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Items: 1 to 50 of 484

1.

Phosphorylation of Parkin at serine 65 is essential for its activation in vivo.

McWilliams TG, Barini E, Pohjolan-Pirhonen R, Brooks SP, Singh F, Burel S, Balk K, Kumar A, Montava-Garriga L, Prescott AR, Hassoun SM, Mouton-Liger F, Ball G, Hills R, Knebel A, Ulusoy A, Di Monte DA, Tamjar J, Antico O, Fears K, Smith L, Brambilla R, Palin E, Valori M, Eerola-Rautio J, Tienari P, Corti O, Dunnett SB, Ganley IG, Suomalainen A, Muqit MMK.

Open Biol. 2018 Nov 7;8(11). pii: 180108. doi: 10.1098/rsob.180108.

2.

Outcome of cell suspension allografts in a patient with Huntington's disease.

Maxan A, Mason S, Saint-Pierre M, Smith E, Ho A, Harrower T, Watts C, Tai Y, Pavese N, Savage JC, Tremblay MÈ, Gould P, Rosser AE, Dunnett SB, Piccini P, Barker RA, Cicchetti F.

Ann Neurol. 2018 Oct 4. doi: 10.1002/ana.25354. [Epub ahead of print]

PMID:
30286516
3.

Generating Excitotoxic Lesion Models of Huntington's Disease.

Lelos MJ, Dunnett SB.

Methods Mol Biol. 2018;1780:209-220. doi: 10.1007/978-1-4939-7825-0_11.

PMID:
29856021
4.

Motor Assessment in Huntington's Disease Mice.

Dunnett SB, Brooks SP.

Methods Mol Biol. 2018;1780:121-141. doi: 10.1007/978-1-4939-7825-0_7.

PMID:
29856017
5.

Pallidal deep brain stimulation in juvenile Huntington's disease: local field potential oscillations and clinical data.

Ferrea S, Groiss SJ, Elben S, Hartmann CJ, Dunnett SB, Rosser A, Saft C, Schnitzler A, Vesper J, Wojtecki L; Surgical Approaches Working Group of the European Huntington’s Disease Network (EHDN).

J Neurol. 2018 Jul;265(7):1573-1579. doi: 10.1007/s00415-018-8880-1. Epub 2018 May 3.

PMID:
29725840
6.

The Effect of Tissue Preparation and Donor Age on Striatal Graft Morphology in the Mouse.

Harrison DJ, Roberton VH, Vinh NN, Brooks SP, Dunnett SB, Rosser AE.

Cell Transplant. 2018 Feb;27(2):230-244. doi: 10.1177/0963689717744788.

7.

Rehabilitation training in neural restitution.

Clinch S, Busse M, Döbrössy MD, Dunnett SB.

Prog Brain Res. 2017;230:305-329. doi: 10.1016/bs.pbr.2016.12.006. Epub 2017 Mar 7.

PMID:
28552234
8.

Mechanisms and use of neural transplants for brain repair.

Dunnett SB, Björklund A.

Prog Brain Res. 2017;230:1-51. doi: 10.1016/bs.pbr.2016.11.002. Epub 2017 Apr 14.

PMID:
28552225
9.

Reprogramming the diseased brain.

Dunnett SB, Rosser AE.

Nat Biotechnol. 2017 May 9;35(5):426-428. doi: 10.1038/nbt.3869. No abstract available.

PMID:
28486448
10.

Corrigendum: Motivational, proteostatic and transcriptional deficits precede synapse loss, gliosis and neurodegeneration in the B6.HttQ111/+ model of Huntington's disease.

Bragg RM, Coffey SR, Weston RM, Ament SA, Cantle JP, Minnig S, Funk CC, Shuttleworth DD, Woods EL, Sullivan BR, Jones L, Glickenhaus A, Anderson JS, Anderson MD, Dunnett SB, Wheeler VC, MacDonald ME, Brooks SP, Price ND, Carroll JB.

Sci Rep. 2017 Mar 28;7:44960. doi: 10.1038/srep44960. No abstract available.

11.

Motivational, proteostatic and transcriptional deficits precede synapse loss, gliosis and neurodegeneration in the B6.HttQ111/+ model of Huntington's disease.

Bragg RM, Coffey SR, Weston RM, Ament SA, Cantle JP, Minnig S, Funk CC, Shuttleworth DD, Woods EL, Sullivan BR, Jones L, Glickenhaus A, Anderson JS, Anderson MD, Dunnett SB, Wheeler VC, MacDonald ME, Brooks SP, Price ND, Carroll JB.

Sci Rep. 2017 Feb 8;7:41570. doi: 10.1038/srep41570. Erratum in: Sci Rep. 2017 Mar 28;7:44960.

12.

Is there a place for human fetal-derived stem cells for cell replacement therapy in Huntington's disease?

Precious SV, Zietlow R, Dunnett SB, Kelly CM, Rosser AE.

Neurochem Int. 2017 Jun;106:114-121. doi: 10.1016/j.neuint.2017.01.016. Epub 2017 Jan 27. Review.

13.

Transplantation site influences the phenotypic differentiation of dopamine neurons in ventral mesencephalic grafts in Parkinsonian rats.

Fjodorova M, Torres EM, Dunnett SB.

Exp Neurol. 2017 May;291:8-19. doi: 10.1016/j.expneurol.2017.01.010. Epub 2017 Jan 25.

14.

Predictive Markers Guide Differentiation to Improve Graft Outcome in Clinical Translation of hESC-Based Therapy for Parkinson's Disease.

Kirkeby A, Nolbrant S, Tiklova K, Heuer A, Kee N, Cardoso T, Ottosson DR, Lelos MJ, Rifes P, Dunnett SB, Grealish S, Perlmann T, Parmar M.

Cell Stem Cell. 2017 Jan 5;20(1):135-148. doi: 10.1016/j.stem.2016.09.004. Epub 2016 Oct 27.

15.

Lickometry: A novel and sensitive method for assessing functional deficits in rats after stroke.

Ahmed J, Dwyer DM, Farr TD, Harrison DJ, Dunnett SB, Trueman RC.

J Cereb Blood Flow Metab. 2017 Mar;37(3):755-761. doi: 10.1177/0271678X16684141. Epub 2017 Jan 6.

16.

SMAD transcription factors are altered in cell models of HD and regulate HTT expression.

Bowles KR, Stone T, Holmans P, Allen ND, Dunnett SB, Jones L.

Cell Signal. 2017 Feb;31:1-14. doi: 10.1016/j.cellsig.2016.12.005. Epub 2016 Dec 14.

17.

Influence of chronic L-DOPA treatment on immune response following allogeneic and xenogeneic graft in a rat model of Parkinson's disease.

Breger LS, Kienle K, Smith GA, Dunnett SB, Lane EL.

Brain Behav Immun. 2017 Mar;61:155-164. doi: 10.1016/j.bbi.2016.11.014. Epub 2016 Nov 15.

18.

Intraspinal stem cell transplantation for amyotrophic lateral sclerosis: Ready for efficacy clinical trials?

Atassi N, Beghi E, Blanquer M, Boulis NM, Cantello R, Caponnetto C, Chiò A, Dunnett SB, Feldman EL, Vescovi A, Mazzini L; attendees of the International Workshop on Progress in Stem Cells Research for ALS/MND.

Cytotherapy. 2016 Dec;18(12):1471-1475. doi: 10.1016/j.jcyt.2016.08.005. Epub 2016 Oct 6.

19.

Correction: Huntingtin Subcellular Localisation Is Regulated by Kinase Signalling Activity in the StHdhQ111 Model of HD.

Bowles KR, Brooks SP, Hughes AC, Dunnett SB, Jones L.

PLoS One. 2016 Oct 13;11(10):e0165069. doi: 10.1371/journal.pone.0165069. eCollection 2016.

20.

A Longitudinal Operant Assessment of Cognitive and Behavioural Changes in the HdhQ111 Mouse Model of Huntington's Disease.

Yhnell E, Dunnett SB, Brooks SP.

PLoS One. 2016 Oct 4;11(10):e0164072. doi: 10.1371/journal.pone.0164072. eCollection 2016.

21.

Systematic and detailed analysis of behavioural tests in the rat middle cerebral artery occlusion model of stroke: Tests for long-term assessment.

Trueman RC, Diaz C, Farr TD, Harrison DJ, Fuller A, Tokarczuk PF, Stewart AJ, Paisey SJ, Dunnett SB.

J Cereb Blood Flow Metab. 2017 Apr;37(4):1349-1361. doi: 10.1177/0271678X16654921. Epub 2016 Jan 1.

22.

Targeting delivery in Parkinson's disease.

Newland B, Dunnett SB, Dowd E.

Drug Discov Today. 2016 Aug;21(8):1313-20. doi: 10.1016/j.drudis.2016.06.003. Epub 2016 Jun 14. Review.

PMID:
27312875
23.

A Longitudinal Motor Characterisation of the HdhQ111 Mouse Model of Huntington's Disease.

Yhnell E, Dunnett SB, Brooks SP.

J Huntingtons Dis. 2016 May 31;5(2):149-61. doi: 10.3233/JHD-160191.

24.

Comparison of mHTT Antibodies in Huntington's Disease Mouse Models Reveal Specific Binding Profiles and Steady-State Ubiquitin Levels with Disease Development.

Bayram-Weston Z, Jones L, Dunnett SB, Brooks SP.

PLoS One. 2016 May 19;11(5):e0155834. doi: 10.1371/journal.pone.0155834. eCollection 2016.

25.

Cognitive training modifies disease symptoms in a mouse model of Huntington's disease.

Yhnell E, Lelos MJ, Dunnett SB, Brooks SP.

Exp Neurol. 2016 Aug;282:19-26. doi: 10.1016/j.expneurol.2016.05.008. Epub 2016 May 7.

26.

Amelioration of non-motor dysfunctions after transplantation of human dopamine neurons in a model of Parkinson's disease.

Lelos MJ, Morgan RJ, Kelly CM, Torres EM, Rosser AE, Dunnett SB.

Exp Neurol. 2016 Apr;278:54-61. doi: 10.1016/j.expneurol.2016.02.003. Epub 2016 Feb 4.

27.

Using Actiwatch to monitor circadian rhythm disturbance in Huntington' disease: A cautionary note.

Townhill J, Hughes AC, Thomas B, Busse ME, Price K, Dunnett SB, Hastings MH, Rosser AE.

J Neurosci Methods. 2016 May 30;265:13-8. doi: 10.1016/j.jneumeth.2016.01.009. Epub 2016 Jan 14.

28.

Direct Comparison of Rat- and Human-Derived Ganglionic Eminence Tissue Grafts on Motor Function.

Lelos MJ, Roberton VH, Vinh NN, Harrison C, Eriksen P, Torres EM, Clinch SP, Rosser AE, Dunnett SB.

Cell Transplant. 2016;25(4):665-75. doi: 10.3727/096368915X690297. Epub 2015 Dec 29.

PMID:
26727032
29.

Similar striatal gene expression profiles in the striatum of the YAC128 and HdhQ150 mouse models of Huntington's disease are not reflected in mutant Huntingtin inclusion prevalence.

Bayram-Weston Z, Stone TC, Giles P, Elliston L, Janghra N, Higgs GV, Holmans PA, Dunnett SB, Brooks SP, Jones L.

BMC Genomics. 2015 Dec 21;16:1079. doi: 10.1186/s12864-015-2251-4.

30.

Huntingtin Subcellular Localisation Is Regulated by Kinase Signalling Activity in the StHdhQ111 Model of HD.

Bowles KR, Brooks SP, Dunnett SB, Jones L.

PLoS One. 2015 Dec 14;10(12):e0144864. doi: 10.1371/journal.pone.0144864. eCollection 2015. Erratum in: PLoS One. 2016 Oct 13;11(10 ):e0165069.

31.

Optimising Golgi-Cox staining for use with perfusion-fixed brain tissue validated in the zQ175 mouse model of Huntington's disease.

Bayram-Weston Z, Olsen E, Harrison DJ, Dunnett SB, Brooks SP.

J Neurosci Methods. 2016 May 30;265:81-8. doi: 10.1016/j.jneumeth.2015.09.033. Epub 2015 Oct 13.

32.

A Prospective Pilot Trial for Pallidal Deep Brain Stimulation in Huntington's Disease.

Wojtecki L, Groiss SJ, Ferrea S, Elben S, Hartmann CJ, Dunnett SB, Rosser A, Saft C, Südmeyer M, Ohmann C, Schnitzler A, Vesper J; Surgical Approaches Working Group of the European Huntington's Disease Network (EHDN).

Front Neurol. 2015 Aug 18;6:177. doi: 10.3389/fneur.2015.00177. eCollection 2015.

33.

The utilisation of operant delayed matching and non-matching to position for probing cognitive flexibility and working memory in mouse models of Huntington's disease.

Yhnell E, Dunnett SB, Brooks SP.

J Neurosci Methods. 2016 May 30;265:72-80. doi: 10.1016/j.jneumeth.2015.08.022. Epub 2015 Aug 28.

34.

The 6-OHDA mouse model of Parkinson's disease - Terminal striatal lesions provide a superior measure of neuronal loss and replacement than median forebrain bundle lesions.

Bagga V, Dunnett SB, Fricker RA.

Behav Brain Res. 2015 Jul 15;288:107-17. doi: 10.1016/j.bbr.2015.03.058. Epub 2015 Apr 2.

PMID:
25841616
35.

Activin A directs striatal projection neuron differentiation of human pluripotent stem cells.

Arber C, Precious SV, Cambray S, Risner-Janiczek JR, Kelly C, Noakes Z, Fjodorova M, Heuer A, Ungless MA, Rodríguez TA, Rosser AE, Dunnett SB, Li M.

Development. 2015 Apr 1;142(7):1375-86. doi: 10.1242/dev.117093.

36.

Differentiation of pluripotent stem cells into striatal projection neurons: a pure MSN fate may not be sufficient.

Reddington AE, Rosser AE, Dunnett SB.

Front Cell Neurosci. 2014 Dec 2;8:398. doi: 10.3389/fncel.2014.00398. eCollection 2014. Review.

37.

Translation of cell therapies to the clinic: characteristics of cell suspensions in large-diameter injection cannulae.

Torres EM, Trigano M, Dunnett SB.

Cell Transplant. 2015;24(4):737-49. doi: 10.3727/096368914X685429. Epub 2014 Nov 13.

PMID:
25396691
38.

Nigral 6-hydroxydopamine lesion impairs performance in a lateralised choice reaction time task--impact of training and task parameters.

Lindgren HS, Klein A, Dunnett SB.

Behav Brain Res. 2014 Jun 1;266:207-15. doi: 10.1016/j.bbr.2014.02.043. Epub 2014 Mar 5.

PMID:
24613237
39.

Identification of novel alternative splicing events in the huntingtin gene and assessment of the functional consequences using structural protein homology modelling.

Hughes AC, Mort M, Elliston L, Thomas RM, Brooks SP, Dunnett SB, Jones L.

J Mol Biol. 2014 Apr 3;426(7):1428-38. doi: 10.1016/j.jmb.2013.12.028. Epub 2014 Jan 3.

PMID:
24389360
40.

Mouse Models of Huntington's Disease.

Brooks SP, Dunnett SB.

Curr Top Behav Neurosci. 2015;22:101-33. doi: 10.1007/7854_2013_256. Review.

PMID:
24357436
41.

The effect of additional noradrenergic and serotonergic depletion on a lateralised choice reaction time task in rats with nigral 6-OHDA lesions.

Lindgren HS, Demirbugen M, Bergqvist F, Lane EL, Dunnett SB.

Exp Neurol. 2014 Mar;253:52-62. doi: 10.1016/j.expneurol.2013.11.015. Epub 2013 Dec 12.

PMID:
24333808
42.

Is the adult mouse striatum a hostile host for neural transplant survival?

Roberton VH, Evans AE, Harrison DJ, Precious SV, Dunnett SB, Kelly CM, Rosser AE.

Neuroreport. 2013 Dec 18;24(18):1010-5. doi: 10.1097/WNR.0000000000000066.

43.

The 12th International Symposium on Neural Transplantation and Restoration.

Lane EL, Dunnett SB, Fricker RA.

Neuroreport. 2013 Dec 18;24(18):997-9. doi: 10.1097/WNR.0000000000000101. No abstract available.

PMID:
24257247
44.

Long-term restorative effects of bromocriptine on operant responding in the 6-hydroxydopamine-lesioned rat.

Murphy EM, Lelos MJ, O'Neill MJ, Lane EL, Dunnett SB.

Neuroreport. 2013 Dec 18;24(18):1019-24. doi: 10.1097/WNR.0000000000000060.

PMID:
24145771
45.

The lateral neostriatum is necessary for compensatory ingestive behaviour after intravascular dehydration in female rats.

Lelos MJ, Harrison DJ, Rosser AE, Dunnett SB.

Appetite. 2013 Dec;71:287-94. doi: 10.1016/j.appet.2013.09.003. Epub 2013 Sep 14.

PMID:
24045209
46.

Exercise attenuates neuropathology and has greater benefit on cognitive than motor deficits in the R6/1 Huntington's disease mouse model.

Harrison DJ, Busse M, Openshaw R, Rosser AE, Dunnett SB, Brooks SP.

Exp Neurol. 2013 Oct;248:457-69. doi: 10.1016/j.expneurol.2013.07.014. Epub 2013 Jul 30.

47.

Challenges for taking primary and stem cells into clinical neurotransplantation trials for neurodegenerative disease.

Dunnett SB, Rosser AE.

Neurobiol Dis. 2014 Jan;61:79-89. doi: 10.1016/j.nbd.2013.05.004. Epub 2013 May 18. Review.

PMID:
23688854
48.

Lesions of the dorsomedial striatum impair formation of attentional set in rats.

Lindgren HS, Wickens R, Tait DS, Brown VJ, Dunnett SB.

Neuropharmacology. 2013 Aug;71:148-53. doi: 10.1016/j.neuropharm.2013.03.034. Epub 2013 Apr 11.

PMID:
23583929
49.

Behavioural recovery on simple and complex tasks by means of cell replacement therapy in unilateral 6-hydroxydopamine-lesioned mice.

Heuer A, Vinh NN, Dunnett SB.

Eur J Neurosci. 2013 May;37(10):1691-704. doi: 10.1111/ejn.12150. Epub 2013 Feb 25.

PMID:
23432656
50.

Dopamine-rich grafts alleviate deficits in contralateral response space induced by extensive dopamine depletion in rats.

Heuer A, Lelos MJ, Kelly CM, Torres EM, Dunnett SB.

Exp Neurol. 2013 Sep;247:485-95. doi: 10.1016/j.expneurol.2013.01.020. Epub 2013 Jan 27.

PMID:
23360805

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