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Arnold-Chiari Type I Manifesting as Bipolar Disorder.

Hong J, Lee J, Kim S, Dunn NR, Swift RG.

Prim Care Companion CNS Disord. 2019 Apr 11;21(2). pii: 18l02368. doi: 10.4088/PCC.18l02368. No abstract available.


GATA6 Cooperates with EOMES/SMAD2/3 to Deploy the Gene Regulatory Network Governing Human Definitive Endoderm and Pancreas Formation.

Chia CY, Madrigal P, Denil SLIJ, Martinez I, Garcia-Bernardo J, El-Khairi R, Chhatriwala M, Shepherd MH, Hattersley AT, Dunn NR, Vallier L.

Stem Cell Reports. 2019 Jan 8;12(1):57-70. doi: 10.1016/j.stemcr.2018.12.003.


The endoderm from a diverse perspective.

Dunn NR, Hogan BLM.

Development. 2018 Aug 16;145(17). pii: dev163550. doi: 10.1242/dev.163550. Review.


Functional analysis of a hypomorphic allele shows that MMP14 catalytic activity is the prime determinant of the Winchester syndrome phenotype.

de Vos IJHM, Tao EY, Ong SLM, Goggi JL, Scerri T, Wilson GR, Low CGM, Wong ASW, Grussu D, Stegmann APA, van Geel M, Janssen R, Amor DJ, Bahlo M, Dunn NR, Carney TJ, Lockhart PJ, Coull BJ, van Steensel MAM.

Hum Mol Genet. 2018 Aug 15;27(16):2775-2788. doi: 10.1093/hmg/ddy168.


MINDY1 Is a Downstream Target of the Polyamines and Promotes Embryonic Stem Cell Self-Renewal.

James C, Zhao TY, Rahim A, Saxena P, Muthalif NA, Uemura T, Tsuneyoshi N, Ong S, Igarashi K, Lim CY, Dunn NR, Vardy LA.

Stem Cells. 2018 Aug;36(8):1170-1178. doi: 10.1002/stem.2830. Epub 2018 Apr 22.


Directed differentiation of periocular mesenchyme from human embryonic stem cells.

Lovatt M, Yam GH, Peh GS, Colman A, Dunn NR, Mehta JS.

Differentiation. 2018 Jan - Feb;99:62-69. doi: 10.1016/j.diff.2017.11.003. Epub 2017 Nov 16.


PRDM15 safeguards naive pluripotency by transcriptionally regulating WNT and MAPK-ERK signaling.

Mzoughi S, Zhang J, Hequet D, Teo SX, Fang H, Xing QR, Bezzi M, Seah MKY, Ong SLM, Shin EM, Wollmann H, Wong ESM, Al-Haddawi M, Stewart CL, Tergaonkar V, Loh YH, Dunn NR, Messerschmidt DM, Guccione E.

Nat Genet. 2017 Sep;49(9):1354-1363. doi: 10.1038/ng.3922. Epub 2017 Jul 24.


ELABELA deficiency promotes preeclampsia and cardiovascular malformations in mice.

Ho L, van Dijk M, Chye STJ, Messerschmidt DM, Chng SC, Ong S, Yi LK, Boussata S, Goh GH, Afink GB, Lim CY, Dunn NR, Solter D, Knowles BB, Reversade B.

Science. 2017 Aug 18;357(6352):707-713. doi: 10.1126/science.aam6607. Epub 2017 Jun 29.


Long-Term Culture of Self-renewing Pancreatic Progenitors Derived from Human Pluripotent Stem Cells.

Trott J, Tan EK, Ong S, Titmarsh DM, Denil SLIJ, Giam M, Wong CK, Wang J, Shboul M, Eio M, Cooper-White J, Cool SM, Rancati G, Stanton LW, Reversade B, Dunn NR.

Stem Cell Reports. 2017 Jun 6;8(6):1675-1688. doi: 10.1016/j.stemcr.2017.05.019.


Methadone-Induced Hyperhidrosis Treated With Oxybutynin.

Hong J, Lee J, Totouom-Tangho H, Dunn NR, Swift RG.

J Addict Med. 2017 May/Jun;11(3):237-238. doi: 10.1097/ADM.0000000000000300.


Re-engineered RNA-Guided FokI-Nucleases for Improved Genome Editing in Human Cells.

Havlicek S, Shen Y, Alpagu Y, Bruntraeger MB, Zufir NB, Phuah ZY, Fu Z, Dunn NR, Stanton LW.

Mol Ther. 2017 Feb 1;25(2):342-355. doi: 10.1016/j.ymthe.2016.11.007.


Ptk7 and Mcc, Unfancied Components in Non-Canonical Wnt Signaling and Cancer.

Dunn NR, Tolwinski NS.

Cancers (Basel). 2016 Jul 16;8(7). pii: E68. doi: 10.3390/cancers8070068. Review.


Cyclobenzaprine-Induced Hallucinosis.

Bulbena-Cabre A, Dunn NR, Swift RG.

Prim Care Companion CNS Disord. 2015 Jun 25;17(3). doi: 10.4088/PCC.14l01773. eCollection 2015. No abstract available.


ELABELA Is an Endogenous Growth Factor that Sustains hESC Self-Renewal via the PI3K/AKT Pathway.

Ho L, Tan SY, Wee S, Wu Y, Tan SJ, Ramakrishna NB, Chng SC, Nama S, Szczerbinska I, Chan YS, Avery S, Tsuneyoshi N, Ng HH, Gunaratne J, Dunn NR, Reversade B.

Cell Stem Cell. 2015 Oct 1;17(4):435-47. doi: 10.1016/j.stem.2015.08.010. Epub 2015 Sep 17. Erratum in: Cell Stem Cell. 2015 Nov 5;17(5):635. Sczerbinska, Iwona [corrected to Szczerbinska, Iwona].


PDX1 binds and represses hepatic genes to ensure robust pancreatic commitment in differentiating human embryonic stem cells.

Teo AK, Tsuneyoshi N, Hoon S, Tan EK, Stanton LW, Wright CV, Dunn NR.

Stem Cell Reports. 2015 Apr 14;4(4):578-90. doi: 10.1016/j.stemcr.2015.02.015. Epub 2015 Apr 2.


The PDZ domain protein Mcc is a novel effector of non-canonical Wnt signaling during convergence and extension in zebrafish.

Young T, Poobalan Y, Tan EK, Tao S, Ong S, Wehner P, Schwenty-Lara J, Lim CY, Sadasivam A, Lovatt M, Wang ST, Ali Y, Borchers A, Sampath K, Dunn NR.

Development. 2014 Sep;141(18):3505-16. doi: 10.1242/dev.114033.


Psychosis after right temporal lobe tumor resection and recurrence.

Krayem BH, Dunn NR, Swift RG.

J Neuropsychiatry Clin Neurosci. 2014 Winter;26(1):E47. doi: 10.1176/appi.neuropsych.13030051. No abstract available.


Guards at the gate to embryonic stem cell differentiation.

Tsuneyoshi N, Dunn NR.

Cell. 2013 Apr 11;153(2):281-3. doi: 10.1016/j.cell.2013.03.037.


The SMAD2/3 corepressor SNON maintains pluripotency through selective repression of mesendodermal genes in human ES cells.

Tsuneyoshi N, Tan EK, Sadasivam A, Poobalan Y, Sumi T, Nakatsuji N, Suemori H, Dunn NR.

Genes Dev. 2012 Nov 15;26(22):2471-6. doi: 10.1101/gad.201772.112.


Activin and BMP4 synergistically promote formation of definitive endoderm in human embryonic stem cells.

Teo AK, Ali Y, Wong KY, Chipperfield H, Sadasivam A, Poobalan Y, Tan EK, Wang ST, Abraham S, Tsuneyoshi N, Stanton LW, Dunn NR.

Stem Cells. 2012 Apr;30(4):631-42. doi: 10.1002/stem.1022.


Dandy walker variant with treatment-resistant bipolar disorder.

Aimua F, Dunn NR, Swift RG.

J Neuropsychiatry Clin Neurosci. 2012 Winter;24(1):E50. doi: 10.1176/appi.neuropsych.11030068. No abstract available.


Mutated in colorectal cancer (Mcc), a candidate tumor suppressor, is dynamically expressed during mouse embryogenesis.

Young T, Poobalan Y, Ali Y, Siew Tein W, Sadasivam A, Ee Kim T, Erica Tay P, Dunn NR.

Dev Dyn. 2011 Sep;240(9):2166-74. doi: 10.1002/dvdy.22712.


Activin/Nodal signaling controls divergent transcriptional networks in human embryonic stem cells and in endoderm progenitors.

Brown S, Teo A, Pauklin S, Hannan N, Cho CH, Lim B, Vardy L, Dunn NR, Trotter M, Pedersen R, Vallier L.

Stem Cells. 2011 Aug;29(8):1176-85. doi: 10.1002/stem.666.


Pluripotency factors regulate definitive endoderm specification through eomesodermin.

Teo AK, Arnold SJ, Trotter MW, Brown S, Ang LT, Chng Z, Robertson EJ, Dunn NR, Vallier L.

Genes Dev. 2011 Feb 1;25(3):238-50. doi: 10.1101/gad.607311. Epub 2011 Jan 18.


p38MAPK controls expression of multiple cell cycle inhibitors and islet proliferation with advancing age.

Wong ES, Le Guezennec X, Demidov ON, Marshall NT, Wang ST, Krishnamurthy J, Sharpless NE, Dunn NR, Bulavin DV.

Dev Cell. 2009 Jul;17(1):142-9. doi: 10.1016/j.devcel.2009.05.009.


Teratoma formation by human embryonic stem cells: evaluation of essential parameters for future safety studies.

Hentze H, Soong PL, Wang ST, Phillips BW, Putti TC, Dunn NR.

Stem Cell Res. 2009 May;2(3):198-210. doi: 10.1016/j.scr.2009.02.002. Epub 2009 Feb 12.


The generation of six clinical-grade human embryonic stem cell lines.

Crook JM, Peura TT, Kravets L, Bosman AG, Buzzard JJ, Horne R, Hentze H, Dunn NR, Zweigerdt R, Chua F, Upshall A, Colman A.

Cell Stem Cell. 2007 Nov;1(5):490-4. No abstract available.


Self-renewal made simple.

Dunn NR.

Cell Stem Cell. 2008 Jul 3;3(1):7-8. doi: 10.1016/j.stem.2008.06.007.


Directed differentiation of human embryonic stem cells into the pancreatic endocrine lineage.

Phillips BW, Hentze H, Rust WL, Chen QP, Chipperfield H, Tan EK, Abraham S, Sadasivam A, Soong PL, Wang ST, Lim R, Sun W, Colman A, Dunn NR.

Stem Cells Dev. 2007 Aug;16(4):561-78.


Three-dimensional extracellular matrix stimulates gastrulation-like events in human embryoid bodies.

Rust WL, Sadasivam A, Dunn NR.

Stem Cells Dev. 2006 Dec;15(6):889-904.


A potential novel strategy to separate therapeutic- and side-effects that are mediated via the same receptor: beta-arrestin2/G-protein coupling antagonists.

Bruns IR, Chhum S, Dinh AT, Doerr H, Dunn NR, Ly YT, Mitman CL, Rickards HD, Sol C, Wan EW, Raffa RB.

J Clin Pharm Ther. 2006 Apr;31(2):119-28. Review. No abstract available.


Repressed by a NuRD.

Crook JM, Dunn NR, Colman A.

Nat Cell Biol. 2006 Mar;8(3):212-4. No abstract available.


Multiple genetic loci from CAST/EiJ chromosome 1 affect vBMD either positively or negatively in a C57BL/6J background.

Edderkaoui B, Baylink DJ, Beamer WG, Wergedal JE, Dunn NR, Shultz KL, Mohan S.

J Bone Miner Res. 2006 Jan;21(1):97-104. Epub 2005 Oct 17.


The zinc finger transcriptional repressor Blimp1/Prdm1 is dispensable for early axis formation but is required for specification of primordial germ cells in the mouse.

Vincent SD, Dunn NR, Sciammas R, Shapiro-Shalef M, Davis MM, Calame K, Bikoff EK, Robertson EJ.

Development. 2005 Mar;132(6):1315-25.


Mice exclusively expressing the short isoform of Smad2 develop normally and are viable and fertile.

Dunn NR, Koonce CH, Anderson DC, Islam A, Bikoff EK, Robertson EJ.

Genes Dev. 2005 Jan 1;19(1):152-63.


Differential requirements for Smad4 in TGFbeta-dependent patterning of the early mouse embryo.

Chu GC, Dunn NR, Anderson DC, Oxburgh L, Robertson EJ.

Development. 2004 Aug;131(15):3501-12. Epub 2004 Jun 23.


Combinatorial activities of Smad2 and Smad3 regulate mesoderm formation and patterning in the mouse embryo.

Dunn NR, Vincent SD, Oxburgh L, Robertson EJ, Bikoff EK.

Development. 2004 Apr;131(8):1717-28. Epub 2004 Mar 17.


Case and control recruitment, and validation of cases for the MICA case-control study in England, Scotland and Wales.

Dunn NR, Arscott A, Thorogood M, Thomas S, Davison H, Richardson J.

Pharmacoepidemiol Drug Saf. 1999 Jul;8(4):285-90.


Prescription-event monitoring (PEM) in 1996-a method of non-interventional observational cohort pharmacovigilance.

Mann RD, Wilton LV, Pearce GL, Mackay FJ, Dunn NR.

Pharmacoepidemiol Drug Saf. 1997 Oct;6 Suppl 3:S5-11. No abstract available.


Cell fate decisions within the mouse organizer are governed by graded Nodal signals.

Vincent SD, Dunn NR, Hayashi S, Norris DP, Robertson EJ.

Genes Dev. 2003 Jul 1;17(13):1646-62.


Mouse embryos lacking Smad1 signals display defects in extra-embryonic tissues and germ cell formation.

Tremblay KD, Dunn NR, Robertson EJ.

Development. 2001 Sep;128(18):3609-21.


How does the mouse get its trunk?

Dunn NR, Hogan BL.

Nat Genet. 2001 Apr;27(4):351-2. No abstract available.


Adverse effects associated with the use of donepezil in general practice in England.

Dunn NR, Pearce GL, Shakir SA.

J Psychopharmacol. 2000;14(4):406-8.


Association between SSRIs and upper gastrointestinal bleeding. SSRIs are no more likely than other drugs to cause such bleeding.

Dunn NR, Pearce GL, Shakir SA.

BMJ. 2000 May 20;320(7246):1405-6. No abstract available.


Regional variation in incidence and case fatality of myocardial infarction among young women in England, Scotland and Wales.

Dunn NR, Arscott A, Thorogood M, Faragher B, de Caestecker L, MacDonald TM, McCollum C, Thomas S, Mann RD.

J Epidemiol Community Health. 2000 Apr;54(4):293-8.

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