biol. 1998 Sep 21;142(6):1559-69.


Identification of a novel 81-kDa component of the Xenopus origin recognition complex.

Carpenter PB, Dunphy WG.

J Biol Chem. 1998 Sep 18;273(38):24891-7.


Regulation of Xenopus Cdc25 protein.

Kumagai A, Dunphy WG.

Methods Enzymol. 1997;283:564-71. No abstract available.


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