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Nano-particle mediated M2 macrophage polarization enhances bone formation and MSC osteogenesis in an IL-10 dependent manner.

Mahon OR, Browe DC, Gonzalez-Fernandez T, Pitacco P, Whelan IT, Von Euw S, Hobbs C, Nicolosi V, Cunningham KT, Mills KHG, Kelly DJ, Dunne A.

Biomaterials. 2020 Jan 31;239:119833. doi: 10.1016/j.biomaterials.2020.119833. [Epub ahead of print]


Osteoarthritis-associated basic calcium phosphate crystals alter immune cell metabolism and promote M1 macrophage polarization.

Mahon OR, Kelly DJ, McCarthy GM, Dunne A.

Osteoarthritis Cartilage. 2019 Nov 12. pii: S1063-4584(19)31247-6. doi: 10.1016/j.joca.2019.10.010. [Epub ahead of print]


Trypanosoma brucei Secreted Aromatic Ketoacids Activate the Nrf2/HO-1 Pathway and Suppress Pro-inflammatory Responses in Primary Murine Glia and Macrophages.

Campbell NK, Williams DG, Fitzgerald HK, Barry PJ, Cunningham CC, Nolan DP, Dunne A.

Front Immunol. 2019 Sep 11;10:2137. doi: 10.3389/fimmu.2019.02137. eCollection 2019.


Patient and family perspectives of paediatric psychogenic non-epileptic seizures: A systematic review.

Dunne A, Carolan R, Swords L, Fortune G.

Seizure. 2019 Oct;71:279-285. doi: 10.1016/j.seizure.2019.08.014. Epub 2019 Aug 28. Review.


The Role of Macrophages in the Infarcted Myocardium: Orchestrators of ECM Remodeling.

O'Rourke SA, Dunne A, Monaghan MG.

Front Cardiovasc Med. 2019 Jul 31;6:101. doi: 10.3389/fcvm.2019.00101. eCollection 2019. Review.


Calcium crystals and auto-inflammation.

McCarthy GM, Dunne A.

Rheumatology (Oxford). 2020 Jan 1;59(1):247-248. doi: 10.1093/rheumatology/kez296. No abstract available.


Assessing Schema Modes Using Self- and Observer-Rated Instruments: Associations With Aggression.

Lewis D, Dunne AL, Meyer D, Daffern M.

J Interpers Violence. 2019 Jul 13:886260519860088. doi: 10.1177/0886260519860088. [Epub ahead of print]


Glyoxal cross-linking of solubilized extracellular matrix to produce highly porous, elastic, and chondro-permissive scaffolds for orthopedic tissue engineering.

Browe DC, Mahon OR, Díaz-Payno PJ, Cassidy N, Dudurych I, Dunne A, Buckley CT, Kelly DJ.

J Biomed Mater Res A. 2019 Oct;107(10):2222-2234. doi: 10.1002/jbm.a.36731. Epub 2019 Jun 11.


S100A8 acts as an autocrine priming signal for heme-induced human Mϕ pro-inflammatory responses in hemolytic inflammation.

Silveira AAA, Mahon OR, Cunningham CC, Corr EM, Mendonça R, Saad STO, Costa FF, Dunne A, Conran N.

J Leukoc Biol. 2019 Jul;106(1):35-43. doi: 10.1002/JLB.3MIA1118-418RR. Epub 2019 May 15.


Plant-Derived Polyphenols Modulate Human Dendritic Cell Metabolism and Immune Function via AMPK-Dependent Induction of Heme Oxygenase-1.

Campbell NK, Fitzgerald HK, Fletcher JM, Dunne A.

Front Immunol. 2019 Mar 1;10:345. doi: 10.3389/fimmu.2019.00345. eCollection 2019.


Chronic neurodegeneration induces type I interferon synthesis via STING, shaping microglial phenotype and accelerating disease progression.

Nazmi A, Field RH, Griffin EW, Haugh O, Hennessy E, Cox D, Reis R, Tortorelli L, Murray CL, Lopez-Rodriguez AB, Jin L, Lavelle EC, Dunne A, Cunningham C.

Glia. 2019 Jul;67(7):1254-1276. doi: 10.1002/glia.23592. Epub 2019 Jan 25.


Astrocytes: Heterogeneous and Dynamic Phenotypes in Neurodegeneration and Innate Immunity.

Cunningham C, Dunne A, Lopez-Rodriguez AB.

Neuroscientist. 2019 Oct;25(5):455-474. doi: 10.1177/1073858418809941. Epub 2018 Nov 17.


Direct Inhibitory Effect of the PDE4 Inhibitor Roflumilast on Neutrophil Migration in Chronic Obstructive Pulmonary Disease.

Dunne AE, Kawamatawong T, Fenwick PS, Davies CM, Tullett H, Barnes PJ, Donnelly LE.

Am J Respir Cell Mol Biol. 2019 Apr;60(4):445-453. doi: 10.1165/rcmb.2018-0065OC.


Tissue-specific extracellular matrix scaffolds for the regeneration of spatially complex musculoskeletal tissues.

Cunniffe GM, Díaz-Payno PJ, Sheehy EJ, Critchley SE, Almeida HV, Pitacco P, Carroll SF, Mahon OR, Dunne A, Levingstone TJ, Moran CJ, Brady RT, O'Brien FJ, Brama PAJ, Kelly DJ.

Biomaterials. 2019 Jan;188:63-73. doi: 10.1016/j.biomaterials.2018.09.044. Epub 2018 Oct 4.


Comparison of fluticasone propionate and budesonide on COPD macrophage and neutrophil function.

Belchamber KB, Thomas CM, Dunne AE, Barnes PJ, Donnelly LE.

Int J Chron Obstruct Pulmon Dis. 2018 Sep 17;13:2883-2897. doi: 10.2147/COPD.S169337. eCollection 2018.


Calcium crystal deposition diseases - beyond gout.

McCarthy GM, Dunne A.

Nat Rev Rheumatol. 2018 Oct;14(10):592-602. doi: 10.1038/s41584-018-0078-5. Review.


Naturally derived Heme-Oxygenase 1 inducers attenuate inflammatory responses in human dendritic cells and T cells: relevance for psoriasis treatment.

Campbell NK, Fitzgerald HK, Malara A, Hambly R, Sweeney CM, Kirby B, Fletcher JM, Dunne A.

Sci Rep. 2018 Jul 6;8(1):10287. doi: 10.1038/s41598-018-28488-6.


Disease-Associated Particulates and Joint Inflammation; Mechanistic Insights and Potential Therapeutic Targets.

Mahon OR, Dunne A.

Front Immunol. 2018 May 28;9:1145. doi: 10.3389/fimmu.2018.01145. eCollection 2018. Review.


Micro-Capillary Coatings Based on Spiropyran Polymeric Brushes for Metal Ion Binding, Detection, and Release in Continuous Flow.

Dunne A, Delaney C, McKeon A, Nesterenko P, Paull B, Benito-Lopez F, Diamond D, Florea L.

Sensors (Basel). 2018 Apr 4;18(4). pii: E1083. doi: 10.3390/s18041083.


Effect of Salt on the Metabolism of 'Candidatus Accumulibacter' Clade I and II.

Wang Z, Dunne A, van Loosdrecht MCM, Saikaly PE.

Front Microbiol. 2018 Mar 16;9:479. doi: 10.3389/fmicb.2018.00479. eCollection 2018.


Photoswitchable Layer-by-Layer Coatings Based on Photochromic Polynorbornenes Bearing Spiropyran Side Groups.

Campos PP, Dunne A, Delaney C, Moloney C, Moulton SE, Benito-Lopez F, Ferreira M, Diamond D, Florea L.

Langmuir. 2018 Apr 10;34(14):4210-4216. doi: 10.1021/acs.langmuir.8b00137. Epub 2018 Mar 30.


The role of aggression-related early maladaptive schemas and schema modes in aggression in a prisoner sample.

Dunne AL, Gilbert F, Lee S, Daffern M.

Aggress Behav. 2018 May;44(3):246-256. doi: 10.1002/ab.21747. Epub 2018 Jan 25.


Core Temperature Responses to Cold-Water Immersion Recovery: A Pooled-Data Analysis.

Stephens JM, Sharpe K, Gore C, Miller J, Slater GJ, Versey N, Peiffer J, Duffield R, Minett GM, Crampton D, Dunne A, Askew CD, Halson SL.

Int J Sports Physiol Perform. 2018 Aug 1;13(7):917-925. doi: 10.1123/ijspp.2017-0661. Epub 2018 Jul 30.


Orthopaedic implant materials drive M1 macrophage polarization in a spleen tyrosine kinase- and mitogen-activated protein kinase-dependent manner.

Mahon OR, O'Hanlon S, Cunningham CC, McCarthy GM, Hobbs C, Nicolosi V, Kelly DJ, Dunne A.

Acta Biomater. 2018 Jan;65:426-435. doi: 10.1016/j.actbio.2017.10.041. Epub 2017 Nov 2.


Investigating the Relationship Between DSM-5 Personality Disorder Domains and Facets and Aggression in an Offender Population Using the Personality Inventory for the DSM-5.

Dunne AL, Gilbert F, Daffern M.

J Pers Disord. 2018 Oct;32(5):668-693. doi: 10.1521/pedi_2017_31_322. Epub 2017 Oct 3.


A novel gain-of-function mutation in the ITPR1 suppressor domain causes spinocerebellar ataxia with altered Ca2+ signal patterns.

Casey JP, Hirouchi T, Hisatsune C, Lynch B, Murphy R, Dunne AM, Miyamoto A, Ennis S, van der Spek N, O'Hici B, Mikoshiba K, Lynch SA.

J Neurol. 2017 Jul;264(7):1444-1453. doi: 10.1007/s00415-017-8545-5. Epub 2017 Jun 15.


Thiol-Ene Photo-Click Collagen-PEG Hydrogels: Impact of Water-Soluble Photoinitiators on Cell Viability, Gelation Kinetics and Rheological Properties.

Holmes R, Yang XB, Dunne A, Florea L, Wood D, Tronci G.

Polymers (Basel). 2017 Jun 14;9(6). pii: E226. doi: 10.3390/polym9060226.


Eyes of Things.

Deniz O, Vallez N, Espinosa-Aranda JL, Rico-Saavedra JM, Parra-Patino J, Bueno G, Moloney D, Dehghani A, Dunne A, Pagani A, Krauss S, Reiser R, Waeny M, Sorci M, Llewellynn T, Fedorczak C, Larmoire T, Herbst M, Seirafi A, Seirafi K.

Sensors (Basel). 2017 May 21;17(5). pii: E1173. doi: 10.3390/s17051173.


Cibinetide Improves Corneal Nerve Fiber Abundance in Patients With Sarcoidosis-Associated Small Nerve Fiber Loss and Neuropathic Pain.

Culver DA, Dahan A, Bajorunas D, Jeziorska M, van Velzen M, Aarts LPHJ, Tavee J, Tannemaat MR, Dunne AN, Kirk RI, Petropoulos IN, Cerami A, Malik RA, Brines M.

Invest Ophthalmol Vis Sci. 2017 May 1;58(6):BIO52-BIO60. doi: 10.1167/iovs.16-21291.


Toxigenic Clostridium difficile colonization among hospitalised adults; risk factors and impact on survival.

Behar L, Chadwick D, Dunne A, Jones CI, Proctor C, Rajkumar C, Sharratt P, Stanley P, Whiley A, Wilks M, Llewelyn MJ.

J Infect. 2017 Jul;75(1):20-25. doi: 10.1016/j.jinf.2017.04.006. Epub 2017 Apr 21.


Vegetarianism and meat consumption: A comparison of attitudes and beliefs between vegetarian, semi-vegetarian, and omnivorous subjects in Belgium.

Mullee A, Vermeire L, Vanaelst B, Mullie P, Deriemaeker P, Leenaert T, De Henauw S, Dunne A, Gunter MJ, Clarys P, Huybrechts I.

Appetite. 2017 Jul 1;114:299-305. doi: 10.1016/j.appet.2017.03.052. Epub 2017 Apr 6.


Growth plate extracellular matrix-derived scaffolds for large bone defect healing.

Cunniffe GM, Díaz-Payno PJ, Ramey JS, Mahon OR, Dunne A, Thompson EM, O'Brien FJ, Kelly DJ.

Eur Cell Mater. 2017 Feb 14;33:130-142. doi: 10.22203/eCM.v033a10.


Osteoarthritis-associated basic calcium phosphate crystals activate membrane proximal kinases in human innate immune cells.

Corr EM, Cunningham CC, Helbert L, McCarthy GM, Dunne A.

Arthritis Res Ther. 2017 Feb 7;19(1):23. doi: 10.1186/s13075-017-1225-0.


Dynamic population pharmacokinetic-pharmacodynamic modelling and simulation supports similar efficacy in glycosylated haemoglobin response with once or twice-daily dosing of canagliflozin.

de Winter W, Dunne A, de Trixhe XW, Devineni D, Hsu CH, Pinheiro J, Polidori D.

Br J Clin Pharmacol. 2017 May;83(5):1072-1081. doi: 10.1111/bcp.13180. Epub 2017 Jan 31.


MyD88 adapter-like (Mal) is phosphorylated by Bruton's tyrosine kinase during TLR2 and TLR4 signal transduction.

Gray P, Dunne A, Brikos C, Jefferies CA, Doyle SL, O Neill LA.

J Biol Chem. 2016 Dec 9;291(50):26240. No abstract available.


IRAK1 and IRAK4 promote phosphorylation, ubiquitination, and degradation of MyD88 adaptor-like (Mal).

Dunne A, Carpenter S, Brikos C, Gray P, Strelow A, Wesche H, Morrice N, O'Neill LA.

J Biol Chem. 2016 Nov 18;291(47):24802. No abstract available.


Suppression of human alloreactive T cells by linear tetrapyrroles; relevance for transplantation.

Basdeo SA, Campbell NK, Sullivan LM, Flood B, Creagh EM, Mantle TJ, Fletcher JM, Dunne A.

Transl Res. 2016 Dec;178:81-94.e2. doi: 10.1016/j.trsl.2016.07.011. Epub 2016 Jul 21.


Intra-articular basic calcium phosphate and monosodium urate crystals inhibit anti-osteoclastogenic cytokine signalling.

Cunningham CC, Corr EM, McCarthy GM, Dunne A.

Osteoarthritis Cartilage. 2016 Dec;24(12):2141-2152. doi: 10.1016/j.joca.2016.07.001. Epub 2016 Jul 15.


Cholesterol crystals activate Syk and PI3 kinase in human macrophages and dendritic cells.

Corr EM, Cunningham CC, Dunne A.

Atherosclerosis. 2016 Aug;251:197-205. doi: 10.1016/j.atherosclerosis.2016.06.035. Epub 2016 Jun 22.


Adsorption and desorption of arsenate on sandy sediments from contaminated and uncontaminated saturated zones: Kinetic and equilibrium modeling.

Hafeznezami S, Zimmer-Faust AG, Dunne A, Tran T, Yang C, Lam JR, Reynolds MD, Davis JA, Jay JA.

Environ Pollut. 2016 Aug;215:290-301. doi: 10.1016/j.envpol.2016.05.029. Epub 2016 May 21.


Oxygen Mass Transport in Stented Coronary Arteries.

Murphy EA, Dunne AS, Martin DM, Boyle FJ.

Ann Biomed Eng. 2016 Feb;44(2):508-22. doi: 10.1007/s10439-015-1501-6. Epub 2015 Nov 16.


NAA10 mutation causing a novel intellectual disability syndrome with Long QT due to N-terminal acetyltransferase impairment.

Casey JP, Støve SI, McGorrian C, Galvin J, Blenski M, Dunne A, Ennis S, Brett F, King MD, Arnesen T, Lynch SA.

Sci Rep. 2015 Nov 2;5:16022. doi: 10.1038/srep16022.


Population Pharmacokinetic Modeling of Canagliflozin in Healthy Volunteers and Patients with Type 2 Diabetes Mellitus.

Hoeben E, De Winter W, Neyens M, Devineni D, Vermeulen A, Dunne A.

Clin Pharmacokinet. 2016 Feb;55(2):209-23. doi: 10.1007/s40262-015-0307-x.


The method of averaging applied to pharmacokinetic/pharmacodynamic indirect response models.

Dunne A, de Winter W, Hsu CH, Mariam S, Neyens M, Pinheiro J, Woot de Trixhe X.

J Pharmacokinet Pharmacodyn. 2015 Aug;42(4):417-26. doi: 10.1007/s10928-015-9426-0. Epub 2015 Jul 5.


Discovery of GSK2795039, a Novel Small Molecule NADPH Oxidase 2 Inhibitor.

Hirano K, Chen WS, Chueng AL, Dunne AA, Seredenina T, Filippova A, Ramachandran S, Bridges A, Chaudry L, Pettman G, Allan C, Duncan S, Lee KC, Lim J, Ma MT, Ong AB, Ye NY, Nasir S, Mulyanidewi S, Aw CC, Oon PP, Liao S, Li D, Johns DG, Miller ND, Davies CH, Browne ER, Matsuoka Y, Chen DW, Jaquet V, Rutter AR.

Antioxid Redox Signal. 2015 Aug 10;23(5):358-74. doi: 10.1089/ars.2014.6202.


Investigating inflammasome activation under conditions of cellular stress and injury.

Cunningham CC, Corr EM, Cox DJ, Dunne A.

Methods Mol Biol. 2015;1292:105-13. doi: 10.1007/978-1-4939-2522-3_8.


DNA sensors are expressed in astrocytes and microglia in vitro and are upregulated during gliosis in neurodegenerative disease.

Cox DJ, Field RH, Williams DG, Baran M, Bowie AG, Cunningham C, Dunne A.

Glia. 2015 May;63(5):812-25. doi: 10.1002/glia.22786. Epub 2015 Jan 27.


ARA 290, a nonerythropoietic peptide engineered from erythropoietin, improves metabolic control and neuropathic symptoms in patients with type 2 diabetes.

Brines M, Dunne AN, van Velzen M, Proto PL, Ostenson CG, Kirk RI, Petropoulos IN, Javed S, Malik RA, Cerami A, Dahan A.

Mol Med. 2015 Mar 13;20:658-66. doi: 10.2119/molmed.2014.00215.


A novel TLR2 agonist from Bordetella pertussis is a potent adjuvant that promotes protective immunity with an acellular pertussis vaccine.

Dunne A, Mielke LA, Allen AC, Sutton CE, Higgs R, Cunningham CC, Higgins SC, Mills KH.

Mucosal Immunol. 2015 May;8(3):607-17. doi: 10.1038/mi.2014.93. Epub 2014 Oct 15.


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